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• The Molecular and Clinical Role of microRNA in Obesity Induced Nephropathy

  Lin, H.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Indoxyl Sulfate, Chronic Kidney Disease and Heat Shock Protein Modulate the Atrial Electrophysiological Characteristics

  Hsieh, M.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Evaluation of Therapeutic Correlation of Nanomedicine with Tea Polyphenol for Inhibition of Ocular Surface Inflammation in Rabbit Dry Eye Model

  Tseng, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Explore of Toll-Like Receptors Associated Mirna Expression in Ischemic Stroke Patients (I)

  Wu, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• TMU101-AE1-B64

  Fang, S.

  8/1/13 → 7/31/16

  Project: C - Project of Alliance › u - Taipei Medical University Shuang Ho Hospital

• Use the organometal catalytic reaction to synthesize the heterocycle-based anticancer agents

  Liou, J.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Ffects of Different Sources of n-3 Fatty Acids on Bone Loss, Body Fat and Inflammatory Markers in Osteoporotic Condition with Diabetes

  Chiu, W.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• The effect of endothelin-1 on myofibroblast transformation of pleural mesothelial cells and its implications for pleural and pulmonary fibrosis

  Chung, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Trade, Economic Factors, Envrionmental Hazards, and Risks of Infant and Child Mortality in Developing Countries

  Chuang, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Cellular and Molecular Mechanisms of Nicotine and Nitrosamines Promote Tumorigenic Behaviors in Renal Cell Carcinoma (Ii)

  Cheng, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Glucagon-Like Peptide-1 in the Regulation of PPARs and Calcium Handling in Hyperglycemia or Hypertensive HL-1 Cells

  Huang, J.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Explore of Toll-Like Receptors Associated Mirna Expression in Ischemic Stroke Patients (I)

  Wu, C.

  8/1/13 → 7/31/14

  Project: B - Project of TMU › i - Other (Funded by TMU)

• Studies on a Thermosensitive Hydrogel of Doxorubicin as Locally Controlled Delivery of Cancer Therapeutics

  Ho, H.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Study the Therapeutic Effects and Novel Molecular Mechanisms of Resveratrol in Human Osteosarcoma: the Treatment of Metastatic Cancer

  Chien, M.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Investigation on developing novel biomarkers and treatments in the patients with fibromyalgia

  Kang, J.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Using Cometing Risk Model for Death and Multi-state Stochastic Process for the Behaviour of Betel-quid Chewing and Smoking to Estimate the Potential Years of Life Lost Due to Betel Quid and to Estiamte the Impact of Qutiing Betel-quid chewing

  Yen, M.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Effects of Electroconvulsive Therapy on Health Services Utilization, Positive and Negative Syndrome, and Sleep among Psychiatric Patients

  Chung, M.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Sleep and Memory Consilidation in Alzheimer Disease

  Hu, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• 設計並評估新型含藥人工骨凝膠對齒槽骨缺損的修復作用

  Lee, S.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Novel activities of gamma-aminobutyric acid-mediated regulation of platelet activation, apoptosis, and autophagy: the non-genomic functions of NF-kappaB signal in anucleated cells

  Sheu, J.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• 榖胱甘月太硫轉移酉每參與乳癌致癌之分子機制探討(2/3)

  Wu, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Association between lipid, glucose related genes and prognosis of intra- and extra-cranial stenosis in stroke patients

  Chiou, H.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• New Strategies of Parkinson’s Disease Treatment

  Chiang, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Association Study of Genetic Polymorphisms of Toll-Like Receptors on Ischemic Stroke (I)

  Chiou, H.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Development of Strontium-Impregnated Bioabsorbable Bone Screw for Fracture Fixation in Osteoporotic Bone

  Yang, K.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• To Predict the Recurrence of Major Depressive Disorder Within an Integrated Bio-Psycho-Social Framework---A Follow-up Study

  Lee, H.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effects and Mechanisms of Massotherapy of Acupoints, Gene Polymorphisms of RRM1 and RRM2 on Relieving Chemotherapy-Induced Myelossupression among Patients with Cervical Cancer

  Tsai, H.

  8/1/13 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• The influence of Porphyromonas gingivalis GroEL in vascular cells

  Lin, F.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Model Comparison Within Diagnostic Accuracy Test Model in Meta-Analysis

  Chen, J.

  8/1/13 → 10/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Dissected the role of Glucosed-regulated portein 78 in the progression, metastasis and therapy of colorectal cancer

  Wei, P.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• 利用基因工程誘導性潛能幹細胞治療巴金森氏症之研究

  Chiang, Y.

