Personal profile
Education
- 2014.12 Ph.D., Bioinformatics and Biosignal Transduction National Cheng Kung University, Taiwan
- 2009.07 M.S., Bioinformatics National Cheng Kung University, Taiwan
- 2007.06 B.S., Bioagricultural Sciences National Chiayi University, Taiwan
Experience
- 2024.02- 臺北醫學大學神經醫學研究中心助理教授
- 2021.06- Assistant Research Fellow, Brain tumor research, Taipei Medical University, Taiwan
- 2017.04-2021.05 Postdoctoral Fellow, Graduate Institute of Medical Sciences, Taipei Medical University, Taiwan
- 2016.03-2017.03 Postdoctoral Fellow, National Chiao Tung University, Taiwan
- 2015.03-2016.03 Postdoctoral Fellow, National Health Research Institutes, Taiwan
Awards
- Exhibition of Excellent Poster by the 34th Joint Annual Conference of Biomedical Science (Mar, 2019)
- Exhibition of Excellent Poster by the 3rd International Symposium on Infectious Disease and Signal Transduction (Nov, 2013)
Research Interests
- Molecular Biology
- Cell Biology
- Cancer Biology
- Bioinformatics
- Big Data Analytics
Other
Skills
- Interdisciplinary Considerations (biomedicine and computational science).
- Design the experiment independently and do the troubleshooting with colleagues.
- Confidently report information and research findings in writing.
- Patent analysis and patent portfolio.
- Big Data analytics and bioinformatics: Single-cell analysis (including scATAC-seq and scRNA-seq) using Cell Ranger and R language (Seurat package), high-throughput sequence analysis (RNA-seq, DNA methylation and cDNA microarray) using CLC Genomics Workbench and R language, functional analysis using MetaCore and Ingenuity Pathway Analysis, writing and editing a C program, and constructing a local MySQL relational database.
- Drug discovery: Post processing of protein-compound docking for structure-based drug discovery and development, systemic approaches to identify potential targets and drugs for drug repositioning in several diseases.
- Biochemistry and Molecular Biology: Protein purification from coli, western blot, plasmid construction, isolation and purification of genomic DNA, mRNA and microRNA, real-time PCR, agarose gel electrophoresis, SNP technology, and yeast two-hybrid screening.
- Cell Biology: Cell-related assays techniques (such as cell culture), microscopy imaging techniques (using confocal and time-lapse microscopy), and flow cytometry.
- Animal model: Zebrafish model, xenograft, metastasis, TBI, and orthotopic GBM mice model.
- Proteomics: Desalting and Mass Spectrometry (LTQ Orbitrap LC-MS/MS system), including in-gel or in-solution protein digestion, purification, MS/MS analysis, and analysis of proteomics data.
Fingerprint
- 1 Similar Profiles
Collaborations and top research areas from the last five years
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To Clarify Γ-Aminobutyric Acid-Mediated Epigenetic Changes Associated with Temozolomide Resistance in Glioblastoma
Yang, W.-B. (PI)
8/1/25 → 7/31/26
Project: A - Government Institution › b - National Science and Technology Council
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To Clarify Γ-Aminobutyric Acid-Mediated Epigenetic Changes Associated with Temozolomide Resistance in Glioblastoma
Yang, W.-B. (PI)
8/1/24 → 7/31/25
Project: A - Government Institution › b - National Science and Technology Council
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To Clarify the Role of Glutamate-Mediated Γ-Aminobutyric Acid Signaling in Recurrent Glioblastoma
Yang, W.-B. (PI)
2/1/22 → 7/31/23
Project: A - Government Institution › b - National Science and Technology Council
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新聘教師研究補助
Yang, W.-B. (PI)
9/15/21 → 9/14/22
Project: B - Project of TMU › g - Research Grants for Newly Hired Faculty
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Chronic cerebral hypoperfusion exacerbates amyloid and tau pathology by impairing glymphatic transport via AQP4- and VEGF-mediated pathways: insights from a vascular to mixed-type dementia model
Chen, J. H., Chang, C. W., Chen, Y. Y., Yang, C. H., Yang, W. B., Hsieh, Y. C., Liang, Y. W., Li, S. J. & Hu, C. J., Mar 2026, In: Alzheimer's and Dementia. 22, 3, e71290.Research output: Contribution to journal › Article › peer-review
Open Access -
A novel dual CDC25-HDAC inhibitor suppresses glioblastoma progression via chromosomal passenger complex disruption
Upadhyay, R., Sethy, B., Yang, W. B., Wu, M. H., Liou, K. C., Wu, A. C., Narwanti, I., Nepali, K., Liou, J. P. & Chuang, J. Y., Dec 2025, In: Biomedicine and Pharmacotherapy. 193, 118816.Research output: Contribution to journal › Article › peer-review
Open Access -
Chitinase-3-like-1: a multifaceted player in neuroinflammation and degenerative pathologies with therapeutic implications
Mwale, P. F., Hsieh, C. T., Yen, T. L., Jan, J. S., Taliyan, R., Yang, C. H. & Yang, W. B., Dec 2025, In: Molecular Neurodegeneration. 20, 1, 7.Research output: Contribution to journal › Review article › peer-review
