TMU Research Center of Thoracic Medicine

2025

A real-world study to evaluate effectiveness of mepolizumab in treating severe asthma in Taiwan (REMIT)

Cheng, S. L., Lin, S. M., Peng, C. K., Chan, M. C., Shen, S. Y., Kuo, P. H., Lai, C. H., Lan, C. C., Chen, C. Y., Lin, C. H., Liao, K. M., Feng, P. H., Wu, J. T., Wei, Y. F., Xu, X., Alfonso-Christancho, R., Lai, T., Navarro, A., Milea, D. & Perng, D. W., Jan 1 2025, In: Therapeutic Advances in Respiratory Disease. 19, p. 17534666241308406

Research output: Contribution to journal › Article › peer-review

Open Access

Aspartame consumption linked to delayed puberty and mitochondrial Dysfunction: Evidence from human and animal studies

Chen, Y. C., Wang, Z. L., Lin, Y. F., Lin, C. Y., Hsu, S. Y., Nacis, J. S. & Hsieh, R. H., Jun 2025, In: Journal of Nutritional Biochemistry. 140, 109889.

Research output: Contribution to journal › Article › peer-review

Assessment of delirium in Indonesian pediatric intensive care unit: a psychometric evaluation of the Cornell Assessment of Pediatric Delirium

Rohmah, I., Lusdiana, I., Maulina, R., Widodo, A. F. & Chiu, H. Y., Jan 24 2025, In: European Journal of Pediatrics. 184, 2, p. 153 1 p., 153.

Research output: Contribution to journal › Article › peer-review

Association between the risk of aberrant driving behavior and sleep disorder indices: A pilot study involving urban taxi drivers

Wang, P., Chen, Z., Liu, W. T., Majumdar, A. & Tsai, C. Y., Feb 2025, In: Journal of Transport and Health. 40, 101942.

Research output: Contribution to journal › Article › peer-review

Associations of COVID-19 vaccination with risks for post-infectious cardiovascular complications: an international cohort study in cancer patients with SARS-CoV-2 infection

COVID-19 and Cancer Consortium, Apr 2025, In: The Lancet Regional Health - Americas. 44, 101038.

Research output: Contribution to journal › Article › peer-review

Open Access

Automatic Detect Incorrect Lifting Posture with the Pose Estimation Model

Hsu, G. S. J., Wu, J. S., Huang, Y. K. D., Chiu, C. C. & Kang, J. H., Mar 2025, In: Life. 15, 3, 358.

Research output: Contribution to journal › Article › peer-review

Open Access

Cross-linked copolyimide-P84/CAU-10-H/branched polyethyleneimine membranes for organic solvent nanofiltration

Kebede Hundessa, N., Hu, C. C., Kang, D. Y., Chou, P. C., Hung, W. S., Tsai, H. C., Lee, K. R. & Lai, J. Y., Mar 1 2025, In: Separation and Purification Technology. 355, 129663.

Research output: Contribution to journal › Article › peer-review

Development of BACE2-IN-1/tranylcypromine-based compounds to induce steroidogenesis-dependent neuroprotection

Banerjee, S., Hsu, Y. T., Nguyen, D. H., Yeh, S. H., Liou, K. C., Liu, J. J., Liou, J. P. & Chuang, J. Y., Feb 2025, In: Biomedicine and Pharmacotherapy. 183, 117851.

Research output: Contribution to journal › Article › peer-review

Open Access

Diagnostic performance of rapid on-site evaluation during bronchoscopy for lung cancer: A comprehensive meta-analysis

Chen, C. C., Lu, S. C., Chang, Y. K., Bai, C. H., Hsiao, K. Y., Lee, K. Y. & Wang, Y. H., Jan 2025, In: Cancer cytopathology. 133, 1, e22908.

Research output: Contribution to journal › Article › peer-review

Do phenolic contents relate to their in-vitro cytotoxicity against colorectal cancer cell lines from Calvatia lilacina (puffball mushroom)?

Cao, J. L., Guo, J. H., Leung, W., Liu, Y. T., Tsai, I. L., Huang, S. L., Wang, Y. S. & Lai, Y. H., Apr 2025, In: Food Bioscience. 66, 106193.

Research output: Contribution to journal › Article › peer-review

Durvalumab, Tremelimumab, and Platinum Chemotherapy in EGFR Mutation–Positive NSCLC: An Open-Label Phase 2 Trial (ILLUMINATE)

Lee, C. K., Liao, B. C., Subramaniam, S., Chiu, C. H., Mersiades, A. J., Ho, C. C., Brown, C., Lai, C. L., Hughes, B. G. M., Yang, T. Y., O'Byrne, K., Luo, Y. H., Yip, S., Ho, C. L., Bray, V., Su, W. C., Moore, M., Feng, W. L., Bai, Y. Y. & Ford, K. & 5 others, Cummins, M. M., Stockler, M. R., Solomon, B. J., John, T. & Chih-Hsin Yang, J., Feb 2025, In: JTO Clinical and Research Reports. 6, 2, 100771.

