Projects per year
Personal profile
Education
- 2012 Ph.D. ISF College of Pharmacy, Punjab, India
- 2008 M.S. ISF College of Pharmacy, Punjab, India
- 2006 B.S. Rajiv Academy For Pharmacy. U.P,, India
Experience
- 2023- Associate Professor, Department of Pharmaceutical Sciences, Taipei Medical UniversityTaipei Medical University
- 2019-2023 Assistant Professor, Department of Pharmaceutical Sciences, Taipei Medical University
- 2014-2019 Post-Doctoral Research Fellow, Taipei Medical University
- 2011-2014 Assistant Professor, Guru Nanak Dev University
- 2008-2011 Assistant Professor, Punjab Technical University
Awards
- Editorial board member - Mini Reviews in Medicinal chemistry (IF - 2.91, Chemistry/Medicinal)
- Plum Blossom Card (Permanent Resident Certificate) by Government of Taiwan 2020
- Outstanding Post Doctoral Fellow (Medicinal Chemistry), 2018, Taipei Medical University, Taiwan.
Project title: The use of organometallic reaction in the synthesis of anticancer agents (2/2)
- Outstanding Post Doctoral Fellow (Medicinal Chemistry), 2017, Taipei Medical University, Taiwan.
Project title: The use of organometallic reaction in the synthesis of anticancer agents
- Outstanding contribution in reviewing EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017.
- Outstanding Post Doctoral Fellow (Medicinal Chemistry), 2016, Taipei Medical University, Taiwan.
Project title: Application of regioselective substitution on 1,4- Benzoquinone derivatives to provide potent anticancer agents
- Outstanding contribution in reviewing BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS, 2016.
- Outstanding Post Doctoral Fellow (Medicinal Chemistry), 2015, Taipei Medical University, Taiwan.
Project title: Preclinical development for novel HSP90 inhibitors as anticancer drugs
- Outstanding Post Doctoral Fellow (Medicinal Chemistry), 2015, Taipei Medical University, Taiwan
Project title: Development of ITCHE3 ubiquitin ligase inhibitors as anticancer drug
Research Interests
- Natural product chemistry
- Organic synthesis
- Medicinal chemistry
- Drug design
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Structural Engineering of Biaryls, Alkaloids, Flavones and Coumarins to Furnish Anti-Fibrotic Agents for Idiopathic Pulmonary Fibrosis
8/1/22 → 7/31/23
Project: A - Government Institution › b - Ministry of Science and Technology
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Prudent Design of Anti-Gastric Cancer Agents: Structural Simplification Approach, Scaffold Hopping Strategy and Exhaustive Exploration of Silica Supported Protic Acid/Lewis Acid Catalysis for Multicomponent Reactions
8/1/21 → 7/31/22
Project: A - Government Institution › b - Ministry of Science and Technology
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多靶點抗癌藥物之設計與合成(2/2)
8/1/20 → 7/1/21
Project: A - Government Institution › b - Ministry of Science and Technology
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Rational Design and Synthesis of Multitargeting Antitumor Agents(1/2)
8/1/19 → 7/31/20
Project: A - Government Institution › b - Ministry of Science and Technology
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Research Grants for Newly Hired Faculty
5/1/19 → 4/30/20
Project: B - Project of TMU › g - Research Grants for Newly Hired Faculty
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Rational design of synthetically tractable HDAC6/HSP90 dual inhibitors to destroy immune-suppressive tumor microenvironment
Wu, T. Y., Chen, M., Chen, I. C., Chen, Y. J., Chen, C. Y., Wang, C. H., Cheng, J. J., Nepali, K., Chuang, K. H. & Liou, J. P., Apr 2023, In: Journal of Advanced Research. 46, p. 159-171Research output: Contribution to journal › Article › peer-review
Open Access2 Citations (Scopus) -
Rationally designed donepezil-based hydroxamates modulate Sig-1R and HDAC isoforms to exert anti-glioblastoma effects
Nepali, K., Wu, A. C., Lo, W. L., Chopra, B., Lai, M. J., Chuang, J. Y. & Liou, J. P., Feb 2023, In: European Journal of Medicinal Chemistry. 248, 115054.Research output: Contribution to journal › Article › peer-review
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Accommodation of ring C expanded deoxyvasicinone in the HDAC inhibitory pharmacophore culminates into a tractable anti-lung cancer agent and pH-responsive nanocarrier
Sharma, R., Chatterjee, E., Mathew, J., Sharma, S., Rao, N. V., Pan, C. H., Lee, S. B., Dhingra, A., Grewal, A. S., Liou, J. P., Guru, S. K. & Nepali, K., Oct 5 2022, In: European Journal of Medicinal Chemistry. 240, 114602.Research output: Contribution to journal › Article › peer-review
2 Citations (Scopus) -
Beyond the vaccines: a glance at the small molecule and peptide-based anti-COVID19 arsenal
Nepali, K., Sharma, R., Sharma, S., Thakur, A. & Liou, J. P., Sept 2022, In: Journal of Biomedical Science. 29, 1, p. 65 1 p., 65.Research output: Contribution to journal › Review article › peer-review
Open Access8 Citations (Scopus) -
Glioblastoma: Current Status, Emerging Targets, and Recent Advances
Thakur, A., Faujdar, C., Sharma, R., Sharma, S., Malik, B., Nepali, K. & Liou, J. P., Jul 2022, In: Journal of Medicinal Chemistry. 65, 13, p. 8596-8685 90 p.Research output: Contribution to journal › Review article › peer-review
Open Access2 Citations (Scopus)
Datasets
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Design, synthesis and evaluation of 2,4-diarylpyrano[3,2-c]chromen-5(4H)-one as a new class of non-purine xanthine oxidase inhibitors
Virdi, H. S. (Creator), Sharma, S. (Contributor), Mehndiratta, S. (Creator), Bedi, P. M. S. (Contributor) & Nepali, K. (Contributor), Figshare, 2015
DOI: 10.6084/m9.figshare.1568378.v1, https://figshare.com/articles/Design_synthesis_and_evaluation_of_2_4_diarylpyrano_3_2_c_chromen_5_4H_one_as_a_new_class_of_non_purine_xanthine_oxidase_inhibitors/1568378/1
Dataset