Projects per year
Personal profile
Education
- 1976.01-1978.03 Research Associate; University of California at San Francisco School of Medicine, San Francisco, California (Drs. M. J. Bishop and H.E. Varmus)
- 1975 Ph.D. in Molecular Biology; California Institute of Technology, Pasadena, California (Dr. N. Davidson's lab)
- 1969 B.S. in Chemistry; National Taiwan University, Taipei, Taiwan, R.O.C.
Experience
- 2018- Chair Professor, Taipei Medical University, Taipei, Taiwan
- 2017.02-2017.09 Acting Director of Institute of Molecular and Genomic Medicine, National Health Research Institutes, Zhunan, Taiwan
- 2012-2017 Distinguished Investigator, Institute of Molecular and Genomic Medicine, National Health Research Institutes, Zhunan, Taiwan
- 2012-2015 President, National Health Research Institutes, Zhunan, Taiwan
- 2008- Distinguished Professor of Biochemistry and Molecular Medicine, U. C. Davis, Medical School
- 1998-2012 Deputy Director and Director of Basic Research, U. C. Davis Cancer Center
- 1998-2008 Professor of Biochemistry and Molecular Medicine, U. C. Davis, Medical School
- 1997-1998 Director of Division of Molecular and Genomic Medicine, National Health Research Institutes, Taiwan, ROC
- 1990-1998 Associate Director of Case Western Reserve University Cancer Center
- 1989-1998 Professor of Medicine, Case Western Reserve University, School of Medicine
- 1988.07-1998.09 Professor of Molecular Biology and Microbiology, Case Western Reserve University, School of Medicine
- 1987-1988 Visiting Professor of Institute of Molecular Biology, Academia Sinica, Taiwan, ROC
- 1984.06-1988.07 Associate Professor of Molecular Biology and Microbiology, Case Western Reserve University, School of Medicine
- 1982.07-1984.06 Associate Professor of Biochemistry, Michigan State University
- 1978.03-1982.06 Assistant Professor of Biochemistry, Michigan State University, March
- 1976.01-1978.02 Postdoctoral Fellow of University of California at San Francisco Medical School
Awards
- Distinguished Chair Professor, National Chiao Tung University, 2013-present
- NIH Norman Salzman Lectureship, 2012
- Distinguished Chair Professor of Taiwan Medical University, 2011-present
- Distinguished Chair Professor of National Tsing-Hua University, 2010-present
- Distinguished Chair Professor of Translational Medicine and Integrated Lab, Taipei, Medical University, 2010-present
- Distinguished Chair Professor of College of Life Science, National Tsing-Hua University, 2009-present
- Honorary Distinguished Fellow, National Health Research Institute, Taiwan, 2008-present
- Auburn Community Cancer Endowed Chair in Basic Science, 2007
- Joan Oettinger Memorial Award in Lung and Cancer Research, 2006
- Society of American Asian Scientists in Cancer Research (SAASCR), recipient of annual award, 2006
- UC Davis School of Medicine Faculty Research Award, 2005
- CaP CURE Research Award, 1999
- Academician, Academia Sinica, Taiwan, ROC, since 1998
- Goodman-Blum Professor in Cancer Research, Case Western Reserve University, 1997
- NCI MERIT Award, CA46613, 1993-2002
- NCI MERIT Award, CA39207, 1991-2000
- American Cancer Society Faculty Research Development Award, 1983-1988
- Faculty Research Award, American Cancer Society, 1983-1987
- Fellow of Leukemia Society of America, 1976-1977
Research Interests
- Cancer Virology
- Genetics
- Epigenetics
- Therapeutics
Dr.Kung’s lab has a long standing interest in tyrosine kinases, histone demethylases and androgen receptor regulation. His lab was credited for the original discovery of erbB/EGFR as a target gene for retroviral insertion, establishing this locus as a protooncogene, initial cloning of human c-src gene and demonstrating oncogenecity of v-src DNA. In the area of prostate cancer, his lab was the first to establish: a tyrosine kinase profile, IL-6 induced neuroendocrine differentiation, the involvement of Src/Etk/FAK trio-kinase complex in androgen-independent growth. More recently, his lab contributed to the identification of the origin of the newest human retrovirus, XMRV and dispelled its direct relationship to prostate cancer and chronic fatigue syndrome.
