Projects per year
Personal profile
Education
- 1993-1997 Ph.D., Institute of Biochemistry, College of Sciences, National Taiwan University
- 1991-1993 M.S., Institute of Biochemistry, College of Sciences, National Taiwan University
- 1985-1989 B.S., Department of Chemistry, National Taiwan Normal University
Experience
- 2017.08- Professor, International Master/Ph.D. Program in Medicine, College of Medicine, Taipei Medical University
- 2017.08- Professor, International Ph.D. Program for Cell Therapy and Regeneration Medicine, Taipei Medical University
- 2016- Member of Director Board, TaiGen Biotechnology (Presenter for National Development Fund, Executive Yuan, Taiwan 行政院國家發展基金會)
- 2016- Director, Cell Therapy and Regeneration Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan
- 2016- Director, TMU GTP Laboratory, Taipei Medical University, Taipei, Taiwan
- 2016- Distinguished Professor, Department of Biochemistry and Molecular Cell Biology, Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan
- 2015- Committee Member of Regeneration Medicine and Cell Therapy Development Board, Ministry of Health and Welfare (MOWH衛生福利部再生醫學及細胞治療發展諮議會委員)
- 2019.08-2022.07 Executive Director, TMU Center for Cell Therapy and Regeneration Medicine, Taipei Medical University, Taipei, Taiwan
- 2019.01-2021.12 Dean, Office of Research and Development, Taipei Medical University
- 2018.06-2022.07 Director, Core Laboratory of Good Tissue Practice, Office of Research & Development, Taipei Medical University
- 2019.01-2021.12 Dean, Research and Development, Taipei Medical University
- 2016.09-2018.12 Director, International Ph.D. Program for Cell Therapy and Regeneration Medicine, Taipei Medical University
- 2015.08-2018.12 Dirtector,TMU Research Center of Cell Therapy and Regeneration Medicine
- 2015.04-2019.07 Director, International Ph.D. Program for Cell Therapy and Regeneration Medicine, Taipei Medical University
- 2014.08-2018.12 Professor Department of Biochemistry and Molecular Cell Biology, Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan
- 2014.02- The Ph.D. Program for Translational Medicine, Taipei Medical University
- 2014.02-2014.07 Director, Department of Biochemistry and Molecular Cell Biology, Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan
- 2014- Member of Director Board, Taiwan Society for Stem Cell Research (TSSCR), Taiwan
- 2014- Member of Director Board, Taiwan Association for Cell Therapy (TACT)
- 2014- Committee member of JIRB, Taipei Medical University (TMU-JIRB), Taiwan
- 2014- Committee member of Regeneration Medicine Board, Food and Drug Administration, Taiwan (TFDA 再生醫學諮議小組委員會)
- 2013.04-2014.07 Professor, Department of Biochemistry and Molecular Cell Biology, Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan
- 2011-2013 Secretary General, Taiwan Society for Stem Cell Research (TSSCR), Taiwan
- 2007.08- Assistant Professor, Graduate Institute of Medical Sciences, Taipei Medical University, Taiwan
- 2007.02-2013.03 Associate Professor, Department of Biochemistry and Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan
- 2009- Visiting Scholarship, the Stem Cell Core, NTU Research Center for Medical Excellence, National Taiwan University, Taipei, Taiwan
- 2002-2006 Assistant Professor, Department of Biochemistry and Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan
- 2003-2004 Visiting Scholarship, Stem Cell Program, the Genomic Research Center, Academia Sinica, Taipei, Taiwan
- 2002.02-2007.01 Assistant Professor, Department of Biochemistry and Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan
- 2001-2002 Postdoctoral Fellow, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
- 1998-2001 Postdoctoral Fellow, Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan
- 1997.08-1998.07 Postdoctoral Fellow, Institute of Biomedical Sciences, College of Life Sciences, National Taiwan University
- 1990.01-1991.06 Teaching Assistant, Department of Chemistry, National Taiwan Normal University
Awards
2017
- 2017 Project Review Board, Food and Health Bureau (FHB) of The Government of the HKSAR, Hong Kong
- 2017 The Best Paper Award, “IGF-1R Promotes Symmetric Self-Renewal and Migration of Alkaline Phosphatase-Positive Germ Stem Cells”, 2017 International Conference of Development Biology, Stem Cells and Regenerative Medicine-From Basic Research to Applications (2017 DBSRM), Taipei, Taiwan
- 2017 The Best Paper Award, “IL-6 Upregulates the OCT4 Expression through STAT3-Dependent DNMT3b-OCT4-DNMT1 Axis in HBV-related Hepatocellular Carcinoma”, 2017 International Conference of Development Biology, Stem Cells and Regenerative Medicine-From Basic Research to Applications (2017 DBSRM), Taipei, Taiwan
2016
- 2016 臺北醫學大學特聘教授
- 2016 Distinguished Professor, Taipei Medical University, Taipei, Taiwan
- 2016 台灣癌症醫學會 董大成博士癌症基礎醫學研究傑出獎
- 2016 The Outstanding Basic Research Award for Cancer Medicine of Dr. Da-Cheng Tung, The Chinese Oncology Society (COS).
