Projects per year
Personal profile
Education
- 2008 Ph.D., Institute of Biochemistry, Microbiology and Immunology, Chung Shan Medical University
- 2004 M.S., Institute of Biochemistry, Microbiology and Immunology, Chung Shan Medical University
Experience
- 2025.07 Deputy Director, Department of Medical Research, Taipei Municipal Wanfang Hospital
- 2021.02- Associate Professor, Department of Urology, School of Medicine, College of Medicine, Taipei Medical University
- 2015.11-2021.01 Assistant Professor, Department of Urology, School of Medicine, College of Medicine, Taipei Medical University
- 2013.04- Assistant Researcher, Taipei Municipal Wanfang Hospital
- 2012.08-2013.03 Research Assistant, Division of Cardiology, Tao-Yuan General Hospital, Ministry of Health and Welfare
- 2008.08-2011.07 Postdoctoral Researcher, Graduate Institute of Toxicology, College of Medicine, National Taiwan University
Research Interests
- 醫學之生化及分子生物
- 藥理及毒理
Awards
- 2015 萬芳醫學中心論文獎(第二名)
Fingerprint
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Investigating the Therapeutic Effect and Molecular Mechanisms of Antroquinonol, a Derivative from Antrodia Cinnamomea, in Blocking L1cam/Ret-Mediated Drug Resistance and Immune Suppression in Renal Cell Carcinoma: a Translational Medical Study Targeting Drug-Resistant Renal Cell Carcinoma.( I )
Lee, W.-J. (PI)
8/1/24 → 7/31/27
Project: A - Government Institution › b - National Science and Technology Council
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Investigating the Therapeutic Effect and Molecular Mechanisms of Antroquinonol, a Derivative from Antrodia Cinnamomea, in Blocking L1cam/Ret-Mediated Drug Resistance and Immune Suppression in Renal Cell Carcinoma: a Translational Medical Study Targeting Drug-Resistant Renal Cell Carcinoma.( I )
Lee, W.-J. (PI)
8/1/25 → 7/31/26
Project: A - Government Institution › b - National Science and Technology Council
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應用人源性腫瘤組織異種移植模型發展熱療作為膀胱原位癌患者的輔助治療策略
Lee, W.-J. (PI)
1/1/21 → 12/31/21
Project: B - Project of TMU › h - Higher Education Sprout Project
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Elucidating the Underlying Mechanisms of Spock1/Pi3k/Akt Signaling in Sunitinib Resistance of Clear Cell Renal Cell Carcinoma
Lee, W.-J. (PI)
8/1/20 → 7/1/21
Project: A - Government Institution › b - National Science and Technology Council
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應用人源性腫瘤組織異種移植模型發展熱療作為膀胱原位癌患者的輔助治療策略
Lee, W.-J. (PI)
1/1/20 → 12/1/20
Project: B - Project of TMU › h - Higher Education Sprout Project
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Programmable local immunochemotherapy for triple-negative breast cancer via spatiotemporally controlled release of CpG oligodeoxynucleotides, gemcitabine, and paclitaxel
Hsieh, C. H., Hsu, M. Y., Lin, C. F., Liu, C. C., Kuo, Y. H., Huang, Y. T., Chen, W. Y., Liu, S. J. & Lee, W. J., Dec 2026, In: npj Breast Cancer. 12, 1, 45.Research output: Contribution to journal › Article › peer-review
Open Access1 Link opens in a new tab Citation (Scopus) -
Cyclic increase in the histamine receptor H1-ADAM9-Snail/Slug axis as a potential therapeutic target for EMT-mediated progression of oral squamous cell carcinoma
Ding, Y. F., Ho, K. H., Lee, W. J., Chen, L. H., Hsieh, F. K., Tung, M. C., Lin, S. H., Hsiao, M., Yang, S. F., Yang, Y. C. & Chien, M. H., Dec 2025, In: Cell Death and Disease. 16, 1, 191.Research output: Contribution to journal › Article › peer-review
Open Access9 Link opens in a new tab Citations (Scopus) -
MAOB promotes ROS-mediated DNA damage, triggering a cyclic MAOB-HNF1A-53BP1-p53 axis that suppresses the malignancy of clear cell renal cell carcinoma
Ho, K. H., Lin, Y. W., Huang, H. C., Lai, F. R., Yang, Y. C., Lai, C. H., Wen, Y. C., Hsieh, F. K., Lee, W. J. & Chien, M. H., Dec 1 2025, In: Redox Biology. 88, p. 103945 1 p., 103945.Research output: Contribution to journal › Article › peer-review
Open Access3 Link opens in a new tab Citations (Scopus) -
