TMU Research Center of Drug Discovery

Projects

Projects per year 2010 2013 2014 2015 2016 2017 2018 2027

• 4 Active
• 137 Finished

Projects per year

Search results

• Finished

  小分子結合位相之預測與分析

  Hsu, K.-C. (PI)

  8/1/23 → 7/31/24

  Project: A - Government Institution › f - Other (Funded by Government)

• DYRK1B於胰臟癌中的轉譯研究與其抑制劑之活體藥效測試

  Huang, H.-L. (PI)

  1/1/21 → 12/31/21

  Project: B - Project of TMU › h - Higher Education Sprout Project

• 探討非選擇性與選擇性組蛋白去乙醯?抑制劑與免疫檢查點抑制劑合併治療之效用及其機轉(1/3)

  Huang, H.-L. (PI)

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - National Science and Technology Council

• 標的蛋白降解技術: 含氮三環化合物為骨架利用有機金屬耦合反應合成系列衍生物

  Liu, Y.-M. (PI)

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - National Science and Technology Council

• 合成可雙重抑制組織蛋白去乙醯酶6與熱休克蛋白90，並同時調節PD-L1之雜環類抗癌化合物

  Lai, M.-J. (PI)

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - National Science and Technology Council

• 研發新穎性TBK1抑制劑並探討其對胰臟癌之抗癌作用機轉

  Huang, H.-L. (PI)

  7/1/20 → 2/1/21

  Project: A - Government Institution › b - National Science and Technology Council

• 新穎性ＲＯＣＫ２抑制劑於胰臟癌之藥物研發與其作用機轉探討

  Huang, H.-L. (PI)

  7/1/20 → 2/1/21

  Project: A - Government Institution › b - National Science and Technology Council

• DYRK1B於胰臟癌中的轉譯研究與其抑制劑之活體藥效測試

  Huang, H.-L. (PI)

  1/1/20 → 12/1/20

  Project: B - Project of TMU › h - Higher Education Sprout Project

• The Mechanism and Efficacy Investigation of Using Histone Deacetylase Inhibitors to Enhance the Immune Modulation of Immune Checkpoint Blockade Agent

  Huang, H.-L. (PI)

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - National Science and Technology Council

• Anti-Heat Shock Protein Inhibitors: Pyrimidine as Core Structure for the Use of Organometallic Coupling Reaction in the Synthesis of Series Derivatives

  Liu, Y.-M. (PI)

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - National Science and Technology Council

• 探討Aroylindoline衍生物類小分子藥物應用於眼腦血管與神經相關之視網膜病變-小分子應用治療視網膜病變之合成

  Liu, Y.-M. (PI)

  1/1/19 → 12/1/19

  Project: A - Government Institution › d - Ministry of Education

• The Use of Organometallic Reaction in the Syntheses of Anticancer Agents(2/2)

  Liou, J.-P. (PI)

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - National Science and Technology Council

• Pharmacological Investigations and the Study of the Potential Biological Effects of Nitric Oxide Releasing Nano-Carrier System in Blue Light Induced Retinopathy(II)(2/3)

  Cheng, Y.-W. (PI)

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - National Science and Technology Council

• Tlk Function and Regulation in Chromatin Replication (2nd Years)

  Lee, S.-B. (PI)

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - National Science and Technology Council

  • Phosphotransferase 100%
  • Kinase 100%
  • Proteomics 11%
  • Replisome 5%
  • Epigenetics 5%

• Drug Discovery and Pharmacological Investigation of Novel Selective Hdac Inhibitors as Anticancer Drugs(1/3)

  Pan, S.-L. (PI)

  8/1/18 → 7/31/19

  Project: A - Government Institution › b - National Science and Technology Council

• Exploiting Acridine Scaffold to Develop Novel Anticancer Agents Based on a Dual Target Strategy

  Huang, W.-J. (PI)

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - National Science and Technology Council

  • DNA Topoisomerase 100%
  • Acridine 100%
  • Anticancer Drug 100%
  • Histone Deacetylase Inhibitor 83%
  • DNA Topoisomerase Inhibitor 66%

• Development of Anti-Α9nachr/Anti-Polyethylene Glycol Bispecific Antibody to Enhance the Therapeutic Efficacy of Nano-Drugs against Breast Cancer(II)(2/3)

  Chuang, K.-H. (PI)

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - National Science and Technology Council

• Investigating the Role of Ck1 Delta in Tumor Progression, and as a Therapeutic Target for New Drug Discovery in Bladder Cancer.

