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  Functional Role of Transcription Factor Sp1 in Brain Neuronal Injury (II)

  Chang, W.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effect of pacemaker current inhibitor (Ivabradine) on sinoatrial node function and pulmonary vein arrhythmogenesis

  Lin, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• New Strategies of Parkinson’s Disease Treatment

  Chiang, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Prp: Platelet-Rich Plasma Effects in the Articular Chondrocytes and Synovial Fibroblasts with the Associated Mechanism---A Fibronectin Fragment Model

  Lee, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Characterization of 5-Hydroxymethylcytosine and Ten-to-Eleven Translocation Gene (TET) in Cervical Cancer

  Lai, H.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• A Clinical Correlation study of DNA Methyltransferases Alterations in Breast Cancer and Evaluation of DNA Methyltransferases as a Therapeutic Target in Cell and Animal Models

  Lin, R.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Investigating of Transcranial Direct Current Stimulation and Robot-Assisted Gait Training Effects in Subjects with Stroke

  Lai, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Role of ADAM 17 in Hypoxia-Induced CTGF Expression and Pulmonary Fibrosis (I)

  Chen, B.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• A Study on the Influence of Classical Mathematics Reading Course on Medical Students Beliefs about Mathematics

  Ying, J.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Cultivation of Young Scholars: Philosophy of Consciousness

  Lane, T. J.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Writing for Scholarly Publication in English for Researchers in the Fields of Social Sciences, Natural Sciences, Engineering, and Medicine in Higher Education in Taiwan

  Chien, S.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Novel activities of gamma-aminobutyric acid-mediated regulation of platelet activation, apoptosis, and autophagy: the non-genomic functions of NF-kappaB signal in anucleated cells

  Sheu, J.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Investigating the Differential Effects and the Mechanisms of Flavonols on Osteogenic Differentiation of Human Dental Pulp Stem Cells

  Lee, S.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Pulmonary effects of chorioamnionitis and postnatal hyperoxia in rat offspring

  Chen, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effects of a program of mind-body interventions on psychological resilience, vagal tone, emotional states, and outcomes of heart failure

  Tsai, P.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Study of Antidepressive and Cognition Improvement Property of N-3 Fatty Acids on Metabolic Syndroms

  Huang, S.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Analyses the Role of ADAM9-Hemidesmosome Components Interaction in Malignant Cancer Metastasis and Future Therapeutic Strategy

  Sung, S.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• To Investigate the Functions of Shikonin and Its Derivatives in Applied Age-Related Macular Degeneration and Wound Healining

  Cheng, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• 晚期乳癌組織中尼古丁受體(α9-nAChR)表現與Trastuzumab (Herceptin®)產生抗藥性之分子機制探討

  Ho, Y.

  8/1/13 → 7/31/14

  Project: B - Project of TMU › i - Other (Funded by TMU)

• Evaluation of Therapeutic Correlation of Nanomedicine with Tea Polyphenol for Inhibition of Ocular Surface Inflammation in Rabbit Dry Eye Model

  Tseng, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• The role and molecular mechanism of PPARα in acute kidney injury: focus on the protective effect in renal tubular cell

  Hsu, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• The relationship and predictors of electrocardiography, inflammatory markers, clinical features in older bipolar and schizophrenia patients concurrent with coronary heart and cerebro-vascular diseases

  Tsai, S.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• 《Understanding International Conflicts：An Introduction to Theory and History》Translation and Annotation Project

  Chang, K.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Effects of Neurofeedback and Rsa Biofeedback on Quality of Sleep in Patients in the Chronic Phase of Traumatic Brain Injury(1/3)

  Tsai, P.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Translational studies of Mycobacterium tuberculosis-induced lung and pleural fibrosis

  Lin, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• 三陰性乳癌周邊微環境之研究平台建立：以玻尿酸合成酉每Ⅲ抑癌作用為例(1/3)

  Ho, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Study the Klf10 alters metabolic pathways in genetic-deficient mice and human pancreatic ductal carcinomas

  Chang, H.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Survey and Intervention of Health Literacy among Older Adults

  Chi, M.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Epigenetic Control of IL-6-STAT3 Targeting Dnas in the Cell of Dihydropyridine-Induced Gingival Overgrowth

  Lu, H.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Optimization of Human Meniscus Imaging and Its Clinical Application for Osteoarthritis

  Tsai, P.

  8/1/13 → 10/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• 榖胱甘月太硫轉移酉每參與乳癌致癌之分子機制探討(2/3)

  Wu, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Impact of Coping Skills Training on Stress, Symptom Distress in Children with Cancer

  Chen, S.