Research output: Contribution to journal › Article › peer-review

Open Access

Early fungal colonization and infection as an independent predictor of in-hospital mortality in mechanically ventilated COVID-19 patients: A nationwide target trial emulation study in Taiwan

Wu, Y. K., Chung, H. W., Chen, W. C., Yang, K. Y., Jao, L. Y., Chang, H. T., Tseng, C. H., Chen, T. T., Ku, S. C., Huang, T. T. M., Chiu, T. H., Kao, K. C., Wang, C. J., Wang, C. H., Yang, T. B., Suk, C. W., Peng, C. K., Shen, C. H., Chien, Y. S. & Kuo, L. K. & 17 others, Lin, C. C., Lin, C. M., Liu, W. L., Wu, H. P., Chiu, M. H., Chan, M. C., Lin, C. M., Lee, C. S., Chang, C. H., Keng, L. T., Chen, H. C., Chen, Y. T., Chang, S. C., Lai, Y. C., Chen, C. M., Fang, W. F. & Su, W. L., Jul 2025, In: Journal of Infection and Public Health. 18, 7, 102767.

Research output: Contribution to journal › Article › peer-review

Open Access

Effects of continuous positive airway pressure on renal function in adults with obstructive sleep apnea: a systematic review and meta-analysis

Peng, H. H., Hu, C. E., Wu, Y. L., Liu, W. T., Tsai, C. Y. & Kuan, Y. C., Mar 2025, In: Sleep and Breathing. 29, 1, 102.

Research output: Contribution to journal › Article › peer-review

Effects of DELIMA education programme on nurses’ knowledge, confidence, attitude, and screening accuracy for delirium in paediatric intensive care units

Rohmah, I., Pangarsih, D. S., Rahayu, S., Widodo, A. F., Chang, K. M., Ho, M. H., Tseng, Y. H. & Chiu, H. Y., Apr 2025, In: Intensive and Critical Care Nursing. 87, 103938.

Research output: Contribution to journal › Article › peer-review

Effects of Personalized DiaBetes TEXT Messaging Combined with Peer Support Education on Patients With Type 2 Diabetes: A Randomized Controlled Trial

Romadlon, D. S., Huang, H. C., Chen, Y. C., Hu, S. H., Kurniawan, R., Tarigan, T. J. E., Al Baqi, S., Hasan, F. & Chiu, H. Y., 2025, (Accepted/In press) In: Journal of diabetes science and technology.

Research output: Contribution to journal › Article › peer-review

Glabridin Suppresses Macrophage Activation by Lipoteichoic Acid In Vitro: The Crucial Role of MAPKs-IL-1β-iNOS Axis Signals in Peritoneal and Alveolar Macrophages

Hou, S. M., Yang, C. M., Huang, W. C., Cheng, S. W., Yen, T. L., Hsia, C. W., Hsieh, C. Y. & Hsia, C. H., Feb 2025, In: Biomolecules. 15, 2, 174.

Research output: Contribution to journal › Article › peer-review

Open Access

Global prevalence and risk factors of delirium among patients following acute stroke: A systematic review and meta-analysis

Mukminin, M. A., Yeh, T. H., Lin, H. C., Rohmah, I. & Chiu, H. Y., Feb 2025, In: Journal of Stroke and Cerebrovascular Diseases. 34, 2, 108221.

Research output: Contribution to journal › Article › peer-review

Open Access

Gut microbiome and body composition with sorbitol intake during early lifespan

Chu, Y. Y., Yang, Y. C. S. H., Hsu, S. Y., Fan, H. Y., Hwang, L. D., Nacis, J. S. & Chen, Y. C., Feb 2025, In: Nutrition. 130, 112614.

Research output: Contribution to journal › Article › peer-review

High Intelectin-1 Expression Associated with Aggressive Tumor Behavior and Worse Survival in Rectal Cancer

Chou, C. L., Lin, C. W., Li, W. S., Chen, T. J., Lee, S. W., Tian, Y. F., Kuo, Y. H., Tsai, H. H., Wu, L. C., Yeh, C. F., Shiue, Y. L., Lai, H. Y. & Yang, C. C., 2025, In: OncoTargets and Therapy. 18, p. 15-26 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Impact of deep learning on pediatric elbow fracture detection: a systematic review and meta-analysis

Binh, L. N., Nhu, N. T., Nhi, P. T. U., Son, D. L. H., Bach, N., Huy, H. Q., Le, N. Q. K. & Kang, J. H., Dec 2025, In: European Journal of Trauma and Emergency Surgery. 51, 1, 115.