- 2016 The Prize Poster Award, “Niche ECM Laminin Mediates the Expressions of Pluripotent Transcription Factor Oct4 through IGF-IR- HIF-2α- CD49f Circuit Loop in Mouse Germline Stem Cells” 2016 Taiwan Society for Stem Cell Research (2016 TSSCR), Taipei, Taiwan
- 2016 科技部105年度補助大專校院獎勵特殊優秀人才獎勵
- 2016 臺灣女科技人群像介紹
2015
- 2015臺北醫學大學國際頂尖論文獎 2015 The International Top Journal Research Award of Taipei Medical University
- 2015 臺北醫學大學研究論文獎—優良獎 2015 The Excellent Prize Research Award of Taipei Medical University
- 2015 科技部104年度補助大專校院獎勵特殊優秀人才獎勵
- 2015 The Prize Oral Award, “Insulin-like Growth Factor I Stimulates Cell Migration Through SDF-1/CXCR4 Regulation in Mouse Germline Stem Cells”, 2015 Taiwan Society For Stem Cell Research (2015 TSSCR), Taipei, Taiwan
- 2015 The Prize Poster Award, “Insulin-like Growth Factor I Stimulates the Expressions of HIF-2α and Oct-4 Requiring α6 Integrin in Mouse Germline Stem Cells”, 2014 Taiwan Society For Stem Cell Research (2015 TSSCR), Taipei, Taiwan
2014
- 2014 The Prize Poster Award, “Insulin-like Growth Factor I Stimulates the Expressions of HIF-2α and Oct-4 Requiring α6 Integrin in Mouse Germline Stem Cells”, 2014 Taiwan Society For Stem Cell Research (2014 TSSCR), Taipei, Taiwan
- 2014 科技部103年度補助大專校院獎勵特殊優秀人才獎勵
2013
- 2013 臺北醫學大學師鐸獎 2013 Faculty Award of Taipei Medical University in Excellence of Teaching, Administration, and Research.
- 2013 The First Prize Oral Award, “IGF-1R-HIF-2 Signal Loop Supports the Proliferation and Oct-4 Maintenance of Alkaline Phosphatase Positive Mouse Germline Stem Cells Under Hypoxia. 2013 TSRM, Annual Meeting of Taiwan Society for Reproductive Medicine
- 2013 The Prize Poster Award, “Interleukin-6 Regulates Stemness Expression and Early Recurrence of HBV-related Hepatocellular Carcinoma via IGF-IR Activation” & “Role of IGF-1R Signaling in Oct-4 Maintenance of Alkaline Phosphatase Positive Germline Stem Cells”. 2013 The 27th Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan.
- 2013 The Excellent Research Paper Award,” Interleukin-6 Regulates Stemness Expression and Early Recurrence of HBV-related Hepatocellular Carcinoma via IGF-IR Activation “. 2013 Teachers and Students Joint Academic Research Symposium,Taipei Medical University, Taipei, Taiwan
- 2013 The Prize Poster Award, “ IGF-IR-HIF-2 Signaling Loop Supports the Cell Proliferation and Oct4 Maintenance of Alkaline Phosphatase Positive Mouse Germline Stem Cell. 2013 Taiwan Society for Stem Cell Research (2013 TSSCR), Taipei, Taiwan.
