Cheng-ying Hsieh

Projects

Projects per year 2013 2014 2015 2016 2018 2019 2020 2021 2022 2024 2025

• 2 Active
• 23 Finished

Projects per year

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• Finished

  金雞納主要生物鹼cinchonidine對小鼠急性缺血性腦中風的神經保護作用研究：闡明對p53訊息傳遞路徑的抑制機制及低毒性cinchonidine奈米凝膠研發

  Hsieh, C.-Y. (PI)

  8/1/23 → 7/31/24

  Project: A - Government Institution › b - National Science and Technology Council

• 銀杏素改善自體血栓栓塞性腦中風引起微小神經膠細胞和神經元活化的神經再生作用

  Hsieh, C.-Y. (PI)

  3/1/22 → 2/28/23

  Project: C - Project of Alliance › o - Chi Mei Medical Center

• 探討SHANK3與其訊息傳遞蛋白: RBFA, TRIM5, and GPR68影響缺血性中風相關之發炎調控

  Hsieh, C.-Y. (PI)

  1/1/22 → 12/31/22

  Project: B - Project of TMU › h - Higher Education Sprout Project

• A Breakthrough Therapeutic Strategy against Ischemic Brain Injury- the Senolytic Treatment Dramatically Expands Therapeutic Time Window of Acute Ischemic Stroke

  Hsieh, C.-Y. (PI)

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - National Science and Technology Council

• Esculetin對改善周邊血管平滑肌細胞增生及大腦血管內皮細胞發炎反應的活性評估及機轉探討

  Hsieh, C.-Y. (PI)

  3/1/21 → 2/28/22

  Project: C - Project of Alliance › o - Chi Mei Medical Center

• 利用蛋白質體學研究方式探討glyoxalase 1改善急性缺血性腦中風造成血腦障壁傷害之作用機制

  Hsieh, C.-Y. (PI)

  1/1/21 → 12/31/21

  Project: B - Project of TMU › h - Higher Education Sprout Project

• Study of Shank3, a Synaptic Scaffolding Protein, Modulated Neuroinflammation in the Pathology of Acute Ischemic Stroke

  Hsieh, C.-Y. (PI)

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - National Science and Technology Council

• 新合成的α-tocopherol衍生物2,2,5,7,8-pentamethyl-6-hydroxychromane對PDGF-BB刺激血管平滑肌引起細胞發炎反應的分子藥理作用機轉

  Hsieh, C.-Y. (PI)

  3/1/20 → 2/1/21

  Project: C - Project of Alliance › o - Chi Mei Medical Center

• 利用蛋白質體學研究方式探討glyoxalase 1改善急性缺血性腦中風造成血腦障壁傷害之作用機制

  Hsieh, C.-Y. (PI)

  1/1/20 → 12/1/20

  Project: B - Project of TMU › h - Higher Education Sprout Project

• The Involvement of Il-21-Regulated Circulating Fibrocyte Activation in Chronic Obstructive Asthma( II )

  Hsieh, C.-Y. (PI)

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - National Science and Technology Council

• 細胞膜連結支架蛋白Shank3在大腦缺血反應中的病理生理角色-SHANK3 調控微小神經膠細胞活化暨細胞交互作用於缺血性中風中之角色

  Hsieh, C.-Y. (PI)

  1/1/19 → 12/1/19

  Project: A - Government Institution › d - Ministry of Education

• Study of Reactive Dicarbonyl Species-Induced Epithelial to Mesenchymal Transition in Diabetes Exacerbating Pulmonary Fibrosis (Ii)－Clarification of Age/Rage-Independent Pathways and Analysis of Correlation with Clinical Outcome(2/2)

  Hsieh, C.-Y. (PI)

  8/1/18 → 7/31/19

  Project: A - Government Institution › b - National Science and Technology Council

  • Lung Fibrosis 100%
  • Methylglyoxal 42%
  • Diabetes Mellitus 35%
  • Advanced Glycation End Product Receptor 28%
  • Advanced Glycation End Product 21%

• 探討hinokitiol抑制自體凝血塊引起急性腦中風的分子作用機轉: caspases, HIF1-與TNF-所扮演的核心角色

  Hsieh, C.-Y. (PI)

  3/1/18 → 2/28/19

  Project: C - Project of Alliance › n - Yuan's General Hospital

• Study of Reactive Dicarbonyl Species-Induced Epithelial to Mesenchymal Transition in Diabetes Exacerbating Pulmonary Fibrosis (Ii)－Clarification of Age/Rage-Independent Pathways and Analysis of Correlation with Clinical Outcome

  Hsieh, C.-Y. (PI)

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - National Science and Technology Council

  • Lung Fibrosis 100%
  • Methylglyoxal 42%
  • Diabetes Mellitus 35%
  • Advanced Glycation End Product Receptor 28%
  • Advanced Glycation End Product 21%

• Study of Reactive Dicarbonyl Species-Induced Epithelial to Mesenchymal Transition in Diabetes Exacerbating Pulmonary Fibrosis

  Hsieh, C.-Y. (PI)

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - National Science and Technology Council

  • Lung Fibrosis 100%
  • Methylglyoxal 53%
  • Advanced Glycation End Product Receptor 30%
  • Advanced Glycation End Product 23%
  • Glyoxal 23%

• Hinokitiol抑制PDGF-BB引起血管平滑肌增生的機轉探討

  Hsieh, C.-Y. (PI)

  3/1/16 → 2/28/17

  Project: C - Project of Alliance › o - Chi Mei Medical Center

• Redox Modulation of Protein Phosphatases by Protein Carbonylation/De-Carbonylation Process in Arterial Neointimal Hyperplasia

  Hsieh, C.-Y. (PI)

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - National Science and Technology Council

  • Protein Carbonylation 100%
  • Carbonylation 100%
  • Phosphoprotein Phosphatase 100%
  • Protein Tyrosine Phosphatase 30%
  • Hydrogen Peroxide 30%

• Caffeic acid phenethyl ester抑制血小板所誘導的去內皮主動脈血管收縮之機轉探討

  Hsieh, C.-Y. (PI)

  5/1/15 → 4/30/16

  Project: C - Project of Alliance › n - Yuan's General Hospital

• 探討andrographolide抑制血管平滑肌細胞發炎反應的機轉探討: JNK-p65 訊息傳遞路徑所扮演的重要角色

  Hsieh, C.-Y. (PI)

  3/1/15 → 2/29/16

  Project: C - Project of Alliance › o - Chi Mei Medical Center

• 氧化還原作用調控蛋白質去磷酸酉每羰基化和去羰基化反應對動脈血管內膜增生之影響(1/2)

  Hsieh, C.-Y. (PI)

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - National Science and Technology Council

• 在血管內皮細胞中粒腺體所扮演的病理角色及其調節的細胞死亡之機轉探討

  Hsieh, C.-Y. (PI)

  5/1/14 → 5/31/15

  Project: C - Project of Alliance › n - Yuan's General Hospital

• 探討baicalein改善內毒血症老鼠心臟收縮功能之分子機轉

  Hsieh, C.-Y. (PI)

  3/1/14 → 3/31/15

  Project: C - Project of Alliance › o - Chi Mei Medical Center

• TMU102-AE1-B20

  Hsieh, C.-Y. (PI)

  8/1/13 → 7/31/16

  Project: B - Project of TMU › g - Research Grants for Newly Hired Faculty