Research output per year
Research output per year
Research output
- 1 - 50 out of 748 results
Search results
-
2025
Advancing glioblastoma therapy: Learning from the past and innovations for the future
Rana, M., Liou, K. C., Thakur, A., Nepali, K. & Liou, J. P., May 1 2025, In: Cancer Letters. 617, 217601.Research output: Contribution to journal › Article › peer-review
-
Cogstate Brief Battery performance in assessing cognitive impairment in Taiwan: A prospective, multi-center study
Kuan, Y. C., Jhang, K. M., Wang, W. F., Yeh, Y. C., Chen, C. S., Yang, C. C. & Hu, C. J., 2025, In: Journal of the Formosan Medical Association.Research output: Contribution to journal › Article › peer-review
Open Access -
Cyclic increase in the histamine receptor H1-ADAM9-Snail/Slug axis as a potential therapeutic target for EMT-mediated progression of oral squamous cell carcinoma
Ding, Y. F., Ho, K. H., Lee, W. J., Chen, L. H., Hsieh, F. K., Tung, M. C., Lin, S. H., Hsiao, M., Yang, S. F., Yang, Y. C. & Chien, M. H., Dec 2025, In: Cell Death and Disease. 16, 1, 191.Research output: Contribution to journal › Article › peer-review
Open Access1 Citation (Scopus) -
Cytotoxicity-guided isolation of elatostemanosides I-VI from Elatostema tenuicaudatum W. T. Wang and their cytotoxic activities
Huynh, Q. D. T., Phan, T. T. T., Liu, T. W., Duong, T. L. T., Hsu, S. J., Kuo, C. C., Chu, M. H., Wang, Y. H., Nguyen, T. V., Shen, Y. A., Fan, Y. J., Nguyen, D. K., Vo, T. H. & Lee, C. K., Apr 4 2025, In: RSC Advances. 15, 14, p. 10639-10652 14 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Design, preparation, and characterization of injectable thermosensitive polymer-based hydrogels with enhanced mechanical properties for sustained liraglutide release
Cheng, W. J., Yeh, T. Y., Hsieh, C. Y., Chuang, H. Y., Chao, F. C., Liou, J. P. & Hsieh, C. M., Jun 2025, In: Journal of Drug Delivery Science and Technology. 108, 106909.Research output: Contribution to journal › Article › peer-review
-
Development of a tumor-region-selective activation monoclonal antibody targeting the 4-1BB receptor for enhanced therapeutic efficacy and safety
Liao, T. Y., Liu, Y. L., Chen, C. Y., Wu, B. T., Liu, E. S., Hong, S. T., Huang, B. C., Cheng, Y. A., Chen, M., Chuang, K. H., Lin, W. W., Chuang, C. H., Chen, F. M., Ho, K. W. & Cheng, T. L., May 2025, In: International Journal of Biological Macromolecules. 305, 141003.Research output: Contribution to journal › Article › peer-review
-
Development of BACE2-IN-1/tranylcypromine-based compounds to induce steroidogenesis-dependent neuroprotection
Banerjee, S., Hsu, Y. T., Nguyen, D. H., Yeh, S. H., Liou, K. C., Liu, J. J., Liou, J. P. & Chuang, J. Y., Feb 2025, In: Biomedicine and Pharmacotherapy. 183, 117851.Research output: Contribution to journal › Article › peer-review
Open Access -
Discovery and biological evaluation of potent 2-trifluoromethyl acrylamide warhead-containing inhibitors of protein disulfide isomerase
Chu, J. C., Tsai, K. C., Wang, T. Y., Chen, T. Y., Tsai, J. Y., Lee, T., Lin, M. H., Hsieh, Y. S. Y., Wu, C. C. & Huang, W. J., Feb 5 2025, In: European Journal of Medicinal Chemistry. 283, p. 117169 117169.Research output: Contribution to journal › Article › peer-review
1 Citation (Scopus) -