- 2013 The Prize Poster Award, “ HBx Stimulates the Expression of Stemness-related Properties through SENP1in HBV-related Hepatocellular Carcinomas. 2013 Taiwan Society for Stem Cell Research (2013 TSSCR), Taipei, Taiwan.
- 2013 2013 The Best Teacher Award, School of Medicine, Taipei Medical University, Taipei, Taiwan
2012
- 2012 The Prize Poster Award, “ IL-6 stimulates stemness properties and early recurrence of HCC through IGF-IR activation. 2012 Taiwan Society for Stem Cell Research (2012 TSSCR), Taipei, Taiwan.
- 2012 2012 The Second Prize Award of Excellent Research, Taipei Medical University, Taipei, Taiwan
- 2012 The Best Teacher Award, School of Medicine, Taipei Medical University, Taipei, Taiwan
2011
- 2011 The Second Prize Oral Award, “ SENP1 Regulates OCT4 Under Hypoxia: Effect of Sumoylation on Protein Stability and Drug Susceptibility of Human Pluripotent Germ Cell Tumors” 2011 International Symposium on Recent Advances in Pluripotent Stem Cells & 7th Annual Meeting of Taiwan Society for Stem Cell Research (2011 TSSCR).
- 2011 The First Prize Oral Award, “Inflammation enhances the transformation of epithelial-like endometrium stem cells and initiates endometriosis”. 2011 Taiwan Society for Reproductive Medicine, Taipei, Taiwan (2011 TSRM)
- 2011 The First Prize Award of Excellent Research, “Role of IL-6-IGF-1R Signaling in Early Recurrence and OCT4/NANOG Expression of HBV-related HCCs”. Taipei Medical University, Taipei, Taiwan
- 2011 The Best Teacher Award, School of Medicine, Taipei Medical University, Taipei, Taiwan
2010
- 2010 臺北醫學大學第一屆校級優良教師
- 2010 2010 Prize Poster Award, “Crosstalking of Hypoxia and IGF-1 Signaling in Transformation of Mouse Germline Stem Cells”. The 18th Conference of The Chinese Society of Cell and Molecular Biology, Kaoshung, Taiwan
- 2010 The First Prize Poster Award, “Role of inflammation in transformation of epithelial-like endometrium stem cells and it’s implication on endometriosis”. 2010 Taiwan Society for Reproductive Medicine, Taipei, Taiwan (2010 TSRM)
- 2010 The First Prize Award of Excellent Research, “Role of Inflammation in Transformation of Epithelial-like Endometrium Stem Cells and its Implication on Endometriosis”, Taipei Medical University, Taipei, Taiwan
- 2010 The Second Prize Award of Excellent Research, “IGF-1 is Required for Maintenance of Pluripotency of Mouse Spermatogonial Stem Cells”, Taipei Medical University, Taipei, Taiwan
- 2010 The Best Teacher Award, School of Medicine, Taipei Medical University, Taipei, Taiwan
2009
- 2009 Prize Award, The 7th Conference of the Pacific Rim Society for Fertility and Sterility (PRSFS 2009) – “ Hypoxia Stress Enhances the IGF-1 Signaling in Pluripotent Mouse Germline Stem Cells” , Taipei, Taiwan (2009 PRSFS)
- 2009 Prize Award, The 7th Conference of the Pacific Rim Society for Fertility and Sterility (PRSFS 2009)- “Role of IGF-1/IGF-1R Signaling in Mouse Germline Stem Cells’ Pluripotency and Tumorigenesis”, Taipei, Taiwan (2009 PRSFS)
- 2009 Prize Poster Award, “Insulin-like Growth Factor 1 is Required for Pluripotency of Mouse Spermatogonial Stem Cells”. The 17th Conference of The Chinese Society of Cell and Molecular Biology, Kaoshung, Taiwan
- 2009 The First Prize Award of Excellent Research,“Cross-talking of Hypoxia and IGF-1 Signaling in Pluripotent Spermatogonial Stem Cells“, Taipei Medical University, Taipei, Taiwan
- 2009 The Best Teacher Award, School of Medicine, Taipei Medical University, Taipei, Taiwan
2008
