Projects per year
Personal profile
Education
- 2010 Ph.D., Pharmaceutical Sciences, National Taiwan University
- 2001 B.S., School of Pharmacy, Taipei Medical University
Experience
- 2022- Professor, Master Program in Clinical Pharmacogenomics and Pharmacoproteomics, Taipei Medical University
- 2022- Professor, Department of Pharmaceutical Sciences, Taipei Medical University
- 2020-2022 Associate Professor, Master Program in Clinical Pharmacogenomics and Pharmacoproteomics, Taipei Medical University
- 2018-2022 Associate Professor, Department of Pharmaceutical Sciences, Taipei Medical University
- 2016-2017 Assistant Professor, Ph.D. Program in Drug Discovery and Development Industry, Taipei Medical University
- 2015-2018 Assistant Professor, Department of Pharmaceutical Sciences, Taipei Medical University
- 2013-2015 Project Assistant Research Fellow, Department of Pharmaceutical Sciences, Taipei Medical University
- 2012-2013 Assistant Researcher, Department of Pharmaceutical Sciences, Taipei Medical University
Research Interests
- Traditional and computer-aided design of bioactive compounds treating diseases.
- Development of kinase inhibitors aganist cancer cells.
- Conducting modern synthetic methodologies, such as parallel synthesis and photochemistry.
- Total synthesis of natural products.
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Development of Kinase Inhibitors with Pancreatic Cancer Inhibitory Activity
8/1/22 → 7/31/23
Project: A - Government Institution › b - Ministry of Science and Technology
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開發1,3-二芳基取代之五元雜環作為抗胰臟癌劑(3/3)
8/1/21 → 7/31/22
Project: A - Government Institution › b - Ministry of Science and Technology
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開發1,3-二芳基取代之五元雜環作為抗胰臟癌劑(2/3)
8/1/20 → 7/1/21
Project: A - Government Institution › b - Ministry of Science and Technology
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In silico identification and biological evaluation of a selective MAP4K4 inhibitor against pancreatic cancer
Chang, C. D., Chao, M. W., Lee, H. Y., Liu, Y. T., Tu, H. J., Lien, S. T., Lin, T. E., Sung, T. Y., Yen, S. C., Huang, S. H., Hsu, K. C. & Pan, S. L., 2023, In: Journal of Enzyme Inhibition and Medicinal Chemistry. 38, 1, 2166039.Research output: Contribution to journal › Article › peer-review
Open Access1 Citation (Scopus) -
A novel HDAC1/2 inhibitor suppresses colorectal cancer through apoptosis induction and cell cycle regulation
Lee, H. Y., Tang, D. W., Liu, C. Y. & Cho, E. C., Jan 25 2022, In: Chemico-Biological Interactions. 352, 109778.Research output: Contribution to journal › Article › peer-review
2 Citations (Scopus) -
Design, synthesis and biological evaluation of bisindole derivatives as anticancer agents against Tousled-like kinases
Lee, S. B., Chang, T. Y., Lee, N. Z., Yu, Z. Y., Liu, C. Y. & Lee, H. Y., Jan 5 2022, In: European Journal of Medicinal Chemistry. 227, 113904.Research output: Contribution to journal › Article › peer-review
1 Citation (Scopus) -
Structure-based virtual screening and biological evaluation of novel small-molecule BTK inhibitors
Lin, T. E., Sung, L. C., Chao, M. W., Li, M., Zheng, J. H., Sung, T. Y., Hsieh, J. H., Yang, C. R., Lee, H. Y., Cho, E. C. & Hsu, K. C., 2022, In: Journal of Enzyme Inhibition and Medicinal Chemistry. 37, 1, p. 226-235 10 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Citation (Scopus) -
Effect of 3-subsitution of quinolinehydroxamic acids on selectivity of histone deacetylase isoforms
Mehndiratta, S., Chen, M. C., Chao, Y. H., Lee, C. H., Liou, J. P., Lai, M. J. & Lee, H. Y., Jan 1 2021, In: Journal of Enzyme Inhibition and Medicinal Chemistry. 36, 1, p. 74-84 11 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Citation (Scopus)
Datasets
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Structure-guided design of anti-cancer ribonucleotide reductase inhibitors
Misko, T. A. (Contributor), Liu, Y. (Contributor), Harris, M. E. (Contributor), Oleinick, N. L. (Contributor), Pink, J. (Contributor), Lee, H. (Contributor) & Dealwis, C. G. (Contributor), Unknown Publisher, Jan 1 2019
DOI: 10.6084/m9.figshare.7553114.v1, https://tandf.figshare.com/articles/Structure-guided_design_of_anti-cancer_ribonucleotide_reductase_inhibitors/7553114/1
Dataset
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Effect of 3-subsitution of quinolinehydroxamic acids on selectivity of histone deacetylase isoforms
Lai, M. (Creator), Lee, C. (Creator), Chao, Y. (Creator), Mehndiratta, S. (Creator), Chen, M. (Creator), Liou, J. (Creator) & Lee, H. (Creator), Taylor & Francis, 2020
DOI: 10.6084/m9.figshare.13207104.v1, https://tandf.figshare.com/articles/journal_contribution/Effect_of_3-subsitution_of_quinolinehydroxamic_acids_on_selectivity_of_histone_deacetylase_isoforms/13207104/1
Dataset
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Ring size changes in the development of class I HDAC inhibitors
Lee, H. (Contributor), Cho, E. (Contributor), Tang, D. (Contributor) & Liu, C. (Contributor), figshare Academic Research System, Jan 1 2021
DOI: 10.6084/m9.figshare.14843703.v1, https://tandf.figshare.com/articles/journal_contribution/Ring_size_changes_in_the_development_of_class_I_HDAC_inhibitors/14843703/1
Dataset
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Structure-based virtual screening and biological evaluation of novel small-molecule BTK inhibitors
Lin, T. E. (Creator), Sung, L. (Creator), Chao, M. (Creator), Li, M. (Creator), Zheng, J. (Creator), Sung, T. (Creator), Hsieh, J. (Creator), Yang, C. (Creator), Lee, H. (Creator), Cho, E. (Creator) & Hsu, K. (Creator), Taylor & Francis, 2021
DOI: 10.6084/m9.figshare.17162118.v1, https://tandf.figshare.com/articles/journal_contribution/Structure-based_virtual_screening_and_biological_evaluation_of_novel_small-molecule_BTK_inhibitors/17162118/1
Dataset