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Dive into the research topics where Mei-Jung Lai is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Projects
- 5 Finished
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合成可雙重抑制組織蛋白去乙醯酶6與熱休克蛋白90，並同時調節PD-L1之雜環類抗癌化合物
8/1/20 → 7/1/21
Project: A - Government Institution › b - Ministry of Science and Technology
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組蛋白去乙醯酶在血管認知功能損傷中的作用-組蛋白去乙醯酶調節者在血管認知損傷動物可作為新的治療
1/1/19 → 12/1/19
Project: A - Government Institution › d - Ministry of Education
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Design and Synthesis of Biaryl and Biphenylamino Sulfonamides as Novel Anticancer Agents
8/1/16 → 7/31/17
Project: A - Government Institution › b - Ministry of Science and Technology
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設計與合成新穎苯甲醯胺與醯基羥胺取代之雜環化合物分別抑制微小管與組織蛋白去乙醯酉每6為抗癌藥物
11/1/14 → 10/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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TMU103-AE1-B09
11/1/14 → 10/31/16
Project: B - Project of TMU › g - Research Grants for Newly Hired Faculty
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Rationally designed donepezil-based hydroxamates modulate Sig-1R and HDAC isoforms to exert anti-glioblastoma effects
Nepali, K., Wu, A. C., Lo, W. L., Chopra, B., Lai, M. J., Chuang, J. Y. & Liou, J. P., Feb 2023, In: European Journal of Medicinal Chemistry. 248, 115054.Research output: Contribution to journal › Article › peer-review
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CAP rigidification of MS-275 and chidamide leads to enhanced antiproliferative effects mediated through HDAC1, 2 and tubulin polymerization inhibition
Singh, A., Chang, T. Y., Kaur, N., Hsu, K. C., Yen, Y., Lin, T. E., Lai, M. J., Lee, S. B. & Liou, J. P., Apr 5 2021, In: European Journal of Medicinal Chemistry. 215, 113169.Research output: Contribution to journal › Article › peer-review
10 Citations (Scopus) -
Effect of 3-subsitution of quinolinehydroxamic acids on selectivity of histone deacetylase isoforms
Mehndiratta, S., Chen, M. C., Chao, Y. H., Lee, C. H., Liou, J. P., Lai, M. J. & Lee, H. Y., Jan 1 2021, In: Journal of Enzyme Inhibition and Medicinal Chemistry. 36, 1, p. 74-84 11 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Citation (Scopus) -
Pragmatic recruitment of memantine as the capping group for the design of HDAC inhibitors: A preliminary attempt to unravel the enigma of glioblastoma
Nepali, K., Hsu, T. I., Hsieh, C. M., Lo, W. L., Lai, M. J., Hsu, K. C., Lin, T. E., Chuang, J. Y. & Liou, J. P., May 5 2021, In: European Journal of Medicinal Chemistry. 217, 113338.Research output: Contribution to journal › Article › peer-review
11 Citations (Scopus) -
Ring-opening of five-membered heterocycles conjugated 4-isopropylresorcinol scaffold-based benzamides as HSP90 inhibitors suppressing tumor growth in vitro and in vivo
Liu, Y. M., Tu, H. J., Wu, C. H., Lai, M. J., Yu, S. C., Chao, M. W., Wu, Y. W., Teng, C. M., Pan, S. L. & Liou, J. P., Jul 5 2021, In: European Journal of Medicinal Chemistry. 219, 113428.Research output: Contribution to journal › Article › peer-review
6 Citations (Scopus)
Datasets
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Additional file 1: of Combination treatment strategy for pancreatic cancer involving the novel HDAC inhibitor MPT0E028 with a MEK inhibitor beyond K-Ras status
Chao, M. (Contributor), Chang, L. (Contributor), Tu, H. (Contributor), Chang, C. (Contributor), Lai, M. (Contributor), Chen, Y. (Creator), Liou, J. (Creator), Teng, C. (Contributor) & Pan, S. (Contributor), Figshare, 2019
DOI: 10.6084/m9.figshare.8202881.v1, https://springernature.figshare.com/articles/Additional_file_1_of_Combination_treatment_strategy_for_pancreatic_cancer_involving_the_novel_HDAC_inhibitor_MPT0E028_with_a_MEK_inhibitor_beyond_K-Ras_status/8202881/1
Dataset
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Additional file 2: of Combination treatment strategy for pancreatic cancer involving the novel HDAC inhibitor MPT0E028 with a MEK inhibitor beyond K-Ras status
Chao, M. (Contributor), Chang, L. (Contributor), Tu, H. (Contributor), Chang, C. (Contributor), Lai, M. (Contributor), Chen, Y. (Creator), Liou, J. (Creator), Teng, C. (Contributor) & Pan, S. (Contributor), Figshare, 2019
DOI: 10.6084/m9.figshare.8202887.v1, https://springernature.figshare.com/articles/Additional_file_2_of_Combination_treatment_strategy_for_pancreatic_cancer_involving_the_novel_HDAC_inhibitor_MPT0E028_with_a_MEK_inhibitor_beyond_K-Ras_status/8202887/1
Dataset
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Additional file 5: of Combination treatment strategy for pancreatic cancer involving the novel HDAC inhibitor MPT0E028 with a MEK inhibitor beyond K-Ras status
Chang, L. (Contributor), Liou, J. (Creator), Lai, M. (Contributor), Chang, C. (Contributor), Tu, H. (Contributor), Chao, M. (Contributor), Pan, S. (Contributor), Chen, Y. (Creator) & Teng, C. (Contributor), Figshare, 2019
DOI: 10.6084/m9.figshare.8202902.v1, https://doi.org/10.6084%2Fm9.figshare.8202902.v1
Dataset
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Combination treatment strategy for pancreatic cancer involving the novel HDAC inhibitor MPT0E028 with a MEK inhibitor beyond K-Ras status
Chao, M. (Contributor), Chang, L. (Contributor), Tu, H. (Contributor), Chang, C. (Contributor), Lai, M. (Contributor), Chen, Y. (Creator), Liou, J. (Creator), Teng, C. (Contributor) & Pan, S. (Contributor), Figshare, 2019
DOI: 10.6084/m9.figshare.c.4522856.v1, https://springernature.figshare.com/collections/Combination_treatment_strategy_for_pancreatic_cancer_involving_the_novel_HDAC_inhibitor_MPT0E028_with_a_MEK_inhibitor_beyond_K-Ras_status/4522856/1
Dataset
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Effect of 3-subsitution of quinolinehydroxamic acids on selectivity of histone deacetylase isoforms
Lai, M. (Creator), Lee, C. (Creator), Chao, Y. (Creator), Mehndiratta, S. (Creator), Chen, M. (Creator), Liou, J. (Creator) & Lee, H. (Creator), Taylor & Francis, 2020
DOI: 10.6084/m9.figshare.13207104.v1, https://tandf.figshare.com/articles/journal_contribution/Effect_of_3-subsitution_of_quinolinehydroxamic_acids_on_selectivity_of_histone_deacetylase_isoforms/13207104/1
Dataset