  8/1/13 → 10/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Huntingtin-Associated Protein-Regulated Biomarkers in Neurodegenerative Diseases

  Lin, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Reflex Pelvic Floor Muscle Activities in Women with Urinary Incontinence (II)

  Yang, J.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Studies on a Thermosensitive Hydrogel of Doxorubicin as Locally Controlled Delivery of Cancer Therapeutics

  Ho, H.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Ffects of Different Sources of n-3 Fatty Acids on Bone Loss, Body Fat and Inflammatory Markers in Osteoporotic Condition with Diabetes

  Chiu, W.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effects and Mechanisms of Massotherapy of Acupoints, Gene Polymorphisms of RRM1 and RRM2 on Relieving Chemotherapy-Induced Myelossupression among Patients with Cervical Cancer

  Tsai, H.

  8/1/13 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Preclinical Assessment of the Potential Prognostic and Therapeutic Values of Hippo Signaling Cascade in Targeting Therapy-Resistant Cancer Stem Cells in Hepatocellular Carcinoma

  Lee, W.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Application of Hyaluronic Acid and Resveratrol Modified Carbon Nanotube Scaffolds for Tissue Engineering

  Sheu, S.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Association Study of Persistent Metabolic Syndrome, Inflammatory Markers and Mild Cognitive Decline

  Bai, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Distribution of the Number of False Discoveries in Genome-Wide Linkage Scan

  Wang, W.

  8/1/13 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Studies on the carcinogenic mechanisms of histamine N-methyltransferase-mediated breast cancer formation

  Wu, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Research of Harmful Substances in Water on Human Reproductive and Neuronal Cells Toxicity Translation Assessment (I)

  Mai, F.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Synaptic Plasticity by Nogo-1 Receptor Overexpression and Exendin-4 Administration on Behavioral and Electrophysiological Recovery after Mild Traumatic Brain Injury (II)

  Tsai, S.

  8/1/13 → 7/31/14

  Project: B - Project of TMU › i - Other (Funded by TMU)

• Model Comparison Within Diagnostic Accuracy Test Model in Meta-Analysis

  Chen, J.

  8/1/13 → 10/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Saliva Alkaloids of Areca Nut or Tobacco, Inflammatory and Antioxidants Status and Oral Hygiene in Periodontitis Patients

  Huang, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Deferasirox Plasma Concentration Analysis and Effects of Potential Iron Chelators on Iron Overload and Safety Evaluation

  Wu, T.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Temozolomide-Mediated Gene and microRNA Expression Networks in the Inhibition of Glioblastoma Multiforme Formation by High Through-Put Sequencing Analysis

  Chen, K.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• 大腸直腸癌已躍居世界上癌症死亡率第二名，屬於固體型腫瘤，缺氧常見於此類 腫瘤，並誘發HIF-1α 表現而導致抗藥性及預後較差，因此抑制HIF-1α 被視為新的抗 癌策略。Zebularine (Zeb)是較穩定之DNA methyltransferase (DNMT)抑制劑，可殺死癌 細胞而不影響正常細胞，對小鼠也不具毒性。我們初步結果顯示，Zeb 可抑制人類大 腸癌細胞株HCT116 之HIF-1α表現，代表Zeb 是治療大腸直腸癌之潛力藥物。我們的 初步也證明Zeb對HCT116具毒殺性，對小鼠大腸癌也有療效。細胞自我吞噬(autophagy) 是指細胞在惡劣環境下，經由吞噬細胞內物質產生能量渡過外界壓力的一種保護機 制；也有研究報導指出，藥物會誘導癌細胞產生autophagy，造成細胞過度吞噬其內容 物而死亡，因此，autophagy在癌細胞為保護或是引發毒殺作用，目前仍無定論。缺氧 也會透過HIF-1α 導致autophagy 而促進細胞存活，但嚴重缺氧或無氧狀態則可透過活 化AMPK及unfolded protein response (UPR)造成autophagic cell death。我們初步結果顯 示，除抑制HIF-1α 表現外，Zeb 也可活化AMPK、UPR/ER stress、以及autophagy， 因此我們推測Zeb 可在缺氧狀態下，促進autophagic cell death。3 年內我們將執行4 項 目標： (1) 探討Zeb 在各種癌細胞及活體模式之抗癌作用。（第一年） (2) 研究Zeb 抑制HIF-1α表現之分子機轉。（第一年到第二年） (3) 研究Zeb 誘發autophagy之分子機轉。（第二年到第三年） (4) 探討Zeb 對缺氧導致抗藥性之作用。（第三年）

  Yang, P.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Study of Postoperative Adverse Outcomes of Surgical Patients Using Taiwan National Health Insurance Database

  Chen, T.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology