Projects per year
Personal profile
Education
- 2000-2005 Ph.D., Graduate Institute of Toxicology, College of Medicine, National Taiwan University
- 1998-2000 M.S., Graduate Institute of Toxicology, College of Medicine, National Taiwan University
- 1994-1998 B.S., Department of Plant Pathology and Microbiology, College of Medicine, National Taiwan University
Experience
- 2024.04- Director, Department of Physiology, School of Medicine, College of Medicine, Taipei Medical University
- 2022.02- Professor, Department of Physiology, School of Medicine, Taipei Medical University
- 2017.02-2022.01 Associate Professor, Department of Physiology, School of Medicine, Taipei Medical University
- 2012.09-2017.01 Assistant Professor, Department of Physiology, School of Medicine, Taipei Medical University
- 2012.08-2012.08 Assistant Researcher, Department of Physiology, School of Medicine, Taipei Medical University
Research Interests
- Physiology
- Environmental Toxicology
- NanoToxicology
- Safety Toxicology
- Cardiovascular Physiology
Fingerprint
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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探討在藍光和黑暗情形下視網膜內皮細胞的特殊蛋白melanopsin和GNAZ之病生理機轉及可能的臨床應用
Li, C.-H. (PI)
8/1/25 → 7/31/26
Project: A - Government Institution › b - National Science and Technology Council
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Study the Pathophysiology Role of Retinal Endothelial Cell Specific Protein Melanopsin and Gnaz upon the Dark and Blue-Light Condition, as Well as Their Clinical Application
Li, C.-H. (PI)
8/1/24 → 7/31/25
Project: A - Government Institution › b - National Science and Technology Council
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探討奈米塑膠活化脂肪細胞，促進脂肪細胞激素分泌之毒理效應
Li, C.-H. (PI)
7/1/23 → 2/29/24
Project: A - Government Institution › b - National Science and Technology Council
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Ahr Defect Changes Integrin Signaling in Retinal Pigment Epithelial Cells, Resulting Retinal Inflammation and Function Impairment( III )
Li, C.-H. (PI)
8/1/22 → 7/31/23
Project: A - Government Institution › b - National Science and Technology Council
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Explore the Pathophysiology Role of Vascular Endothelial Cell and Adam 17 during Blue Light-Induced Retinopathy, and the Therapeutic Strategy.
Li, C.-H. (PI)
8/1/22 → 7/31/23
Project: A - Government Institution › b - National Science and Technology Council
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Aryl Hydrocarbon Receptor Deficiency Upregulates Intercellular Adhesion Molecule 1 in Retinal Pigment Epithelial Cells and Contributes to Retinal Inflammation
Yang, T. M., Fang, T. C., Lee, Y. C., Lee, C. C., Chan, Y. J., Fitriana, I., Cheng, Y. W. & Li, C. H., Sept 2025, In: Laboratory Investigation. 105, 9, 104197.Research output: Contribution to journal › Article › peer-review
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Impact of polyethylene terephthalate and polylactic acid nanoplastics on cellular uptake and lipid metabolism in differentiated 3T3-L1 adipocytes
Jhang, Y. T., Li, C. H., Yeh, C. E., Chan, Y. J., Yang, T. M., Reyes, C. J. Q., Lin, C. W. & Hsiao, I. L., Sept 1 2025, In: Ecotoxicology and Environmental Safety. 302, 118628.Research output: Contribution to journal › Article › peer-review
Open Access -
Maintaining KEAP1 levels in retinal pigment epithelial cells preserves their viability during prolonged exposure to artificial blue light
Li, C. H., Yang, T. M., Fitriana, I., Fang, T. C., Wu, L. H., Hsiao, G. & Cheng, Y. W., Nov 2024, In: Journal of Photochemistry and Photobiology B: Biology. 260, 113037.Research output: Contribution to journal › Article › peer-review
1 Citation (Scopus) -
Activation of aryl hydrocarbon receptor by azatyrosine-phenylbutyric hydroxamide inhibits progression of diabetic retinopathy mice
