Kuo-Hsiang Chuang

Projects

Projects per year 2012 2014 2016 2017 2018 2019 2020 2021 2022 2025

• 1 Active
• 36 Finished

Projects per year

Search results

• Active

  Development of Humanized Antagonistic Bace-2 Antibody and Its Derivative Pd-L1 Fusion Protein Drug as a Novel Islet-Protective Strategy for Comprehensive Application in the Treatment of Type 1 and Type 2 Diabetes

  Chuang, K.-H. (PI)

  8/1/24 → 7/31/25

  Project: A - Government Institution › b - National Science and Technology Council

• Finished

  開發人類化拮抗型BACE-2抗體及其衍生PD-L1融合蛋白新藥之新穎胰島保護策略以全面應用於第一型與第二型糖尿病治療(1/3)

  Chuang, K.-H. (PI)

  8/1/23 → 7/31/24

  Project: A - Government Institution › b - National Science and Technology Council

• 開發可刺激胰島beta細胞增生之拮抗型BACE-2抗體以改善第二型糖尿病(3/3)

  Chuang, K.-H. (PI)

  8/1/23 → 7/31/24

  Project: A - Government Institution › b - National Science and Technology Council

• Development of Antagonistic Bace-2 Antibodies to Improve Type 2 Diabetes by Inducing Pancreatic Beta-Cells Proliferation( II )

  Chuang, K.-H. (PI)

  8/1/22 → 7/31/23

  Project: A - Government Institution › b - National Science and Technology Council

• Development of Anti-Α9nachr/Anti-Cd3 Bispecific Antibody to One-Step Construct an Armed T Cell Immunotherapy for Efficiently Eliminating Breast Tumor( III )

  Chuang, K.-H. (PI)

  8/1/22 → 7/31/23

  Project: A - Government Institution › b - National Science and Technology Council

• 以第二型糖尿病模式小鼠模式小鼠評估新穎抗體藥物對於血糖控制與胰島保護療效

  Chuang, K.-H. (PI)

  7/1/22 → 2/28/23

  Project: A - Government Institution › b - National Science and Technology Council

• 開發串聯式人類第二型乙型轉化生長因子受體重組蛋白以去除細胞外液中乙型轉化生長因子之醫療應用

  Chuang, K.-H. (PI)

  7/1/22 → 2/28/23

  Project: A - Government Institution › b - National Science and Technology Council

• 利用內生性報告基因轉殖鼠以開發第一型糖尿病之治療藥物及其應用策略

  Chuang, K.-H. (PI)

  1/1/22 → 12/31/22

  Project: A - Government Institution › a - National Health Research Institutes

• Development of Antagonistic Bace-2 Antibodies to Improve Type 2 Diabetes by Inducing Pancreatic Beta-Cells Proliferation( I )

  Chuang, K.-H. (PI)

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - National Science and Technology Council

• Development of Anti-Α9nachr/Anti-Cd3 Bispecific Antibody to One-Step Construct an Armed T Cell Immunotherapy for Efficiently Eliminating Breast Tumor( II )

  Chuang, K.-H. (PI)

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - National Science and Technology Council

• 利用內生性報告基因轉殖鼠以開發第一型糖尿病之治療藥物及其應用策略

  Chuang, K.-H. (PI)

  1/1/21 → 12/31/21

  Project: A - Government Institution › a - National Health Research Institutes

• Development of Anti-Α9nachr/Anti-Cd3 Bispecific Antibody to One-Step Construct an Armed T Cell Immunotherapy for Efficiently Eliminating Breast Tumor( I )

  Chuang, K.-H. (PI)

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - National Science and Technology Council

• 開發新型EGFR專一性之武裝型T細胞(Anti-EGFR BsAb Armed T cell)以應用於三陰性乳癌之治療

  Chuang, K.-H. (PI)

  7/1/20 → 2/1/21

  Project: A - Government Institution › b - National Science and Technology Council

• 開發拮抗型BACE-2抗體逆轉第二型糖尿病胰島凋亡之病程

  Chuang, K.-H. (PI)

