Personal profile
Education
- 2008 Ph.D. Medical Sciences, Tzu Chi University
- 2003 M.S. Human Genetics, Tzu Chi University
Experience
- 2024.08- Director, Ph.D. Program for Cancer Molecular Biology and Drug Discovery, Taipei Medical University
- 2024.08- Director, Master Program in Graduate Institute of Cancer Biology and Drug Discovery, Taipei Medical University
- 2022-2023 Visiting Research Scholar, Cancer Immunology and Virology, Dana-Farber Cancer Institute, Harvard Medical School
- 2019- Professor, Master Program in Graduate Institute of Cancer Biology and Drug Discovery, Taipei Medical University
- 2019- Professor, Graduate Institute of Cancer Biology and Drug Discovery, Taipei Medical University
- 2018-2019 Associate Professor, Master Program in Graduate Institute of Cancer Biology and Drug Discovery, Taipei Medical University
- 2017-2018 Visiting Research Scholar, Department of Pathology, Duke University Medical Center
- 2016-2019 Associate Professor, Graduate Institute of Cancer Biology and Drug Discovery, Taipei Medical University
- 2012-2016 Assistant Professor, Graduate Institute of Cancer Biology and Drug Discovery, Taipei Medical University
- 2009 Postdoctoral Researcher, National Institutes of Health (NIH), USA
Awards
- 2018 Ta-You Wu Memorial Award, National Science and Technology Council, Taiwan
- 2018 Young Researcher Cancer Research Excellence Award, Taiwan Oncology Society, Taiwan
- 2015 Young Scholar Award, Taipei Medical University, Taiwan
- 2014 Excellent Research Award, Taipei Medical University, Taiwan
- 2014 Young Scholar Award, Taipei Medical University, Taiwan
Research Interests
- Molecular and Cellular Biology
- Tumor Metastasis and Signal Transduction
- Cancer Metabolism
- Cancer immunotherapy
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Collaborations and top research areas from the last five years
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整合代謝基因調控機轉與合成基因電路載體在神經內分泌前列腺癌免疫治療的應用
Liu, Y.-N. (PI)
1/1/26 → 12/31/26
Project: A - Government Institution › a - National Health Research Institutes
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Next-Generation Tumor Immunotherapy for Neuroendocrine Prostate Cancer
Liu, Y.-N. (PI)
8/1/25 → 7/31/26
Project: A - Government Institution › b - National Science and Technology Council
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(精準醫療)探索前列腺癌神經內分泌分化與免疫逃脫機制及其生物標記和治療標靶的開發
Liu, Y.-N. (PI)
3/1/25 → 2/28/26
Project: C - Project of Alliance › o - Chi Mei Medical Center
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開發針對酸性腫瘤微環境 基因電路感測器並探索前列腺癌代謝機制與靶向藥物治療策略
Liu, Y.-N. (PI)
1/1/25 → 12/31/25
Project: B - Project of TMU › h - Higher Education Sprout Project
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研究IL1RN 和CCL7在M2-like 巨噬細胞分化中的調控作用及對前列腺癌腫瘤微環境中CCL20 驅動的神經內分泌分化的分子機制
Liu, Y.-N. (PI)
1/1/25 → 12/31/25
Project: B - Project of TMU › i - Other (Funded by TMU)
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A calcium-sensing MCTP1/FYN/MEF2C circuit drives therapy-induced neuroendocrine prostate cancer
Dung, P. V. T., Chen, W. Y., Liu, M. K., Yeh, S. D., Kajla, G., Yeh, H. L., Chen, W. H., Jiang, K. C., Li, H. R., Chen, C. S., Beltran, H., Wen, Y. C. & Liu, Y. N., Jan 2026, In: Neoplasia (United States). 71, 101251.Research output: Contribution to journal › Article › peer-review
Open Access -
Repurposing piroxicam enhances the antineoplastic effects of docetaxel and enzalutamide in prostate cancer cells using 2D and 3D in vitro culture models
Yehya, A., Ghamlouche, F., Karami, R., Hachem, S., Salhab, Z., Liu, Y. N., Daoud, G. & Abou-Kheir, W., 2025, In: Frontiers in Cell and Developmental Biology. 13, 1551010.Research output: Contribution to journal › Article › peer-review
Open Access -
Research Paper Implications of the KHDC4-TRAF2 axis in the context of prostate cancer prognosis
Hu, S. W., Wu, C. C., Dong, S. W., Tzou, K. Y., Chen, C. H., Wang, Y. H., Liu, Y. N., Liao, C. C. & Li, C. H., Jun 30 2025, In: Aging. 17, 6, p. 1544-1570 27 p.Research output: Contribution to journal › Article › peer-review
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Binding of interleukin-1 receptor antagonist to cholinergic receptor muscarinic 4 promotes immunosuppression and neuroendocrine differentiation in prostate cancer
Liu, Y. N., Liu, M. K., Wen, Y. C., Li, C. H., Yeh, H. L., Dung, P. V. T., Jiang, K. C., Chen, W. H., Li, H. R., Huang, J. & Chen, W. Y., Aug 28 2024, In: Cancer Letters. 598, 217090.Research output: Contribution to journal › Article › peer-review
Open Access11 Link opens in a new tab Citations (Scopus) -
Correction: CHRM4/AKT/MYCN upregulates interferon alpha-17 in the tumor microenvironment to promote neuroendocrine differentiation of prostate cancer (Cell Death & Disease, (2023), 14, 5, (304), 10.1038/s41419-023-05836-7)
Wen, Y. C., Tram, V. T. N., Chen, W. H., Li, C. H., Yeh, H. L., Thuy Dung, P. V., Jiang, K. C., Li, H. R., Huang, J., Hsiao, M., Chen, W. Y. & Liu, Y. N., Jan 2024, In: Cell Death and Disease. 15, 1, 92.Research output: Contribution to journal › Comment/debate › peer-review
Open Access1 Link opens in a new tab Citation (Scopus)
Datasets
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Disruption of ETV6 leads to TWIST1-dependent progression and resistance to epidermal growth factor receptor tyrosine kinase inhibitors in prostate cancer
Tsai, Y.-C. (Contributor), Zeng, T. (Creator), Abou-Kheir, W. (Creator), Yeh, H.-L. (Contributor), Yin, J. J. (Creator), Lee, Y.-C. (Creator), Chen, W.-Y. (Creator) & Liu, Y.-N. (Contributor), Figshare, 2018
DOI: 10.6084/m9.figshare.c.4008787.v1, https://doi.org/10.6084%2Fm9.figshare.c.4008787.v1
Dataset
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Additional file 1: of Disruption of ETV6 leads to TWIST1-dependent progression and resistance to epidermal growth factor receptor tyrosine kinase inhibitors in prostate cancer
Tsai, Y.-C. (Contributor), Zeng, T. (Creator), Abou-Kheir, W. (Creator), Yeh, H.-L. (Contributor), Yin, J. J. (Creator), Lee, Y.-C. (Creator), Chen, W.-Y. (Creator) & Liu, Y.-N. (Contributor), Figshare, 2018
DOI: 10.6084/m9.figshare.5900626.v1, https://springernature.figshare.com/articles/Additional_file_1_of_Disruption_of_ETV6_leads_to_TWIST1-dependent_progression_and_resistance_to_epidermal_growth_factor_receptor_tyrosine_kinase_inhibitors_in_prostate_cancer/5900626/1
Dataset