Projects per year
Personal profile
Education
- 1988-1992 Ph.D., Postdoctoral Research Fellow, Graduate Institute of Immunology, College of Medicine, National Taiwan University
- 1984-1988 B.S., School of Pharmacy, Taipei Medical University
Experience
- 2024.04- Deputy Dean, College of Medicine, Taipei Medical University
- 2018.02- Professor, Graduate Institute of Metabolism and Obesity Sciences, Taipei Medical University
- 2018.02- Professor, International Master/Ph.D. Program in Medicine, College of Medicine, Taipei Medical University
- 2017.08- Professor, School of Pharmacy, Taipei Medical University
- 2020.08-2024.03 Deputy Dean, College of Medicine, Taipei Medical University
- 2016.11-2017.10 Professor, International Master/Ph.D. Program in Medicine, College of Medicine, Taipei Medical University
- 2014.03-2014.12 Taipei Medical University
- 2013.08- The Ph.D., Program for Neural Regenerative Medicine, Taipei Medical University
- 2012.09-2016.01 Dean, Office of Research and Development, Taipei Medical University
- 2012.08- The Ph.D. Program for Translational Medicine, Taipei Medical University
- 2010.08-2012.08 Deputy Director, College of Medicine, Taipei Medical University
- 2009.09- Professor, School of Pharmacy, Taipei Medical University
- 2007.08- Professor, Graduate Institute of Medical Sciences, Taipei Medical University, Taiwan
- 2003.09-2007.07 Director, School of Pharmacy, Taipei Medical University
- 2001.08-2004.09 Director, School of Medicine, Taipei Medical University
- 2001-2014 Chairman, Department of Pharmacology, Taipei Medical University
- 2010-2012, Deputy Dean, College of Medicine, Taipei Medical University
- 2008 Professor, Graduate Institute of Medical Sciences, Taipei Medical University
- 1999.08-2014.01 Director, School of Pharmacy, Taipei Medical University
- 1999.08-2007.07 Professor, School of Medicine, Taipei Medical University
- 1995.08-1999.07 Associate Professor, School of Medicine, Taipei Medical University
- 1993.10-1995.06 Instructor, Department & Graduate Institute of Pharmacology, National Defense Medical Center
Awards
- 2019 Research Dissertation Award - Merit Award, Taipei Medical University
- 2009 TMU Academic Research Award
- 2007-2014 MOST Reward special talents
Research Interests
- Cardiovascular Molecular Pharmacology
- Stroke
- Thrombosis and Coagulation
- Signaling
- Molecular Biology
Fingerprint
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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The Pathophysiologcal Roles of Membrane-Associated Scaffold Protein, Shank3, in Platelet Activation, Autophagy and Ischemic Stroke: the Inhibitory Mechanisms of Glabridin by Targeting Shank3-Mediated Signals
Sheu, J.-R. (PI)
8/1/23 → 7/31/26
Project: A - Government Institution › b - National Science and Technology Council
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Novel Mechanisms and Effectiveness of Ginkgetin against Platelet Activation Associated with Autophagy in Humans and Facilitating Recovery from Vascular Thrombosis in Mice: the Modulation of Nf-Κb with Integrin Αiibβ3 Inside-Out and Outside-In Signals
Sheu, J.-R. (PI)
8/1/22 → 7/31/25
Project: A - Government Institution › b - National Science and Technology Council
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Ginkgetin抑制Shank3引起的血小板活化與自噬作用之機轉探討
Sheu, J.-R. (PI)
3/1/24 → 2/28/25
Project: C - Project of Alliance › o - Chi Mei Medical Center
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探討Aldose reductase對腦血管退化之關鍵角色
Sheu, J.-R. (PI)
3/1/23 → 2/29/24
Project: C - Project of Alliance › o - Chi Mei Medical Center
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藉由整合基因、分子及臨床研究來解析SHANK3及其下游訊息傳遞蛋白於腦中風嚴重性之重要性
Sheu, J.-R. (PI)
1/1/23 → 12/31/23
Project: B - Project of TMU › h - Higher Education Sprout Project
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Beyond metabolic messengers: Bile acids and TGR5 as pharmacotherapeutic intervention for psychiatric disorders
Darmanto, A. G., Yen, T. L., Jan, J. S., Linh, T. T. D., Taliyan, R., Yang, C. H. & Sheu, J. R., Jan 2025, In: Pharmacological Research. 211, 107564.Research output: Contribution to journal › Review article › peer-review
