Projects per year
Personal profile
Education
- 2007 Ph.D., Institute of Molecular Medicine, National Taiwan University, Taipei, Taiwan, R.O.C.
- 2000 Master, Institute of Medical Technology, National Taiwan University, Taipei, Taiwan, R.O.C.
- 1998 Bachelor, Medical Technology. National Taiwan University, Taipei, Taiwan, R.O.C.
Experience
- 2021- Associate Professor, Ph.D Program for Cancer Molecular Biology and Drug Discovery, Taipei Medical University
- 2021- Associate Professor, Graduate Institute of Cancer Biology and Drug Discovery, Taipei Medical University
- 2019-2021 Assistant Professor, Ph.D Program for Cancer Molecular Biology and Drug Discovery, Taipei Medical University
- 2018-2021 Assistant Professor, Graduate Institute of Cancer Biology and Drug Discovery, Taipei Medical University
- 2015-2018 Assistant Professor, Ph.D Program for Cancer Molecular Biology and Drug Discovery, Taipei Medical University.
- 2013-2015 Project -appointed assistant professor, Graduate Program of Cancer Cell Biology and Drug Discovery, Taipei Medical University.
- 2013 Project -appointed assistant research fellow, Graduate Program of Cancer Cell Biology and Drug Discovery, Taipei Medical University.
- 20017-2013 Postdoctoral Fellow, Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan, R.O.C.
Awards
- 2013 Outstanding Research Paper Award for Postdoctoral Fellow, National Science Council
- 2012 Poster Presentation Distinguished Achievement Award, The 20th Symposium on Recent Advances in Cellular and Molecular Biology, Kenting, Taiwan
- 2010 Regular Postdoctoral Fellowship Award, Academia Sinica, Institute of Biological Chemistry
- 2008 Regular Postdoctoral Fellowship Award, Academia Sinica, Institute of Biological Chemistry
- 2005 Outstanding Research Paper Award (1st place), National Taiwan University, College of Medicine
- 2005 Excellent Research Paper Award (4rd place) from Dr. Chien-Tien Hsu’s Foundation, The 13th Symposium on Recent Advances in Cellular and Molecular Biology, Taiwan.
- 2004 Poster Presentation Distinguished Achievement Award, The 12th Symposium on Recent Advances in Cellular and Molecular Biology, Kenting, Taiwan
- 2003 Travel Award from Ministry of Education, Taiwan.
Research Interests
- Tumor biology
- MicroRNA
- Protein turnover
- Signal transduction
Fingerprint
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- 1 Similar Profiles
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Investigation of Mir31hg/Lnchifcar Involved Molecular Interplay in Pdac Metastasis and Microenvironment and Development Anti-Sense Oligos Based Target Therapy( II )
Chen, H.-Y. (PI)
8/1/24 → 7/31/25
Project: A - Government Institution › b - National Science and Technology Council
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Target Long Noncoding Rna Smyca Impairs Homologous Recombination to Inspire Anti-Tumor Immunity to Serve as a Potential Therapeutic Strategy for Cancer
Chen, H.-Y. (PI)
8/1/24 → 7/31/25
Project: A - Government Institution › b - National Science and Technology Council
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研發新穎高選擇性GSK抑制劑對於胰臟癌 治療及藥理機轉探討
Chen, H.-Y. (PI)
7/1/24 → 2/28/25
Project: A - Government Institution › b - National Science and Technology Council
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Investigation of Mir31hg/Lnchifcar Involved Molecular Interplay in Pdac Metastasis and Microenvironment and Development Anti-Sense Oligos Based Target Therapy( I )
Chen, H.-Y. (PI)
8/1/23 → 7/31/24
Project: A - Government Institution › b - National Science and Technology Council
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Long Noncoding Rna Smyca Promotes Homologous Recombination and Immune Suppression to Define a Tnbc Therapeutic Target
