Projects per year
Personal profile
Education
- 2001.09-2005.11 Ph.D., Biological Sciences-Genetics & Complex Diseases, Graduate School of Arts & Sciences, Harvard University
- 1986.09-1993.06 M.D., School of Medicine, College of Medicine, Taipei Medical University
Experience
Postdoctoral Training
- 2005-2007 Postdoctoral Fellow, Institute for Medicine and Engineering, University of Pennsylvania, PA, USA
- 2005-2007 Postdoctoral Fellow, Department of Surgery and Center for Bioengineering & Tissue Regeneration, University of California, San Francisco, CA, USA
- 1998-2000 Clinical Fellow, Division of Critical Care, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
- 1996-1998 Chief Resident, Division of Gastroenterology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
- 1993-1996 Resident, Department of Medicine, Taipei Veterans General Hospital, Taiwan
Academic Appointments
- 2023.10- Director, Core Laboratory of Organoids Technology
- 2022.11- Director, Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University
- 2022.07- Joint Investigator, National Institute of Cancer Research, National Health Research Institutes, Taiwan
- 2021.01- Professor, Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University
- 2018.02- Associate Professor, International Master/PhD Program in Medicine
- 2017-2022 Joint Associate Investigator, National Institute of Cancer Research, National Health Research Institutes, Taiwan
- 2014.08- Associate Professor, Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University
- 2014- Associate Professor of Medicine, Graduate Institute of Clinical Research, School of Medicine, TMU
- 2014-2017 Associate Investigator, National Institute of Cancer Research, National Health Research Institutes
- 2008-2013 Assistant Investigator, National Institute of Cancer Research, National Health Research Institutes
- Clinical Appointments
- 2008.08-2014.07 Assistant Professor, Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University
- 2007.09-2008.07 Assistant Professor, Department of Internal Medicine, School of Medicine, Taipei Medical University
Clinical Appointments
- 2017- Deputy Director, Integrative Therapy Center for Gastroenterological Cancers, Wan Fan Hospital, Taipei Medical University
- 2019-2023 Director, Clinical Research Center, Wan Fang Hospital, Taipei Medical University
- 2008.08-2017.10 Attending Physician, National Institute of Cancer Research, National Health Research Institutes
- 2009-2017 Attending Physician, Division of Hematology-oncology, Department of Medicine, National Cheng-Kung University Hospital, Tainan, Taiwan
- 2000.10-2004.09 Attending Physician, Department of Medicine, Taipei Veterans General Hospital
- 1993.09-2000.09 Resident Physician, Department of Medicine, Taipei Veterans General Hospital
Awards
- 2019 Research Dissertation Award - Clinical Research Award and Large Project Research Awards, Taipei Medical University
- 2018 Outstanding Research Award (Life Science), Ministry of Science and Technology (MOST), Taiwan
- 2018 The 5th Kobayashi's Foundation Award, Kobayashi Foundation for Cancer Research, Japan
- 2017 Ta-Cheng Tung's Basic Cancer Research Award, Taiwan Oncology Society
- 2017 The Breast Journal Award, Wiley-Blackwell, USA
- 2016 Research Prize, NCKUH, Taiwan
- 2014 Young Scientist Research Achievement Award, National Health Research Institutes, Taiwan
- 2014 Research Prize, NCKUH, Taiwan
- 2012 Merit Award, Asian Clinical Oncology Society (ACOS)
- 2005 Ruth L. Kirschstein National Research Service Award, National Institutes of Health (NIH), USA
- 2004 Harvard Presidential Scholar, Harvard University, Cambridge, MA, USA
- 2004 Glenn/AFAR Scholar, American Federation for Aging Research, USA
- 2001-2003 Government Scholar, Ministry of Education (MOE), Taiwan
- 2001 Scholarship of the Ivy Association for Cultural and Educational Exchange, Taiwan
- 1999 Research Prize, TVGH, Taiwan
Research Interests
- Cell and Molecular Biology
- Cancer Stem Cells
- Cancer Molecular Medicine
- Pancreatic Cancer
- Cancer Treatment Resistance
- Cancer Experimental Treatment
- Neoplasm