  7/1/20 → 2/1/21

  Project: A - Government Institution › b - National Science and Technology Council

• 利用內生性報告基因轉殖鼠以開發第一型糖尿病之治療藥物及其應用策略

  Chuang, K.-H. (PI)

  1/1/20 → 12/31/20

  Project: A - Government Institution › a - National Health Research Institutes

• Development of an Innovative Bispecific Engager Simultaneously Binding Pd-L1 and Cd28 to Reverse Immunosuppressive Tumor Microenvironment for Enhancing Anti-Cancer Efficacy of T Cell-Based Therapies

  Chuang, K.-H. (PI)

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - National Science and Technology Council

• Development of Anti-Α9nachr/Anti-Polyethylene Glycol Bispecific Antibody to Enhance the Therapeutic Efficacy of Nano-Drugs against Breast Cancer( III )Development of Anti-Α9nachr/Anti-Polyethylene Glycol Bispecific Antibody to Enhance the Therapeutic Efficacy of Nano-Drugs against Breast Cancer( III )

  Chuang, K.-H. (PI)

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - National Science and Technology Council

• 108年度毛豆機能性產品動物功效驗證

  Chuang, K.-H. (PI)

  3/29/19 → 12/29/19

  Project: A - Government Institution › e - Council of Agriculture

• Development of Anti-Α9nachr/Anti-Polyethylene Glycol Bispecific Antibody to Enhance the Therapeutic Efficacy of Nano-Drugs against Breast Cancer(II)(2/3)

  Chuang, K.-H. (PI)

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - National Science and Technology Council

• Development of the Fully Humanized Bispecific Antibody to One-Step Expand and Arm T Cells for Selective Tumor Therapy(3/3)

  Chuang, K.-H. (PI)

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - National Science and Technology Council

  • Arm 100%
  • Bispecific Antibody 100%
  • T Cell 100%
  • CD3 Antigen 63%
  • Colon 15%

• 「大豆(毛豆)機能性產品動物功效驗證」委辦勞務採購案

  Chuang, K.-H. (PI)

  4/13/18 → 12/15/18

  Project: A - Government Institution › e - Council of Agriculture

• Development of the Fully Humanized Bispecific Antibody to One-Step Expand and Arm T Cells for Selective Tumor Therapy

  Chuang, K.-H. (PI)

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - National Science and Technology Council

  • Arm 100%
  • Bispecific Antibody 100%
  • T Cell 100%
  • CD3 Antigen 63%
  • Colon 15%

• Development of Anti-Α9nachr/Anti-Polyethylene Glycol Bispecific Antibody to Enhance the Therapeutic Efficacy of Nano-Drugs against Breast Cancer( I )

  Chuang, K.-H. (PI)

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - National Science and Technology Council

• 表現膜抗體報告基因於第一型糖尿病鼠之胰島細胞以非侵犯性造影自體免疫型糖尿病之病程

  Chuang, K.-H. (PI)

  7/1/17 → 2/28/18

  Project: A - Government Institution › b - National Science and Technology Council

• 106年度「大豆(毛豆)機能性產品動物功效驗證」研究委辦勞務採購

  Chuang, K.-H. (PI)

  2/22/17 → 12/25/17

  Project: A - Government Institution › e - Council of Agriculture

• Development of the Fully Humanized Bispecific Antibody to One-Step Expand and Arm T Cells for Selective Tumor Therapy

  Chuang, K.-H. (PI)

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - National Science and Technology Council

  • Arm 100%
  • Bispecific Antibody 100%
  • T Cell 100%
  • CD3 Antigen 63%
  • Colon 15%

• 105年度大豆(毛豆)產品動物功效驗證之研究委辦計畫

  Chuang, K.-H. (PI)

  2/1/16 → 12/15/16

  Project: A - Government Institution › e - Council of Agriculture

• Generate an Endogenous Reporter Transgenic Mouse to Track Cell Fates and Transplant Survival

  Chuang, K.-H. (PI)

