Projects per year
Personal profile
Education
- 2014.12 Ph.D., Bioinformatics and Biosignal Transduction National Cheng Kung University, Taiwan
- 2009.07 M.S., Bioinformatics National Cheng Kung University, Taiwan
- 2007.06 B.S., Bioagricultural Sciences National Chiayi University, Taiwan
Experience
- 2021.06- Assistant Research Fellow, Brain tumor research, Taipei Medical University, Taiwan
- 2017.04-2021.05 Postdoctoral Fellow, Graduate Institute of Medical Sciences, Taipei Medical University, Taiwan
- 2016.03-2017.03 Postdoctoral Fellow, National Chiao Tung University, Taiwan
- 2015.03-2016.03 Postdoctoral Fellow, National Health Research Institutes, Taiwan
Awards
- Exhibition of Excellent Poster by the 34th Joint Annual Conference of Biomedical Science (Mar, 2019)
- Exhibition of Excellent Poster by the 3rd International Symposium on Infectious Disease and Signal Transduction (Nov, 2013)
Research Interests
- Molecular Biology
- Cell Biology
- Cancer Biology
- Bioinformatics
- Big Data Analytics
Other
Skills
- Interdisciplinary Considerations (biomedicine and computational science).
- Design the experiment independently and do the troubleshooting with colleagues.
- Confidently report information and research findings in writing.
- Patent analysis and patent portfolio.
- Big Data analytics and bioinformatics: Single-cell analysis (including scATAC-seq and scRNA-seq) using Cell Ranger and R language (Seurat package), high-throughput sequence analysis (RNA-seq, DNA methylation and cDNA microarray) using CLC Genomics Workbench and R language, functional analysis using MetaCore and Ingenuity Pathway Analysis, writing and editing a C program, and constructing a local MySQL relational database.
- Drug discovery: Post processing of protein-compound docking for structure-based drug discovery and development, systemic approaches to identify potential targets and drugs for drug repositioning in several diseases.
- Biochemistry and Molecular Biology: Protein purification from coli, western blot, plasmid construction, isolation and purification of genomic DNA, mRNA and microRNA, real-time PCR, agarose gel electrophoresis, SNP technology, and yeast two-hybrid screening.
- Cell Biology: Cell-related assays techniques (such as cell culture), microscopy imaging techniques (using confocal and time-lapse microscopy), and flow cytometry.
- Animal model: Zebrafish model, xenograft, metastasis, TBI, and orthotopic GBM mice model.
- Proteomics: Desalting and Mass Spectrometry (LTQ Orbitrap LC-MS/MS system), including in-gel or in-solution protein digestion, purification, MS/MS analysis, and analysis of proteomics data.
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Collaborations and top research areas from the last five years
Projects
- 2 Finished
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To Clarify the Role of Glutamate-Mediated Γ-Aminobutyric Acid Signaling in Recurrent Glioblastoma
2/1/22 → 7/31/23
Project: A - Government Institution › b - National Science and Technology Council
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CCAAT/Enhancer-Binding Protein Delta Regulates Glioblastoma Survival through Catalase-Mediated Hydrogen Peroxide Clearance
Lin, H. Y., Lim, S. W., Hsu, T. I., Yang, W. B., Huang, C. C., Tsai, Y. T., Chang, W. C. & Ko, C. Y., 2022, In: Oxidative Medicine and Cellular Longevity. 2022, 4081380.Research output: Contribution to journal › Article › peer-review
Open Access2 Citations (Scopus) -
Estradiol-mediated inhibition of Sp1 decreases miR-3194-5p expression to enhance CD44 expression during lung cancer progression
Young, M. J., Chen, Y. C., Wang, S. A., Chang, H. P., Yang, W. B., Lee, C. C., Liu, C. Y., Tseng, Y. L., Wang, Y. C., Sun, H. S., Chang, W. C. & Hung, J. J., Jan 17 2022, In: Journal of Biomedical Science. 29, 1, p. 3 3.Research output: Contribution to journal › Article › peer-review
Open Access9 Citations (Scopus) -
HDAC6 involves in regulating the lncRNA-microRNA-mRNA network to promote the proliferation of glioblastoma cells
Wu, A. C., Yang, W. B., Chang, K. Y., Lee, J. S., Liou, J. P., Su, R. Y., Cheng, S. M., Hwang, D. Y., Kikkawa, U., Hsu, T. I., Wang, C. Y., Chang, W. C., Chen, P. Y. & Chuang, J. Y., Dec 2022, In: Journal of Experimental and Clinical Cancer Research. 41, 1, 47.Research output: Contribution to journal › Article › peer-review
Open Access7 Citations (Scopus) -
