Projects per year
Personal profile
Education
- 耶魯大學生物化學及生物物理學博士
- 國立臺灣大學化學系學士
Experience
- 2015.01- University Chair Professor, College of Biomedical Engineering, Taipei Medical University
- 2013.01- 中研院奈米醫學計畫中心主任
- 2013.01- 中央研究院生物化學研究所特聘研究員
- 2011.08-2013.01 中研院生化所合聘特聘研究員
- 2011.08-2013.01 中研院化學所所長
- 2010.08-2011.08 中央研究院生物化學研究所特聘研究員
- 2002-2010 美國國家衛生研究院肌肉生物學實驗室主任
- 1997-2002 美國國家衛生研究院關節炎、肌肉骨骼和皮膚病研究所,生物物理學實驗室主任
- 1996 杜克大學醫學院細胞生物學系客座教授
- 1984-1989 美國心臟協會傑出研究員
- 1984-1985 美國國家衛生研究院心肺和血液病研究所及細胞生物學實驗室客座科學家
- 1989-1998 德州大學奧斯汀分校化學和生化系教授
- 1984-1989 德州大學奧斯汀分校化學和生化系副教授
- 1974-1976 德州大學奧斯汀分校化學和生化系助理教授
- 1974-1976 加州大學聖地牙哥分校博士後研究
Research Interests
- Intrinsically Disordered Proteins: Interplay of Form, Function and Force
- Combination Drugs and Targeted Drug Delivery at the Nanomedicine Program
- Mechanobiology: Giant Elastic Proteins and Elastic Myofilaments in Striated Muscles
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Collaborations and top research areas from the last five years
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Projects
- 4 Finished
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探討CEACAM6 的致病機制及其抗體脂質衍生物在胰臟癌的標靶治療效果
Kuan, W. (PI)
8/1/23 → 7/31/24
Project: A - Government Institution › b - National Science and Technology Council
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標靶整合素αvβ3-FAK訊號網絡的膽管癌診療策略開發-利用體外與腫瘤異種移植探討CEACAM6抗體強化DL-N2在膽管癌之診療效果(3/3)
Kuan, W. (PI)
8/1/23 → 7/31/24
Project: A - Government Institution › b - National Science and Technology Council
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To Enhance Theranostic Effect of Dl-N2-Payload with Anti-Ceacam6 Antibodies in Cholangiocarcinoma in Vitro and in Xenograft Models( II )
Kuan, W. (PI)
8/1/22 → 7/31/23
Project: A - Government Institution › b - National Science and Technology Council
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To Enhance Theranostic Effect of Dl-N2-Payload with Anti-Ceacam6 Antibodies in Cholangiocarcinoma in Vitro and in Xenograft Models( I )
Kuan, W. (PI)
8/1/21 → 7/31/22
Project: A - Government Institution › b - National Science and Technology Council
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Heteronemin suppresses EGF‑induced proliferation through the PI3K/PD‑L1 signaling pathways in cholangiocarcinoma
Yang, Y. C. S. H., Tsai, C. C., Yang, Y. N., Liu, F. C., Lee, S. Y., Yang, J. C., Crawford, D. R., Chiu, H. C., Lu, M. C., Li, Z. L., Chen, Y. C., Chu, T. Y., Whang-Peng, J., Lin, H. Y. & Wang, K., Mar 2025, In: Oncology Reports. 53, 3, 32.Research output: Contribution to journal › Article › peer-review
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A new potential therapeutic approach for ALS: A case report with NGS analysis
Hu, C. J., Chen, P. C., Padmanabhan, N., Zahn, A., Ho, C. M., Wang, K. & Yen, Y., Mar 1 2024, In: Medicine (United States). 103, 9, p. E37401Research output: Contribution to journal › Article › peer-review
Open Access1 Citation (Scopus) -
Progesterone modulates cell growth via integrin αvβ3-dependent pathway in progesterone receptor-negative MDA-MB-231 cells
Tsai, C. C., Yang, Y. N., Wang, K., Chen, Y. C. E., Chen, Y. F., Yang, J. C., Li, Z. L., Huang, H. M., Pedersen, J. Z., Incerpi, S., Lee, S. Y., Lin, H. Y. & Whang-Peng, J., Jul 15 2024, In: Heliyon. 10, 13, e34006.Research output: Contribution to journal › Article › peer-review
Open Access -
Heteronemin and tetrac derivatives suppress non-small cell lung cancer growth via ERK1/2 inhibition
Chung, C. C., Huang, T. Y., Chu, H. R., De Luca, R., Candelotti, E., Huang, C. H., Yang, Y. C. S. H., Incerpi, S., Pedersen, J. Z., Lin, C. Y., Huang, H. M., Lee, S. Y., Li, Z. L., ChangOu, C. A., Li, W. S., Davis, P. J., Lin, H. Y., Whang-Peng, J. & Wang, K., Mar 2022, In: Food and Chemical Toxicology. 161, 112850.Research output: Contribution to journal › Article › peer-review
10 Citations (Scopus) -
Heteronemin and Tetrac Induce Anti-Proliferation by Blocking EGFR-Mediated Signaling in Colorectal Cancer Cells
Unson, S., Chang, T.-C., Yang, Y. N., Wang, S. H., Huang, C. H., Crawford, D. R., Huang, H.-M., Li, Z. L., Lin, H. Y., Whang-Peng, J., Kuan, W., Davis, P. J. & Li, W. S., Jul 27 2022, In: Marine Drugs. 20, 8, 482.Research output: Contribution to journal › Article › peer-review
Open Access7 Citations (Scopus)