Projects per year
Personal profile
Education
- 2004-2010 Ph.D., Graduate Institute of Medical Sciences, Taipei Medical University, Taiwan
- 2002-2004 M.S., School of Pharmacy, Taipei Medical University
- 1994-1998 B.S., College of Pharmacy , China Medical University
Experience
- 2024.02- Professor, School of Pharmacy, Taipei Medical University
- 2018.08-2024.01 Associate Professor, School of Pharmacy, Taipei Medical University
- 2013.08-2018.07 Assistant professor, School of Medicine, Taipei Medical University
- 2011.09-2013.07 Postdoctoral Research Fellow, Taipei Medical University
Research Interests
- Free radical biology, protein modification, translational research
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Collaborations and top research areas from the last five years
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Investigation into the Neuro-Protective Effects and Mechanism of Action of Natural Alkaloids with Senolytic Activity against Brain Injury Induced by Acute Ischemic Stroke
Hsieh, C.-Y. (PI)
8/1/24 → 7/31/25
Project: A - Government Institution › b - National Science and Technology Council
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Study of the Neuroprotective Effects of Cinchonidine, a Major Cinchona Alkaloid, against Acute Ischemic Stroke in Mice: Clarifying the Inhibitory Mechanism on P53 Signaling Pathway and Developing a Low-Toxic Nanogel of Cinchonidine
Hsieh, C.-Y. (PI)
8/1/23 → 7/31/24
Project: A - Government Institution › b - National Science and Technology Council
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銀杏素改善自體血栓栓塞性腦中風引起微小神經膠細胞和神經元活化的神經再生作用
Hsieh, C.-Y. (PI)
3/1/22 → 2/28/23
Project: C - Project of Alliance › o - Chi Mei Medical Center
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探討SHANK3與其訊息傳遞蛋白: RBFA, TRIM5, and GPR68影響缺血性中風相關之發炎調控
Hsieh, C.-Y. (PI)
1/1/22 → 12/31/22
Project: B - Project of TMU › h - Higher Education Sprout Project
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A Breakthrough Therapeutic Strategy against Ischemic Brain Injury- the Senolytic Treatment Dramatically Expands Therapeutic Time Window of Acute Ischemic Stroke
Hsieh, C.-Y. (PI)
8/1/21 → 7/31/22
Project: A - Government Institution › b - National Science and Technology Council
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Glabridin Suppresses Macrophage Activation by Lipoteichoic Acid In Vitro: The Crucial Role of MAPKs-IL-1β-iNOS Axis Signals in Peritoneal and Alveolar Macrophages
Hou, S. M., Yang, C. M., Huang, W. C., Cheng, S. W., Yen, T. L., Hsia, C. W., Hsieh, C. Y. & Hsia, C. H., Feb 2025, In: Biomolecules. 15, 2, 174.Research output: Contribution to journal › Article › peer-review
Open Access -
Ability of Local Clearance of Senescent Cells in Ipsilateral Hemisphere to Mitigate Acute Ischemic Brain Injury in Mice
Lu, K. J., Sheu, J. R., Teng, R. D., Jayakumar, T., Chung, C. L. & Hsieh, C. Y., 2023, In: International Journal of Biological Sciences. 19, 9, p. 2835-2847 13 p.Research output: Contribution to journal › Article › peer-review
Open Access12 Citations (Scopus) -
Attenuation of indoxyl sulfate–induced cell damage by cinchonidine—a Cinchona alkaloid—through the downregulation of p53 signaling pathway by promoting MDM2 cytoplasmic-nuclear shuttling in endothelial cells
Teng, R. D., Yang, C. H., Chung, C. L., Sheu, J. R. & Hsieh, C. Y., Apr 1 2023, In: Life Sciences. 318, 121477.Research output: Contribution to journal › Article › peer-review
Open Access -
Morin hydrate suppresses lipoteichoic acid-induced oxidative stress-mediated inflammatory events in macrophages via augmenting Nrf2/HO-1 and antioxidant defense molecules
Hsieh, C. Y., Jayakumar, T., Lin, K. C., Yen, T. L., Hsia, C. W., Huang, W. C., Sheu, J. R. & Hsia, C. H., 2023, In: European Journal of Inflammation. 21Research output: Contribution to journal › Article › peer-review
Open Access3 Citations (Scopus) -
Overexpressing glyoxalase 1 attenuates acute hyperglycemia–exacerbated neurological deficits of ischemic stroke in mice
Lu, K. J., Yang, C. H., Sheu, J. R., Chung, C. L., Jayakumar, T., Chen, C. M. & Hsieh, C. Y., Nov 2023, In: Translational Research. 261, p. 57-68 12 p.Research output: Contribution to journal › Article › peer-review
1 Citation (Scopus)
Datasets
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Platelet autophagic machinery involved in thrombosis through a novel linkage of AMPK-MTOR to sphingolipid metabolism
Chang, C.-C. (Contributor), Hsiung, Y.-C. (Contributor), Jayakumar, T. (Contributor), Lin, K.-H. (Contributor), Hsieh, C.-Y. (Creator), Trang, N. T. T. (Contributor), Lee, C.-Y. (Creator), Chen, R.-J. (Contributor), Chang, T.-H. (Contributor), Lu, W.-J. (Contributor), Changou, C. A. (Creator), Lee, T.-Y. (Creator), Sheu, J.-R. (Contributor) & Yang, C.-H. (Contributor), Taylor & Francis, 2021
DOI: 10.6084/m9.figshare.14259880.v1, https://doi.org/10.6084%2Fm9.figshare.14259880.v1
Dataset
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Platelet autophagic machinery involved in thrombosis through a novel linkage of AMPK-MTOR to sphingolipid metabolism
Lee, T.-Y. (Creator), Lu, W.-J. (Creator), Changou, C. A. (Creator), Hsiung, Y.-C. (Creator), Trang, N. T. T. (Creator), Lee, C.-Y. (Creator), Chang, T.-H. (Creator), Jayakumar, T. (Creator), Hsieh, C.-Y. (Creator), Yang, C.-H. (Creator), Chang, C.-C. (Creator), Chen, R.-J. (Creator), Sheu, J.-R. (Creator) & Lin, K.-H. (Creator), Taylor & Francis, 2021
DOI: 10.6084/m9.figshare.14259880.v3, https://tandf.figshare.com/articles/dataset/Platelet_autophagic_machinery_involved_in_thrombosis_through_a_novel_linkage_of_AMPK-MTOR_to_sphingolipid_metabolism/14259880/3
Dataset