Genetic variants of IGF2BP2 as potential predictors for perineural invasion of prostate cancer in a Taiwanese population
Weng, W. C., Lin, Y. W., Lai, C. H., Lin, C. Y., Wen, Y. C., Chang, L. C., Yang, S. F. & Chien, M. H., 2025, In: International Journal of Medical Sciences. 22, 6, p. 1269-1277 9 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Hypoxia enhances IL-8 signaling through inhibiting miR-128-3p expression in glioblastomas
Ho, K. H., Hsu, S. Y., Chen, P. H., Cheng, C. H., Liu, A. J., Chien, M. H. & Chen, K. C., Feb 2025, In: Biochimica et Biophysica Acta - Molecular Cell Research. 1872, 2, 119885.Research output: Contribution to journal › Article › peer-review
-
Identification and Biological Evaluation of a Novel CLK4 Inhibitor Targeting Alternative Splicing in Pancreatic Cancer Using Structure-Based Virtual Screening
Yang, C. L., Wu, Y. W., Tu, H. J., Yeh, Y. H., Lin, T. E., Sung, T. Y., Li, M. C., Yen, S. C., Hsieh, J. H., Yu, M. C., Hsieh, S. Y., Hsieh, H. P., Pan, S. L. & Hsu, K. C., 2025, (Accepted/In press) In: Advanced Science.Research output: Contribution to journal › Article › peer-review
Open Access -
Intranasal delivery of epigallocatechin gallate-laden platelet extracellular vesicles for mitigating retinal glaucoma
Pan, W. Y., Weng, P. W., Wu, S. H., Hsiao, C. H., Jheng, P. R., Nguyen, H. N. T., Tseng, C. L., Burnouf, T., Rethi, L., Nguyen, H. T., Huang, W. Y., Wang, T. J. & Chuang, A. E. Y., May 10 2025, In: Journal of Controlled Release. 381, 113596.Research output: Contribution to journal › Article › peer-review
-
Melatonin reverses bisphenol A-induced toxicity in granulosa cells: Restoration of FSHR and connexin 43 expression
Lin, T. C., Wang, K. H., Chuang, K. H., Kao, A. P. & Kuo, T. C., 2025, (Accepted/In press) In: Taiwanese Journal of Obstetrics and Gynecology.Research output: Contribution to journal › Article › peer-review
-
Nonshrinkable Thermosensitive Hydrogels Combined with Bispecific Anti-PSMA/CD3 T-Cell Engager for Effective Against Tumors in Mice Model
Wei, P. S., Chou, P. Y., Hsu, H. Y., Chen, M., Chen, Y. J., Tsai, T. H., Wen, B. Y., Sheu, M. T., Chuang, K. H. & Lin, H. L., 2025, In: International Journal of Nanomedicine. 20, p. 3083-3111 29 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Optimization of the poloxamer 407-conjugated gelatin to synthesize pH-sensitive nanocarriers for controlled paclitaxel delivery
Ly, H. Q., Chen, Y. J., Nguyen, V. T. & Tseng, C. L., Feb 2025, In: Journal of Polymer Research. 32, 2, 38.Research output: Contribution to journal › Article › peer-review
Open Access1 Citation (Scopus) -
Platelet-derived extracellular vesicle drug delivery system loaded with kaempferol for treating corneal neovascularization
Liu, G. S., Chen, H. A., Chang, C. Y., Chen, Y. J., Wu, Y. Y., Widhibrata, A., Yang, Y. H., Hsieh, E. H., Delila, L., Lin, I. C., Burnouf, T. & Tseng, C. L., Aug 2025, In: Biomaterials. 319, 123205.Research output: Contribution to journal › Article › peer-review
Open Access -
Repurposing Linezolid in Conjunction with Histone Deacetylase Inhibitor Access in the Realm of Glioblastoma Therapies
Chen, I. C., Lin, H. Y., Liu, Z. Y., Cheng, W. J., Yeh, T. Y., Yang, W. B., Tran, H. Y., Lai, M. J., Wang, C. H., Kao, T. Y., Hung, C. Y., Huang, Y. L., Liou, K. C., Hsieh, C. M., Hsu, T. I. & Liou, J. P., 2025, In: Journal of Medicinal Chemistry. 68, 3, p. 2779-2803 25 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Ribonuclease 1 Induces T-Cell Dysfunction and Impairs CD8+ T-Cell Cytotoxicity to Benefit Tumor Growth through Hijacking STAT1
