Personal profile
Education
- 1988-1992 Ph.D., Postdoctoral Research Fellow, Graduate Institute of Immunology, College of Medicine, National Taiwan University
- 1984-1988 B.S., School of Pharmacy, Taipei Medical University
Experience
- 2024.04- Deputy Dean, College of Medicine, Taipei Medical University
- 2018.02- Professor, Graduate Institute of Metabolism and Obesity Sciences, Taipei Medical University
- 2018.02- Professor, International Master/Ph.D. Program in Medicine, College of Medicine, Taipei Medical University
- 2017.08- Professor, School of Pharmacy, Taipei Medical University
- 2020.08-2024.03 Deputy Dean, College of Medicine, Taipei Medical University
- 2016.11-2017.10 Professor, International Master/Ph.D. Program in Medicine, College of Medicine, Taipei Medical University
- 2014.03-2014.12 Taipei Medical University
- 2013.08- The Ph.D., Program for Neural Regenerative Medicine, Taipei Medical University
- 2012.09-2016.01 Dean, Office of Research and Development, Taipei Medical University
- 2012.08- The Ph.D. Program for Translational Medicine, Taipei Medical University
- 2010.08-2012.08 Deputy Director, College of Medicine, Taipei Medical University
- 2009.09- Professor, School of Pharmacy, Taipei Medical University
- 2007.08- Professor, Graduate Institute of Medical Sciences, Taipei Medical University, Taiwan
- 2003.09-2007.07 Director, School of Pharmacy, Taipei Medical University
- 2001.08-2004.09 Director, School of Medicine, Taipei Medical University
- 2001-2014 Chairman, Department of Pharmacology, Taipei Medical University
- 2010-2012, Deputy Dean, College of Medicine, Taipei Medical University
- 2008 Professor, Graduate Institute of Medical Sciences, Taipei Medical University
- 1999.08-2014.01 Director, School of Pharmacy, Taipei Medical University
- 1999.08-2007.07 Professor, School of Medicine, Taipei Medical University
- 1995.08-1999.07 Associate Professor, School of Medicine, Taipei Medical University
- 1993.10-1995.06 Instructor, Department & Graduate Institute of Pharmacology, National Defense Medical Center
Awards
- 2019 Research Dissertation Award - Merit Award, Taipei Medical University
- 2009 TMU Academic Research Award
- 2007-2014 MOST Reward special talents
Research Interests
- Cardiovascular Molecular Pharmacology
- Stroke
- Thrombosis and Coagulation
- Signaling
- Molecular Biology
Fingerprint
- 1 Similar Profiles
Collaborations and top research areas from the last five years
-
Targeting the Integrin Αiibβ3-Mediated Outside-In Signaling through Cpla2-Nf-Κb Axis by Syringetin to Alleviate Platelet Activation on Immobilized Fibrinogen: Mechanistic Insights and Preclinical Evaluation for Cardio/Cerebral Arterial Thrombosis Recovery
Sheu, J.-R. (PI)
8/1/25 → 7/31/26
Project: A - Government Institution › b - National Science and Technology Council
-
The Pathophysiologcal Roles of Membrane-Associated Scaffold Protein, Shank3, in Platelet Activation, Autophagy and Ischemic Stroke: the Inhibitory Mechanisms of Glabridin by Targeting Shank3-Mediated Signals
Sheu, J.-R. (PI)
8/1/25 → 7/31/26
Project: A - Government Institution › b - National Science and Technology Council
-
The Pathophysiologcal Roles of Membrane-Associated Scaffold Protein, Shank3, in Platelet Activation, Autophagy and Ischemic Stroke: the Inhibitory Mechanisms of Glabridin by Targeting Shank3-Mediated Signals
Sheu, J.-R. (PI)
8/1/23 → 7/31/26
Project: A - Government Institution › b - National Science and Technology Council
-
Ginkgetin抑制血小板凋亡的機轉探討: JAK2/STAT3與NF-κB在無核細胞中的關鍵角色
Sheu, J.-R. (PI)
3/1/25 → 2/28/26
Project: C - Project of Alliance › o - Chi Mei Medical Center
-
解析TRIM5 藉由調節上皮損傷、間皮-間質轉變、纖維母細胞到肌纖維母細胞轉變以及血小板活化而影響特發性肺纖維化病理中之重要作用
Sheu, J.-R. (PI)
1/1/25 → 12/31/25
Project: B - Project of TMU › h - Higher Education Sprout Project
-
A Novel KGD-Based αIIbβ3 Antagonist Prevents Arterial Thrombosis While Preserving Hemostasis and Avoiding Thrombocytopenia
Kuo, Y. J., Chung, C. H., Chen, C. C., Liu, J. C., Chiou, K. R., Sheu, J. R., Chuang, W. J. & Huang, T. F., May 2025, In: International journal of molecular sciences. 26, 10, 4530.Research output: Contribution to journal › Article › peer-review