Open Access -
Eugenol: A Potential Modulator of Human Platelet Activation and Mouse Mesenteric Vascular Thrombosis via an Innovative cPLA2-NF-κB Signaling Axis
Chang, Y., Hsia, C. W., Chiou, K. R., Yen, T. L., Jayakumar, T., Sheu, J. R. & Huang, W. C., Aug 2024, In: Biomedicines. 12, 8, 1689.Research output: Contribution to journal › Article › peer-review
Open Access1 Citation (Scopus) -
Eugenol Suppresses Platelet Activation and Mitigates Pulmonary Thromboembolism in Humans and Murine Models
Huang, W. C., Shu, L. H., Kuo, Y. J., Lai, K. S. L., Hsia, C. W., Yen, T. L., Hsia, C. H., Jayakumar, T., Yang, C. H. & Sheu, J. R., Feb 2024, In: International journal of molecular sciences. 25, 4, 2098.Research output: Contribution to journal › Article › peer-review
Open Access2 Citations (Scopus) -
Ginkgetin effectively mitigates collagen and AA-induced platelet activation via PLCγ2 but not cyclic nucleotide-dependent pathway in human
Hsia, C. W., Shu, L. H., Lee, A. W., Tran, O. T., Yang, C. H., Yen, T. L., Huang, W. C., Hsia, C. H., Jayakumar, T., Chiou, K. R. & Sheu, J. R., Feb 2024, In: Journal of Cellular and Molecular Medicine. 28, 4, e18139.Research output: Contribution to journal › Article › peer-review
Open Access3 Citations (Scopus) -
Glabridin Suppresses LPS-Induced Inflammatory Cascade by Targeting AMPK/JAK2/STAT3 Pathways in Macrophages
Hou, S. M., Cheng, S. W., Lin, K. C., Yen, T. L., Hsia, C. W., Huang, W. C., Sheu, J. R. & Hsia, C. H., Dec 2024, In: Natural Product Communications. 19, 12Research output: Contribution to journal › Article › peer-review
Open Access
Datasets
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MOESM2 of The neuroprotective effects of Tao-Ren-Cheng-Qi Tang against embolic stroke in rats
Jayakumar, T. (Contributor), Sheu, J.-R. (Contributor), Chang, N.-C. (Contributor), Yen, T.-L. (Contributor), Yu, M.-C. (Contributor), Hsu, L.-W. (Creator), Thomas, P. A. (Creator) & Shiao, W.-C. (Creator), Figshare, 2017
DOI: 10.6084/m9.figshare.c.3678886_d3.v1, https://doi.org/10.6084%2Fm9.figshare.c.3678886_d3.v1
Dataset
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MOESM1 of The neuroprotective effects of Tao-Ren-Cheng-Qi Tang against embolic stroke in rats
Yen, T.-L. (Contributor), Thomas, P. A. (Creator), Shiao, W.-C. (Creator), Sheu, J.-R. (Contributor), Jayakumar, T. (Contributor), Chang, N.-C. (Contributor), Yu, M.-C. (Contributor) & Hsu, L.-W. (Creator), Figshare, 2017
DOI: 10.6084/m9.figshare.c.3678886_d1.v1, https://doi.org/10.6084%2Fm9.figshare.c.3678886_d1.v1
Dataset
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The neuroprotective effects of Tao-Ren-Cheng-Qi Tang against embolic stroke in rats
Shiao, W.-C. (Creator), Yen, T.-L. (Contributor), Hsu, L.-W. (Creator), Chang, N.-C. (Contributor), Jayakumar, T. (Contributor), Yu, M.-C. (Contributor), Thomas, P. A. (Creator) & Sheu, J.-R. (Contributor), Figshare, 2017
DOI: 10.6084/m9.figshare.c.3678886.v1, https://doi.org/10.6084%2Fm9.figshare.c.3678886.v1
Dataset
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MOESM3 of The neuroprotective effects of Tao-Ren-Cheng-Qi Tang against embolic stroke in rats
Thomas, P. A. (Creator), Yu, M.-C. (Contributor), Chang, N.-C. (Contributor), Shiao, W.-C. (Creator), Hsu, L.-W. (Creator), Yen, T.-L. (Contributor), Jayakumar, T. (Contributor) & Sheu, J.-R. (Contributor), Figshare, 2017
DOI: 10.6084/m9.figshare.c.3678886_d2.v1, https://doi.org/10.6084%2Fm9.figshare.c.3678886_d2.v1
Dataset
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Platelet autophagic machinery involved in thrombosis through a novel linkage of AMPK-MTOR to sphingolipid metabolism
Chang, C.-C. (Contributor), Hsiung, Y.-C. (Contributor), Jayakumar, T. (Contributor), Lin, K.-H. (Contributor), Hsieh, C.-Y. (Creator), Trang, N. T. T. (Contributor), Lee, C.-Y. (Creator), Chen, R.-J. (Contributor), Chang, T.-H. (Contributor), Lu, W.-J. (Contributor), Changou, C. A. (Creator), Lee, T.-Y. (Creator), Sheu, J.-R. (Contributor) & Yang, C.-H. (Contributor), Taylor & Francis, 2021
DOI: 10.6084/m9.figshare.14259880.v1, https://doi.org/10.6084%2Fm9.figshare.14259880.v1
Dataset