  8/1/13 → 7/31/14

  Project: B - Project of TMU › i - Other (Funded by TMU)

• Molecular and cellular mechanism of adipocyte modulatory effects on pulmonary vein and atrium

  Chen, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Synaptic Plasticity by Nogo-1 Receptor Overexpression and Exendin-4 Administration on Behavioral and Electrophysiological Recovery after Mild Traumatic Brain Injury (II)

  Tsai, S.

  8/1/13 → 7/31/14

  Project: B - Project of TMU › i - Other (Funded by TMU)

• SHE(Smart Health Elderly)的社區照護

  Shiao, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › d - Ministry of Education

• Impact of Coping Skills Training on Stress, Symptom Distress in Children with Cancer

  Chen, S.

  8/1/13 → 10/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Huntingtin-Associated Protein-Regulated Biomarkers in Neurodegenerative Diseases

  Lin, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Victorian Sanitation: Narratives of Poverty, Filth and Economy of Morality

  Chen, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Investigating of Transcranial Direct Current Stimulation and Robot-Assisted Gait Training Effects in Subjects with Stroke

  Lai, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Enhancement of immuno-modulatory capacity by shear stress in mesenchymal stem cells

  Ho, J.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Smart Microtube Array Membrane Scaffold for Nerve Regeneration---Fabrication, in vitro and in vivo Evaluation

  Chen, C.

  8/1/13 → 10/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Temozolomide-Mediated Gene and microRNA Expression Networks in the Inhibition of Glioblastoma Multiforme Formation by High Through-Put Sequencing Analysis

  Chen, K.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Real-Time Single-Cell Probing of the Action Mechanism of Amphotericin B Ion Channels---From Extracellular to Intracellular

  Yang, T.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• 102年台北市立聯合醫院忠孝院區員工體適能檢測計畫

  Kan, N.

  8/1/13 → 12/31/13

  Project: A - Government Institution › f - Other (Funded by Government)

• Therapeutic Strategies for Traumatic Brain Injury with Novelly Desinged Drugs (II)

  Wang, J.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Assessment of Iron Status in Overweight and Obese Adolescents

  Chang, J.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Immune Alteration and Immunogenic Cell Death in Advanced Non-Small Cell Lung Cancer Patients

  Feng, P.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• TMU101-AE1-B66

  Lin, J. A.

  8/1/13 → 12/31/14

  Project: C - Project of Alliance › p - Taipei Medical University Hospital

• Studies on the anti-islet hypertrophy and anti-osteoporosis constituents from Formosan Fern

  Hsu, F.

  8/1/13 → 12/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Trends in Surgical Litigation and Media Coverage of Medical Malpractice: Implications for Medical Education

  Lyu, S.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• 大腸直腸癌已躍居世界上癌症死亡率第二名，屬於固體型腫瘤，缺氧常見於此類 腫瘤，並誘發HIF-1α 表現而導致抗藥性及預後較差，因此抑制HIF-1α 被視為新的抗 癌策略。Zebularine (Zeb)是較穩定之DNA methyltransferase (DNMT)抑制劑，可殺死癌 細胞而不影響正常細胞，對小鼠也不具毒性。我們初步結果顯示，Zeb 可抑制人類大 腸癌細胞株HCT116 之HIF-1α表現，代表Zeb 是治療大腸直腸癌之潛力藥物。我們的 初步也證明Zeb對HCT116具毒殺性，對小鼠大腸癌也有療效。細胞自我吞噬(autophagy) 是指細胞在惡劣環境下，經由吞噬細胞內物質產生能量渡過外界壓力的一種保護機 制；也有研究報導指出，藥物會誘導癌細胞產生autophagy，造成細胞過度吞噬其內容 物而死亡，因此，autophagy在癌細胞為保護或是引發毒殺作用，目前仍無定論。缺氧 也會透過HIF-1α 導致autophagy 而促進細胞存活，但嚴重缺氧或無氧狀態則可透過活 化AMPK及unfolded protein response (UPR)造成autophagic cell death。我們初步結果顯 示，除抑制HIF-1α 表現外，Zeb 也可活化AMPK、UPR/ER stress、以及autophagy， 因此我們推測Zeb 可在缺氧狀態下，促進autophagic cell death。3 年內我們將執行4 項 目標： (1) 探討Zeb 在各種癌細胞及活體模式之抗癌作用。（第一年） (2) 研究Zeb 抑制HIF-1α表現之分子機轉。（第一年到第二年） (3) 研究Zeb 誘發autophagy之分子機轉。（第二年到第三年） (4) 探討Zeb 對缺氧導致抗藥性之作用。（第三年）

  Yang, P.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology