Projects per year
Personal profile
Education
- 2001-2005 Ph.D., Biological Sciences-Genetics & Complex Diseases, Graduate School of Arts & Sciences, Harvard University
- 1986-1993 M.D., School of Medicine, College of Medicine, Taipei Medical University
Experience
Postdoctoral Training
- 2005-2007 Postdoctoral Fellow, Institute for Medicine and Engineering, University of Pennsylvania, PA, USA
- 2005-2007 Postdoctoral Fellow, Department of Surgery and Center for Bioengineering & Tissue Regeneration, University of California, San Francisco, CA, USA
- 1998-2000 Clinical Fellow, Division of Critical Care, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
- 1996-1998 Chief Resident, Division of Gastroenterology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
- 1993-1996 Resident, Department of Medicine, Taipei Veterans General Hospital, Taiwan
Academic Appointments
- 2022.11- Director, Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University
- 2022.07- Joint Investigator, National Institute of Cancer Research, National Health Research Institutes, Taiwan
- 2021.01- Professor, Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University
- 2017-2022 Joint Associate Investigator, National Institute of Cancer Research, National Health Research Institutes, Taiwan
- 2014.08- Associate Professor, Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University
- 2014- Associate Professor of Medicine, Graduate Institute of Clinical Research, School of Medicine, TMU
- 2014-2017 Associate Investigator, National Institute of Cancer Research, National Health Research Institutes
- 2008-2013 Assistant Investigator, National Institute of Cancer Research, National Health Research Institutes
- Clinical Appointments
- 2008.08-2014.07 Assistant Professor, Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University
- 2007.09-2008.07 Assistant Professor, Department of Internal Medicine, School of Medicine, Taipei Medical University
Clinical Appointments
- 2019- Director, Clinical Research Center, Wan Fang Hospital, Taipei Medical University
- 2017- Deputy Director, Integrative Therapy Center for Gastroenterological Cancers, Wan Fan Hospital, Taipei Medical University
- 2008.08-2017.10 Attending Physician, National Institute of Cancer Research, National Health Research Institutes
- 2009-2017 Attending Physician, Division of Hematology-oncology, Department of Medicine, National Cheng-Kung University Hospital, Tainan, Taiwan
- 2000.10-2004.09 Attending Physician, Department of Medicine, Taipei Veterans General Hospital
- 1993.09-2000.09 Resident Physician, Department of Medicine, Taipei Veterans General Hospital
Awards
- 2019 Research Dissertation Award - Clinical Research Award and Large Project Research Awards, Taipei Medical University
- 2018 Outstanding Research Award (Life Science), Ministry of Science and Technology (MOST), Taiwan
- 2018 The 5th Kobayashi's Foundation Award, Kobayashi Foundation for Cancer Research, Japan
- 2017 Ta-Cheng Tung's Basic Cancer Research Award, Taiwan Oncology Society
- 2017 The Breast Journal Award, Wiley-Blackwell, USA
- 2016 Research Prize, NCKUH, Taiwan
- 2014 Young Scientist Research Achievement Award, National Health Research Institutes, Taiwan
- 2014 Research Prize, NCKUH, Taiwan
- 2012 Merit Award, Asian Clinical Oncology Society (ACOS)
- 2005 Ruth L. Kirschstein National Research Service Award, National Institutes of Health (NIH), USA
- 2004 Harvard Presidential Scholar, Harvard University, Cambridge, MA, USA
- 2004 Glenn/AFAR Scholar, American Federation for Aging Research, USA
- 2001-2003 Government Scholar, Ministry of Education (MOE), Taiwan
- 2001 Scholarship of the Ivy Association for Cultural and Educational Exchange, Taiwan
- 1999 Research Prize, TVGH, Taiwan
Research Interests
- Cell and Molecular Biology
- Cancer Biology
- Cancer Stem Cells
- Cancer Molecular Medicine
- Pancreatic Cancer
- Breast Cancer
- Cancer Treatment Resistance
Other