Yang, W. H., Huang, B. Y., Rao, H. Y., Ye, P., Chen, B., Wang, H. C., Chung, C. H., Wu, H. H., Yen, H. R., Wang, S. C., Cha, J. H., Yan, X., Yang, M. H. & Hung, M. C., 2025, (Accepted/In press) In: Advanced Science. 12, 13, 2404961.Research output: Contribution to journal › Article › peer-review
Open Access -
Structural optimization and biological evaluation of indolin-2-one derivatives as novel CDK8 inhibitors for idiopathic pulmonary fibrosis
Hsu, J. Y., Hsu, K. C., Chou, C. H., He, T. Y., Lin, T. E., Sung, T. Y., Yen, S. C., Hsieh, J. H., Yang, C. R. & Huang, W. J., Mar 2025, In: Biomedicine and Pharmacotherapy. 184, 117891.Research output: Contribution to journal › Article › peer-review
Open Access -
The off‑target effect of loratadine triggers autophagy‑mediated apoptosis in lung adenocarcinoma cells by deactivating JNK, p38, and STAT3 signaling through both PP2A‑dependent and independent pathways
Chien, M. H., Hung, W. Y., Lai, T. C., Tsai, C. H., Lee, K. L., Hsieh, F. K., Lee, W. J. & Chang, J. H., Apr 2025, In: International Journal of Molecular Medicine. 55, 4, 54.Research output: Contribution to journal › Article › peer-review
-
Therapeutic Assessment of Diverse Doxycycline-Based Formulations in Promoting Deep Corneal Wound Healing: Evidence from a Rat Model
Chan, S. M., Tseng, C. L., Huang, W. H. & Lin, C. T., Feb 2025, In: Veterinary Sciences. 12, 2, 143.Research output: Contribution to journal › Article › peer-review
Open Access -
Ultrasensitive Assays Detect Different Conformations of Plasma β Amyloids
Li, C. Y., Fan, L. Y., Lin, C. H., Hu, C. J. & Chiu, M. J., Feb 25 2025, In: ACS Omega. 10, 7, p. 7256-7263 8 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2024
An ensemble machine learning model generates a focused screening library for the identification of CDK8 inhibitors
Lin, T. E., Yen, D., HuangFu, W. C., Wu, Y. W., Hsu, J. Y., Yen, S. C., Sung, T. Y., Hsieh, J. H., Pan, S. L., Yang, C. R., Huang, W. J. & Hsu, K. C., Jun 2024, In: Protein Science. 33, 6, e5007.Research output: Contribution to journal › Article › peer-review
Open Access2 Citations (Scopus) -
A novel HDAC8 inhibitor H7E exerts retinoprotective effects against glaucomatous injury via ameliorating aberrant Müller glia activation and oxidative stress
Wu, L. H., Cheng, Y. W., Lin, F. L., Hsu, K. C., Wang, M. H., Yen, J. L., Wang, T. J., Lin, T. E., Liu, Y. C., Huang, W. J. & Hsiao, G., May 2024, In: Biomedicine and Pharmacotherapy. 174, 116538.Research output: Contribution to journal › Article › peer-review
Open Access2 Citations (Scopus) -
ASPM stabilizes the NOTCH intracellular domain 1 and promotes oncogenesis by blocking FBXW7 binding in hepatocellular carcinoma cells
Chan, T. S., Cheng, L. H., Hsu, C. C., Yang, P. M., Liao, T. Y., Hsieh, H. Y., Lin, P. C., HuangFu, W. C., Chuu, C. P. & Tsai, K. K., 2024, (Accepted/In press) In: Molecular Oncology. 18, 3, p. 562-579 18 p.Research output: Contribution to journal › Article › peer-review
Open Access4 Citations (Scopus) -
Association of glutaminase expression with immune-suppressive tumor microenvironment, clinicopathologic features, and clinical outcomes in endometrial cancer