- 2008 Travel Award of theInternational Society for Stem Cell Research 6th Annual Meeting, Philadephia, USA
- 2008 Prize Poster Award, The 17th Conference of Cell and Molecular Biology- “IGF-1 is Required for Maintenance of Pluripotency in Mouse Germ Line Stem Cells”. Kaoshing, Taiwan
- 2008 The First Prize Award of Excellent Research, “IGF-1 is Required for Maintenance of Pluripotency of Mouse Spermatogonial Stem Cells”, Taipei Medical University, Taipei, Taiwan
- 2008 The Second Prize Award of Excellent Research, Taipei Medical University, Taipei, Taiwan
- 2008 The Best Teacher Award, School of Medicine, Taipei Medical University, Taipei, Taiwan
2007
- 2007 The First Prize Award of Excellent Research, “Functional Characterization of a Novel Human Guanylyl Cyclase in Sperm“, Taipei Medical University, Taipei, Taiwan
- 2007 Best Teacher Award, School of Medicine, Taipei Medical University, Taipei, Taiwan
2006
- 2006 The Second Prize Award of Excellent Research, “Functional Characterization of an Orphan Receptor, Gguanylyl Cyclase G, in Mouse Sperm”, Taipei Medical University, Taipei, Taiwan
- 2006 Travel Award of theInternational Society for Stem Cell Research 4th Annual Meeting, Toronto, Canada
- 2006 Best Teacher Award, School of Medicine, Taipei Medical University, Taipei, Taiwan
2005
- 2005 Best Teacher Award, School of Medicine, Taipei Medical University, Taipei, Taiwan
2004
- 2004 Best Teacher Award, School of Medicine, Taipei Medical University, Taipei, Taiwan
- 2004 Visiting Scholarship, Stem Cell Program, the Genomic Research Center, Academia Sinica, Taipei, Taiwan
2003
- 2003 Best Teacher Award, School of Medicine, Taipei Medical University, Taipei, Taiwan
- 2003 Visiting Scholarship, Stem Cell Program, the Genomic Research Center, Academia Sinica, Taipei, Taiwan
2002
- 2002 Visiting Scholarship, Stem Cell Program, the Genomic Research Center, Academia Sinica, Taipei, Taiwan
2001
- 2001 Postdoctoral Fellowship Award, Academia Sinica, Taipei, Taiwan
2000
- 2000 The Prize Award of The 8th K.T.Li General Scientific Composition of K.T.Li Foundation for the Development of Science and Technology, Taipei, Taiwan
- 2000 Postdoctoral Fellowship Award, Academia Sinica, Taipei, Taiwan
1999
- 1999 The Prize Award of The 7th K.T.Li General Scientific Composition of K.T.Li Foundation for the Development of Science and Technology, Taipei, Taiwan
- Postdoctoral Fellowship Award, Academia Sinica, Taipei, Taiwan
1998
- 1998 Postdoctoral Fellowship Award, Academia Sinica, Taipei, Taiwan
Research Interests
- Stem cells and cancer stem cytology, Stem cell therapy, cytology, biochemistry, molecular biology
Fingerprint
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Collaborations and top research areas from the last five years
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標靶蕾沙瓦(Sorafenib)耐藥性肝細胞癌治療策略: 一種可原位注射熱敏性水膠包覆IGF1R/CD3雙功能抗體之新穎T細胞免疫治療策略與前臨床3D 類器官模式(3/3)
Huang, Y.-H. (PI)
8/1/24 → 7/31/25
Project: A - Government Institution › b - National Science and Technology Council
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A Novel Igf-1r Car Msc Exosome-Based Drug Delivery System for Sorafenib-Resistant Hccs: Focusing Safety, Efficacy, Bio-Distribution, and Immune-Omics Molecular Mechanism( I )
Huang, Y.-H. (PI)
8/1/24 → 7/31/25
Project: A - Government Institution › b - National Science and Technology Council
-
A Novel Igf-1r Car Msc Exosome-Based Drug Delivery System for Sorafenib-Resistant Hccs: Focusing Safety, Efficacy, Bio-Distribution, and Immune-Omics Molecular Mechanism( I )
