Projects per year
Personal profile
Education
- 2014.12 Ph.D., Bioinformatics and Biosignal Transduction National Cheng Kung University, Taiwan
- 2009.07 M.S., Bioinformatics National Cheng Kung University, Taiwan
- 2007.06 B.S., Bioagricultural Sciences National Chiayi University, Taiwan
Experience
- 2024.02- 臺北醫學大學神經醫學研究中心助理教授
- 2021.06- Assistant Research Fellow, Brain tumor research, Taipei Medical University, Taiwan
- 2017.04-2021.05 Postdoctoral Fellow, Graduate Institute of Medical Sciences, Taipei Medical University, Taiwan
- 2016.03-2017.03 Postdoctoral Fellow, National Chiao Tung University, Taiwan
- 2015.03-2016.03 Postdoctoral Fellow, National Health Research Institutes, Taiwan
Awards
- Exhibition of Excellent Poster by the 34th Joint Annual Conference of Biomedical Science (Mar, 2019)
- Exhibition of Excellent Poster by the 3rd International Symposium on Infectious Disease and Signal Transduction (Nov, 2013)
Research Interests
- Molecular Biology
- Cell Biology
- Cancer Biology
- Bioinformatics
- Big Data Analytics
Other
Skills
- Interdisciplinary Considerations (biomedicine and computational science).
- Design the experiment independently and do the troubleshooting with colleagues.
- Confidently report information and research findings in writing.
- Patent analysis and patent portfolio.
- Big Data analytics and bioinformatics: Single-cell analysis (including scATAC-seq and scRNA-seq) using Cell Ranger and R language (Seurat package), high-throughput sequence analysis (RNA-seq, DNA methylation and cDNA microarray) using CLC Genomics Workbench and R language, functional analysis using MetaCore and Ingenuity Pathway Analysis, writing and editing a C program, and constructing a local MySQL relational database.
- Drug discovery: Post processing of protein-compound docking for structure-based drug discovery and development, systemic approaches to identify potential targets and drugs for drug repositioning in several diseases.
- Biochemistry and Molecular Biology: Protein purification from coli, western blot, plasmid construction, isolation and purification of genomic DNA, mRNA and microRNA, real-time PCR, agarose gel electrophoresis, SNP technology, and yeast two-hybrid screening.
- Cell Biology: Cell-related assays techniques (such as cell culture), microscopy imaging techniques (using confocal and time-lapse microscopy), and flow cytometry.
- Animal model: Zebrafish model, xenograft, metastasis, TBI, and orthotopic GBM mice model.
- Proteomics: Desalting and Mass Spectrometry (LTQ Orbitrap LC-MS/MS system), including in-gel or in-solution protein digestion, purification, MS/MS analysis, and analysis of proteomics data.
Fingerprint
- 1 Similar Profiles
Collaborations and top research areas from the last five years
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釐清γ-氨基丁酸介導的膠質母細胞瘤中與帝盟多抗藥性相關的表觀遺傳變化(1/3)
Yang, W.-B. (PI)
8/1/24 → 7/31/25
Project: A - Government Institution › b - National Science and Technology Council
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To Clarify the Role of Glutamate-Mediated Γ-Aminobutyric Acid Signaling in Recurrent Glioblastoma
Yang, W.-B. (PI)
2/1/22 → 7/31/23
Project: A - Government Institution › b - National Science and Technology Council
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新聘教師研究補助
Yang, W.-B. (PI)
9/15/21 → 9/14/22
Project: B - Project of TMU › g - Research Grants for Newly Hired Faculty
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Repurposing Linezolid in Conjunction with Histone Deacetylase Inhibitor Access in the Realm of Glioblastoma Therapies
Chen, I. C., Lin, H. Y., Liu, Z. Y., Cheng, W. J., Yeh, T. Y., Yang, W. B., Tran, H. Y., Lai, M. J., Wang, C. H., Kao, T. Y., Hung, C. Y., Huang, Y. L., Liou, K. C., Hsieh, C. M., Hsu, T. I. & Liou, J. P., 2025, (Accepted/In press) In: Journal of Medicinal Chemistry.Research output: Contribution to journal › Article › peer-review
Open Access -
CXCR7 activation evokes the anti-PD-L1 antibody against glioblastoma by remodeling CXCL12-mediated immunity
Liu, C. C., Yang, W. B., Chien, C. H., Wu, C. L., Chuang, J. Y., Chen, P. Y., Chu, J. M., Cheng, S. M., Qiu, L. Y., Chang, Y. C., Hwang, D. Y., Huang, C. Y., Lee, J. S. & Chang, K. Y., Jun 2024, In: Cell Death and Disease. 15, 6, 434.Research output: Contribution to journal › Article › peer-review
Open Access2 Citations (Scopus) -
Dual inhibition of CYP17A1 and HDAC6 by abiraterone-installed hydroxamic acid overcomes temozolomide resistance in glioblastoma through inducing DNA damage and oxidative stress
