Projects per year
Personal profile
Education
- 2000-2008 Ph.D., Graduate Institute of Life Sciences, National Defense Medical Center
- 1998-2000 M.S., Institute of Physiology & Biophysics, National Defense Medical Center
Experience
- 2026.05- Associate Director, Graduate Institute of Clinical Medicine, Taipei Medical University
- 2024.08- Professor, Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University
- 2018.02- Associate Professor, International Master/Ph.D. Program in Medicine, College of Medicine, Taipei Medical University
- 2016.11-2017.10 Associate Professor, International Master/Ph.D. Program in Medicine, College of Medicine, Taipei Medical University
- 2016.02-2024.07 Associate Professor, Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University
- 2013.02-2016.01 Assistant Professor, Graduate Institute of Clinical Medicine, Taipei Medical University
- 2012- Medical Researcher, Wan Fang Hospital, Taipei Medical University
- 2008-2012 Postdoc, Graduate Institute of Clinical Medicine, Taipei Medical University
Awards
- 2015 Research Award in Taipei Medical University
Research Interests
- Epigenetic regulation in cardiac pathophysiology
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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SDG 7 Affordable and Clean Energy
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SDG 9 Industry, Innovation, and Infrastructure
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SDG 12 Responsible Consumption and Production
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Collaborations and top research areas from the last five years
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探討miR-452於心肌炎誘導心律不整與細胞代謝失調之病理機制:外泌體奈米藥物的治療潛力與挑戰-發展具心肌炎特異性心臟靶向胜肽的工程化外泌體miR-452傳遞系統以調控心肌炎誘導的心臟免疫(2/2)
Kao, Y.-H. (PI)
8/1/26 → 7/31/27
Project: A - Government Institution › b - National Science and Technology Council
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Development of a Myocarditis-Specific Engineered Exosome-Based Mir-452 Delivery System Using Heart-Targeting Peptides to Regulate Cardiac Immune Dysregulation( I )
Kao, Y.-H. (PI)
8/1/25 → 7/31/26
Project: A - Government Institution › b - National Science and Technology Council
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Metabolomics Perspective and Single-Cell Transcriptomics Insights in Dysregulated Interleukin-6 and Cardiac Metabolic Stress in Sodium Channel Heart Disorders
Kao, Y.-H. (PI)
8/1/25 → 7/31/26
Project: A - Government Institution › b - National Science and Technology Council
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Nav1.5 Deficiency on Cardiac Fibrogenesis and Therapeutic Potential of Exosome-Based Mirna Delivery
Kao, Y.-H. (PI)
8/1/23 → 7/31/25
Project: A - Government Institution › b - National Science and Technology Council
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Targeting Spike S1 Protein of Sars-Cov-2-Mediated Electrical and Structural Remodeling as a Novel Therapeutic Strategy
Kao, Y.-H. (PI)
8/1/21 → 7/31/22
Project: A - Government Institution › b - National Science and Technology Council
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3-Hydroxybutyrate Prevents Pulmonary Vein Arrhythmogenesis by Regulating Calcium/Calmodulin-Dependent Protein Kinase II Signaling and Oxidative Stress
Chin, C. G., Lin, F. J., Chen, Y. C., Lin, Y. K., Lu, Y. Y., Higa, S., Kao, Y. H., Chen, S. A. & Chen, Y. J., Mar 20 2026, In: Pharmacology. p. 1-16 16 p.Research output: Contribution to journal › Article › peer-review
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Advanced glycation end products enhance human atrial fibroblast activity through activation of interferon/signal transducer and activator of transcription signaling
Cheng, T. Y., Li, S. J., Lee, T. W., Lee, T. I., Chen, Y. C., Kao, Y. H., Higa, S., Chen, P. H. & Chen, Y. J., Mar 2026, In: Gene Reports. 42, 102423.Research output: Contribution to journal › Article › peer-review
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Therapeutic Lithium Enhances Klotho Expression and Mitochondrial Size and Branching in Human Cardiac Fibroblasts Involving Nuclear Factor-kappa B Inhibition
Chen, P. H., Lee, T. W., Liu, S. H., Cheng, T. Y., Kao, Y. H. & Chen, Y. J., 2026, In: Clinical Psychopharmacology and Neuroscience. 24, 3, p. 597-608 12 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Link opens in a new tab Citation (Scopus) -
Uremic toxin p‑cresyl sulfate enhances the calcification of aortic valvular interstitial cells via klotho/sirtuin‑1 signaling
Li, S. J., Cheng, T. Y., Kao, Y. H., Chen, W. Y., Chung, C. C., Trang, N. N., Chen, P. H. & Chen, Y. J., Jun 1 2026, In: Molecular Medicine Reports. 33, 6, 162.Research output: Contribution to journal › Article › peer-review
Open Access -
Calcitriol deficiency reduces myocardial ATP production with disturbed mitochondrial dynamics and increased uncoupling protein 2 expression
Lee, T. W., Lee, T. I., Higa, S., Kao, Y. H. & Chen, Y. J., Sept 5 2025, In: European Journal of Pharmacology. 1002, 177858.Research output: Contribution to journal › Article › peer-review
3 Link opens in a new tab Citations (Scopus)
Datasets
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Activation of Class I histone deacetylases contributes to mitochondrial dysfunction in cardiomyocytes with altered complex activities
Lee, T.-W. (Contributor), Cheng, W.-L. (Creator), Kao, Y.-H. (Contributor), Lee, T.-I. (Contributor), Chen, Y.-J. (Contributor) & Lkhagva, B. (Contributor), Taylor & Francis, 2018
DOI: 10.6084/m9.figshare.6220217.v1, https://doi.org/10.6084%2Fm9.figshare.6220217.v1
Dataset
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Supplementary Material for: Novel Histone Deacetylase Inhibitor Modulates Cardiac Peroxisome Proliferator-Activated Receptors and Inflammatory Cytokines in Heart Failure
Lkhagva, B. (Creator), Lin, Y.-K. (Creator), Kao, Y.-H. (Creator), Chazo, T.-F. (Creator), Chung, C.-C. (Creator), Chen, S.-A. (Creator) & Chen, Y.-J. (Creator), Karger Publishers, 2015
DOI: 10.6084/m9.figshare.5128564.v1, https://karger.figshare.com/articles/dataset/Supplementary_Material_for_Novel_Histone_Deacetylase_Inhibitor_Modulates_Cardiac_Peroxisome_Proliferator-Activated_Receptors_and_Inflammatory_Cytokines_in_Heart_Failure/5128564/1
Dataset