Asaka, S., Verma, N., Yen, T. T., Hicks, J. L., Nonogaki, H., Shen, Y. A., Hong, J., Asaka, R., DeMarzo, A. M., Wang, T. L., Shih, I. M. & Gaillard, S., Nov 4 2024, In: International Journal of Gynecological Cancer. 34, 11, p. 1737-1744 8 p.Research output: Contribution to journal › Article › peer-review
1 Citation (Scopus) -
Associations of the Expression Levels and Risk Variants of CDKN2B-AS1 Long Noncoding RNA With the Susceptibility and Progression of Prostate Cancer
Tung, M. C., Lin, C. Y., Wen, Y. C., Chang, L. C., Yang, S. F. & Chien, M. H., Dec 2024, In: Journal of Cellular and Molecular Medicine. 28, 23, e70264.Research output: Contribution to journal › Article › peer-review
Open Access -
A tumor on a chip for studying immune-cell infiltration into tumor under chemo/immunotherapy treatments
Chen, Y. C., Lee, K. Y., Liao, H. J., Sun, W. L., Huang, W. C., Wang, Y. S., Chang, W. C. & Liu, C. H., May 1 2024, In: Sensors and Actuators B: Chemical. 406, 135409.Research output: Contribution to journal › Article › peer-review
6 Citations (Scopus) -
Bioactive matrix scaffold of oxidized sacchachitin via green catalyst of siliacat tempo for enhancing bone regeneration
Sheu, M. T., Lin, S. Y., Cheng, W. J., Lin, H. L., Hsieh, C. M., Ho, H. O., Chen, L. C. & Wu, M. H., Dec 2024, In: Carbohydrate Polymer Technologies and Applications. 8, 100576.Research output: Contribution to journal › Article › peer-review
Open Access -
Celecoxib attenuates interleukin 33-induced expression of vascular cell adhesion molecule-1 in human ovarian endometriotic stromal cells
Lin, T. C., Wang, K. H., Chuang, K. H., Kao, A. P. & Kuo, T. C., Mar 2024, In: Taiwanese Journal of Obstetrics and Gynecology. 63, 2, p. 178-185 8 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Citation (Scopus) -
Characterization of primary Sjögren's syndrome in the Taiwan Han population through a genome-wide association study and polygenic risk score analysis
Liu, T. Y., Lin, M. R., Lu, H. F., Chen, Y. C., Lin, H. J., Chou, W. H., Wei, C. Y., Palupi, P. D., Liao, C. C., Chang, Y. T., Chang, W. C. & Tsai, F. J., Dec 2024, In: Clinical Immunology. 269, 110381.Research output: Contribution to journal › Article › peer-review
Open Access1 Citation (Scopus) -
Combined HDAC8 and checkpoint kinase inhibition induces tumor-selective synthetic lethality in preclinical models
Chang, T. Y., Yan, Y., Yu, Z. Y., Rathore, M., Lee, N. Z., Tseng, H. J., Cheng, L. H., Huang, W. J., Zhang, W., Chan, E. R., Qing, Y., Kang, M. L., Wang, R., Tsai, K. K., Pink, J. J., Harte, W. E., Gerson, S. L. & Lee, S. B., Dec 2 2024, In: Journal of Clinical Investigation. 134, 23, e165448.Research output: Contribution to journal › Article › peer-review
Open Access -
Corrigendum to "Chemical constituents from a marine medicinal brown alga-derived Xylaria acuta SC1019" [J Food Drug Anal 32 (2) (2024)
Hsi, H. Y., Wang, S. W., Hsiao, G., Chang, L. K., Cheng, Y. C., Huang, S. J., Lu, Y. S. & Lee, T. H., Sept 13 2024, In: Journal of Food and Drug Analysis. 32, 3, p. 384 1 p.Research output: Contribution to journal › Article › peer-review
-
CXCR7 activation evokes the anti-PD-L1 antibody against glioblastoma by remodeling CXCL12-mediated immunity