His current research specifically focuses on the identification of genetic and epigenetic factors contributing to the development of human malignancies including prostate cancer and Kaposi's sarcoma. Kaposi’s sarcoma is caused by Kaposi’s sarcoma associated herpesviruses (KSHV). The lab discovered that KSHV encodes a SUMO-E3 ligase and a SUMO-targeting Ubiquitin ligase (STUbL). Under investigations are posttranslational modifiers of signal molecules and chromatins, which include kinases, E3 SUMO ligases and histone demethylases. In collaborative studies, the lab is also involved in developing inhibitors or therapeutic agents which target these oncogenes, resulting in specific and enhanced killing of tumor cells. More recent work has been directed toward the understanding of autophagy (self-eating) as a modulator of apoptosis (self-killing). Efforts are being made to develop effective means to measure autophagy and to modulate this process.
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- 1 Similar Profiles
Collaborations and top research areas from the last five years
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外泌體循環RNA作為肌肉衰老的生物標誌物及介質
Kung, H.-J. (PI)
1/1/25 → 12/31/25
Project: A - Government Institution › a - National Health Research Institutes
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解析頭頸癌上皮可塑之表觀遺傳調控並制定治療策略-靶向頭頸部鱗狀細胞癌中與上皮細胞間質轉化所相關的長鏈非編碼RNA(3/3)
Kung, H.-J. (PI)
8/1/24 → 7/31/25
Project: A - Government Institution › b - National Science and Technology Council
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探討TEAD4調控粒線體活性及引發攝護腺癌症的機制(4/5)
Kung, H.-J. (PI)
8/1/24 → 7/31/25
Project: A - Government Institution › b - National Science and Technology Council
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T-Star Center Ⅰ:台灣癌症尖端研究中心(1/5)
Kung, H.-J. (PI)
1/1/24 → 3/31/25
Project: A - Government Institution › b - National Science and Technology Council
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跨機構合作的癌症轉譯研究計畫-建立台灣攝護腺癌治療新模式:精進診斷、提升品質和延長生命(第3年)
Kung, H.-J. (PI)
1/1/24 → 12/31/24
Project: A - Government Institution › c - Ministry of Health and Welfare
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Hydrogen sulfide coordinates glucose metabolism switch through destabilizing tetrameric pyruvate kinase M2
Wang, R. H., Chen, P. R., Chen, Y. T., Chen, Y. C., Chu, Y. H., Chien, C. C., Chien, P. C., Lo, S. Y., Wang, Z. L., Tsou, M. C., Chen, S. Y., Chiu, G. S., Chen, W. L., Wu, Y. H., Wang, L. H. C., Wang, W. C., Lin, S. Y., Kung, H. J., Wang, L. H. & Cheng, H. C. & 1 others, , Dec 2024, In: Nature Communications. 15, 1, 7463.Research output: Contribution to journal › Article › peer-review
Open Access3 Citations (Scopus) -
Fatty acid oxidation fuels glioblastoma radioresistance with CD47-mediated immune evasion
Jiang, N., Xie, B., Xiao, W., Fan, M., Xu, S., Duan, Y., Hamsafar, Y., Evans, A. C., Huang, J., Zhou, W., Lin, X., Ye, N., Wanggou, S., Chen, W., Jing, D., Fragoso, R. C., Dugger, B. N., Wilson, P. F., Coleman, M. A. & Xia, S. & 9 others, , Dec 2022, In: Nature Communications. 13, 1, 1511.Research output: Contribution to journal › Article › peer-review
Open Access135 Citations (Scopus) -
Inhibition of KDM4C/c-Myc/LDHA signalling axis suppresses prostate cancer metastasis via interference of glycolytic metabolism
Lin, C.-Y., Wang, B.-J., Fu, Y.-K., Huo, C., Wang, Y.-P., Chen, B.-C., Liu, W.-Y., Tseng, J.-C., Jiang, S. S., Sie, Z.-L., Tsai, K. K., Yuh, C.-H., Wang, W.-C., Kung, H.-J. & Chuu, C.-P., Mar 2022, In: Clinical and Translational Medicine. 12, 3, p. e764Research output: Contribution to journal › Article › peer-review