  Chen, C.-H. (PI)

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - National Science and Technology Council

  • Drug Discovery 100%
  • Bladder Cancer 100%
  • Tumor Growth 100%
  • Catenin 23%
  • Casein Kinase Idelta 7%

• Development of Novel Dyrk1a Inhibitors for the Treatment of Alzheimer'S Disease

  HuangFu, W.-C. (PI)

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - National Science and Technology Council

  • Phosphotransferase 100%
  • Diseases 100%
  • Kinase 100%
  • Protein Phosphorylation 88%
  • Alzheimer's Disease 77%

• Discovery and Design of Kinase Inhibitors for Cancer Treatment

  Hsu, K.-C. (PI)

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - National Science and Technology Council

  • Malignant Neoplasm 100%
  • Phosphotransferase Inhibitor 100%
  • Janus Kinase 45%
  • Phosphotransferase 36%
  • Drug Development 36%

• Development of the Fully Humanized Bispecific Antibody to One-Step Expand and Arm T Cells for Selective Tumor Therapy(3/3)

  Chuang, K.-H. (PI)

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - National Science and Technology Council

  • Arm 100%
  • Bispecific Antibody 100%
  • T Cell 100%
  • CD3 Antigen 63%
  • Colon 15%

• Pharmacological Investigations of Phenylethanoid Glycosides in Blue Light and N-Retinylidene-N-Retinylethanolamine Induced Retinal Degeneration and Their Protective Effects in Retinopathy

  Cheng, Y.-W. (PI)

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - National Science and Technology Council

• Development and Characterization of Zein-Sodium Caseinate Nanoparticles-Hydrogel Composite for Localized and Sustained Sirna Delivery(3/3)

  Hsieh, C.-M. (PI)

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - National Science and Technology Council

  • Zein 100%
  • Nanoparticle 100%
  • Sodium 100%
  • Hydrogel 100%
  • Composite Material 100%

• Application of High-Throughput Sequencing Approaches in Immunogenomic Research : Diversity and Clonal Selection in the Human T-Cell Repertoire for Colonrectal Cancers(3/4)

  Chang, W.-C. (PI)

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - National Science and Technology Council

• To Study the Role of Sp1 in Cancer Drug Resistance(3/3)

  Chuang, J.-Y. (PI)

  8/1/18 → 10/1/19

  Project: A - Government Institution › b - National Science and Technology Council

• 新聘教師研究補助

  Hsieh, C.-M. (PI)

  1/1/18 → 12/31/18

  Project: B - Project of TMU › g - Research Grants for Newly Hired Faculty

• 選擇性抗癌標靶藥物HDAC6抑制劑臨床前試驗研究

  Pan, S.-L. (PI)

  12/1/17 → 10/31/18

  Project: A - Government Institution › b - National Science and Technology Council

• Application of High-Throughput Sequencing Approaches in Immunogenomic Research : Diversity and Clonal Selection in the Human T-Cell Repertoire for Colonrectal Cancers

  Chang, W.-C. (PI)

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - National Science and Technology Council

  • Clonal Selection 100%
  • Immune Repertoire 100%
  • High Throughput Sequencing 100%
  • T Cell 100%
  • T Cell Receptor 75%

• Integrated Bioinformatics Approaches to Study the Mechanisms and Discover Drugs of Hcv-Induced Type 2 Diabetes Mellitus( I )

  Hsu, K.-C. (PI)

  8/1/17 → 7/1/18

  Project: A - Government Institution › b - National Science and Technology Council

• The Use of Organometallic Reaction in the Syntheses of Anticancer Agents.( I )

  Liou, J.-P. (PI)

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - National Science and Technology Council

  • Carboxamide 100%
  • Organometallic Reaction 100%
  • Uracil 50%
  • Organometal 50%
  • new drug 50%

• Pharmacological Investigations and the Study of the Potential Biological Effects of Nitric Oxide Releasing Nano-Carrier System in Blue Light Induced Retinopathy( I )

  Cheng, Y.-W. (PI)

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - National Science and Technology Council

• Development and Characterization of Zein-Sodium Caseinate Nanoparticles-Hydrogel Composite for Localized and Sustained Sirna Delivery

  Hsieh, C.-M. (PI)

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - National Science and Technology Council

  • Composite Material 100%
  • Zein 100%
  • Nanoparticle 100%
  • Sodium 100%
  • Hydrogel 100%

• Tlk Function and Regulation in Chromatin Replication

  Lee, S.-B. (PI)

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - National Science and Technology Council

  • Histone 100%
  • DNA Synthesis 100%
  • Micrococcal Nuclease 50%
  • Copurification 50%
  • Chromosome Instability 50%

• Pharmacological Investigations of Phenylethanoid Glycosides in Blue Light and N-Retinylidene-N-Retinylethanolamine Induced Retinal Degeneration and Their Protective Effects in Retinopathy

  Cheng, Y.-W. (PI)

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - National Science and Technology Council

• 以小分子化合物開發新穎且具選擇性塗藥用於血管支架(先期補助)

  Huang, W.-J. (PI)

  8/1/17 → 7/31/18

  Project: A - Government Institution › f - Other (Funded by Government)

• To Study the Role of Sp1 in Cancer Drug Resistance( II )

  Chuang, J.-Y. (PI)