Research output: Contribution to journal › Article › peer-review

Impact of PM_2.5, relative humidity, and temperature on sleep quality: a cross-sectional study in Taipei

Thanh Tung, N., Lee, Y. L., Liu, W. T., Lin, Y. C., Chang, J. H., Xuan Thao, H. N., Ba Dung, H., Viet Trung, L., Phan Chung Thuy, T., Thi Hien, N., Tsai, C. Y., Lo, C. C., Lo, K., Ho, K. F., Chuang, K. J. & Chuang, H. C., 2025, In: Annals of Medicine. 57, 1, 2448733.

Research output: Contribution to journal › Article › peer-review

Open Access

Investigating T Cell Immune Dynamics and IL-6’s Duality in a Microfluidic Lung Tumor Model

Sardarabadi, P., Lee, K. Y., Sun, W. L., Kojabad, A. A. & Liu, C. H., Jan 2025, In: ACS Applied Materials and Interfaces. 17, 3, p. 4354-4367 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Citation (Scopus)

Joint effects of temperature and humidity with PM_2.5 on COPD

Tran, H. M., Tsai, F. J., Wang, Y. H., Lee, K. Y., Chang, J. H., Chung, C. L., Tseng, C. H., Su, C. L., Lin, Y. C., Chen, T. T., Chen, K. Y., Ho, S. C., Yang, F. M., Wu, S. M., Chung, K. F., Ho, K. F., Chuang, K. J. & Chuang, H. C., Dec 2025, In: BMC Public Health. 25, 1, 424.

Research output: Contribution to journal › Article › peer-review

Open Access

Maternal aspartame exposure alters lung Th1/Th2 cytokine balance in offspring through nuclear factor-κB activation

Chuang, H. C., Yang, Y. C. S. H., Chou, H. C. & Chen, C. M., Jan 3 2025, In: International Immunopharmacology. 145, 113800.

Research output: Contribution to journal › Article › peer-review

Open Access

Mediating role of obstructive sleep apnea in altering slow-wave activity and elevating Alzheimer's disease risk: Pilot study from a northern Taiwan cohort

Tsai, C. Y., Su, C. L., Huang, H. T., Lin, H. W., Lin, J. W., Hei, N. C., Cheng, W. H., Chen, Y. L., Majumdar, A., Kang, J. H., Lee, K. Y., Chen, Z., Lin, Y. C., Wu, C. J., Kuan, Y. C., Lin, Y. T., Hsu, C. R., Lee, H. C. & Liu, W. T., 2025, In: Sleep Health. 11, 1, p. 80-90 11 p.

Research output: Contribution to journal › Article › peer-review

OCT4 promotes lung cancer progression through upregulation of VEGF-correlated chemokine-1

Su, B. H., Wang, C. T., Chang, J. M., Chen, H. Y., Huang, T. H., Yen, Y. T., Tseng, Y. L., Chang, M. Y., Lee, C. H., Cheng, L. H., Wu, Y. C., Wu, C. L., Ling, P. & Shiau, A. L., 2025, In: International Journal of Medical Sciences. 22, 3, p. 680-695 16 p.

Research output: Contribution to journal › Article › peer-review

Personal exposure to fine particles, inflammation and oxidative stress among commuters before, during and after COVID-19 outbreak in Taipei

Lee, Y. L., Chuang, K. J., Hong, G. B., Chen, H. W., Chuang, H. C., Sharifa Ezat, W. P. & Liu, I. J., Apr 2025, In: Atmospheric Environment. 346, 121080.

Research output: Contribution to journal › Article › peer-review

Psoriasis Risk Is Lower in Type 2 Diabetes Patients Using Dipeptidyl Peptidase-4 Inhibitors or Thiazolidinediones Compared to Sulfonylureas

Chen, W. S., Lin, T. M., Chang, Y. S., Shen, Y. C., Hsu, H. C., Kuo, T. T., Chen, S. C., Chen, J. H. & Chang, C. C., Mar 2025, In: Clinical and Translational Science. 18, 3, e70177.