Open Access31 Link opens in a new tab Citations (Scopus) -
Contribution of Prostaglandin E2-Induced Neuronal Excitation to Drug Resistance in Glioblastoma Countered by a Novel Blood–Brain Barrier Crossing Celecoxib Derivative
Shen, C. J., Chen, H. C., Lin, C. L., Thakur, A., Onuku, R., Chen, I. C., Li, H. Y., Chang, K. Y., Chuang, J. Y., Yang, W. B., Lin, H. Y., Shen, Y. R., Liou, J. P., Chang, W. C. & Hsu, T. I., Oct 13 2025, In: Advanced Science. 12, 38, e06336.Research output: Contribution to journal › Article › peer-review
Open Access7 Link opens in a new tab Citations (Scopus) -
Repurposing Linezolid in Conjunction with Histone Deacetylase Inhibitor Access in the Realm of Glioblastoma Therapies
Chen, I. C., Lin, H. Y., Liu, Z. Y., Cheng, W. J., Yeh, T. Y., Yang, W. B., Tran, H. Y., Lai, M. J., Wang, C. H., Kao, T. Y., Hung, C. Y., Huang, Y. L., Liou, K. C., Hsieh, C. M., Hsu, T. I. & Liou, J. P., 2025, In: Journal of Medicinal Chemistry. 68, 3, p. 2779-2803 25 p.Research output: Contribution to journal › Article › peer-review
Open Access7 Link opens in a new tab Citations (Scopus)
Datasets
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Additional file 2 of Estradiol-mediated inhibition of Sp1 decreases miR-3194-5p expression to enhance CD44 expression during lung cancer progression
Young, M.-J. (Creator), Chen, Y.-C. (Creator), Wang, S.-A. (Creator), Chang, H.-P. (Creator), Yang, W.-B. (Creator), Lee, C.-C. (Creator), Liu, C.-Y. (Creator), Tseng, Y.-L. (Creator), Wang, Y.-C. (Creator), Sun, H. S. (Creator), Chang, W.-C. (Creator) & Hung, J.-J. (Creator), Figshare, 2022
DOI: 10.6084/m9.figshare.18517662.v1, https://springernature.figshare.com/articles/figure/Additional_file_2_of_Estradiol-mediated_inhibition_of_Sp1_decreases_miR-3194-5p_expression_to_enhance_CD44_expression_during_lung_cancer_progression/18517662/1
Dataset
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MOESM4 of Enrichment of superoxide dismutase 2 in glioblastoma confers to acquisition of temozolomide resistance that is associated with tumor-initiating cell subsets
Lo, W.-L. (Creator), Chu, J.-M. (Contributor), Yang, K.-Y. (Creator), Liu, M.-S. (Creator), Liu, J.-J. (Creator), Chen, P.-Y. (Contributor), Chung, P.-H. (Contributor), Chuang, J.-Y. (Creator), Chien, C.-H. (Contributor), Chang, K.-Y. (Contributor), Yang, W.-B. (Creator), Huang, C.-Y. (Contributor), Yang, S.-T. (Creator), Chen, S.-H. (Contributor), Chou, S.-W. (Creator) & Hsu, T.-I. (Contributor), Figshare, 2019
DOI: 10.6084/m9.figshare.10006862.v1, https://doi.org/10.6084%2Fm9.figshare.10006862.v1
Dataset
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Reprogramming of arachidonate metabolism confers temozolomide resistance to glioblastoma through enhancing mitochondrial activity in fatty acid oxidation
Tsai, Y.-T. (Creator), Lo, W.-L. (Creator), Chen, P.-Y. (Creator), Ko, C.-Y. (Creator), Chuang, J.-Y. (Creator), Kao, T.-J. (Creator), Yang, W.-B. (Creator), Chang, K.-Y. (Creator), Hung, C.-Y. (Creator), Kikkawa, U. (Creator), Chang, W.-C. (Creator) & Hsu, T.-I. (Creator), Figshare, 2022
DOI: 10.6084/m9.figshare.c.5916320.v1, https://springernature.figshare.com/collections/Reprogramming_of_arachidonate_metabolism_confers_temozolomide_resistance_to_glioblastoma_through_enhancing_mitochondrial_activity_in_fatty_acid_oxidation/5916320/1
Dataset
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MOESM3 of Enrichment of superoxide dismutase 2 in glioblastoma confers to acquisition of temozolomide resistance that is associated with tumor-initiating cell subsets
Liu, J.-J. (Creator), Hsu, T.-I. (Contributor), Chou, S.-W. (Creator), Chuang, J.-Y. (Creator), Yang, W.-B. (Creator), Chen, P.-Y. (Contributor), Chen, S.-H. (Contributor), Yang, S.-T. (Creator), Chu, J.-M. (Contributor), Huang, C.-Y. (Contributor), Yang, K.-Y. (Creator), Chien, C.-H. (Contributor), Chung, P.-H. (Contributor), Lo, W.-L. (Creator), Liu, M.-S. (Creator) & Chang, K.-Y. (Contributor), Figshare, 2019
DOI: 10.6084/m9.figshare.10006856.v1, https://doi.org/10.6084%2Fm9.figshare.10006856.v1
Dataset
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MOESM8 of Enrichment of superoxide dismutase 2 in glioblastoma confers to acquisition of temozolomide resistance that is associated with tumor-initiating cell subsets
Chung, P.-H. (Contributor), Chen, S.-H. (Contributor), Hsu, T.-I. (Contributor), Liu, M.-S. (Creator), Lo, W.-L. (Creator), Chu, J.-M. (Contributor), Yang, K.-Y. (Creator), Yang, S.-T. (Creator), Liu, J.-J. (Creator), Chuang, J.-Y. (Creator), Yang, W.-B. (Creator), Huang, C.-Y. (Contributor), Chien, C.-H. (Contributor), Chang, K.-Y. (Contributor), Chen, P.-Y. (Contributor) & Chou, S.-W. (Creator), Figshare, 2019
DOI: 10.6084/m9.figshare.10006883.v1, https://doi.org/10.6084%2Fm9.figshare.10006883.v1
Dataset