Liu, C. C., Yang, W. B., Chien, C. H., Wu, C. L., Chuang, J. Y., Chen, P. Y., Chu, J. M., Cheng, S. M., Qiu, L. Y., Chang, Y. C., Hwang, D. Y., Huang, C. Y., Lee, J. S. & Chang, K. Y., Jun 2024, In: Cell Death and Disease. 15, 6, 434.Research output: Contribution to journal › Article › peer-review
Open Access3 Citations (Scopus) -
Design, synthesis, and biological evaluation of adenosine derivatives targeting DOT1L and HAT as anti-leukemia agents
Sethy, B., Yu, Z. Y., Narwanti, I., Upadhyay, R., Lai, M. J., Lee, S. B. & Liou, J. P., Dec 2024, In: Bioorganic Chemistry. 153, 107771.Research output: Contribution to journal › Article › peer-review
-
Dietary contributions in the genetic variation of liver fibrosis: a genome-wide association study of fibrosis-4 index in the liver fibrosis development
Palupi, P. D., Wei, C. Y., Chou, W. H., Lin, M. R., Wan, Y. J. Y. & Chang, W. C., Dec 2024, In: Cell and Bioscience. 14, 1, 141.Research output: Contribution to journal › Article › peer-review
Open Access1 Citation (Scopus) -
Discovering a novel dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) inhibitor and its impact on tau phosphorylation and amyloid-β formation
Tu, H. J., Chao, M. W., Lee, C. C., Peng, C. S., Wu, Y. W., Lin, T. E., Chang, Y. W., Yen, S. C., Hsu, K. C., Pan, S. L. & HuangFu, W. C., 2024, In: Journal of Enzyme Inhibition and Medicinal Chemistry. 39, 1, 2418470.Research output: Contribution to journal › Article › peer-review
Open Access -
Discovery of a mu-opioid receptor modulator that in combination with morphinan antagonists induces analgesia
Huang, Y. H., Lin, S. Y., Ou, L. C., Huang, W. C., Chao, P. K., Chang, Y. C., Chang, H. F., Lee, P. T., Yeh, T. K., Kuo, Y. H., Tien, Y. W., Xi, J. H., Tao, P. L., Chen, P. Y., Chuang, J. Y., Shih, C., Chen, C. T., Tung, C. W., Loh, H. H. & Ueng, S. H. & 1 others, , 2024, (Accepted/In press) In: Cell Chemical Biology. 31, 11, p. 1885-1898.e10Research output: Contribution to journal › Article › peer-review
1 Citation (Scopus) -
Discovery of dual-specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) inhibitors using an artificial intelligence model and their effects on tau and tubulin dynamics
Chen, J. H., Tu, H. J., Lin, T. E., Peng, Z. X., Wu, Y. W., Yen, S. C., Sung, T. Y., Hsieh, J. H., Lee, H. Y., Pan, S. L., HuangFu, W. C. & Hsu, K. C., Dec 2024, In: Biomedicine and Pharmacotherapy. 181, 117688.Research output: Contribution to journal › Article › peer-review
Open Access -
Discovery of Novel Spike Inhibitors against SARS-CoV-2 Infection
Tai, L. T., Yeh, C. Y., Chang, Y. J., Liu, J. F., Hsu, K. C., Cheng, J. C. & Lu, C. H., Jun 2024, In: International journal of molecular sciences. 25, 11, 6105.Research output: Contribution to journal › Article › peer-review
Open Access1 Citation (Scopus) -
Discovery of novel TANK-Binding Kinase 1 (TBK1) inhibitor against pancreatic ductal adenocarcinoma
Shih, W. H., Huang, H. L., HuangFu, W. C., Lin, T. E., Sung, T. Y., Li, M. C., Huang, G. L., Chang, Y. W., Yen, S. C., Hsieh, H. P., Hsu, K. C. & Pan, S. L., Dec 2024, In: International Journal of Biological Macromolecules. 283, 137296.Research output: Contribution to journal › Article › peer-review
Open Access1 Citation (Scopus) -
Disulfiram inhibits coronaviral main protease by conjugating to its substrate entry site
