Projects per year
Personal profile
Education
- 1988-1992 Ph.D., Postdoctoral Research Fellow, Graduate Institute of Immunology, College of Medicine, National Taiwan University
- 1984-1988 B.S., School of Pharmacy, Taipei Medical University
Experience
- 2024.04- Deputy Dean, College of Medicine, Taipei Medical University
- 2018.02- Professor, Graduate Institute of Metabolism and Obesity Sciences, Taipei Medical University
- 2018.02- Professor, International Master/Ph.D. Program in Medicine, College of Medicine, Taipei Medical University
- 2017.08- Professor, School of Pharmacy, Taipei Medical University
- 2020.08-2024.03 Deputy Dean, College of Medicine, Taipei Medical University
- 2016.11-2017.10 Professor, International Master/Ph.D. Program in Medicine, College of Medicine, Taipei Medical University
- 2014.03-2014.12 Taipei Medical University
- 2013.08- The Ph.D., Program for Neural Regenerative Medicine, Taipei Medical University
- 2012.09-2016.01 Dean, Office of Research and Development, Taipei Medical University
- 2012.08- The Ph.D. Program for Translational Medicine, Taipei Medical University
- 2010.08-2012.08 Deputy Director, College of Medicine, Taipei Medical University
- 2009.09- Professor, School of Pharmacy, Taipei Medical University
- 2007.08- Professor, Graduate Institute of Medical Sciences, Taipei Medical University, Taiwan
- 2003.09-2007.07 Director, School of Pharmacy, Taipei Medical University
- 2001.08-2004.09 Director, School of Medicine, Taipei Medical University
- 2001-2014 Chairman, Department of Pharmacology, Taipei Medical University
- 2010-2012, Deputy Dean, College of Medicine, Taipei Medical University
- 2008 Professor, Graduate Institute of Medical Sciences, Taipei Medical University
- 1999.08-2014.01 Director, School of Pharmacy, Taipei Medical University
- 1999.08-2007.07 Professor, School of Medicine, Taipei Medical University
- 1995.08-1999.07 Associate Professor, School of Medicine, Taipei Medical University
- 1993.10-1995.06 Instructor, Department & Graduate Institute of Pharmacology, National Defense Medical Center
Awards
- 2019 Research Dissertation Award - Merit Award, Taipei Medical University
- 2009 TMU Academic Research Award
- 2007-2014 MOST Reward special talents
Research Interests
- Cardiovascular Molecular Pharmacology
- Stroke
- Thrombosis and Coagulation
- Signaling
- Molecular Biology
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Projects
- 48 Finished
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The Pathophysiologcal Roles of Membrane-Associated Scaffold Protein, Shank3, in Platelet Activation, Autophagy and Ischemic Stroke: the Inhibitory Mechanisms of Glabridin by Targeting Shank3-Mediated Signals
Sheu, J.-R. (PI)
8/1/25 → 7/31/26
Project: A - Government Institution › b - National Science and Technology Council
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Targeting the Integrin Αiibβ3-Mediated Outside-In Signaling through Cpla2-Nf-Κb Axis by Syringetin to Alleviate Platelet Activation on Immobilized Fibrinogen: Mechanistic Insights and Preclinical Evaluation for Cardio/Cerebral Arterial Thrombosis Recovery
Sheu, J.-R. (PI)
8/1/25 → 7/31/26
Project: A - Government Institution › b - National Science and Technology Council
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Ginkgetin抑制血小板凋亡的機轉探討: JAK2/STAT3與NF-κB在無核細胞中的關鍵角色
Sheu, J.-R. (PI)
3/1/25 → 2/28/26
Project: C - Project of Alliance › o - Chi Mei Medical Center
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解析TRIM5 藉由調節上皮損傷、間皮-間質轉變、纖維母細胞到肌纖維母細胞轉變以及血小板活化而影響特發性肺纖維化病理中之重要作用
Sheu, J.-R. (PI)
1/1/25 → 12/31/25
Project: B - Project of TMU › h - Higher Education Sprout Project
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Ginkgetin抑制Shank3引起的血小板活化與自噬作用之機轉探討
Sheu, J.-R. (PI)
3/1/24 → 2/28/25
Project: C - Project of Alliance › o - Chi Mei Medical Center
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Correction: Naringin Potentiates Docetaxel-Induced Apoptosis in Breast Cancer Cells via Transient Interaction with the TUBB3 GTP-Binding Site (Cell Biochemistry and Biophysics, (2026), 10.1007/s12013-026-02055-7)
Kativa, M., Balupillai, A., Jayakumar, T. & Sheu, J. R., 2026, In: Cell Biochemistry and Biophysics.Research output: Contribution to journal › Comment/debate › peer-review