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - National Science and Technology Council

• Antitumor Activity and Pharmacological Mechanisms of Pik3c3 Inhibitor in Bladder Cancer Cells

  Chen, C.-H. (PI)

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - National Science and Technology Council

  • Bladder Cancer 100%
  • Cancer Cell 100%
  • Antineoplastic Activity 100%
  • Autophagy 100%
  • Antitumor Activity 100%

• Exploiting Acridine Scaffold to Develop Novel Anticancer Agents Based on a Dual Target Strategy

  Huang, W.-J. (PI)

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - National Science and Technology Council

  • DNA Topoisomerase 100%
  • Acridine 100%
  • Anticancer Drug 100%
  • Histone Deacetylase Inhibitor 83%
  • DNA Topoisomerase Inhibitor 66%

• Drug Discovery and Pharmacological Investigation of Selective Hdac1 and 2 Inhibitors as Novel Anticancer Drugs

  Pan, S.-L. (PI)

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - National Science and Technology Council

  • Drug Discovery 100%
  • Colorectal Carcinoma 100%
  • Anticancer Drug 100%
  • Histone Deacetylase 1 85%
  • Histone Deacetylase 2 57%

• 臨床藥物基因體科技在血管支架再阻塞的預測及藥物開發之應用(先期補助)

  Chang, W.-C. (PI)

  8/1/17 → 7/31/18

  Project: A - Government Institution › f - Other (Funded by Government)

• Mechanism of Anticancer Activity of Dihydroartemisinin Derivatives for Colorectal Cancer Treatment

  Chen, M.-C. (PI)

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - National Science and Technology Council

  • Dihydroartemisinin 100%
  • Dihydroartemisinin Derivative 100%
  • Colorectal Carcinoma 100%
  • Artemisinin 66%
  • Antitumor Activity 22%

• Discovery of Selective Inhibitors for Oncoprotein Kinases

  Hsu, K.-C. (PI)

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - National Science and Technology Council

  • Oncoprotein 100%
  • Protein Kinases 100%
  • Malignant Neoplasm 50%
  • Diseases 30%
  • Abdominal Cancer 20%

• Development of the Fully Humanized Bispecific Antibody to One-Step Expand and Arm T Cells for Selective Tumor Therapy

  Chuang, K.-H. (PI)

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - National Science and Technology Council

  • Arm 100%
  • Bispecific Antibody 100%
  • T Cell 100%
  • CD3 Antigen 63%
  • Colon 15%

• Development of Anti-Α9nachr/Anti-Polyethylene Glycol Bispecific Antibody to Enhance the Therapeutic Efficacy of Nano-Drugs against Breast Cancer( I )

  Chuang, K.-H. (PI)

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - National Science and Technology Council

• Roles of Hdac6-Mediated Sp1 Deacetylation in the Evolution of Acquired Temozolomide Resistance in Glioblastoma

  Chuang, J.-Y. (PI)

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - National Science and Technology Council

  • Temozolomide 100%
  • Deacetylation 100%
  • Glioblastoma 100%
  • Histone Deacetylase 100%
  • Histone Deacetylase 6 90%

• 療藥物與植物性醣蛋白暨代謝酵素雙效抑制劑之自組裝型奈米膠體圓粒劑型及胃滯留劑型的處方設計與適宜化暨其組合處方的口服投與之藥物動力暨藥效學試驗(先期補助)

  Hsieh, C.-M. (PI)

  8/1/17 → 7/31/18

  Project: A - Government Institution › f - Other (Funded by Government)

• 表現膜抗體報告基因於第一型糖尿病鼠之胰島細胞以非侵犯性造影自體免疫型糖尿病之病程

  Chuang, K.-H. (PI)

  7/1/17 → 2/28/18

  Project: A - Government Institution › b - National Science and Technology Council

• Syntheses of Anti-Lung Cancer Agents(1/2)

  Liou, J.-P. (PI)

  6/1/17 → 5/31/18

  Project: A - Government Institution › b - National Science and Technology Council

  • Carcinogen 100%
  • Lung Cancer 100%
  • Crizotinib 50%
  • Malignant Neoplasm 25%
  • Anaplastic Lymphoma Kinase Inhibitor 25%

• Two Populations-Based Pharmacogenomics Investigation in Osteoporosis Susceptibility and Raloxifene Treatment Efficacy – across Taiwanese and Japanese

  Chang, W.-C. (PI)

  4/1/17 → 3/31/18

  Project: A - Government Institution › b - National Science and Technology Council

  • Raloxifene 100%
  • Genome-Wide Association Study 100%
  • Bone Density 100%
  • Pharmacogenomics 100%
  • Genetics 66%

• 研究辛二醯基苯胺羥胺酸提升神經保護因子Znf179表達的作用

  Chuang, J.-Y. (PI)

  4/1/17 → 3/31/18

  Project: C - Project of Alliance › n - Yuan's General Hospital