The off‑target effect of loratadine triggers autophagy‑mediated apoptosis in lung adenocarcinoma cells by deactivating JNK, p38, and STAT3 signaling through both PP2A‑dependent and independent pathways
Chien, M. H., Hung, W. Y., Lai, T. C., Tsai, C. H., Lee, K. L., Hsieh, F. K., Lee, W. J. & Chang, J. H., Apr 2025, In: International Journal of Molecular Medicine. 55, 4, 54.Research output: Contribution to journal › Article › peer-review
5 Link opens in a new tab Citations (Scopus) -
Cyclic increase in the ADAMTS1-L1CAM-EGFR axis promotes the EMT and cervical lymph node metastasis of oral squamous cell carcinoma
Chien, M. H., Yang, Y. C., Ho, K. H., Ding, Y. F., Chen, L. H., Chiu, W. K., Chen, J. Q., Tung, M. C., Hsiao, M. & Lee, W. J., Jan 2024, In: Cell Death and Disease. 15, 1, p. 82 82.Research output: Contribution to journal › Article › peer-review
Open Access18 Link opens in a new tab Citations (Scopus)
Datasets
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Additional file 1: of Targeting the SPOCK1-snail/slug axis-mediated epithelial-to-mesenchymal transition by apigenin contributes to repression of prostate cancer metastasis
Huang, H.-C. (Contributor), Lin, Y.-W. (Contributor), Wen, Y.-C. (Contributor), Lee, W.-J. (Contributor), Yang, Y.-C. (Contributor), Chang, J.-L. (Contributor), Chien, M.-H. (Contributor) & Hsiao, M. (Creator), Figshare, 2019
DOI: 10.6084/m9.figshare.8252111.v1, https://doi.org/10.6084%2Fm9.figshare.8252111.v1
Dataset
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Additional file 1: Table S1. of The Gαh-PLCδ1 signaling axis drives metastatic progression in triple-negative breast cancer
Huang, S.-P. (Contributor), Liu, P.-Y. (Contributor), Kuo, C.-J. (Contributor), Chen, C.-L. (Contributor), Lee, W.-J. (Contributor), Tsai, Y.-H. (Contributor) & Lin, Y.-F. (Contributor), Unknown Publisher, Jun 2 2017
DOI: 10.6084/m9.figshare.c.3794620_d1.v1, https://springernature.figshare.com/articles/journal_contribution/Additional_file_1_Table_S1_of_The_G_h-PLC_1_signaling_axis_drives_metastatic_progression_in_triple-negative_breast_cancer/5072119/1
Dataset
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Penfluridol triggers cytoprotective autophagy and cellular apoptosis through ROS induction and activation of the PP2A-modulated MAPK pathway in acute myeloid leukemia with different FLT3 statuses
Wu, S.-Y. (Contributor), Wen, Y.-C. (Contributor), Ku, C.-C. (Creator), Yang, Y.-C. (Contributor), Chow, J.-M. (Contributor), Yang, S.-F. (Contributor), Lee, W.-J. (Contributor) & Chien, M.-H. (Contributor), Figshare, 2019
DOI: 10.6084/m9.figshare.c.4650602.v1, https://springernature.figshare.com/collections/Penfluridol_triggers_cytoprotective_autophagy_and_cellular_apoptosis_through_ROS_induction_and_activation_of_the_PP2A-modulated_MAPK_pathway_in_acute_myeloid_leukemia_with_different_FLT3_statuses/4650602/1
Dataset
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Targeting the SPOCK1-snail/slug axis-mediated epithelial-to-mesenchymal transition by apigenin contributes to repression of prostate cancer metastasis
Chien, M.-H. (Contributor), Lin, Y.-W. (Contributor), Wen, Y.-C. (Contributor), Yang, Y.-C. (Contributor), Hsiao, M. (Creator), Chang, J.-L. (Contributor), Huang, H.-C. (Contributor) & Lee, W.-J. (Contributor), Figshare, 2019
DOI: 10.6084/m9.figshare.c.4535717.v1, https://doi.org/10.6084%2Fm9.figshare.c.4535717.v1
Dataset
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Additional file 1: of Penfluridol triggers cytoprotective autophagy and cellular apoptosis through ROS induction and activation of the PP2A-modulated MAPK pathway in acute myeloid leukemia with different FLT3 statuses
Wu, S.-Y. (Contributor), Lee, W.-J. (Contributor), Chow, J.-M. (Contributor), Chien, M.-H. (Contributor), Yang, S.-F. (Contributor), Yang, Y.-C. (Contributor), Ku, C.-C. (Creator) & Wen, Y.-C. (Contributor), Figshare, 2019
DOI: 10.6084/m9.figshare.9756398.v1, https://doi.org/10.6084%2Fm9.figshare.9756398.v1
Dataset