Ruei-Ming Chen

Projects

Projects per year 2010 2010 2012 2014 2015 2016 2017 2018 2019 2020 2021 2024

• 45 Finished

Projects per year

Search results

• Finished

  GATA Binding Protein 3訊息傳遞軸於慢性腎臟病併發骨折和癒合延遲過程中可能扮演的角色研究(2/3)

  Chen, R.-M. (PI)

  8/1/23 → 7/31/24

  Project: A - Government Institution › b - National Science and Technology Council

• Roles of the Gata Binding Protein 3-Signaling Axis in Chronic Kidney Disease-Associated Bone Fracture and Delay of Fracture Healing (1/3)

  Chen, R.-M. (PI)

  8/1/22 → 7/31/23

  Project: A - Government Institution › b - National Science and Technology Council

• 緩激肽B1 受體新穎拮抗劑R954 抑制BK-BIR 訊號軸誘發GBM 細胞藥物和放射拮抗性的效能與機轉研究

  Chen, R.-M. (PI)

  1/1/22 → 12/31/22

  Project: B - Project of TMU › h - Higher Education Sprout Project

• Roles of the Hdacs/Sp1-Mediated Microrna-106b~25 Axis in Drug Resistance of Glioblastomas( III )

  Chen, R.-M. (PI)

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - National Science and Technology Council

• 睪固酮-雄性激素受體訊息傳遞軸在多型性膠質母細胞瘤產生抗藥性過程中所扮演的角色研究

  Chen, R.-M. (PI)

  7/1/21 → 2/28/22

  Project: A - Government Institution › b - National Science and Technology Council

• 睪固酮-雄性激素受體訊息軸在膠質母細胞瘤產生抗藥性過程中扮演的角色研究

  Chen, R.-M. (PI)

  3/1/21 → 2/28/22

  Project: C - Project of Alliance › o - Chi Mei Medical Center

• 雄性激素-雄性激素受體軸在調控膠質母細胞瘤水通道蛋白4 基因表現與藥物拮抗性的角色研究

  Chen, R.-M. (PI)

  1/1/21 → 12/31/21

  Project: B - Project of TMU › h - Higher Education Sprout Project

• A Translational Study to Verify Roles of Circulating Mir-19b and Mir-93 as Biomarker Signatures for Early Diagnosis of Osteoporosis in Men

  Chen, R.-M. (PI)

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - National Science and Technology Council

• Roles of the Hdacs/Sp1-Mediated Microrna-106b~25 Axis in Drug Resistance of Glioblastomas( II )

  Chen, R.-M. (PI)

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - National Science and Technology Council

• 神經生長因子在人類骨母細胞鈣化扮演的角色研究 (Roles of nerve growth factor in calcification of osteoblasts)

  Chen, R.-M. (PI)

  7/1/20 → 2/1/21

  Project: A - Government Institution › b - National Science and Technology Council

• 緩激肽-B1/B2受體軸調控膠質母細胞瘤細胞水通道蛋白4基因表現的訊息傳遞路徑研究

  Chen, R.-M. (PI)

  3/1/20 → 2/1/21

  Project: C - Project of Alliance › o - Chi Mei Medical Center

• 探討雌激素受體alpha在骨頭癒合過程所扮演的角色：轉譯動物驗證研究

  Chen, R.-M. (PI)

  3/1/20 → 2/1/21

  Project: C - Project of Alliance › n - Yuan's General Hospital

• 雄性激素-雄性激素受體軸在調控膠質母細胞瘤水通道蛋白4 基因表現與藥物拮抗性的角色研究

  Chen, R.-M. (PI)

  1/1/20 → 12/1/20

  Project: B - Project of TMU › h - Higher Education Sprout Project

• Roles of the Hdacs/Sp1-Mediated Microrna-106b~25 Axis in Drug Resistance of Glioblastomas(1/3)

  Chen, R.-M. (PI)

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - National Science and Technology Council

• A Translational Study to Verify Roles of Circulating Mir-19b and Mir-93 as Biomarker Signatures for Early Diagnosis of Osteoporosis in Men(2/3)

  Chen, R.-M. (PI)

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - National Science and Technology Council

• 調節第一型神經衍生孤兒核受體 (Neuron-derived orphan receptor 1, NOR-1)之蛋白質表現可能是 Pomalidomide對創傷性腦損傷之神經保護作用之一

  Chen, R.-M. (PI)

  7/1/19 → 2/1/20

  Project: A - Government Institution › b - National Science and Technology Council

• 激肽釋放酶-激肽系統調控惡性神經膠質瘤細胞基質金屬蛋白酶表現之機轉

  Chen, R.-M. (PI)