Medical Licensure
- 2011 ECFMG Certificate, USA
- 1999 Board Certified, Gastroenterology, Taiwan
- 1999 Board Certified, Digestive Endoscopy, Taiwan
- 1996 Board Certified, Internal Medicine, Taiwan
Memberships
- 2015- Taiwan Oncology Society
- 2013- American Association for Cancer Research
- 2006- The American Society for Cell Biology
- 2006- Harvard Alumni Association
- 1999- The Digestive Endoscopy Society of Taiwan
- 1999- The Gastroenterology Society of Taiwan
- 1996- Taiwan Society of Internal Medicine
Fingerprint
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Network
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Integrated Proteomic,Genetic,Small-Molecule, and Functional Screening of Novel and Targetable Invadopodial Regulators in Stem-Like Cancer Cells: Focusing on Cell-Surface Amfr as a Prioritized Therapeutic Target in Invasive Gastroenterological Cancers( III )
8/1/22 → 7/31/23
Project: A - Government Institution › b - Ministry of Science and Technology
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Rescuing Chemotherapy-Induced Epigenetic Alterations in Cancer Fibroblasts as a Novel Therapeutic Strategy in Advanced Pancreatic Ductal Adenocarcinoma (1/3)
8/1/22 → 7/31/23
Project: A - Government Institution › b - Ministry of Science and Technology
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2-1-3 精進核心研究服務平台-研究型主治醫師蔡坤志
1/1/22 → 12/31/22
Project: B - Project of TMU › h - Higher Education Sprout Project
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ASPM-PAR-PCP訊息軸於侵犯性癌幹細胞造成癌轉移的角色與其標靶治療(3/3)
8/1/21 → 7/31/22
Project: A - Government Institution › b - Ministry of Science and Technology
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進展性胰臟癌新穎增進免疫療法的治療策略與生物指標-節拍式化學治療增進基質硬化性胰臟癌免疫監督與免疫檢查點阻斷療法: 聚焦於腫瘤基質與髓源性抑制細胞(3/3)
8/1/21 → 7/31/22
Project: A - Government Institution › b - Ministry of Science and Technology
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ASPM activates Hedgehog and Wnt signaling to promote small cell lung cancer stemness and progression
Cheng, L-H., Hsu, C-C., Tsai, H-W., Liao, W-Y., Yang, P-M., Liao, T-Y., Hsieh, H-Y., Chan, T-S. & Tsai, K. K., Jan 1 2023, In: Cancer Research.Research output: Contribution to journal › Article › peer-review
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Inhibition of KDM4C/c-Myc/LDHA signalling axis suppresses prostate cancer metastasis via interference of glycolytic metabolism
Lin, C-Y., Wang, B-J., Fu, Y-K., Huo, C., Wang, Y-P., Chen, B-C., Liu, W-Y., Tseng, J-C., Jiang, S. S., Sie, Z-L., Tsai, K. K., Yuh, C-H., Wang, W-C., Kung, H-J. & Chuu, C-P., Mar 2022, In: Clinical and Translational Medicine. 12, 3, p. e764Research output: Contribution to journal › Article › peer-review
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Screening of organoids derived from patients with breast cancer implicates the repressor NCOR2 in cytotoxic stress response and antitumor immunity
Tsai, K. K., Huang, S-S., Northey, J. J., Liao, W-Y., Hsu, C-C., Cheng, L-H., Werner, M. E., Chuu, C-P., Chatterjee, C., Lakins, J. N. & Weaver, V. M., Jun 2022, In: Nature Cancer. 3, 6, p. 734-752 19 p.Research output: Contribution to journal › Article › peer-review
5 Citations (Scopus) -
A multi-mode Wnt- and stemness-regulatory module dictated by FOXM1 and ASPM isoform I in gastric cancer
Hsu, C. C., Liao, W. Y., Chang, K. Y., Chan, T. S., Huang, P. J., Chiang, C. T., Shan, Y. S., Cheng, L. H., Liao, T. Y. & Tsai, K. K., May 2021, In: Gastric Cancer. 24, 3, p. 624-639 16 p.Research output: Contribution to journal › Article › peer-review
5 Citations (Scopus) -
A Novel Invadopodia-Specific Marker for Invasive and Pro-Metastatic Cancer Stem Cells
Huang, S. S., Liao, W. Y., Hsu, C. C., Chan, T. S., Liao, T. Y., Yang, P. M., Chen, L. T., Sung, S. Y. & Tsai, K. K., May 31 2021, In: Frontiers in Oncology. 11, p. 638311 638311.Research output: Contribution to journal › Article › peer-review
Open Access1 Citation (Scopus)