Projects per year
Personal profile
Education
- 2012 Ph.D., Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University
- 1981-1985 M.D., School of Medicine, University of Santo Tomas
- 1978-1981 B.S., Department of Science Accelerated, University of Santo Tomas
Experience
- 2022.02- Professor, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University
- Director, Division of Metabolism, Department of Internal Medicine, Taipei Municipal Wanfang Hospital
- 2019.08- Director, Department of Metabolism, School of Medicine, College of Medicine, Taipei Medical University
- 2012- Examiner OSCE Taiwan Institute of Medical Education
- 1997- Consultant & Head, Diabetic Education Center, Wan Fang Hospital
- 2021.02-2022.01 Associate Professor, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University
- 2014.02-2021.01 Associate Professor, School of Medicine, College of Medicine, Taipei Medical University
- 2013-2018 Board Committee, Taipei Military Services
- 2003.08-2009.07 Instructor, School of Medicine, Taipei Medical University
- 2012-2016 Executive board The Endocrine Society of Republic of China
- 2011-2017 Representative of Society of Internal Medicine
- 2009.08-2014.01 Assistant Professor, School of Medicine, Taipei Medical University
- 2009-2011 Board Committee National Conspiracy Agency, Ministry of the Interior, Military Services
- 2005-2017 Representative of Taiwan Association of Diabetes Education
- 1996.08-1999.09 Attending Physician, Central Clinic Hospital
- 1996.08-2007.12 Physician, Taipei Veterans General Hospital
- 1996.07-1997.06 Clinical Instructor, National Defense Medical Center
- 1994.08-1996.07 Fellowship training Endocrinology and Metabolism, Taipei Veterans General Hospital
- 1996-1997 Clinical Instructor, School of Medicine, National Defense Medical Center
- 1996-2007 Visiting consultant, Taipei Veterans General Hospital 9
- 1997-2000 Consultant, Central Health Insurance Bureau of Taipei Joint Outpatient Clinic
- 1996-1999 Executive board, Taiwan Association of Diabetes Education
- 1989.07-1994.06 Chief Resident Physician, Department of Internal Medicine, Central Clinic & Hospital
Awards
- 2015 The Diabetes Association and Endocrine Society of Republic of China, Outstanding Paper Award
- 2014 Taipei Medical Center Diabetes Shared Care Medical Quality-2nd prize
- 2013 Taipei Medical Center Diabetes Shared Care Medical Quality 2nd Prize
- 2012 Taipei Medical Center Diabetes Shared Care Medical Quality 1st Prize
- 2012 Taipei Medical University School of Medicine, Postgraduate Thesis Merit Award
- 2012 Asian-Pacific Bayer Chinese Diabetes Forum 2012 Outstanding Poster Award
- 2012 The Diabetes Association and Endocrine Society of Republic of China, Outstanding Paper Award
Research Interests
- Clinical and basic research in Diabetes
- Clinical and basic research on Endocrine diseases
- Clinical research on new drugs development
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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Collaborations and top research areas from the last five years
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探討miR-452於心肌炎誘導心律不整與細胞代謝失調之病理機制:外泌體奈米藥物的治療潛力與挑戰-心臟特異性靶向外泌體攜帶miR-452於心肌炎引起的粒線體功能障礙和代謝異常之治療機會與機轉(2/2)
Lee, T.-I. (PI)
8/1/26 → 7/31/27
Project: A - Government Institution › b - National Science and Technology Council
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Cardiac-Targeting Exosomal Microrna-452 in Myocarditis: Addressing Mitochondrial Dysfunction and Metabolic–Epigenetic Crosstalk( I )
Lee, T.-I. (PI)
8/1/25 → 7/31/26
Project: A - Government Institution › b - National Science and Technology Council
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Ketone Body Beta-Hydroxybutyrate Mitigates Diabetic Cardiomyopathy via Cross-Talk with Fgf-21 Signaling
Lee, T.-I. (PI)
8/1/22 → 7/31/23
Project: A - Government Institution › b - National Science and Technology Council
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Inhibition of Nlrp3-Inflammasome- a Novel Therapeutic Strategy for Diabetic Cardiomyopathy
Lee, T.-I. (PI)
8/1/20 → 7/1/21
Project: A - Government Institution › b - National Science and Technology Council
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Liraglutide與Empagliflozin在糖尿病心肌病變不同地調控心臟代謝:抗糖尿病藥物的獨特心臟保護作用
Lee, T.-I. (PI)
3/1/20 → 7/31/21
Project: C - Project of Alliance › q - Cathay General Hospital
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Advanced glycation end products enhance human atrial fibroblast activity through activation of interferon/signal transducer and activator of transcription signaling
Cheng, T. Y., Li, S. J., Lee, T. W., Lee, T. I., Chen, Y. C., Kao, Y. H., Higa, S., Chen, P. H. & Chen, Y. J., Mar 2026, In: Gene Reports. 42, 102423.Research output: Contribution to journal › Article › peer-review
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Calcitriol deficiency reduces myocardial ATP production with disturbed mitochondrial dynamics and increased uncoupling protein 2 expression
Lee, T. W., Lee, T. I., Higa, S., Kao, Y. H. & Chen, Y. J., Sept 5 2025, In: European Journal of Pharmacology. 1002, 177858.Research output: Contribution to journal › Article › peer-review
3 Link opens in a new tab Citations (Scopus) -
Metabolic benefits of therapeutic exercise in older adults with type 2 diabetes mellitus and multimorbidity: a retrospective cohort study
Hung, S. E., Lee, T. I., Wang, C. Y., Liu, H. W. & Lee, T. W., Nov 2025, In: Internal Medicine Journal. 55, 11, p. 1891-1898 8 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Short-chain fatty acid butyrate against TMAO activating endoplasmic-reticulum stress and PERK/IRE1-axis with reducing atrial arrhythmia
Cheng, T. Y., Lee, T. W., Li, S. J., Lee, T. I., Chen, Y. C., Kao, Y. H., Higa, S., Chen, P. H. & Chen, Y. J., Jul 2025, In: Journal of Advanced Research. 73, p. 549-560 12 p.Research output: Contribution to journal › Article › peer-review
Open Access26 Link opens in a new tab Citations (Scopus) -
Interleukin-33/ST2 axis involvement in atrial remodeling and arrhythmogenesis
Cheng, T. Y., Chen, Y. C., Li, S. J., Lin, F. J., Lu, Y. Y., Lee, T. I., Lee, T. W., Higa, S., Kao, Y. H. & Chen, Y. J., 2024, (Accepted/In press) In: Translational Research. 268, p. 1-12 12 p.Research output: Contribution to journal › Article › peer-review
15 Link opens in a new tab Citations (Scopus)
Datasets
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Activation of Class I histone deacetylases contributes to mitochondrial dysfunction in cardiomyocytes with altered complex activities
Lee, T.-W. (Contributor), Cheng, W.-L. (Creator), Kao, Y.-H. (Contributor), Lee, T.-I. (Contributor), Chen, Y.-J. (Contributor) & Lkhagva, B. (Contributor), Taylor & Francis, 2018
DOI: 10.6084/m9.figshare.6220217.v1, https://doi.org/10.6084%2Fm9.figshare.6220217.v1
Dataset