Fitriana, I., Wu, C. H., Hsu, T. J., Chan, Y. J., Li, C. H., Lee, C. C., Hsiao, G. & Cheng, Y. W., Sept 2023, In: Biochemical Pharmacology. 215, 115700.Research output: Contribution to journal › Article › peer-review
2 Citations (Scopus) -
Blue light exposure collapses the inner blood-retinal barrier by accelerating endothelial CLDN5 degradation through the disturbance of GNAZ and the activation of ADAM17
Chan, Y. J., Hsiao, G., Wan, W. N., Yang, T. M., Tsai, C. H., Kang, J. J., Lee, Y. C., Fang, T. C., Cheng, Y. W. & Li, C. H., Dec 2023, In: Fluids and Barriers of the CNS. 20, 1, 31.Research output: Contribution to journal › Article › peer-review
Open Access11 Citations (Scopus)
Datasets
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Titanium dioxide nanoparticles impair the inner blood-retinal barrier and retinal electrophysiology through rapid ADAM17 activation and claudin-5 degradation
Chan, Y.-J. (Contributor), Cheng, Y.-W. (Creator), Liao, P.-L. (Contributor), Li, C.-H. (Creator), Lin, F.-L. (Contributor), Ho, J.-D. (Contributor), Chen, C.-Y. (Contributor) & Tsai, C.-H. (Contributor), Figshare, 2021
DOI: 10.6084/m9.figshare.c.5263303.v1, https://doi.org/10.6084%2Fm9.figshare.c.5263303.v1
Dataset
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Additional file 2 of Titanium dioxide nanoparticles impair the inner blood-retinal barrier and retinal electrophysiology through rapid ADAM17 activation and claudin-5 degradation
Li, C.-H. (Creator), Ho, J.-D. (Contributor), Chan, Y.-J. (Contributor), Chen, C.-Y. (Contributor), Cheng, Y.-W. (Creator), Lin, F.-L. (Contributor), Liao, P.-L. (Contributor) & Tsai, C.-H. (Contributor), Figshare, 2021
DOI: 10.6084/m9.figshare.13550761.v1, https://doi.org/10.6084%2Fm9.figshare.13550761.v1
Dataset
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Additional file 1 of Titanium dioxide nanoparticles impair the inner blood-retinal barrier and retinal electrophysiology through rapid ADAM17 activation and claudin-5 degradation
Ho, J.-D. (Contributor), Lin, F.-L. (Contributor), Tsai, C.-H. (Contributor), Liao, P.-L. (Contributor), Chan, Y.-J. (Contributor), Cheng, Y.-W. (Creator), Li, C.-H. (Creator) & Chen, C.-Y. (Contributor), Figshare, 2021
DOI: 10.6084/m9.figshare.13550758.v1, https://doi.org/10.6084%2Fm9.figshare.13550758.v1
Dataset
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Inhaled gold nanoparticles cause cerebral edema and upregulate endothelial aquaporin 1 expression, involving caveolin 1 dependent repression of extracellular regulated protein kinase activity
Chen, C.-Y. (Contributor), Liao, P.-L. (Contributor), Tsai, C.-H. (Contributor), Chan, Y.-J. (Contributor), Cheng, Y.-W. (Creator), Hwang, L.-L. (Creator), Lin, K.-H. (Contributor), Yen, T.-L. (Contributor) & Li, C.-H. (Contributor), Figshare, 2019
DOI: 10.6084/m9.figshare.c.4701761.v1, https://springernature.figshare.com/collections/Inhaled_gold_nanoparticles_cause_cerebral_edema_and_upregulate_endothelial_aquaporin_1_expression_involving_caveolin_1_dependent_repression_of_extracellular_regulated_protein_kinase_activity/4701761/1
Dataset
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MOESM1 of Inhaled gold nanoparticles cause cerebral edema and upregulate endothelial aquaporin 1 expression, involving caveolin 1 dependent repression of extracellular regulated protein kinase activity
Chen, C.-Y. (Contributor), Liao, P.-L. (Contributor), Tsai, C.-H. (Contributor), Chan, Y.-J. (Contributor), Cheng, Y.-W. (Contributor), Hwang, L.-L. (Contributor), Lin, K.-H. (Contributor), Yen, T.-L. (Contributor) & Li, C.-H. (Contributor), Unknown Publisher, Oct 16 2019
DOI: 10.6084/m9.figshare.9994028.v1, https://springernature.figshare.com/articles/MOESM1_of_Inhaled_gold_nanoparticles_cause_cerebral_edema_and_upregulate_endothelial_aquaporin_1_expression_involving_caveolin_1_dependent_repression_of_extracellular_regulated_protein_kinase_activity/9994028/1
Dataset