Projects per year
Personal profile
Education
- 2010 Ph.D., Pharmaceutical Sciences, National Taiwan University
- 2001 B.S., School of Pharmacy, Taipei Medical University
Experience
- 2022- Professor, Master Program in Clinical Pharmacogenomics and Pharmacoproteomics, Taipei Medical University
- 2022- Professor, Department of Pharmaceutical Sciences, Taipei Medical University
- 2023-2024 Visiting Professor, Department of Pharmaceutical Chemistry, University of California San Francisco
- 2020-2022 Associate Professor, Master Program in Clinical Pharmacogenomics and Pharmacoproteomics, Taipei Medical University
- 2018-2022 Associate Professor, Department of Pharmaceutical Sciences, Taipei Medical University
- 2016-2017 Assistant Professor, Ph.D. Program in Drug Discovery and Development Industry, Taipei Medical University
- 2015-2018 Assistant Professor, Department of Pharmaceutical Sciences, Taipei Medical University
- 2013-2015 Project Assistant Research Fellow, Department of Pharmaceutical Sciences, Taipei Medical University
- 2012-2013 Assistant Researcher, Department of Pharmaceutical Sciences, Taipei Medical University
Research Interests
- Traditional and computer-aided design of bioactive compounds treating diseases.
- Development of kinase inhibitors and methyltransferase inhibitors against cancer cells.
- Conducting modern synthetic methodologies, such as parallel synthesis and photochemistry.
- Total synthesis of natural products.
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Collaborations and top research areas from the last five years
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優化與開發紡錘體檢查點抑制劑用於治療三陰性乳癌(1/3)
Lee, H.-Y. (PI)
8/1/24 → 7/31/25
Project: A - Government Institution › b - National Science and Technology Council
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開發高選擇性PLK2抑制劑並探討其對大腸直腸癌之功效與機轉
Lee, H.-Y. (PI)
7/1/23 → 2/29/24
Project: A - Government Institution › b - National Science and Technology Council
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Development of Kinase Inhibitors with Pancreatic Cancer Inhibitory Activity
Lee, H.-Y. (PI)
8/1/22 → 7/31/23
Project: A - Government Institution › b - National Science and Technology Council
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DYRK1B先導抑制劑之優化與合成
Lee, H.-Y. (PI)
1/1/22 → 12/31/22
Project: B - Project of TMU › h - Higher Education Sprout Project
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Development of 1,3-Diaryl-Substituted Five-Membered Heterocycles as Anti-Pancreatic Cancer Agents
Lee, H.-Y. (PI)
8/1/21 → 7/31/22
Project: A - Government Institution › b - National Science and Technology Council
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Discovery of dual-specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) inhibitors using an artificial intelligence model and their effects on tau and tubulin dynamics
Chen, J. H., Tu, H. J., Lin, T. E., Peng, Z. X., Wu, Y. W., Yen, S. C., Sung, T. Y., Hsieh, J. H., Lee, H. Y., Pan, S. L., HuangFu, W. C. & Hsu, K. C., Dec 2024, In: Biomedicine and Pharmacotherapy. 181, 117688.Research output: Contribution to journal › Article › peer-review
Open Access -
Enhancing anti-cancer capacity: Novel class I/II HDAC inhibitors modulate EMT, cell cycle, and apoptosis pathways
Lee, H. Y., Hsu, M. J., Chang, H. H., Chang, W. C., Huang, W. C. & Cho, E. C., Jul 15 2024, In: Bioorganic and Medicinal Chemistry. 109, 117792.Research output: Contribution to journal › Article › peer-review
1 Citation (Scopus) -
6-Regioisomeric 5,8-quinolinediones as potent CDC25 inhibitors against colorectal cancers
Narwanti, I., Yu, Z. Y., Sethy, B., Lai, M. J., Lee, H. Y., Olena, P., Lee, S. B. & Liou, J. P., Oct 2023, In: European Journal of Medicinal Chemistry. 258, 115505.Research output: Contribution to journal › Article › peer-review
7 Citations (Scopus) -
CuI-mediated synthesis of 1-aryl-5,6,7-trimethoxybenzimidazoles as potent antitubulin agents
Peng, C. M., Wang, S. W., Hwang, Y. L., Sun, W. C., Chiu, L. P., Liu, Y. T., Lai, Y. W. & Lee, H. Y., Apr 28 2023, In: RSC Advances. 13, 19, p. 13169-13176 8 p.Research output: Contribution to journal › Article › peer-review
Open Access4 Citations (Scopus) -
Definition of fatty acid transport protein-2 (FATP2) structure facilitates identification of small molecule inhibitors for the treatment of diabetic complications
Kumar, M., Gaivin, R. J., Khan, S., Fedorov, Y., Adams, D. J., Zhao, W., Lee, H. Y., Dai, X., Dealwis, C. G. & Schelling, J. R., Jul 31 2023, In: International Journal of Biological Macromolecules. 244, 125328.Research output: Contribution to journal › Article › peer-review
5 Citations (Scopus)
Datasets
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Ring size changes in the development of class I HDAC inhibitors
Lee, H.-Y. (Contributor), Cho, E.-C. (Contributor), Tang, D.-W. (Contributor) & Liu, C.-Y. (Contributor), figshare Academic Research System, Jan 1 2021
DOI: 10.6084/m9.figshare.14843703.v1, https://tandf.figshare.com/articles/journal_contribution/Ring_size_changes_in_the_development_of_class_I_HDAC_inhibitors/14843703/1
Dataset
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Structure-guided design of anti-cancer ribonucleotide reductase inhibitors
Misko, T. A. (Contributor), Liu, Y.-T. (Contributor), Harris, M. E. (Contributor), Oleinick, N. L. (Contributor), Pink, J. (Contributor), Lee, H.-Y. (Contributor) & Dealwis, C. G. (Contributor), Unknown Publisher, Jan 1 2019
DOI: 10.6084/m9.figshare.7553114.v1, https://tandf.figshare.com/articles/Structure-guided_design_of_anti-cancer_ribonucleotide_reductase_inhibitors/7553114/1
Dataset
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Effect of 3-subsitution of quinolinehydroxamic acids on selectivity of histone deacetylase isoforms
Lai, M.-J. (Creator), Lee, C.-H. (Creator), Chao, Y.-H. (Creator), Mehndiratta, S. (Creator), Chen, M.-C. (Creator), Liou, J.-P. (Creator) & Lee, H.-Y. (Creator), Taylor & Francis, 2020
DOI: 10.6084/m9.figshare.13207104.v1, https://tandf.figshare.com/articles/journal_contribution/Effect_of_3-subsitution_of_quinolinehydroxamic_acids_on_selectivity_of_histone_deacetylase_isoforms/13207104/1
Dataset
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Structure-based virtual screening and biological evaluation of novel small-molecule BTK inhibitors
Lin, T. E. (Creator), Sung, L.-C. (Creator), Chao, M.-W. (Creator), Li, M. (Creator), Zheng, J.-H. (Creator), Sung, T.-Y. (Creator), Hsieh, J.-H. (Creator), Yang, C.-R. (Creator), Lee, H.-Y. (Creator), Cho, E.-C. (Creator) & Hsu, K.-C. (Creator), Taylor & Francis, 2021
DOI: 10.6084/m9.figshare.17162118.v1, https://tandf.figshare.com/articles/journal_contribution/Structure-based_virtual_screening_and_biological_evaluation_of_novel_small-molecule_BTK_inhibitors/17162118/1
Dataset