Huang, Y.-H. (PI)
8/1/24 → 7/31/27
Project: A - Government Institution › b - National Science and Technology Council
-
標靶蕾沙瓦(Sorafenib)耐藥性肝細胞癌治療策略: 一種可原位注射熱敏性水膠包覆IGF1R/CD3雙功能抗體之新穎T細胞免疫治療策略與前臨床3D 類器官模式(2/3)
Huang, Y.-H. (PI)
8/1/23 → 7/31/24
Project: A - Government Institution › b - National Science and Technology Council
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探討急性肺損傷之精準幹細胞治療策略與臨床應用: 肺部微環境修復之分子與細胞圖譜及其作用機制-臨床級胎盤間葉幹細胞對急性肺損傷/急性呼吸窘迫症之免疫調控與肺組織再生之治療機制(3/3)
Huang, Y.-H. (PI)
8/1/23 → 7/31/24
Project: A - Government Institution › b - National Science and Technology Council
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3D organoid cultivation improves the maturation and functional differentiation of cholangiocytes from human pluripotent stem cells
Budi, N. Y. P., Lai, W. Y., Huang, Y. H. & Ho, H. N., 2024, In: Frontiers in Cell and Developmental Biology. 12, 1361084.Research output: Contribution to journal › Article › peer-review
Open Access2 Citations (Scopus) -
Secretome from estrogen-responding human placenta-derived mesenchymal stem cells rescues ovarian function and circadian rhythm in mice with cyclophosphamide-induced primary ovarian insufficiency
Le, D. C., Ngo, M. H. T., Kuo, Y. C., Chen, S. H., Lin, C. Y., Ling, T. Y., Pham, Q. T. T., Au, H. K., Myung, J. & Huang, Y. H., Dec 2024, In: Journal of Biomedical Science. 31, 1, 95.Research output: Contribution to journal › Article › peer-review
Open Access1 Citation (Scopus) -
Corrigendum: Potential of cellular therapy for ALS: current strategies and future prospects(Front. Cell Dev. Biol., (2022), 10, (851613), 10.3389/fcell.2022.851613)
Lin, T. J., Cheng, K. C., Wu, L. Y., Lai, W. Y., Ling, T. Y., Kuo, Y. C. & Huang, Y. H., 2023, In: Frontiers in Cell and Developmental Biology. 11, 1292681.Research output: Contribution to journal › Comment/debate › peer-review
Open Access -
Niclosamide Revitalizes Sorafenib through Insulin-like Growth Factor 1 Receptor (IGF-1R)/Stemness and Metabolic Changes in Hepatocellular Carcinoma
Peng, S.-W., Ngo, M.-H. T., Kuo, Y.-C., Teng, M.-H., Guo, C.-L., Lai, H.-C., Chang, T.-S. & Huang, Y.-H., Feb 2023, In: Cancers. 15, 3, 931.Research output: Contribution to journal › Article › peer-review
Open Access7 Citations (Scopus) -
Exosomes from Human Placenta Choriodecidual Membrane-Derived Mesenchymal Stem Cells Mitigate Endoplasmic Reticulum Stress, Inflammation, and Lung Injury in Lipopolysaccharide-Treated Obese Mice
Chiang, M. D., Chang, C. Y., Shih, H. J., Le, V. L., Huang, Y. H. & Huang, C. J., Apr 2022, In: Antioxidants. 11, 4, 615.Research output: Contribution to journal › Article › peer-review
Open Access10 Citations (Scopus)
Datasets
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Transcriptome expression pattern of E11.5 PGCs, P2 GSCs, and CD49f+GSCs.
Kuo, Y.-C. (Contributor) & Huang, Y.-H. (Contributor), Gene Expression Omnibus, 2017
https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE106664
Dataset
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MOESM1 of DNMT3b/OCT4 expression confers sorafenib resistance and poor prognosis of hepatocellular carcinoma through IL-6/STAT3 regulation
Lai, S.-C. (Contributor), Wu, Y.-C. (Contributor), Chi, C.-C. (Contributor), Lan, P.-C. (Contributor), Lee, K.-F. (Contributor), Yang, M.-H. (Contributor), Su, Y.-T. (Creator), Chang, T.-S. (Contributor), Kuo, Y.-C. (Contributor) & Huang, Y.-H. (Contributor), Figshare, 2019
DOI: 10.6084/m9.figshare.11273585.v1, https://doi.org/10.6084%2Fm9.figshare.11273585.v1
Dataset