  3/1/19 → 2/1/20

  Project: C - Project of Alliance › o - Chi Mei Medical Center

• 具抗藥性多形性膠質母細胞瘤的新穎治療策略研究-Bradykinin-TIMP-MMP 軸在抗藥性神經膠質瘤細胞調控血瘤障壁通透性過程中扮演的角色

  Chen, R.-M. (PI)

  1/1/19 → 12/1/19

  Project: A - Government Institution › d - Ministry of Education

• A Translational Study to Verify Roles of Circulating Mir-19b and Mir-93 as Biomarker Signatures for Early Diagnosis of Osteoporosis in Men

  Chen, R.-M. (PI)

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - National Science and Technology Council

• 緩激肽調控惡性神經膠質瘤細胞基質金屬蛋白酶-13基因表現機轉與細胞侵襲作用之研究

  Chen, R.-M. (PI)

  3/1/18 → 2/28/19

  Project: C - Project of Alliance › s - Shin Kong Wu Ho-Su Memorial Hospital

• 低氧影響具抗帝盟多藥性之惡性神經膠質瘤細胞發生自噬作用的分子機轉研究

  Chen, R.-M. (PI)

  3/1/18 → 2/28/19

  Project: C - Project of Alliance › o - Chi Mei Medical Center

• 抗藥性多形性膠質母細胞瘤的新穎治療策略研究

  Chen, R.-M. (PI)

  1/1/18 → 12/31/18

  Project: B - Project of TMU › h - Higher Education Sprout Project

• Discovering Blood Circulating and Bone Micrornas as Biomarker Signatures for Diagnosis or Therapy of Osteoporosis in Men and Male Osteoporotic Fracture

  Chen, R.-M. (PI)

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - National Science and Technology Council

  • microRNA 100%
  • Fragility Fracture 100%
  • Biological Marker 100%
  • MicroRNA 100%
  • Disease 36%

• 探討p53/PI3K/Akt/mTOR 軸線在低氧誘發人類惡性神經膠質瘤細胞發生自噬性凋亡過程中所扮演的角色

  Chen, R.-M. (PI)

  3/1/17 → 2/28/18

  Project: C - Project of Alliance › o - Chi Mei Medical Center

• 基質金屬蛋白酶-13在緩激肽調控血腦障壁通透性作用中所扮演的角色研究

  Chen, R.-M. (PI)

  3/1/17 → 2/28/18

  Project: C - Project of Alliance › s - Shin Kong Wu Ho-Su Memorial Hospital

• Discovering Blood Circulating and Bone Micrornas as Biomarker Signatures for Diagnosis or Therapy of Osteoporosis in Men and Male Osteoporotic Fracture(2/3)

  Chen, R.-M. (PI)

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - National Science and Technology Council

  • microRNA 100%
  • Fragility Fracture 100%
  • Biological Marker 100%
  • MicroRNA 100%
  • Disease 36%

• 緩激肽調控惡性神經膠瘤細胞基質金屬蛋白酶-13 表現和影響血瘤障壁通透性之研究

  Chen, R.-M. (PI)

  3/1/16 → 2/28/17

  Project: C - Project of Alliance › o - Chi Mei Medical Center

• N-methyl-D-aspartate receptor調控血腦障壁之角色探討

  Chen, R.-M. (PI) & Wu, G.-J. (CoI)

  3/1/16 → 2/28/17

  Project: C - Project of Alliance › s - Shin Kong Wu Ho-Su Memorial Hospital

• Discovering Blood Circulating and Bone Micrornas as Biomarker Signatures for Diagnosis or Therapy of Osteoporosis in Men and Male Osteoporotic Fracture

  Chen, R.-M. (PI)

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - National Science and Technology Council

  • microRNA 100%
  • Fragility Fracture 100%
  • Biological Marker 100%
  • MicroRNA 100%
  • Disease 36%

• 探討細胞自噬在低氧調控多型性神經膠母細胞瘤生成過程所扮演的角色

  Chen, R.-M. (PI)

  3/1/15 → 2/29/16

  Project: C - Project of Alliance › o - Chi Mei Medical Center

• 探討propofol減緩敗血症傷害的機轉: 轉譯醫學研究

  Chen, R.-M. (PI)

  3/1/15 → 2/29/16

  Project: C - Project of Alliance › s - Shin Kong Wu Ho-Su Memorial Hospital

• 104年度「空中救護審核機制計畫」

  Tsai, S.-H. (PI), Whang-Peng, J. (CoI), Liu, L.-F. (CoI), Chang, W.-C. (CoI), Ho, Y.-S. (CoI), Cheng, Y.-W. (CoI), Yeh, S.-D. (CoI), Chen, K.-C. (CoI), Sung, S.-Y. (CoI), Hung, K.-S. (CoI), Chen, R.-M. (CoI), Chiou, H.-Y. (CoI), Chen, C.-Y. (CoI) & Li, Y.-C. (CoI)

