4d Printing Smart Biomedical Scaffold on Biomedical Application

Project: A - Government Institutionb - National Science and Technology Council

Project Details


In the times of industrial 4.0 and health 4.0, the people want to enhance the ability of science and technology, for the current focus of the parties expect. 3D printing technology has been introduced for more than 40 years, initially known as rapid prototyping or laminated manufacturing, its main laser sintering, laser light curing, laser paper folding, extrusion molding, etc., which can quickly and accurately produce the finished product. However, in the intelligent, green energy, biomedicine today, the traditional 3D printing technology has been unable to meet our needs, so 4D print out of it. In 2013, Tibbits first proposed a new combination of material with a 3D printer, creating a linear object, the object into the water, can change the shape, and finally he defined the 3D print with time, that is 4D Printing. The 4D printing is defined to print out the changes over time with the object. Shape memory materials, such as shape memory polymers, shape memory metals, shape memory ceramics and shape memory composites; have been developed for 30 years under different stimuli effect (water, light, heat, electricity, magnetism, pH, etc.) that the shape memory materials can change their shape. So to shape memory materials with 4D print, people can create a 4D print on the next spring. In this project, shape memory materials with 3D printing technology to create 4D porous biomedical scaffold, as bone repair purposes. The project is expected to use polylactic acid (PLA) as the matrix, the mixture of different proportions of graphene, then uses of 3D printing in improved the fused deposition modeling (FDM) to create a porous 3D biomedical scaffold, and the external electric field or heat source to change the shape of 3D biomedical scaffold, so we can develop the 4D printing technology. This project we explores that the 4D biomedical scaffolds with different ratios of graphene are deformed at different electric field strengths (voltages) or different heat source strengths (temperatures)and to restore its prototype when the electric field or heat source is not working. The porosity, strength, degradability, and surface properties (such as hydrophobicity, hydrophilicity) of 4D porous scaffold are discussed, and finally to culture MG63 osteoblast cells and hMSC cells in 4D porous biomedical scaffold to study their biocompatibility.
Effective start/end date8/1/177/31/18


  • 4D printing
  • shape memory composite material
  • improved fused deposition modeling
  • recovery force
  • cell culture


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