  1/1/16 → 12/31/16

  Project: A - Government Institution › a - National Health Research Institutes

  • Cell Fate 100%
  • Transgenic Mouse 100%
  • Polyethylene Glycol 100%
  • Stem Cell 37%
  • Reporter Gene 25%

• Design and Preclinical Translation Study of Mixed-Bispecific/Trispecific Antibody for Enhancing Therapeutic Effectiveness of Anticancer Drug-Loaded Pegylated Nanocarriers by Simultaneously Targeting to Tumor Cells and Cancer/Tumor Associated Fibrobla (I)

  Sheu, M.-T. (PI), Chuang, K.-H. (CoI) & Ho, Y.-S. (CoI)

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - National Science and Technology Council

  • Neoplasm 100%
  • Anticarcinogen 100%
  • Malignant Neoplasm 100%
  • Nanocarrier 100%
  • Bispecific Antibody 72%

• Generate an Endogenous Reporter Transgenic Mouse to Track Cell Fates and Transplant Survival

  Chuang, K.-H. (PI)

  1/1/15 → 12/31/15

  Project: A - Government Institution › a - National Health Research Institutes

  • Cell Fate 100%
  • Transgenic Mouse 100%
  • Polyethylene Glycol 100%
  • Stem Cell 37%
  • Reporter Gene 25%

• Expressing Membrane Antibody Reporter in the Islet Cells of Nonobese Diabetic Mice to Noninvasive Assess the Therapeutic Effects of Drugs or Transgenes for Autoimmune Diabetes

  Chuang, K.-H. (PI)

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - National Science and Technology Council

  • Autoimmune Diabetes 100%
  • Therapy Effect 100%
  • Polyethylene Glycol 100%
  • Transgene 100%
  • Nonobese Diabetic Mouse 100%

• 利用甘草素抑制腸內菌葡萄糖酸??以提升CPT-11化療之安全性及療效

  Chuang, K.-H. (PI)

  6/1/14 → 5/31/15

  Project: C - Project of Alliance › u - Taipei Medical University Shuang Ho Hospital

• Generate an Endogenous Reporter Transgenic Mouse to Track Cell Fates and Transplant Survival

  Chuang, K.-H. (PI)

  1/1/14 → 12/31/14

  Project: A - Government Institution › a - National Health Research Institutes

  • Cell Fate 100%
  • Transgenic Mouse 100%
  • Polyethylene Glycol 100%
  • Stem Cell 37%
  • Reporter Gene 25%

• Expressing Membrane Antibody Reporter in the Islet Cells of Nonobese Diabetic Mice to Noninvasive Assess the Therapeutic Effects of Drugs or Transgenes for Autoimmune Diabetes

  Chuang, K.-H. (PI)

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - National Science and Technology Council

• Generate an Endogenous Reporter Transgenic Mouse to Track Cell Fates and Transplant Survival

  Chuang, K.-H. (PI)

  1/1/13 → 12/31/13

  Project: A - Government Institution › a - National Health Research Institutes

  • Cell Fate 100%
  • Transgenic Mouse 100%
  • Polyethylene Glycol 100%
  • Stem Cell 37%
  • Reporter Gene 25%

• Expressing Membrane Antibody Reporter in the Islet Cells of Nonobese Diabetic Mice to Noninvasive Image the Disease Progression of Autoimmune Diabetes and the Therapeutic Effects of Drugs or Transgenes

  Chuang, K.-H. (PI)

  11/1/12 → 10/31/13

  Project: A - Government Institution › b - National Science and Technology Council

  • Polyethylene Glycol 100%
  • Disease Exacerbation 100%
  • Transgene 100%
  • Autoimmune Diabetes 100%
  • Therapy Effect 100%

• 研發可抑制腸內菌葡萄糖酸??之中草藥萃取物以提升癌症化療之功效

  Chuang, K.-H. (PI)

  5/1/12 → 4/30/13

  Project: C - Project of Alliance › u - Taipei Medical University Shuang Ho Hospital