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  Community-based Screening and Prevention Model for Periodontal Disease

  Chen, L.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effects and Mechanisms of Massotherapy of Acupoints, Gene Polymorphisms of RRM1 and RRM2 on Relieving Chemotherapy-Induced Myelossupression among Patients with Cervical Cancer

  Tsai, H.

  8/1/13 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• TMU102-AE1-B20

  Hsieh, C.

  8/1/13 → 7/31/16

  Project: B - Project of TMU › g - Research Grants for Newly Hired Faculty

• Saliva Alkaloids of Areca Nut or Tobacco, Inflammatory and Antioxidants Status and Oral Hygiene in Periodontitis Patients

  Huang, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Synaptic Plasticity by Nogo-1 Receptor Overexpression and Exendin-4 Administration on Behavioral and Electrophysiological Recovery after Mild Traumatic Brain Injury (II)

  Tsai, S.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• An association study of arsenic exposure, inflammation, oxidative stress and the risk of developing cardiovascular diseases

  Hsieh, F.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Effects of Music Listening on Pain, Heart Rate Variability and Joint Range of Motion for Patints Receving Total Knee Replacement

  Lin, P.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Pulmonary effects of chorioamnionitis and postnatal hyperoxia in rat offspring

  Chen, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Molecular and Clinical Role of microRNA in Obesity Induced Nephropathy

  Lin, H.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Study on the Preventive Effect and Mechanism of Germinated Brown Rice and Its Components on Colorectal Cancer

  Shih, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• TMU101-AE1-B68

  Chiu, Y.

  8/1/13 → 7/31/16

  Project: B - Project of TMU › i - Other (Funded by TMU)

• Role of Androgen on Breast Cancer Development and Treatment

  Lin, H.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Using Cometing Risk Model for Death and Multi-state Stochastic Process for the Behaviour of Betel-quid Chewing and Smoking to Estimate the Potential Years of Life Lost Due to Betel Quid and to Estiamte the Impact of Qutiing Betel-quid chewing

  Yen, M.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effects of Exercise Training on Sleep Disturbances, Anxiety, and Depression among Newly Diagnosed Elderly Lung Cancer Patients

  Lin, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Effects and Regulation of Oxidize Low Density Lipoprotein and High Density Lipoprotein on Human Endothelial Progenitor Cells

  Huang, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Sleep and Memory Consilidation in Alzheimer Disease

  Hu, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Imapct of Oxidative Stress on the Pathogenesis of COPD---An Ivestigation into Its Relationship with Abnormal Inflammation, DNA Instability, Epigenetics and Cell Metabolism

  Lee, K.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Plant metabolomics (1. Agave sisalana, 2. Anoectochilus formosanus, 3. phalaenopsis spp.)

  Lee, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Cellular and Molecular Mechanisms of Nicotine and Nitrosamines Promote Tumorigenic Behaviors in Renal Cell Carcinoma (Ii)

  Cheng, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• 大腸直腸癌已躍居世界上癌症死亡率第二名，屬於固體型腫瘤，缺氧常見於此類 腫瘤，並誘發HIF-1α 表現而導致抗藥性及預後較差，因此抑制HIF-1α 被視為新的抗 癌策略。Zebularine (Zeb)是較穩定之DNA methyltransferase (DNMT)抑制劑，可殺死癌 細胞而不影響正常細胞，對小鼠也不具毒性。我們初步結果顯示，Zeb 可抑制人類大 腸癌細胞株HCT116 之HIF-1α表現，代表Zeb 是治療大腸直腸癌之潛力藥物。我們的 初步也證明Zeb對HCT116具毒殺性，對小鼠大腸癌也有療效。細胞自我吞噬(autophagy) 是指細胞在惡劣環境下，經由吞噬細胞內物質產生能量渡過外界壓力的一種保護機 制；也有研究報導指出，藥物會誘導癌細胞產生autophagy，造成細胞過度吞噬其內容 物而死亡，因此，autophagy在癌細胞為保護或是引發毒殺作用，目前仍無定論。缺氧 也會透過HIF-1α 導致autophagy 而促進細胞存活，但嚴重缺氧或無氧狀態則可透過活 化AMPK及unfolded protein response (UPR)造成autophagic cell death。我們初步結果顯 示，除抑制HIF-1α 表現外，Zeb 也可活化AMPK、UPR/ER stress、以及autophagy， 因此我們推測Zeb 可在缺氧狀態下，促進autophagic cell death。3 年內我們將執行4 項 目標： (1) 探討Zeb 在各種癌細胞及活體模式之抗癌作用。（第一年） (2) 研究Zeb 抑制HIF-1α表現之分子機轉。（第一年到第二年） (3) 研究Zeb 誘發autophagy之分子機轉。（第二年到第三年） (4) 探討Zeb 對缺氧導致抗藥性之作用。（第三年）

