Projects per year
Personal profile
Education
- 2011 國立交通大學生物資訊及系統生物研究所博士
- 2007 國立交通大學生物資訊研究所碩士
- 2005 國立交通大學生物科技學系學士
Experience
- 2022- Professor, Master Program in Clinical Genomics and Proteomics, Taipei Medical University
- 2022- Professor, International Ph.D. Program for Translational Science, Taipei Medical University
- 2022- Graduate Institute of Cancer Biology and Drug Discovery, Taipei Medical University
- 2022- Professor, Ph.D. Program in Biotechnology Research and Development, Taipei Medical University
- 2022- Professor, Ph.D. Program for Cancer Molecular Biology and Drug Discovery, Taipei Medical University
- 2021-2022 Associate Professor, Master Program in Clinical Genomics and Proteomics, Taipei Medical University
- 2021-2022 Associate Professor, International Ph.D. Program for Translational Science, Taipei Medical University
- 2019-2022 Associate Professor, Graduate Institute of Cancer Biology and Drug Discovery, Taipei Medical University
- 2019-2022 Associate Professor, Ph.D. Program in Biotechnology Research and Development, Taipei Medical University
- 2019-2022 Assistant Professor, Ph.D. Program for Cancer Molecular Biology and Drug Discovery, Taipei Medical University
- 2018-2019 Assistant Professor, Graduate Institute of Cancer Biology and Drug Discovery, Taipei Medical University
- 2015-2018 Assistant Professor, Ph.D. Program for Cancer Molecular Biology and Drug Discovery, Taipei Medical University
Research Interests
- 生物學之生化及分子生物
- 生物資訊與醫療資訊
Fingerprint
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Network
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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111年度【產學合作計畫-人工智能技術應用於新穎胰臟癌藥物研發與優化(2/2)】
11/1/22 → 10/31/23
Project: A - Government Institution › b - Ministry of Science and Technology
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Design and Optimization of Novel Protein Kinase Inhibitors for Pancreatic Cancer Treatment and Mechanism Investigation (1/3)
8/1/22 → 7/31/23
Project: A - Government Institution › b - Ministry of Science and Technology
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開發新穎TBK1抑制劑並評估其抑制胰臟癌的功效與探討機轉
7/1/22 → 2/28/23
Project: A - Government Institution › b - Ministry of Science and Technology
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建立以結構為基礎之藥物篩選模型並應用於研發新穎性蛋白激酶抑制劑
7/1/22 → 2/28/23
Project: A - Government Institution › b - Ministry of Science and Technology
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以結構與人工智慧技術研發新穎DYRK1B抑制劑
1/1/22 → 12/31/22
Project: B - Project of TMU › h - Higher Education Sprout Project
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Design, synthesis, and biological evaluation of indolin-2-one derivatives as novel cyclin-dependent protein kinase 8 (CDK8) inhibitors
Hsu, J. Y., Hsu, K. C., Sun, C., Chou, C. H., Lin, T. E., Sung, T. Y., Tseng, H. J., Yen, S. C., Yang, C. R. & Huang, W. J., Mar 2023, In: Biomedicine and Pharmacotherapy. 159, 114258.Research output: Contribution to journal › Article › peer-review
Open Access1 Citation (Scopus) -
In silico identification and biological evaluation of a selective MAP4K4 inhibitor against pancreatic cancer
Chang, C. D., Chao, M. W., Lee, H. Y., Liu, Y. T., Tu, H. J., Lien, S. T., Lin, T. E., Sung, T. Y., Yen, S. C., Huang, S. H., Hsu, K. C. & Pan, S. L., 2023, In: Journal of Enzyme Inhibition and Medicinal Chemistry. 38, 1, 2166039.Research output: Contribution to journal › Article › peer-review
Open Access1 Citation (Scopus) -
Discovery of a novel cyclin-dependent kinase 8 inhibitor with an oxindole core for anti-inflammatory treatment
Lin, T. E., Yang, C. R., Chou, C. H., Hsu, J. Y., Chao, M. W., Sung, T. Y., Hsieh, J. H., Huang, W. J. & Hsu, K. C., Feb 2022, In: Biomedicine and Pharmacotherapy. 146, 112459.Research output: Contribution to journal › Article › peer-review
Open Access4 Citations (Scopus) -
Identification and analysis of a selective DYRK1A inhibitor
Lin, T. E., Chao, M. W., HuangFu, W. C., Tu, H. J., Peng, Z. X., Su, C. J., Sung, T. Y., Hsieh, J. H., Lee, C. C., Yang, C. R., Pan, S. L. & Hsu, K. C., Feb 2022, In: Biomedicine and Pharmacotherapy. 146, 112580.Research output: Contribution to journal › Article › peer-review
Open Access3 Citations (Scopus) -
Identification of a dual FLT3 and MNK2 inhibitor for acute myeloid leukemia treatment using a structure-based virtual screening approach
Yen, S. C., Chen, L. C., Huang, H. L., HuangFu, W. C., Chen, Y. Y., Eight Lin, T., Lien, S. T., Tseng, H. J., Sung, T. Y., Hsieh, J. H., Huang, W. J., Pan, S. L. & Hsu, K. C., Apr 2022, In: Bioorganic Chemistry. 121, p. 105675 105675.Research output: Contribution to journal › Article › peer-review
Open Access6 Citations (Scopus)
Datasets
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Identification of a dual TAOK1 and MAP4K5 inhibitor using a structure-based virtual screening approach
Chao, M. (Creator), Lin, T. E. (Creator), HuangFu, W. (Creator), Chang, C. (Creator), Tu, H. (Creator), Chen, L. (Creator), Yen, S. (Creator), Sung, T. (Creator), Huang, W. (Creator), Yang, C. (Creator), Pan, S. (Creator) & Hsu, K. (Creator), Taylor & Francis, 2020
DOI: 10.6084/m9.figshare.13213424.v1, https://tandf.figshare.com/articles/dataset/Identification_of_a_dual_TAOK1_and_MAP4K5_inhibitor_using_a_structure-based_virtual_screening_approach/13213424/1
Dataset
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CCDC 2000792: Experimental Crystal Structure Determination
Hsu, M. (Contributor), Hsieh, C. (Contributor), Kapoor, M. (Contributor), Chang, J. (Contributor), Chu, H. (Contributor), Cheng, T. (Contributor), Hsu, K. (Contributor), Lin, T. E. (Contributor), Tsai, F. (Contributor) & Horng, J. (Contributor), Cambridge Crystallographic Data Centre, 2020
DOI: 10.5517/ccdc.csd.cc254zp0, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccdc.csd.cc254zp0&sid=DataCite
Dataset
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Additional file 1 of Investigating the potential effects of selective histone deacetylase 6 inhibitor ACY1215 on infarct size in rats with cardiac ischemia-reperfusion injury
Pan, S. (Contributor), Hsu, K. (Creator), Lin, T. E. (Creator), Lin, C. (Creator), Huang, H. (Contributor) & HuangFu, W. (Contributor), Figshare, 2020
DOI: 10.6084/m9.figshare.11992497.v1, https://doi.org/10.6084%2Fm9.figshare.11992497.v1
Dataset
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Investigating the potential effects of selective histone deacetylase 6 inhibitor ACY1215 on infarct size in rats with cardiac ischemia-reperfusion injury
Lin, C. (Creator), Hsu, K. (Creator), HuangFu, W. (Contributor), Lin, T. E. (Creator), Huang, H. (Contributor) & Pan, S. (Contributor), Figshare, 2020
DOI: 10.6084/m9.figshare.c.4896705.v1, https://springernature.figshare.com/collections/Investigating_the_potential_effects_of_selective_histone_deacetylase_6_inhibitor_ACY1215_on_infarct_size_in_rats_with_cardiac_ischemia-reperfusion_injury/4896705/1
Dataset
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Structure-based virtual screening and biological evaluation of novel small-molecule BTK inhibitors
Lin, T. E. (Creator), Sung, L. (Creator), Chao, M. (Creator), Li, M. (Creator), Zheng, J. (Creator), Sung, T. (Creator), Hsieh, J. (Creator), Yang, C. (Creator), Lee, H. (Creator), Cho, E. (Creator) & Hsu, K. (Creator), Taylor & Francis, 2021
DOI: 10.6084/m9.figshare.17162118.v1, https://tandf.figshare.com/articles/journal_contribution/Structure-based_virtual_screening_and_biological_evaluation_of_novel_small-molecule_BTK_inhibitors/17162118/1
Dataset