Other
Medical Licensure
- 2011 ECFMG Certificate, USA
- 1999 Board Certified, Gastroenterology, Taiwan
- 1999 Board Certified, Digestive Endoscopy, Taiwan
- 1996 Board Certified, Internal Medicine, Taiwan
Memberships
- 2015- Taiwan Oncology Society
- 2013- American Association for Cancer Research
- 2006- The American Society for Cell Biology
- 2006- Harvard Alumni Association
- 1999- The Digestive Endoscopy Society of Taiwan
- 1999- The Gastroenterology Society of Taiwan
- 1996- Taiwan Society of Internal Medicine
Fingerprint
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Collaborations and top research areas from the last five years
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拯救化學治療誘發之癌症成纖維細胞表基因變化為進展性胰臟腺癌新穎治療手段(3/3)
Tsai, K.K.-C. (PI)
8/1/24 → 7/31/25
Project: A - Government Institution › b - National Science and Technology Council
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Dissecting a Novel Aspm-Yap1 Regulatory Module of Intestinal Epithelial Regeneration and Tumorigenesis
Tsai, K.K.-C. (PI)
8/1/24 → 7/31/27
Project: A - Government Institution › b - National Science and Technology Council
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Rescuing Chemotherapy-Induced Epigenetic Alterations in Cancer Fibroblasts as a Novel Therapeutic Strategy in Advanced Pancreatic Ductal Adenocarcinoma
Tsai, K.K.-C. (PI)
8/1/22 → 7/31/25
Project: A - Government Institution › b - National Science and Technology Council
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拯救化學治療誘發之癌症成纖維細胞表基因變化為進展性胰臟腺癌新穎治療手段(2/3)
Tsai, K.K.-C. (PI)
8/1/23 → 7/31/24
Project: A - Government Institution › b - National Science and Technology Council
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112年度科研創業計畫:突破性原發與轉移性肝癌樞紐基因標靶脂肪奈米微粒微小RNA療法
Tsai, K.K.-C. (PI)
7/1/23 → 6/30/24
Project: A - Government Institution › b - National Science and Technology Council
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ASPM stabilizes the NOTCH intracellular domain 1 and promotes oncogenesis by blocking FBXW7 binding in hepatocellular carcinoma cells
Chan, T. S., Cheng, L. H., Hsu, C. C., Yang, P. M., Liao, T. Y., Hsieh, H. Y., Lin, P. C., HuangFu, W. C., Chuu, C. P. & Tsai, K. K., 2024, (Accepted/In press) In: Molecular Oncology. 18, 3, p. 562-579 18 p.Research output: Contribution to journal › Article › peer-review
Open Access4 Citations (Scopus) -
Combined HDAC8 and checkpoint kinase inhibition induces tumor-selective synthetic lethality in preclinical models
Chang, T. Y., Yan, Y., Yu, Z. Y., Rathore, M., Lee, N. Z., Tseng, H. J., Cheng, L. H., Huang, W. J., Zhang, W., Chan, E. R., Qing, Y., Kang, M. L., Wang, R., Tsai, K. K., Pink, J. J., Harte, W. E., Gerson, S. L. & Lee, S. B., Dec 2 2024, In: Journal of Clinical Investigation. 134, 23, e165448.Research output: Contribution to journal › Article › peer-review
Open Access -
HSP90/LSD1 dual inhibitors against prostate cancer as well as patient-derived colorectal organoids
Tang, D. W., Chen, I. C., Chou, P. Y., Lai, M. J., Liu, Z. Y., Tsai, K. K., Cheng, L. H., Zhao, J. X., Cho, E. C., Chang, H. H., Lin, T. E., Hsu, K. C., Chen, M. C. & Liou, J. P., Nov 15 2024, In: European Journal of Medicinal Chemistry. 278, 116801.Research output: Contribution to journal › Article › peer-review
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Syntheses of LSD1/HDAC Inhibitors with Demonstrated Efficacy against Colorectal Cancer: In Vitro and In Vivo Studies Including Patient-Derived Organoids
Chou, P. Y., Lai, M. J., Tsai, K. K., Cheng, L. H., Wu, Y. W., Chen, M. C., Pan, S. L., Ho, H. O., Nepali, K. & Liou, J. P., 2024, (Accepted/In press) In: Journal of Medicinal Chemistry. 67, 19, p. 17207-17225 19 p.Research output: Contribution to journal › Article › peer-review
Open Access -
ASPM activates Hedgehog and Wnt signaling to promote small cell lung cancer stemness and progression
Cheng, L.-H., Hsu, C.-C., Tsai, H.-W., Liao, W.-Y., Yang, P.-M., Liao, T.-Y., Hsieh, H.-Y., Chan, T.-S. & Tsai, K. K., Jan 1 2023, In: Cancer Research.Research output: Contribution to journal › Article › peer-review
14 Citations (Scopus)