Open Access1 Link opens in a new tab Citation (Scopus) -
Beyond metabolic messengers: Bile acids and TGR5 as pharmacotherapeutic intervention for psychiatric disorders
Darmanto, A. G., Yen, T. L., Jan, J. S., Linh, T. T. D., Taliyan, R., Yang, C. H. & Sheu, J. R., Jan 2025, In: Pharmacological Research. 211, 107564.Research output: Contribution to journal › Review article › peer-review
Open Access9 Link opens in a new tab Citations (Scopus) -
Lipopolysaccharide Potentiates Platelet Aggregation in Association with Apoptosis Through a Novel TLR4–Bax/Bcl-2-Mitochondrial Dysfunction Axis in Humans
Chen, C. C., Hsia, C. W., Huang, W. C., Chang, C. C., Darmanto, A. G. & Sheu, J. R., Dec 2025, In: Biomolecules. 15, 12, 1638.Research output: Contribution to journal › Article › peer-review
Open Access -
Eugenol: A Potential Modulator of Human Platelet Activation and Mouse Mesenteric Vascular Thrombosis via an Innovative cPLA2-NF-κB Signaling Axis
Chang, Y., Hsia, C. W., Chiou, K. R., Yen, T. L., Jayakumar, T., Sheu, J. R. & Huang, W. C., Aug 2024, In: Biomedicines. 12, 8, 1689.Research output: Contribution to journal › Article › peer-review
Open Access7 Link opens in a new tab Citations (Scopus) -
Eugenol Suppresses Platelet Activation and Mitigates Pulmonary Thromboembolism in Humans and Murine Models
Huang, W. C., Shu, L. H., Kuo, Y. J., Lai, K. S. L., Hsia, C. W., Yen, T. L., Hsia, C. H., Jayakumar, T., Yang, C. H. & Sheu, J. R., Feb 2024, In: International journal of molecular sciences. 25, 4, 2098.Research output: Contribution to journal › Article › peer-review
Open Access10 Link opens in a new tab Citations (Scopus)
Datasets
-
MOESM1 of The neuroprotective effects of Tao-Ren-Cheng-Qi Tang against embolic stroke in rats
Yen, T.-L. (Contributor), Thomas, P. A. (Creator), Shiao, W.-C. (Creator), Sheu, J.-R. (Contributor), Jayakumar, T. (Contributor), Chang, N.-C. (Contributor), Yu, M.-C. (Contributor) & Hsu, L.-W. (Creator), Figshare, 2017
DOI: 10.6084/m9.figshare.c.3678886_d1.v1, https://doi.org/10.6084%2Fm9.figshare.c.3678886_d1.v1
Dataset
-
MOESM3 of The neuroprotective effects of Tao-Ren-Cheng-Qi Tang against embolic stroke in rats
Thomas, P. A. (Creator), Yu, M.-C. (Contributor), Chang, N.-C. (Contributor), Shiao, W.-C. (Creator), Hsu, L.-W. (Creator), Yen, T.-L. (Contributor), Jayakumar, T. (Contributor) & Sheu, J.-R. (Contributor), Figshare, 2017
DOI: 10.6084/m9.figshare.c.3678886_d2.v1, https://doi.org/10.6084%2Fm9.figshare.c.3678886_d2.v1
Dataset
-
Platelet autophagic machinery involved in thrombosis through a novel linkage of AMPK-MTOR to sphingolipid metabolism
Chang, C.-C. (Contributor), Hsiung, Y.-C. (Contributor), Jayakumar, T. (Contributor), Lin, K.-H. (Contributor), Hsieh, C.-Y. (Creator), Trang, N. T. T. (Contributor), Lee, C.-Y. (Creator), Chen, R.-J. (Contributor), Chang, T.-H. (Contributor), Lu, W.-J. (Contributor), Changou, C. A. (Creator), Lee, T.-Y. (Creator), Sheu, J.-R. (Contributor) & Yang, C.-H. (Contributor), Taylor & Francis, 2021
DOI: 10.6084/m9.figshare.14259880.v1, https://doi.org/10.6084%2Fm9.figshare.14259880.v1
Dataset
-
The neuroprotective effects of Tao-Ren-Cheng-Qi Tang against embolic stroke in rats
Shiao, W.-C. (Creator), Yen, T.-L. (Contributor), Hsu, L.-W. (Creator), Chang, N.-C. (Contributor), Jayakumar, T. (Contributor), Yu, M.-C. (Contributor), Thomas, P. A. (Creator) & Sheu, J.-R. (Contributor), Figshare, 2017
DOI: 10.6084/m9.figshare.c.3678886.v1, https://doi.org/10.6084%2Fm9.figshare.c.3678886.v1
Dataset
-
MOESM2 of The neuroprotective effects of Tao-Ren-Cheng-Qi Tang against embolic stroke in rats
Jayakumar, T. (Contributor), Sheu, J.-R. (Contributor), Chang, N.-C. (Contributor), Yen, T.-L. (Contributor), Yu, M.-C. (Contributor), Hsu, L.-W. (Creator), Thomas, P. A. (Creator) & Shiao, W.-C. (Creator), Figshare, 2017
DOI: 10.6084/m9.figshare.c.3678886_d3.v1, https://doi.org/10.6084%2Fm9.figshare.c.3678886_d3.v1
Dataset