Research output: Contribution to journal › Article › peer-review

Open Access

Repurposing Linezolid in Conjunction with Histone Deacetylase Inhibitor Access in the Realm of Glioblastoma Therapies

Chen, I. C., Lin, H. Y., Liu, Z. Y., Cheng, W. J., Yeh, T. Y., Yang, W. B., Tran, H. Y., Lai, M. J., Wang, C. H., Kao, T. Y., Hung, C. Y., Huang, Y. L., Liou, K. C., Hsieh, C. M., Hsu, T. I. & Liou, J. P., 2025, In: Journal of Medicinal Chemistry. 68, 3, p. 2779-2803 25 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Ribonuclease 1 Induces T-Cell Dysfunction and Impairs CD8⁺ T-Cell Cytotoxicity to Benefit Tumor Growth through Hijacking STAT1

Yang, W. H., Huang, B. Y., Rao, H. Y., Ye, P., Chen, B., Wang, H. C., Chung, C. H., Wu, H. H., Yen, H. R., Wang, S. C., Cha, J. H., Yan, X., Yang, M. H. & Hung, M. C., 2025, (Accepted/In press) In: Advanced Science. 12, 13, 2404961.

Research output: Contribution to journal › Article › peer-review

Open Access

Tailored electronic properties of PdAu nanocatalysts via one-step electrodeposition for high-performance glucose sensors

Lu, Y. S., Tso, K. C., Hsu, C. C., Wen, Y. C., Ohta, J., Yu, T. Y. & Li, S. S., Feb 15 2025, In: Applied Surface Science. 682, 161750.

Research output: Contribution to journal › Article › peer-review

Targeting FABP4/UCP2 axis to overcome cetuximab resistance in obesity-driven CRC with drug-tolerant persister cells

Cheng, Y. C., Chen, M. Y., Yadav, V. K., Pikatan, N. W., Fong, I. H., Kuo, K. T., Yeh, C. T. & Tsai, J. T., Mar 2025, In: Translational Oncology. 53, 102274.

Research output: Contribution to journal › Article › peer-review

Open Access

The off‑target effect of loratadine triggers autophagy‑mediated apoptosis in lung adenocarcinoma cells by deactivating JNK, p38, and STAT3 signaling through both PP2A‑dependent and independent pathways

Chien, M. H., Hung, W. Y., Lai, T. C., Tsai, C. H., Lee, K. L., Hsieh, F. K., Lee, W. J. & Chang, J. H., Apr 2025, In: International Journal of Molecular Medicine. 55, 4, 54.

Research output: Contribution to journal › Article › peer-review

The prognostic value of NT-proBNP in 28-day mortality and post-discharge survival in pneumonia: a retrospective cohort study from Taiwan

Nguyen, V. D., Lin, H. C., Lee, W. C., Ju, K. S., Dai, J. E., Hsieh, P. N., Chen, C. Y. & Lee, C. H., 2025, In: Expert Review of Respiratory Medicine. 19, 3, p. 257-267 11 p.

Research output: Contribution to journal › Article › peer-review

Thyroid hormones and frailty in older adults: systematic review and dose–response meta-analysis

Chia, W. C., Chen, Y. C., Xiu, S. L. & Wang, S. T., Dec 2025, In: BMC Geriatrics. 25, 1, 104.

Research output: Contribution to journal › Article › peer-review

Open Access

Two-drug versus three-drug regimens for treating Mycobacterium avium complex infection: A systematic review and meta-analysis

Nguyen, V. D., Duong, H., Lee, M. C., Chen, J. H., Huang, W. C., Chen, H. E., Lin, J. C., Wang, J. Y. & Lee, C. H., May 2025, In: Journal of Infection and Public Health. 18, 5, 102711.

Research output: Contribution to journal › Article › peer-review

Open Access

Unveiling unique effector function-related bulk antibody profiles in long-term hemodialysis patients following COVID-19 mRNA booster vaccination

Chou, C. Y., Cheng, C. Y., Lee, C. H., Kuro-O, M., Chen, T. H., Wang, S. Y., Chuang, Y. K., Yang, Y. J., Lin, Y. H. & Tsai, I. L., Feb 2025, In: Journal of Microbiology, Immunology and Infection. 58, 1, p. 27-37 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Utilizing a Wireless Radar Framework in Combination With Deep Learning Approaches to Evaluate Obstructive Sleep Apnea Severity in Home-Setting Environments

Lee, K. T., Liu, W. T., Lin, Y. C., Chen, Z., Ho, Y. H., Huang, Y. W., Tsai, Z. L., Hsu, C. W., Yeh, S. M., Lin, H. Y., Majumdar, A., Chen, Y. L., Kuan, Y. C., Lee, K. Y., Feng, P. H., Chen, K. Y., Kang, J. H., Lee, H. C., Ho, S. C. & Tsai, C. Y., 2025, In: Journal of Multidisciplinary Healthcare. 18, p. 381-393 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2024