  1/1/15 → 3/31/16

  Project: A - Government Institution › c - Ministry of Health and Welfare

• Roles of Toll-Like Receptor-4 and Hif-1 in Propofol-Involved Protection against Traumatic Brain Injury-Induced Dysfunction of the Blood-Brain Barrier

  Chen, R.-M. (PI)

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - National Science and Technology Council

  • TLR 4 100%
  • Neurotrauma 100%
  • Traumatic Brain Injury 100%
  • Propofol 100%
  • Blood Brain Barrier 100%

• Dexmedetomidine保護腦神經免於腦外傷傷害的轉譯醫學研究

  Chen, R.-M. (PI)

  3/1/14 → 2/28/15

  Project: C - Project of Alliance › s - Shin Kong Wu Ho-Su Memorial Hospital

• miR106b抑制多型性神經膠母細胞瘤生長之角色研究

  Chen, R.-M. (PI)

  3/1/14 → 2/28/15

  Project: C - Project of Alliance › o - Chi Mei Medical Center

• CYP11A1在骨生成過程中所扮演的角色研究: 使用基因剃除鼠為實驗模式

  Chen, R.-M. (PI)

  3/1/13 → 2/28/14

  Project: C - Project of Alliance › s - Shin Kong Wu Ho-Su Memorial Hospital

• 研究血中特異microRNAs以做為診斷多型性神經膠母細胞瘤之生物標誌

  Chen, R.-M. (PI)

  3/1/13 → 2/28/14

  Project: C - Project of Alliance › o - Chi Mei Medical Center

• The Neurotrophic/Neuroprotective Role of Gip in Cellular and Rodent Models of Mild Traumatic Brain Injury.( I )

  Lin, J.-W. (PI) & Chen, R.-M. (CoI)

  8/1/12 → 7/31/13

  Project: B - Project of TMU › i - Other (Funded by TMU)

  • Neurotrauma 100%
  • Neuroprotective Agent 100%
  • Gastric Inhibitory Polypeptide 100%
  • Traumatic Brain Injury 100%
  • Gene Expression 20%

• HIF-1和CREB在小鼠受到TBI損傷過程中所扮演的角色研究

  Chen, R.-M. (PI)

  3/1/12 → 2/28/13

  Project: C - Project of Alliance › o - Chi Mei Medical Center

• Purinergic P2X2受體在退化性關節炎所誘發疼痛過程中所扮演的角色研究

  Chen, R.-M. (PI)

  3/1/12 → 2/28/13

  Project: C - Project of Alliance › s - Shin Kong Wu Ho-Su Memorial Hospital

• 生醫材料幾丁聚醣奈米纖維支架(chitosan nanofibers)影響骨母細胞分化 之分子機轉研究

  Chen, R.-M. (PI)

  3/1/12 → 2/28/13

  Project: C - Project of Alliance › m - National Taiwan University of Science and Technology

• 生醫材料PPC/PLA/TCP 彈性複合材料運用於骨頭修復之轉譯醫學研究 (A translational study on the effects of polypropylene carbonate/ poly(DL-lactic) acid/tricalcium phosphate elastic composite on bone repair)

  Chen, R.-M. (PI)

  1/1/12 → 12/31/12

  Project: C - Project of Alliance › j - National Taipei University of Technology

• Molecular Mechanisms of Anti-Inflammatory Effects of Intravenous Anesthetic Agent Ketamine on Lipopolysaccharide-Activated Macrophages

  Chen, T.-L. (PI) & Chen, R.-M. (CoI)

  8/1/10 → 7/31/11

  Project: A - Government Institution › b - National Science and Technology Council

  • Antiinflammatory Activity 100%
  • Macrophage 100%
  • Ketamine 100%
  • Lipopolysaccharide 100%
  • Intravenous Anesthetic Agent 100%

• Differential Expression of microRNAs in Osteoblasts and Their Roles in Regulation of Cell Survival and Metabolism

  Chen, R.-M. (PI)

  8/1/10 → 7/31/11

  Project: A - Government Institution › b - National Science and Technology Council

  • Cell Survival 100%
  • MicroRNA 100%
  • Cell Metabolism 100%
  • Osteoblast 100%
  • microRNA 100%

• Effects of Propofol on Traumatic Brain Injury-Induced Insults to the Mouse Blood-Brain Barrier and Its Possible Mechanisms

  Chang, H.-C. (PI) & Chen, R.-M. (CoI)

  8/1/10 → 7/31/11

  Project: A - Government Institution › b - National Science and Technology Council

  • Neurotrauma 100%
  • Traumatic Brain Injury 100%
  • Propofol 100%
  • Blood Brain Barrier 100%
  • In Vitro 33%