Kuan, Y., Chu, H. F., Hsu, P. H., Hsu, K. C., Lin, T. H., Huang, C. H. & Chen, W. Y., Sept 2024, In: International Journal of Biological Macromolecules. 276, 133955.Research output: Contribution to journal › Article › peer-review
-
Dual inhibition of CYP17A1 and HDAC6 by abiraterone-installed hydroxamic acid overcomes temozolomide resistance in glioblastoma through inducing DNA damage and oxidative stress
Sharma, R., Chiang, Y. H., Chen, H. C., Lin, H. Y., Yang, W. B., Nepali, K., Lai, M. J., Chen, K. Y., Liou, J. P. & Hsu, T. I., Apr 1 2024, In: Cancer Letters. 586, 216666.Research output: Contribution to journal › Article › peer-review
5 Citations (Scopus) -
Dynamics of T-cell receptor repertoire in patients with ankylosing spondylitis after biologic therapy
Liu, W. C., Chang, C. M., Zhang, Y., Liao, H. T. & Chang, W. C., Jan 25 2024, In: International Immunopharmacology. 127, 111342.Research output: Contribution to journal › Article › peer-review
-
Effect of Sulfotyrosine and Negatively Charged Amino Acid of Leech-Derived Peptides on Binding and Inhibitory Activity Against Thrombin
Chen, T.-Y., Shyur, E., Ma, T.-H., Wijeyewickrema, L., Lin, S.-W., Kao, M.-R., Liang, P.-H., Shie, J.-J., Chuang, E.-Y., Liou, J.-P. & Hsieh, Y. S., Feb 1 2024, In: ChemBioChem. 25, 3, p. e202300744 e202300744.Research output: Contribution to journal › Article › peer-review
Open Access -
Enhancing anti-cancer capacity: Novel class I/II HDAC inhibitors modulate EMT, cell cycle, and apoptosis pathways
Lee, H. Y., Hsu, M. J., Chang, H. H., Chang, W. C., Huang, W. C. & Cho, E. C., Jul 15 2024, In: Bioorganic and Medicinal Chemistry. 109, 117792.Research output: Contribution to journal › Article › peer-review
2 Citations (Scopus) -
Exploring the Synergistic Effects of Erinacines on Microglial Regulation and Alzheimer's Pathology Under Metabolic Stress
Bui, V. T., Wu, K. W., Chen, C. C., Nguyen, A. T., Huang, W. J., Lee, L. Y., Chen, W. P., Huang, C. Y. & Shiao, Y. J., Dec 2024, In: CNS Neuroscience and Therapeutics. 30, 12, e70137.Research output: Contribution to journal › Article › peer-review
Open Access -
From Sea to Science: Coral Aquaculture for Sustainable Anticancer Drug Development
Lin, H. Y., Tsai, T. N., Hsu, K. C., Hsu, Y. M., Chiang, L. C., El-Shazly, M., Chang, K. M., Lin, Y. H., Tu, S. Y., Lin, T. E., Du, Y. C., Liu, Y. C. & Lu, M. C., Jul 2024, In: Marine Drugs. 22, 7, 323.Research output: Contribution to journal › Article › peer-review
Open Access1 Citation (Scopus) -
Ginkgetin effectively mitigates collagen and AA-induced platelet activation via PLCγ2 but not cyclic nucleotide-dependent pathway in human
Hsia, C. W., Shu, L. H., Lee, A. W., Tran, O. T., Yang, C. H., Yen, T. L., Huang, W. C., Hsia, C. H., Jayakumar, T., Chiou, K. R. & Sheu, J. R., Feb 2024, In: Journal of Cellular and Molecular Medicine. 28, 4, e18139.Research output: Contribution to journal › Article › peer-review
Open Access3 Citations (Scopus) -
GRK6 palmitoylation dictates triple-negative breast cancer metastasis via recruiting the β-Arrestin 2/MAPKs/NF-κB signaling axis
Wang, W. K., Lin, H. Y., Lin, C. H., Lee, H. H., Chen, Y. L., Lin, Y. H. K., Chiu, H. W., Sheen-Chen, S. M. & Lin, Y. F., Dec 2024, In: Breast Cancer Research. 26, 1, 193.Research output: Contribution to journal › Article › peer-review
Open Access