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• b - Ministry of Science and Technology

  Association Study of Persistent Metabolic Syndrome, Inflammatory Markers and Mild Cognitive Decline

  Bai, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Steroid and Antihistamin Synergize to Inhibit Rat’s Tracheal Smooth Muscle Contractility and Its Possible Mechanisms

  Wang, H.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• Investigate the Biological and Prognostic Association of Annexin A2 in Nasopharyngeal Carcinoma

  Chen, C. & Lee, F.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• Inhibition of IkB Degradation Reduces Collagen Production via Downregulation of Androgen Receptor Expression in Dihydropyridine-Induced Gingival Overgrowth Cells

  Lu, H.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• Mobile Intelligent Personal Medication Management Platform (III)

  Li, Y.

  11/1/10 → 10/31/11

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Roles of Micrornas in Endothelin-1 and Hypoxia-Induced Ctgf Production

  Chen, Y.

  8/1/11 → 7/31/12

  Project: A - Government Institution › b - Ministry of Science and Technology

• Mechanisms of Biophysical Effects on Differentiation of Mesenchymal Stem Cells and Real-Time Evaluation of Biophysical Effects with Surface Plasmon Resonance Technique

  Ho, J.

  8/1/11 → 7/31/12

  Project: A - Government Institution › b - Ministry of Science and Technology

• A Revolutionary Approach for Disease-Associated Pathways Identification: from Genome-Wide Network Construction, Pathway Discovery, to Pathway-Based Analysis and Validation

  Lee, Y. G.

  8/1/11 → 7/31/12

  Project: A - Government Institution › b - Ministry of Science and Technology

• Building an Ai Imaging Platform to Improve Infarction Core Estimation for Acute Ischemic Stroke on Brain Ct

  Chen, D. C.

  8/1/22 → 7/31/23

  Project: A - Government Institution › b - Ministry of Science and Technology

• 大腸直腸癌已躍居世界上癌症死亡率第二名，屬於固體型腫瘤，缺氧常見於此類 腫瘤，並誘發HIF-1α 表現而導致抗藥性及預後較差，因此抑制HIF-1α 被視為新的抗 癌策略。Zebularine (Zeb)是較穩定之DNA methyltransferase (DNMT)抑制劑，可殺死癌 細胞而不影響正常細胞，對小鼠也不具毒性。我們初步結果顯示，Zeb 可抑制人類大 腸癌細胞株HCT116 之HIF-1α表現，代表Zeb 是治療大腸直腸癌之潛力藥物。我們的 初步也證明Zeb對HCT116具毒殺性，對小鼠大腸癌也有療效。細胞自我吞噬(autophagy) 是指細胞在惡劣環境下，經由吞噬細胞內物質產生能量渡過外界壓力的一種保護機 制；也有研究報導指出，藥物會誘導癌細胞產生autophagy，造成細胞過度吞噬其內容 物而死亡，因此，autophagy在癌細胞為保護或是引發毒殺作用，目前仍無定論。缺氧 也會透過HIF-1α 導致autophagy 而促進細胞存活，但嚴重缺氧或無氧狀態則可透過活 化AMPK及unfolded protein response (UPR)造成autophagic cell death。我們初步結果顯 示，除抑制HIF-1α 表現外，Zeb 也可活化AMPK、UPR/ER stress、以及autophagy， 因此我們推測Zeb 可在缺氧狀態下，促進autophagic cell death。3 年內我們將執行4 項 目標： (1) 探討Zeb 在各種癌細胞及活體模式之抗癌作用。（第一年） (2) 研究Zeb 抑制HIF-1α表現之分子機轉。（第一年到第二年） (3) 研究Zeb 誘發autophagy之分子機轉。（第二年到第三年） (4) 探討Zeb 對缺氧導致抗藥性之作用。（第三年）

  Yang, P.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討真菌天然物成分HMH-1-80-3抑制小神經膠質細胞之活化機制及對內毒素誘發腦部發炎之療效評估

  Hsiao, G.

  7/1/21 → 2/28/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Effect of Acceptance and Commitment Therapy (Act) on Internalized Stigma and Low Self-Esteem among Patients with Schizophrenia

  Chung, M.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effects of Blue-Enriched White Light Therapy on Sleep Quality, Depression, Psychomotor Vigilance, and Symptom Severity in Patients with Fibromyalgia

  Tsai, P.

  8/1/22 → 7/31/23

  Project: A - Government Institution › b - Ministry of Science and Technology

• Development of Immuno-Enhancing Drug-Loaded Mpeg-Nanocarrier to Kill Colon Tumor and to Enhance Anticancer Efficacy of T Cells in Tumor Microenvironment( III )

  Liu, D.

  8/1/22 → 7/31/23

  Project: A - Government Institution › b - Ministry of Science and Technology

• Electrophysiological Activity and Functional Correlates in Female Pelvic Floor Muscles

  Yang, J., Huang, W. & Yang, S.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• Impact of Electron-Transfer-Flavoprotein Dehydrogenase Mutation on Bioenergetic Metabolism and Muscular Differentiation in Vitro

  Kao, S.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Applications of Α-Galactosylceramide-Incorporated Liposome as a Targeting Antigen Carrier for Cancer Vaccine Therapy

  Liu, D.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Molecular Pathogenesis of Cerebral Neuroglia Cells on Tjps and Biabs Expressions as Well as Ups Dysfunction in Neurotoxocariasis That Develops Progressively into Alzheimer's-Like Diseases as Assessed by SP/NK-1R Inhibition

  Fan, C.

  8/1/10 → 7/31/11

  Project: A - Government Institution › b - Ministry of Science and Technology

• Integrated Bioinformatics Approaches to Study the Mechanisms and Discover Drugs of Hcv-Induced Type 2 Diabetes Mellitus( I )

  Hsu, K.