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Natural product myricetin is a pan-KDM4 inhibitor which with poly lactic-co-glycolic acid formulation effectively targets castration-resistant prostate cancer
Liu, J. S., Fang, W. K., Yang, S. M., Wu, M. C., Chen, T. J., Chen, C. M., Lin, T. Y., Liu, K. L., Wu, C. M., Chen, Y. C., Chuu, C. P., Wang, L. Y., Hsieh, H. P., Kung, H. J. & Wang, W. C., May 9 2022, In: Journal of Biomedical Science. 29, 1, p. 29 29.Research output: Contribution to journal › Article › peer-review
Open Access15 Citations (Scopus) -
Arginine is an epigenetic regulator targeting TEAD4 to modulate OXPHOS in prostate cancer cells
Chen, C. L., Hsu, S. C., Chung, T. Y., Chu, C. Y., Wang, H. J., Hsiao, P. W., Yeh, S. D., Ann, D. K., Yen, Y. & Kung, H. J., Dec 2021, In: Nature Communications. 12, 1, 2398.Research output: Contribution to journal › Article › peer-review
Open Access67 Citations (Scopus)
Datasets
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Additional file 1: of Long non-coding RNA and tumor hypoxia: new players ushered toward an old arena
Kung, H.-J. (Contributor) & Shih, J.-W. (Creator), Figshare, 2017
DOI: 10.6084/m9.figshare.c.3846850_d1.v1, https://doi.org/10.6084%2Fm9.figshare.c.3846850_d1.v1
Dataset
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Additional file 1 of Signaling in and out: long-noncoding RNAs in tumor hypoxia
Kuo, T.-C. (Contributor), Shih, J.-W. (Creator) & Kung, H.-J. (Contributor), Figshare, 2020
DOI: 10.6084/m9.figshare.12257777.v1, https://doi.org/10.6084%2Fm9.figshare.12257777.v1
Dataset
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Signaling in and out: long-noncoding RNAs in tumor hypoxia
Kuo, T.-C. (Contributor), Kung, H.-J. (Contributor) & Shih, J.-W. (Creator), Figshare, 2020
DOI: 10.6084/m9.figshare.c.4966148.v1, https://springernature.figshare.com/collections/Signaling_in_and_out_long-noncoding_RNAs_in_tumor_hypoxia/4966148/1
Dataset
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Natural product myricetin is a pan-KDM4 inhibitor which with poly lactic-co-glycolic acid formulation effectively targets castration-resistant prostate cancer
Liu, J.-S. (Creator), Fang, W.-K. (Creator), Yang, S.-M. (Creator), Wu, M.-C. (Creator), Chen, T.-J. (Creator), Chen, C.-M. (Creator), Lin, T.-Y. (Creator), Liu, K.-L. (Creator), Wu, C.-M. (Creator), Chen, Y.-C. (Creator), Chuu, C.-P. (Creator), Wang, L.-Y. (Creator), Hsieh, H.-P. (Creator), Kung, H.-J. (Creator) & Wang, W.-C. (Creator), Figshare, 2022
DOI: 10.6084/m9.figshare.c.5987016.v1, https://springernature.figshare.com/collections/Natural_product_myricetin_is_a_pan-KDM4_inhibitor_which_with_poly_lactic-co-glycolic_acid_formulation_effectively_targets_castration-resistant_prostate_cancer/5987016/1
Dataset
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Additional file 1 of Natural product myricetin is a pan-KDM4 inhibitor which with poly lactic-co-glycolic acid formulation effectively targets castration-resistant prostate cancer
Liu, J.-S. (Creator), Fang, W.-K. (Creator), Yang, S.-M. (Creator), Wu, M.-C. (Creator), Chen, T.-J. (Creator), Chen, C.-M. (Creator), Lin, T.-Y. (Creator), Liu, K.-L. (Creator), Wu, C.-M. (Creator), Chen, Y.-C. (Creator), Chuu, C.-P. (Creator), Wang, L.-Y. (Creator), Hsieh, H.-P. (Creator), Kung, H.-J. (Creator) & Wang, W.-C. (Creator), Figshare, 2022
DOI: 10.6084/m9.figshare.19736397.v1, https://springernature.figshare.com/articles/journal_contribution/Additional_file_1_of_Natural_product_myricetin_is_a_pan-KDM4_inhibitor_which_with_poly_lactic-co-glycolic_acid_formulation_effectively_targets_castration-resistant_prostate_cancer/19736397/1
Dataset