3D organoid cultivation improves the maturation and functional differentiation of cholangiocytes from human pluripotent stem cells

Budi, N. Y. P., Lai, W. Y., Huang, Y. H. & Ho, H. N., 2024, In: Frontiers in Cell and Developmental Biology. 12, 1361084.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Citations (Scopus)

A bronchiole-on-a-chip and a stretching system for studying human disease model of asthma attack

Sun, C. H., Lee, K. Y., Chan, Y. F., Ho, S. C., Liu, C. Y., Wu, S. M., Sun, W., Ke, Y. T. & Liu, C. H., Oct 1 2024, In: Sensors and Actuators B: Chemical. 416, 136031.

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Adaptation behaviors modify the effects of body fat on heat-related symptoms among Taiwanese elderly

Chen, C. H., Lin, W. Y., Lee, K. Y., Sun, W. J., Huang, L. Y. & Guo, Y. L. L., Jan 2024, In: International Journal of Hygiene and Environmental Health. 255, 114296.

Research output: Contribution to journal › Article › peer-review

A dynamic approach to support outbreak management using reinforcement learning and semi-connected SEIQR models

Kao, Y., Chu, P. J., Chou, P. C. & Chen, C. C., Dec 2024, In: BMC Public Health. 24, 1, 751.

Research output: Contribution to journal › Article › peer-review

Open Access

An Antibody of the Secreted Isoform of Disintegrin and Metalloprotease 9 (sADAM9) Inhibits Epithelial–Mesenchymal Transition and Migration of Prostate Cancer Cell Lines

Jotatsu, Y., Sung, S. Y., Wu, M. H., Takeda, S., Hirata, Y., Maeda, K., Fang, S. B., Chen, K. C. & Shigemura, K., Jun 2024, In: International journal of molecular sciences. 25, 12, 6646.

Research output: Contribution to journal › Article › peer-review

Open Access

A nationwide case-referent study on elevated risks of adenocarcinoma lung cancer by long-term PM_2.5 exposure in Taiwan since 1997

Lin, W. C., Shie, R. H., Yuan, T. H., Tseng, C. H., Chiang, C. J., Lee, W. C. & Chan, C. C., Jul 1 2024, In: Environmental Research. 252, 118889.

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Antiviral effects of Sarcodia suae water extracts against vesicular stomatitis virus infection

Chang, T. F., Lin, C. F., Wu, S. Y., Lin, L., Lai, P. C., Liao, C. T., Woodson, C., Chen, S. Y., Lee, P. T., Lee, M. C. & Lin, S. C., 2024, (Accepted/In press) In: European Journal of Phycology. 59, 4, p. 490-500 11 p.

Research output: Contribution to journal › Article › peer-review

A population-based study on the associations of thyroid cancer with chronic periodontitis

Yang, T. H., Cheng, Y. F., Lin, H. C. & Chen, C. S., 2024, (Accepted/In press) In: Journal of Periodontology.

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

AptBCis1, An Aptamer-Cisplatin Conjugate, Is Effective in Lung Cancer Leptomeningeal Carcinomatosis

Huang, B. T., Lai, W. Y., Yeh, C. L., Tseng, Y. T., Peck, K., Yang, P. C. & Lin, E. P. Y., Oct 15 2024, In: ACS Nano. 18, 41, p. 27905-27916 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Citations (Scopus)

Arginine Methylation of DDX3 by PRMT1 Mediates Mitochondrial Homeostasis to Promote Breast Cancer Metastasis

Hsu, W. J., Chiang, M. C., Chao, Y. C., Chang, Y. C., Hsu, M. C., Chung, C. H., Tsai, I. L., Chu, C. Y., Wu, H. C., Yang, C. C., Lee, C. C. & Lin, C. W., Sept 15 2024, In: Cancer Research. 84, 18, p. 3023-3043 21 p.

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Armand Van Deun - pioneering public health physician (1953-2023)

Rieder, H. L., Declercq, E., Rigouts, L., Piubello, A., Billo, N. E., Ba, F., Trébucq, A., Chiang, C. Y. & Portaels, F., Jan 1 2024, In: The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease. 28, 1, p. 68-69 2 p.

Research output: Contribution to journal › Article › peer-review

Aspartame Intake Delayed Puberty Onset in Female Offspring Rats and Girls

Lin, C. Y., Nguyen, N. N., Tsai, W. L., Hsieh, R. H., Wu, H. T. & Chen, Y. C., Mar 2024, In: Molecular Nutrition and Food Research. 68, 5, 2300270.

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

TMU Research Center of Thoracic Medicine

Research output

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