Chen, H.-Y. (PI)
8/1/23 → 7/31/24
Project: A - Government Institution › b - National Science and Technology Council
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Targeting the TRIM21-PD-1 axis potentiates immune checkpoint blockade and CAR-T cell therapy
Shi, J., Zhang, Z., Chen, H. Y., Yao, Y., Ke, S., Yu, K., Shi, J., Xiao, X., He, C., Xiang, B., Sun, Y., Gao, M., Xing, X., Yu, H., Wang, X., Yuan, W. C., Budiarto, B. R., Chen, S. Y., Zhang, T. & Lee, Y. R. & 2 others, , Mar 5 2025, In: Molecular Therapy. 33, 3, p. 1073-1090 18 p.Research output: Contribution to journal › Article › peer-review
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UFL1 ablation in T cells suppresses PD-1 UFMylation to enhance anti-tumor immunity
He, C., Xing, X., Chen, H. Y., Gao, M., Shi, J., Xiang, B., Xiao, X., Sun, Y., Yu, H., Xu, G., Yao, Y., Xie, Z., Xing, Y., Budiarto, B. R., Chen, S. Y., Gao, Y., Lee, Y. R. & Zhang, J., Mar 21 2024, In: Molecular Cell. 84, 6, p. 1120-1138.e8Research output: Contribution to journal › Article › peer-review
Open Access27 Citations (Scopus) -
Para-toluenesulfonamide, a novel potent carbonic anhydrase inhibitor, improves hypoxia-induced metastatic breast cancer cell viability and prevents resistance to αPD-1 therapy in triple-negative breast cancer
Chen, H. Y., Lin, C. E., Wu, S. C., Yang, Z. Y., Chiang, Y. F., Huang, K. C., Wang, K. L., Ali, M., Shieh, T. M., Chang, H. Y., Huang, T. C. & Hsia, S. M., Nov 2023, In: Biomedicine and Pharmacotherapy. 167, 115533.Research output: Contribution to journal › Article › peer-review
Open Access9 Citations (Scopus) -
TRABID inhibition activates cGAS/STING-mediated anti-tumor immunity through mitosis and autophagy dysregulation
Chen, Y. H., Chen, H. H., Wang, W. J., Chen, H. Y., Huang, W. S., Kao, C. H., Lee, S. R., Yeat, N. Y., Yan, R. L., Chan, S. J., Wu, K. P. & Chen, R. H., Dec 2023, In: Nature Communications. 14, 1, 3050.Research output: Contribution to journal › Article › peer-review
Open Access23 Citations (Scopus) -
Correction to: Long noncoding RNA BCRP3 stimulates VPS34 and autophagy activities to promote protein homeostasis and cell survival (Journal of Biomedical Science, (2022), 29, 1, (30), 10.1186/s12929-022-00815-0)
Yan, R. L., Luan, C. L., Liao, C. C., Liu, L. H., Chen, F. Y., Chen, H. Y. & Chen, R. H., Dec 2022, In: Journal of Biomedical Science. 29, 1, 59.Research output: Contribution to journal › Comment/debate › peer-review
Open Access
Datasets
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Long noncoding RNA Smyca coactivates TGF-β/Smad and Myc pathways to drive tumor progression
Chen, H.-Y. (Creator), Chan, S.-J. (Creator), Liu, X. (Creator), Wei, A.-C. (Creator), Jian, R.-I. (Creator), Huang, K.-W. (Creator), Lang, Y.-D. (Creator), Shih, J.-H. (Creator), Liao, C.-C. (Creator), Luan, C.-L. (Creator), Kao, Y.-T. (Creator), Chiang, S.-Y. (Creator), Hsiao, P.-W. (Creator), Jou, Y.-S. (Creator), Chen, Y. (Creator) & Chen, R.-H. (Creator), Figshare, 2022
DOI: 10.6084/m9.figshare.c.6082528.v1, https://springernature.figshare.com/collections/Long_noncoding_RNA_Smyca_coactivates_TGF-_Smad_and_Myc_pathways_to_drive_tumor_progression/6082528/1
Dataset
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Long noncoding RNA BCRP3 stimulates VPS34 and autophagy activities to promote protein homeostasis and cell survival
Yan, R.-L. (Creator), Luan, C.-L. (Creator), Liao, C.-C. (Creator), Liu, L.-H. (Creator), Chen, F.-Y. (Creator), Chen, H.-Y. (Creator) & Chen, R.-H. (Creator), Figshare, 2022
DOI: 10.6084/m9.figshare.c.5990336.v1, https://springernature.figshare.com/collections/Long_noncoding_RNA_BCRP3_stimulates_VPS34_and_autophagy_activities_to_promote_protein_homeostasis_and_cell_survival/5990336/1
Dataset