Open Access -
Costunolide, a Sesquiterpene Lactone, Protects Against Platelet Activation and Thrombus Formation
Sheu, J. R., Lin, K. H., Chen, R. J., Chia, H. P., Chen, T. Y., Jayakumar, T., Wang, H. H., Peng, H. Y., Li, J. Y. & Lu, W. J., May 2026, In: Cells. 15, 10, 938.Research output: Contribution to journal › Article › peer-review
Open Access -
Distinct Thromboxane A₂–Dependent Pathways Regulate Arachidonic Acid–Triggered VASP Phosphorylation at Ser239 and Ser157 in Human Platelets: Real-Time Visualization Reveals Superior Antithrombotic Efficacy by Targeting Thromboxane A₂ Signaling over Cyclooxygenase Inhibition
Sheu, J. R., Huang, W. C., Chang, C. C., Hsia, C. W., Hsia, C. H., Jayakumar, T. & Hou, S. M., Mar 2026, In: Journal of Cellular Physiology. 241, 3, e70160.Research output: Contribution to journal › Article › peer-review
Open Access -
Glabridin attenuates LTA‑induced alveolar macrophage migration via activation of the Nrf2/HO‑1 pathway
Hsia, C. H., Yang, C. M., Chang, C. C., Yen, T. L., Darmanto, A. G., Huang, C. C. & Sheu, J. R., Jan 2026, In: Molecular Medicine Reports. 33, 1, 48.Research output: Contribution to journal › Article › peer-review
Open Access1 Link opens in a new tab Citation (Scopus) -
Metal-based complexes as emerging antiplatelet and antithrombotic agents: Mechanistic insights and therapeutic perspective
Sheu, J. R., Hsieh, C. Y., Hsia, C. W., Saravanabhavan, P., Velusamy, M. & Jayakumar, T., Jul 2026, In: Inorganic Chemistry Communications. 189, P1, 116707.Research output: Contribution to journal › Review article › peer-review
Datasets
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MOESM3 of The neuroprotective effects of Tao-Ren-Cheng-Qi Tang against embolic stroke in rats
Thomas, P. A. (Creator), Yu, M.-C. (Contributor), Chang, N.-C. (Contributor), Shiao, W.-C. (Creator), Hsu, L.-W. (Creator), Yen, T.-L. (Contributor), Jayakumar, T. (Contributor) & Sheu, J.-R. (Contributor), Figshare, 2017
DOI: 10.6084/m9.figshare.c.3678886_d2.v1, https://doi.org/10.6084%2Fm9.figshare.c.3678886_d2.v1
Dataset
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MOESM2 of The neuroprotective effects of Tao-Ren-Cheng-Qi Tang against embolic stroke in rats
Jayakumar, T. (Contributor), Sheu, J.-R. (Contributor), Chang, N.-C. (Contributor), Yen, T.-L. (Contributor), Yu, M.-C. (Contributor), Hsu, L.-W. (Creator), Thomas, P. A. (Creator) & Shiao, W.-C. (Creator), Figshare, 2017
DOI: 10.6084/m9.figshare.c.3678886_d3.v1, https://doi.org/10.6084%2Fm9.figshare.c.3678886_d3.v1
Dataset
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Platelet autophagic machinery involved in thrombosis through a novel linkage of AMPK-MTOR to sphingolipid metabolism
Chang, C.-C. (Contributor), Hsiung, Y.-C. (Contributor), Jayakumar, T. (Contributor), Lin, K.-H. (Contributor), Hsieh, C.-Y. (Creator), Trang, N. T. T. (Contributor), Lee, C.-Y. (Creator), Chen, R.-J. (Contributor), Chang, T.-H. (Contributor), Lu, W.-J. (Contributor), Changou, C. A. (Creator), Lee, T.-Y. (Creator), Sheu, J.-R. (Contributor) & Yang, C.-H. (Contributor), Taylor & Francis, 2021
DOI: 10.6084/m9.figshare.14259880.v1, https://doi.org/10.6084%2Fm9.figshare.14259880.v1
Dataset
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MOESM1 of The neuroprotective effects of Tao-Ren-Cheng-Qi Tang against embolic stroke in rats
Yen, T.-L. (Contributor), Thomas, P. A. (Creator), Shiao, W.-C. (Creator), Sheu, J.-R. (Contributor), Jayakumar, T. (Contributor), Chang, N.-C. (Contributor), Yu, M.-C. (Contributor) & Hsu, L.-W. (Creator), Figshare, 2017
DOI: 10.6084/m9.figshare.c.3678886_d1.v1, https://doi.org/10.6084%2Fm9.figshare.c.3678886_d1.v1
Dataset
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The neuroprotective effects of Tao-Ren-Cheng-Qi Tang against embolic stroke in rats
Shiao, W.-C. (Creator), Yen, T.-L. (Contributor), Hsu, L.-W. (Creator), Chang, N.-C. (Contributor), Jayakumar, T. (Contributor), Yu, M.-C. (Contributor), Thomas, P. A. (Creator) & Sheu, J.-R. (Contributor), Figshare, 2017
DOI: 10.6084/m9.figshare.c.3678886.v1, https://doi.org/10.6084%2Fm9.figshare.c.3678886.v1
Dataset