Reprogramming of arachidonate metabolism confers temozolomide resistance to glioblastoma through enhancing mitochondrial activity in fatty acid oxidation
Tsai, Y. T., Lo, W. L., Chen, P. Y., Ko, C. Y., Chuang, J. Y., Kao, T. J., Yang, W. B., Chang, K. Y., Hung, C. Y., Kikkawa, U., Chang, W. C. & Hsu, T. I., Mar 25 2022, In: Journal of Biomedical Science. 29, 1, p. 21 21.Research output: Contribution to journal › Article › peer-review
Open Access15 Citations (Scopus) -
SH3GLB1-related autophagy mediates mitochondrial metabolism to acquire resistance against temozolomide in glioblastoma
Chien, C. H., Yang, W. B., Chuang, J. Y., Lee, J. S., Liao, W. A., Huang, C. Y., Chen, P. Y., Wu, A. C., Yang, S. T., Lai, C. C., Chi, P. I., Chu, J. M., Cheng, S. M., Liu, C. C., Hwang, D. Y., Chen, S. H. & Chang, K. Y., Dec 2022, In: Journal of Experimental and Clinical Cancer Research. 41, 1, 220.Research output: Contribution to journal › Article › peer-review
Open Access1 Citation (Scopus)
Datasets
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MOESM5 of Enrichment of superoxide dismutase 2 in glioblastoma confers to acquisition of temozolomide resistance that is associated with tumor-initiating cell subsets
Liu, J. (Creator), Chen, P. (Contributor), Chen, S. (Contributor), Chu, J. (Contributor), Chien, C. (Contributor), Yang, W. (Creator), Lo, W. (Creator), Hsu, T. (Contributor), Yang, K. (Creator), Chung, P. (Contributor), Chou, S. (Creator), Chang, K. (Contributor), Yang, S. (Creator), Chuang, J. (Creator), Huang, C. (Contributor) & Liu, M. (Creator), Figshare, 2019
DOI: 10.6084/m9.figshare.10006868.v1, https://doi.org/10.6084%2Fm9.figshare.10006868.v1
Dataset
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MOESM4 of Enrichment of superoxide dismutase 2 in glioblastoma confers to acquisition of temozolomide resistance that is associated with tumor-initiating cell subsets
Lo, W. (Creator), Chu, J. (Contributor), Yang, K. (Creator), Liu, M. (Creator), Liu, J. (Creator), Chen, P. (Contributor), Chung, P. (Contributor), Chuang, J. (Creator), Chien, C. (Contributor), Chang, K. (Contributor), Yang, W. (Creator), Huang, C. (Contributor), Yang, S. (Creator), Chen, S. (Contributor), Chou, S. (Creator) & Hsu, T. (Contributor), Figshare, 2019
DOI: 10.6084/m9.figshare.10006862.v1, https://doi.org/10.6084%2Fm9.figshare.10006862.v1
Dataset
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Enrichment of superoxide dismutase 2 in glioblastoma confers to acquisition of temozolomide resistance that is associated with tumor-initiating cell subsets
Chien, C. (Contributor), Chuang, J. (Creator), Yang, S. (Creator), Yang, W. (Creator), Chen, P. (Contributor), Hsu, T. (Contributor), Huang, C. (Contributor), Lo, W. (Creator), Yang, K. (Creator), Liu, M. (Creator), Chu, J. (Contributor), Chung, P. (Contributor), Liu, J. (Creator), Chou, S. (Creator), Chen, S. (Contributor) & Chang, K. (Contributor), Figshare, 2019
DOI: 10.6084/m9.figshare.c.4705370.v1, https://doi.org/10.6084%2Fm9.figshare.c.4705370.v1
Dataset
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MOESM3 of Enrichment of superoxide dismutase 2 in glioblastoma confers to acquisition of temozolomide resistance that is associated with tumor-initiating cell subsets
Liu, J. (Creator), Hsu, T. (Contributor), Chou, S. (Creator), Chuang, J. (Creator), Yang, W. (Creator), Chen, P. (Contributor), Chen, S. (Contributor), Yang, S. (Creator), Chu, J. (Contributor), Huang, C. (Contributor), Yang, K. (Creator), Chien, C. (Contributor), Chung, P. (Contributor), Lo, W. (Creator), Liu, M. (Creator) & Chang, K. (Contributor), Figshare, 2019
DOI: 10.6084/m9.figshare.10006856.v1, https://doi.org/10.6084%2Fm9.figshare.10006856.v1
Dataset
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Additional file 2 of Estradiol-mediated inhibition of Sp1 decreases miR-3194-5p expression to enhance CD44 expression during lung cancer progression
Young, M. (Creator), Chen, Y. (Creator), Wang, S. (Creator), Chang, H. (Creator), Yang, W. (Creator), Lee, C. (Creator), Liu, C. (Creator), Tseng, Y. (Creator), Wang, Y. (Creator), Sun, H. S. (Creator), Chang, W. (Creator) & Hung, J. (Creator), Figshare, 2022
DOI: 10.6084/m9.figshare.18517662.v1, https://springernature.figshare.com/articles/figure/Additional_file_2_of_Estradiol-mediated_inhibition_of_Sp1_decreases_miR-3194-5p_expression_to_enhance_CD44_expression_during_lung_cancer_progression/18517662/1
Dataset