  Yang, P.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Preparation and Application of New Type Matrix for Aligned Cell Sheet Engineering Use

  Tseng, H.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effects of glutamine supplementation on T cell homeostasis and inflammatory response in inflammatory bowel disease

  Yeh, S.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• A series of studies analyzing exercise behavior and exploring the effects of interventions among pre-diabetes, type 1, and type 2 diabetes

  Jeng, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• 樂活隨身科技-獨居高齡者之周全健康照護計畫

  Chang, C., Tseng, I. J., Chang, C., Liu, M. F. & Hou, W.

  8/1/13 → 7/31/14

  Project: A - Government Institution › d - Ministry of Education

• The effect of vascular endothelial growth factor gene polymorphism in the pathogenesis and therapeutic response of pterygium

  Cheng, Y.

  8/1/13 → 12/31/14

  Project: C - Project of Alliance › r - Tung's Taichung MetroHarbor Hospital

• The relationship and predictors of electrocardiography, inflammatory markers, clinical features in older bipolar and schizophrenia patients concurrent with coronary heart and cerebro-vascular diseases

  Tsai, S.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Role of HBX and IL-6 in Regulating SENP1/Stemness Properties of HBV-Related Hcc under Hypoxia and Its Clinical Implication

  Huang, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Dissected the role of Glucosed-regulated portein 78 in the progression, metastasis and therapy of colorectal cancer

  Wei, P.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Development of Novel Therapeutic Agents for Herceptin Resistance Breast Cancer Cells through Targeting Nicotinic Acetylcholine Receptors

  Lee, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Mobile Phone Use and Walking: A Observational Field Study of Pedestrians' Risky Behaviours and Inattentional Blindness

  Pai, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• 設計並評估新型含藥人工骨凝膠對齒槽骨缺損的修復作用

  Lee, S.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• A Study on the Influence of Classical Mathematics Reading Course on Medical Students Beliefs about Mathematics

  Ying, J.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• 支援在地老化之智慧生活實驗室規畫(3/3)

  Tsai, D.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• SHE(Smart Health Elderly)的社區照護

  Shiao, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › d - Ministry of Education

• Victorian Sanitation: Narratives of Poverty, Filth and Economy of Morality

  Chen, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Optimization of Human Meniscus Imaging and Its Clinical Application for Osteoarthritis

  Tsai, P.

  8/1/13 → 10/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• 抗發炎藥物與生物製劑藥物對類風濕性關節炎病人發生惡性腫瘤之影響：健保資料庫分析研究

  Chen, S. H.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• End-of-Life Care for Elderly with Advanced Dementia in Long-Term Care Facilities

  Chang, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Trends in Surgical Litigation and Media Coverage of Medical Malpractice: Implications for Medical Education

  Lyu, S.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Glucagon-Like Peptide-1 in the Regulation of PPARs and Calcium Handling in Hyperglycemia or Hypertensive HL-1 Cells

  Huang, J.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Indoxyl Sulfate, Chronic Kidney Disease and Heat Shock Protein Modulate the Atrial Electrophysiological Characteristics

  Hsieh, M.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• A Methodology Study of Integrating Systems Thinking and Bayesian Network in Health Policy

  Chuang, S.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Trade, Economic Factors, Envrionmental Hazards, and Risks of Infant and Child Mortality in Developing Countries

  Chuang, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Prp: Platelet-Rich Plasma Effects in the Articular Chondrocytes and Synovial Fibroblasts with the Associated Mechanism---A Fibronectin Fragment Model

  Lee, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Fabricating Bioengineered Corneal Endothelium on Chitosan-Polycaprolactone Blends---Experiment, Mechanism, and Application

  Wang, T.

  8/1/13 → 12/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• In vitro and in vivo evaluation for silk fibroin-coated electrospun resorbable poly(lactic acid) GTR barriers

  Yang, J.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Evaluation on Cervical Cancer Prevention and Treatment Policy in Taiwan

  Tang, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Study on the cancer and non-cancer, including cardovascular diseases, risks in cohort population with prolonged low-dose radiation exposure

  Chang, W.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Explore of Toll-Like Receptors Associated Mirna Expression in Ischemic Stroke Patients (I)

  Wu, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• The role of DDX3 in human papillomavirus-infected lung tumorigenesis

  Lee, H.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology