Joen-Rong Sheu

Finished

銀杏素對抗人類血小板活化與細胞自噬的機轉探討及促進恢復老鼠血管血栓的效力評估: 研究NF-κB在調控integrin αIIbβ3 inside-out 及outside-in 訊息傳遞作用的重要性(2/3)

Sheu, J.-R. (PI)

8/1/23 → 7/31/24

Project: A - Government Institution › b - National Science and Technology Council

細胞膜連結支架蛋白Shank3在血小板活化, 細胞自噬以及在缺血性腦中風的病理及生理角色: glabridin抑制Shank3所調控訊息作用的機轉探討(1/3)

Sheu, J.-R. (PI)

8/1/23 → 7/31/24

Project: A - Government Institution › b - National Science and Technology Council

探討Aldose reductase對腦血管退化之關鍵角色

Sheu, J.-R. (PI)

3/1/23 → 2/29/24

Project: C - Project of Alliance › o - Chi Mei Medical Center

藉由整合基因、分子及臨床研究來解析SHANK3及其下游訊息傳遞蛋白於腦中風嚴重性之重要性

Sheu, J.-R. (PI)

1/1/23 → 12/31/23

Project: B - Project of TMU › h - Higher Education Sprout Project

Novel Mechanisms and Effectiveness of Ginkgetin against Platelet Activation Associated with Autophagy in Humans and Facilitating Recovery from Vascular Thrombosis in Mice: the Modulation of Nf-Κb with Integrin Αiibβ3 Inside-Out and Outside-In Signals (1/3)

Sheu, J.-R. (PI)

8/1/22 → 7/31/23

Project: A - Government Institution › b - National Science and Technology Council

銀杏素抑制血小板活化的機轉探討

Sheu, J.-R. (PI)

3/1/22 → 2/28/23

Project: C - Project of Alliance › o - Chi Mei Medical Center

探討SHANK3與其相關訊息傳遞蛋白: RBFA, TRIM5, and GPR68影響血小板活化及細胞自噬作用

Sheu, J.-R. (PI)

1/1/22 → 12/31/22

Project: B - Project of TMU › h - Higher Education Sprout Project

Novel Activitiy of Rutaecarpine in Regulation of Platelet Activation and Autophagy as Well as Autologus Thromboembolic Stroke in Experimental Animals: the Crucial Role of Nf-Κb in Anucleated Cells

Sheu, J.-R. (PI)

8/1/21 → 7/31/22

Project: A - Government Institution › b - National Science and Technology Council

Morin hydrate對血小板自噬作用以及對血小板活化過程中NF-κB調控路徑的影響

Sheu, J.-R. (PI)

3/1/21 → 2/28/22

Project: C - Project of Alliance › o - Chi Mei Medical Center

糖解作用中的重要金屬酵素glyoxalase 1在血小板活化及自噬作用中的角色探討

Sheu, J.-R. (PI)

1/1/21 → 12/31/21

Project: B - Project of TMU › h - Higher Education Sprout Project

Novel Activitiy of Rutaecarpine in Regulation of Platelet Activation and Autophagy as Well as Autologus Thromboembolic Stroke in Experimental Animals: the Crucial Role of Nf-Κb in Anucleated Cells

Sheu, J.-R. (PI)

8/1/20 → 7/1/21

Project: A - Government Institution › b - National Science and Technology Council

Rutaecarpine經由調控NF-κB路徑對血小板活化與細胞自噬的影響

Sheu, J.-R. (PI)

3/1/20 → 2/1/21

Project: C - Project of Alliance › o - Chi Mei Medical Center

糖解作用中的重要金屬酵素glyoxalase 1在血小板活化及自噬作用中的角色探討

Sheu, J.-R. (PI)

1/1/20 → 12/1/20

Project: B - Project of TMU › h - Higher Education Sprout Project

Novel Activitiy of Rutaecarpine in Regulation of Platelet Activation and Autophagy as Well as Autologus Thromboembolic Stroke in Experimental Animals: the Crucial Role of Nf-Κb in Anucleated Cells(1/3)

Sheu, J.-R. (PI)

8/1/19 → 7/31/20

Project: A - Government Institution › b - National Science and Technology Council

Aldose Reductase and Nf-Κb Signalings in Collagen Receptor Glycoprotein Vi-Mediated Platelet Autophagy: a Regulatory Mechinary of Endogenous Gaba in Anucleate Blood Cells (II)(2/2)

Sheu, J.-R. (PI)

8/1/19 → 7/31/20

Project: A - Government Institution › b - National Science and Technology Council

探討在自體凝血塊引起腦中風後加入hinokitiol的活性評估以及可能的相關機轉探討

Sheu, J.-R. (PI)

3/1/19 → 2/1/20

Project: C - Project of Alliance › o - Chi Mei Medical Center

細胞膜連結支架蛋白Shank3在大腦缺血反應中的病理生理角色-SHANK3調控凝血酶protease-activated receptors (PARs)引起血小板活化的機轉探討

Sheu, J.-R. (PI)

1/1/19 → 12/1/19

Project: A - Government Institution › d - Ministry of Education

Aldose Reductase and Nf-Κb Signalings in Collagen Receptor Glycoprotein Vi-Mediated Platelet Autophagy: a Regulatory Mechinary of Endogenous Gaba in Anucleate Blood Cells (II)

Sheu, J.-R. (PI)

8/1/18 → 7/1/19

Project: A - Government Institution › b - National Science and Technology Council

Aldose reductase (AR)調控膠原蛋白GPVI及凝血酶PAR4所引起血小板活化的新角色:在無核細胞中所扮演的訊息傳遞機制

Sheu, J.-R. (PI)

3/1/18 → 2/28/19

Project: C - Project of Alliance › o - Chi Mei Medical Center

細胞膜連結支架蛋白Shank3在大腦缺血反應中的病理生理角色

Sheu, J.-R. (PI)

1/1/18 → 12/31/18

Project: B - Project of TMU › h - Higher Education Sprout Project

Aldose Reductase and Nf-Kb Signalings in Collagen Receptor Glycoprotein Vi-Mediated Platelet Autophagy: a Regulatory Mechinary of Endogenous Gaba in Anucleate Blood Cells

Sheu, J.-R. (PI)

8/1/17 → 7/31/18

Project: A - Government Institution › b - National Science and Technology Council

細胞膜連結支架蛋白Shank3在大腦缺血反應中的病理生理角色

Sheu, J.-R. (PI)

8/1/17 → 7/31/18

Project: B - Project of TMU › i - Other (Funded by TMU)

發展Benzimidazole 衍生物成為一種新的抗血栓藥物: 化學結構-活性之相關性研究

Sheu, J.-R. (PI)

3/1/17 → 2/28/18

Project: C - Project of Alliance › o - Chi Mei Medical Center

Aldose reductase (AR)調控膠原蛋白GPVI及凝血?PAR4所引起血小板活化及細胞凋亡的新角色: Arf-AR在無核細胞中所扮演的訊息傳遞機制 (II)(2/2)

Sheu, J.-R. (PI)

8/1/16 → 7/31/17

Project: A - Government Institution › b - National Science and Technology Council

探討純化的多醣體CME-1 在ex vivo 和 in vivo實驗中可經由刺激adenylate cyclase/cyclic AMP進而抑制血小板的活化

Sheu, J.-R. (PI)

3/1/16 → 2/28/17

Project: C - Project of Alliance › o - Chi Mei Medical Center

The Novel Roles of Aldose Reductase (AR) in Collagen GPVI- and Thrombin PAR4-Mediated Platelet Activation and Apoptosis: Regulatory Machinery of Arf-AR Signaling in Anucleate Cells (II)

Sheu, J.-R. (PI)

8/1/15 → 7/31/16

Project: A - Government Institution › b - National Science and Technology Council

Caffeic acid phenethyl ester (CAPE)抑制血小板活化反應的機轉探討

Sheu, J.-R. (PI)

5/1/15 → 4/30/16

Project: C - Project of Alliance › n - Yuan's General Hospital

冬蟲夏草純化的新多醣體CME-1抑制巨噬細胞發炎反應的分子機轉探討

Sheu, J.-R. (PI)

3/1/15 → 4/30/16

Project: C - Project of Alliance › o - Chi Mei Medical Center

The Novel Roles of Aldose Reductase (AR) in Collagen GPVI- and Thrombin PAR4-Mediated Platelet Activation and Apoptosis---Regulatory Machinery of Arf-AR Signaling in Anucleate Cells

Sheu, J.-R. (PI)

8/1/14 → 7/31/15

Project: A - Government Institution › b - National Science and Technology Council

在實驗動物發炎模式下自由基所扮演的角色

Sheu, J.-R. (PI)

5/1/14 → 5/31/15

Project: C - Project of Alliance › n - Yuan's General Hospital

HMG CoA抑制劑simvastatin調控血小板活化之分子機轉探討

Sheu, J.-R. (PI)

3/1/14 → 2/28/15

Project: C - Project of Alliance › o - Chi Mei Medical Center

Novel activities of gamma-aminobutyric acid-mediated regulation of platelet activation, apoptosis, and autophagy: the non-genomic functions of NF-kappaB signal in anucleated cells

Sheu, J.-R. (PI)

8/1/13 → 7/31/14

Project: A - Government Institution › b - National Science and Technology Council

氧化壓力在實驗動物模式所引起之後天性淋巴水腫中所扮演的角色

Sheu, J.-R. (PI)

5/1/13 → 4/30/14

Project: C - Project of Alliance › t - Taipei Municipal Wanfang Hospital

Caesalpinia sappan L.活性成分brazilin在血小板中作為collagen受體刺激劑之機轉探討

Sheu, J.-R. (PI)

3/1/13 → 2/28/14

Project: C - Project of Alliance › o - Chi Mei Medical Center

Comparative studies of Tao-Ren-Cheng-Qi Tang or San-Huang-Xie-Xin Tang with aspirin on neuroprotection and lowering the neurobehavioral deficits in rat ischemic stroke: evaluation the risks of inducing gastric bleeding, intracerebral hemorrhage, and subarachnoid hemorrhage (2-2)

Sheu, J.-R. (PI)

1/21/13 → 12/15/13

Project: A - Government Institution › c - Ministry of Health and Welfare

Novel Activities of Gamma-Aminobutyric Acid-Mediated Regulation of Platelet Activation, Apoptosis, and Autophagy: the Non-Genomic Functions of Nf-Kappab Signal in Anucleated Cells

Sheu, J.-R. (PI)

8/1/12 → 7/31/13

Project: A - Government Institution › b - National Science and Technology Council

Study of solid cultivated fruit bodies of Antrodia camphorata combined with or without aspirin on neuroprotection and lowering the neurobehavioral deficits in rat ischemic stroke: evaluating the risks of inducing hemorrhagic side effects.

Sheu, J.-R. (PI)

6/1/12 → 12/31/12

Project: A - Government Institution › e - Council of Agriculture

淋巴管內皮細胞粒腺體導致細胞死亡的關鍵角色探討

Sheu, J.-R. (PI)

5/1/12 → 4/30/13

Project: C - Project of Alliance › t - Taipei Municipal Wanfang Hospital

新的NF-κB抑制劑andrographolide調控血小板活化之機轉探討: NF-κB在p38 MAPK-hydroxyl radical-ERK2路徑的調節角色

Sheu, J.-R. (PI)

3/1/12 → 2/28/13

Project: C - Project of Alliance › o - Chi Mei Medical Center

Comparative studies of Tao-Ren-Cheng-Qi Tang or San-Huang-Xie-Xin Tang with aspirin on neuroprotection and lowering the neurobehavioral deficits in rat ischemic stroke: evaluation the risks of inducing gastric bleeding, intracerebral hemorrhage, and subarachnoid hemorrhage.

Sheu, J.-R. (PI)

2/23/12 → 12/15/12

Project: A - Government Institution › c - Ministry of Health and Welfare

新的alpha-tocopherol衍生物pentamethylchromane阻斷血管平滑肌細胞不正常增生的機制探討

Sheu, J.-R. (PI)

1/1/12 → 12/31/12

Project: C - Project of Alliance › j - National Taipei University of Technology

Novel Activities of Gamma-Aminobutyric Acid-Mediated Regulation of Platelet Activation, Apoptosis, and Autophagy: the Non-Genomic Functions of Nf-Kappab Signal in Anucleated Cells

Sheu, J.-R. (PI)

8/1/11 → 7/31/12

Project: A - Government Institution › b - National Science and Technology Council

Studies the potentiation of Tao-Hong-Si-Wu-Tang and rt-PA in blood clot-induced ischemic stroke and lowering the side effect of subarachidonic hemorrhage

Sheu, J.-R. (PI)

1/13/11 → 12/31/11

Project: A - Government Institution › c - Ministry of Health and Welfare

Regulatory Mechanisms of Mitochondria Involved in Apoptosis, Necrosis and Autophagy in Anuclear Cells, Platelets

Sheu, J.-R. (PI)

8/1/10 → 7/31/11

Project: A - Government Institution › b - National Science and Technology Council

Joen-Rong Sheu

Projects

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