Sharma, R., Chiang, Y. H., Chen, H. C., Lin, H. Y., Yang, W. B., Nepali, K., Lai, M. J., Chen, K. Y., Liou, J. P. & Hsu, T. I., Apr 1 2024, In: Cancer Letters. 586, 216666.Research output: Contribution to journal › Article › peer-review
4 Citations (Scopus) -
First-in-Class Dual EZH2-HSP90 Inhibitor Eliciting Striking Antiglioblastoma Activity In Vitro and In Vivo
Sharma, S., Wang, S. A., Yang, W. B., Lin, H. Y., Lai, M. J., Chen, H. C., Kao, T. Y., Hsu, F. L., Nepali, K., Hsu, T. I. & Liou, J. P., Feb 22 2024, In: Journal of Medicinal Chemistry. 67, 4, p. 2963-2985 23 p.Research output: Contribution to journal › Article › peer-review
Open Access4 Citations (Scopus) -
Progesterone boosts abiraterone-driven target and NK cell therapies against glioblastoma
Chen, H. C., Lin, H. Y., Chiang, Y. H., Yang, W. B., Wang, C. H., Yang, P. Y., Hu, S. L. & Hsu, T. I., Dec 2024, In: Journal of Experimental and Clinical Cancer Research. 43, 1, 218.Research output: Contribution to journal › Article › peer-review
Open Access1 Citation (Scopus)
Datasets
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MOESM8 of Enrichment of superoxide dismutase 2 in glioblastoma confers to acquisition of temozolomide resistance that is associated with tumor-initiating cell subsets
Chung, P.-H. (Contributor), Chen, S.-H. (Contributor), Hsu, T.-I. (Contributor), Liu, M.-S. (Creator), Lo, W.-L. (Creator), Chu, J.-M. (Contributor), Yang, K.-Y. (Creator), Yang, S.-T. (Creator), Liu, J.-J. (Creator), Chuang, J.-Y. (Creator), Yang, W.-B. (Creator), Huang, C.-Y. (Contributor), Chien, C.-H. (Contributor), Chang, K.-Y. (Contributor), Chen, P.-Y. (Contributor) & Chou, S.-W. (Creator), Figshare, 2019
DOI: 10.6084/m9.figshare.10006883.v1, https://doi.org/10.6084%2Fm9.figshare.10006883.v1
Dataset
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MOESM4 of Enrichment of superoxide dismutase 2 in glioblastoma confers to acquisition of temozolomide resistance that is associated with tumor-initiating cell subsets
Lo, W.-L. (Creator), Chu, J.-M. (Contributor), Yang, K.-Y. (Creator), Liu, M.-S. (Creator), Liu, J.-J. (Creator), Chen, P.-Y. (Contributor), Chung, P.-H. (Contributor), Chuang, J.-Y. (Creator), Chien, C.-H. (Contributor), Chang, K.-Y. (Contributor), Yang, W.-B. (Creator), Huang, C.-Y. (Contributor), Yang, S.-T. (Creator), Chen, S.-H. (Contributor), Chou, S.-W. (Creator) & Hsu, T.-I. (Contributor), Figshare, 2019
DOI: 10.6084/m9.figshare.10006862.v1, https://doi.org/10.6084%2Fm9.figshare.10006862.v1
Dataset
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Additional file 2 of Estradiol-mediated inhibition of Sp1 decreases miR-3194-5p expression to enhance CD44 expression during lung cancer progression
Young, M.-J. (Creator), Chen, Y.-C. (Creator), Wang, S.-A. (Creator), Chang, H.-P. (Creator), Yang, W.-B. (Creator), Lee, C.-C. (Creator), Liu, C.-Y. (Creator), Tseng, Y.-L. (Creator), Wang, Y.-C. (Creator), Sun, H. S. (Creator), Chang, W.-C. (Creator) & Hung, J.-J. (Creator), Figshare, 2022
DOI: 10.6084/m9.figshare.18517662.v1, https://springernature.figshare.com/articles/figure/Additional_file_2_of_Estradiol-mediated_inhibition_of_Sp1_decreases_miR-3194-5p_expression_to_enhance_CD44_expression_during_lung_cancer_progression/18517662/1
Dataset
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MOESM3 of Enrichment of superoxide dismutase 2 in glioblastoma confers to acquisition of temozolomide resistance that is associated with tumor-initiating cell subsets
Liu, J.-J. (Creator), Hsu, T.-I. (Contributor), Chou, S.-W. (Creator), Chuang, J.-Y. (Creator), Yang, W.-B. (Creator), Chen, P.-Y. (Contributor), Chen, S.-H. (Contributor), Yang, S.-T. (Creator), Chu, J.-M. (Contributor), Huang, C.-Y. (Contributor), Yang, K.-Y. (Creator), Chien, C.-H. (Contributor), Chung, P.-H. (Contributor), Lo, W.-L. (Creator), Liu, M.-S. (Creator) & Chang, K.-Y. (Contributor), Figshare, 2019
DOI: 10.6084/m9.figshare.10006856.v1, https://doi.org/10.6084%2Fm9.figshare.10006856.v1
Dataset
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MOESM1 of Enrichment of superoxide dismutase 2 in glioblastoma confers to acquisition of temozolomide resistance that is associated with tumor-initiating cell subsets
Yang, K.-Y. (Creator), Chen, S.-H. (Contributor), Chung, P.-H. (Contributor), Chang, K.-Y. (Contributor), Liu, M.-S. (Creator), Chuang, J.-Y. (Creator), Chien, C.-H. (Contributor), Lo, W.-L. (Creator), Hsu, T.-I. (Contributor), Huang, C.-Y. (Contributor), Chen, P.-Y. (Contributor), Chu, J.-M. (Contributor), Liu, J.-J. (Creator), Yang, S.-T. (Creator), Chou, S.-W. (Creator) & Yang, W.-B. (Creator), Figshare, 2019
DOI: 10.6084/m9.figshare.10006847.v1, https://doi.org/10.6084%2Fm9.figshare.10006847.v1
Dataset