  8/1/17 → 7/1/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• Tmu Spark Taiwan-Anchor University Program

  Wu, C.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• The studies on the mechanism of intravenous immunoglobulin (IVIG)-induced inhibitory functions on neutrophil recruitments

  Chang, J. & Chang, C.

  8/1/11 → 7/31/12

  Project: A - Government Institution › b - Ministry of Science and Technology

• Construction and Application of Medical Image Database in Tmu Healthcare System( II )

  Chen, C.

  12/1/18 → 11/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effects of Home-Based Exercise Training on Fatigue, Sleep Disturbance, Symptom Distress and Quality of Life in End-Stage Renal Disease Patients

  Lin, C., Chen, C., Lin, Y. & Wu, M.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• Interrelationships between Growth Trajectory, Pubertal Development and Childhood Atopic Diseases/Symptoms in a Longitudinal Cohort Study

  Chen, Y.

  8/1/17 → 10/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• 利用輸卵管上皮類器官培養技術開發卵巢癌早期偵測之表基因生物標記(1/3)

  Lai, H.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Drug Adherence,Adverse Events,And Impacts on Quality of Life in the Use of Biologic Agents among Patients with Immune-Mediated Inflammatory Diseases

  Tang, C.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Effect of Health Risk Behaviors on Recurrent Traffic Injury

  Chen, P.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Genetic polymorphisms of calcium channel in the risk of breast cancer

  Chang, W.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• New Strategies of Parkinson’s Disease Treatment

  Chiang, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Bullying Experience, Attitude and Suicide Attempts among Adolescents

  Chen, P.

  8/1/12 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effects of Maternal Depressive Symptomatology on Pregnancy Outcomes and Newborn Development---How Is Paternal Psychopathology Involved?

  Chen, Y., Hsu, C., Lin, H. & Huang, K.

  8/1/11 → 7/31/12

  Project: A - Government Institution › b - Ministry of Science and Technology

• Falls and Traumatic Brain Injuries in Elderly People

  Lin, M. & Chiu, W.

  8/1/11 → 7/31/12

  Project: A - Government Institution › b - Ministry of Science and Technology

• Brain Function for Evaluating Post Stroke Recovery Following Robot-Assisted Gait Training and Transcranial Direct Current Stimulation

  Lai, C., Chen, C., Chen, S., Peng, C., Kang, J. & Lin, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• Stochastic Model for Ill-Performed Health Care in Precision Health Science(1/3)

  Yen, M.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討芳香烴受體(AhR)改變血管內皮細胞功能之新角色：經由表觀基因或後轉譯修飾(細胞週期蛋白/內皮細胞一氧化氮合成?)的調控與白蘆黎醇/史達汀臨床治療及應用(1/3)

  Juan, S.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• A Study on Trans-Neuronal Striato-Nigral Degeneration-Induced Movement Disorders after Stroke: Evaluation with Grey Matter Suppression Ir and Diffusion Tensor Imaging( I )

  Chen, C.

  8/1/12 → 10/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• miRNA作為中風後血管性認知障礙生物標記相關性之研究

  Chiou, H.

  7/1/18 → 2/28/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effects of Tashinon IIA on Angiotensin II-Induced Vascular Smooth Muscle Cell Proliferation

  Chan, P. & Cheng, T.

  8/1/11 → 7/31/12

  Project: A - Government Institution › b - Ministry of Science and Technology

• Translational Relevance and Mechanism of Glucose Transporter 3 in Colon Cancer Metastasis

  Lin, C.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討電脈衝刺激強化肌肉細胞的能量代謝及降低肌肉細胞萎縮與壞死的分子機制

  Kao, S.

  7/1/18 → 2/28/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• 以RAW 264.7巨噬細胞探討食品添加物二氧化硫與 ??-tocopherol 或 ascorbic acid 對發炎反應之影響

  Chen, Y.

  7/1/21 → 2/28/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 小分子抗前列腺癌之藥物研發

  Liou, J.

  6/1/16 → 4/30/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• 甲基乙二醛經ChREBP/SREBP1造成腎小管脂毒性進而調控PGC1/SIRT3導致電子傳遞鏈缺陷之糖尿腎病進展-探討水飛薊素(Silybin)合併Metformin之逆轉潛能

  Chen, K.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 臺以(IL)雙邊協議型擴充加值(add-on) 國際合作研究計畫－台灣和以色列中高齡族群數位醫療服務的特質和應用的比較(2/2)

  Yang, S.

  1/1/23 → 12/31/23

  Project: A - Government Institution › b - Ministry of Science and Technology

• Machine Learning-Based Radiogenomics for Connecting Mr Imaging to Immune-Regulated Genes Expression in Glioblastoma(1/3)

  Chen, C.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• 由多尺度系統性角度探討肺癌腦轉移－探討血管外被細胞於肺癌腦轉移之治療效應(1/3)

  Yeh, S.

  8/1/22 → 7/31/23

  Project: A - Government Institution › b - Ministry of Science and Technology

• Risk of Attempted and Completed Suicide among Patients with Major Physical Disorders: an Instrumental Variable Analysis

  Huang, K.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Smokefreebrain: Multidisciplinary Tools for Improving the Efficacy of Public Prevention Measures against Smoking( I )

  Shabbir, S. A.

  5/1/17 → 4/30/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• 以資料探勘技術進行大數據分析，建立術中低血氧與術後休克風險預測模型(1/2)

  Lin, C.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 犬蛔蟲胜?抗伺機性與多重耐藥性金黃色葡萄球菌與鮑氏不動桿菌之機轉、表現、特化與應用

  Fan, C.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology