TMU Research Center of Cell Therapy and Regeneration Medicine

Projects

Projects per year 2010 2013 2014 2015 2016 2017 2018 2023

• 1 Active
• 452 Finished

Projects per year

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• Finished

  Radiogenomics of Malignant Gliomas by Linking Physiological Mr Imaging, Histopathological Patterns, and Genetic Alternations: a Translational Study from Rat to Man

  Chen, C., Tsai, P., Liu, H., Lin, Y. & Chiang, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Glioblastoma 100%
  • Glioma 51%
  • Biomarkers 36%
  • Multiparametric Magnetic Resonance Imaging 15%
  • Neoplasms 14%

• Role of Organic Anion Transporter in Renal Tubular Injury---A Gateway to Hurt

  Wu, M.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Chronic Renal Insufficiency 100%
  • Organic Anion Transporters 52%
  • Kidney 45%
  • Single Nucleotide Polymorphism 40%
  • Messenger RNA 27%

• Developing Theronostic Nanoparticles as CT Contrast Agent and Chemodrug Carrier for Lung Cancer Application via Inhalation Delivery

  Tseng, C.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Lung Neoplasms 100%
  • Nanoparticles 96%
  • Iohexol 75%
  • Inhalation 67%
  • Tomography 61%

• The Protective Effect of PLZF Nuclear Translocation against Advanced Glycation End Product-Induced Endothelial Injury in Diabetes and Its Molecular Mechanism

  Chen, C. & Hsu, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Promyelocytic Leukemia Zinc Finger Protein 100%
  • Protein Transport 32%
  • Human Umbilical Vein Endothelial Cells 27%
  • Advanced Glycation End Products 26%
  • Autophagy 17%

• The Role of Amyloid-Beta in the Late-Onset Post-Stroke Vascular Cognitive Impairment (I)

  Hu, C., Wu, C., Chiou, H. & Chi, N.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Cognitive Dysfunction 100%
  • Blood Vessels 79%
  • Amyloid 57%
  • Stroke 46%
  • Dementia 45%

• Dementia Care and Quality Improvement

  Chien, L., Chiou, H., Chi, N. & Hu, C.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • dementia 100%
  • health insurance 28%
  • Medical records 19%
  • utilization 17%
  • resources 9%

• To See Is to Believe- Visualization of the Spectrum on Chronic Kidney Disease (II)

  Jian, W., Li, Y. & Wu, M.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Health care 100%
  • Data visualization 75%
  • Patient treatment 50%
  • Disease control 49%
  • Health insurance 49%

• Effects of Uteroplacental Insufficiency and Hyperoxia on Lung Development and Epigenetic Alterations in the Rat Offspring

  Chen, C. & Lin, C.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Fetal Growth Retardation 100%
  • Hyperoxia 99%
  • Receptor for Advanced Glycation End Products 74%
  • Epigenomics 69%
  • Lung 48%

• Study of Nano-Size Memberane Tube for Tendon to Bone in Anterior Cruciate Ligament Reconstruction

  Chen, C. & Lee, C.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • tendons 100%
  • anterior cruciate ligament 79%
  • periosteum 55%
  • polyhydroxyalkanoates 53%
  • bones 46%

• To Investigate the Mode of Galectin-1 and Neuropilin-1 Interactions in Carcinoma-Associated Fibroblasts and Its Implications in Oral Cancer Therapy

  Wu, M.

  8/1/15 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Neuropilins 100%
  • Fibroblasts 91%
  • Polysaccharides 77%
  • Carcinoma 72%
  • Mouth Neoplasms 22%

• The Potential Role of Glycogen Synthase Kinase-3 in Dengue Virus-Infected Mononuclear Phagocytes

  Lin, C.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Glycogen Synthase Kinase 3 100%
  • Dengue Virus 93%
  • Virus Diseases 47%
  • Interleukin-10 35%
  • Cellular Immunity 28%

• Study on the Mechanism Involved in Nanoparticles-Induced Tight Junction and Aquaporins Damages in Endothelial Cells, as Well as the Effects on Physiological Function of Endothelial Barriers

  Li, C. & Cheng, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Nanoparticles 100%
  • Blood-Brain Barrier 69%
  • Aquaporins 65%
  • Tight Junction Proteins 39%
  • Permeability 35%

• 發展國際級之「全方位復健研究中心」(第二年)

  Chen, S.

  8/1/15 → 7/31/16

  Project: B - Project of TMU › i - Other (Funded by TMU)

• The Sumoylation of Histone Deacetylase 2 Contributes to CTGF Expression and Pulmonary Fibrosis in Chronic Obstructive Asthma (III)

  Lin, C.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• Whole Organ Decellularizationtrachea Scaffold Tissue Engineering for Whole Segment Tracheal Transplantation/Replacement

  Hung, S., Lee, F. & Tseng, H.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • trachea (vertebrates) 100%
  • cartilage 77%
  • sonication 70%
  • tissues 27%
  • skeleton 25%

• To Investigate the Functions of Shikonin and Its Derivatives in Applied Age-Related Macular Degeneration and Wound Healining

  Cheng, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • shikonin 100%
  • macular degeneration 20%
  • angiogenesis 17%
  • animal injuries 15%
  • tissue repair 15%

• The Study of Therapeutic Effects for Stroke with Phenserine, an Amyloid Precursor Protein Inhibitor, in Rodent Focal Cerebral Ischemia Model

  Chang, C. & Chiang, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • phenserine 100%
  • Stroke 75%
  • Amyloid beta-Protein Precursor 49%
  • Stem Cells 31%
  • pifithrin 27%

• Role of HBX and IL-6 in Regulating SENP1/Stemness Properties of HBV-Related HCC under Hypoxia and Its Clinical Implication

  Huang, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Interleukin-6 100%
  • Hepatocellular Carcinoma 94%
  • Hypoxia 55%
  • Drug Resistance 32%
  • Neoplasms 30%

• Characterization of Thalamocortical Dysrhythmia in Mild Traumatic Brain Injury Using Simultaneous Mri and Eeg Measurements and Pre-Clinical N-Acetylcysteine Treatment Response

  Chen, C., Liu, H., Tseng, S., Lane, T. J., Lu, C., Chiang, Y. & Tsai, P.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Acetylcysteine 44%
  • Post-Concussion Syndrome 17%
  • Neuroimaging 15%
  • Electroencephalography 14%
  • Atrophy 9%

• 幹細胞基礎研究與前臨床動物試驗

  Huang, Y.

  8/1/15 → 7/31/16

  Project: B - Project of TMU › i - Other (Funded by TMU)

• Functional Role of Growth Factor-Induced Metabolic Enzymes Expression in Cancer Cell Anti-Oxidation and Drug Resistance

  Chang, W.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Epidermal Growth Factor 100%
  • Enzymes 83%
  • Neoplasms 82%
  • Drug Resistance 46%
  • Carcinogenesis 39%

• Fabrication of Endometrial Cell Sheet for Fertility Resumption by a Transgenic Mouse Model

  Tseng, H.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • endometrium 100%
  • bioluminescence 37%
  • tissues 26%
  • myometrium 25%
  • genetically modified organisms 22%

• A Mind-Body Approach to Study Irritable Bowel Syndrome: Role of Psychological Distress, Effectiveness and Mechanisms of Mindfulness Training(1/3)

  Tsai, P., Chang, C. & Chen, C.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Mindfulness 100%
  • Depression 82%
  • Anxiety 79%
  • Self-Help Groups 49%
  • Urbanization 35%

• 肺部炎症暨纖維化之轉譯研究

  Lin, C.

  8/1/15 → 7/31/16

  Project: B - Project of TMU › i - Other (Funded by TMU)

• Platelets and Platelet-Derived Microparticles for Trojan Horse Cancer Therapy (THCt)

  Burnouf, T. P. R.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • doxorubicin 100%
  • microparticles 83%
  • cancer therapy 31%
  • drug carriers 16%
  • neoplasms 16%

• TMU103-AE1-B31

  Feng, P.

  8/1/15 → 7/31/16

  Project: B - Project of TMU › i - Other (Funded by TMU)

• Dissected the Role of Glucose-Regulated Protein 94 (GRP94),The Clinically Therapeutic Implication and Drug Development in Colon Cancer

  Wei, P. & Chang, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • glucose-regulated proteins 100%
  • Colonic Neoplasms 43%
  • Colorectal Neoplasms 38%
  • Neoplasms 23%
  • Neoplasm Metastasis 19%

• The Role of Neuropilin-1 Glycosylation in Galectin-1 Induced Activation of Hepatic Stellate Cells and Liver Fibrosis

  Wu, M. & Yang, W.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Galectin 1 100%
  • Neuropilin-1 68%
  • Liver Cirrhosis 28%
  • Platelet-Derived Growth Factor Receptors 24%
  • thiodigalactoside 12%

• Anti-Aging Effect with the Associated Mechanism by PRP (Platelet-Rich Plasma) in Cartilage---A Fibronectin Fragment Model

  Lee, C.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • fibronectins 100%
  • cartilage 63%
  • Toll-like receptor 2 58%
  • osteoarthritis 50%
  • chondrocytes 42%

• The Effect and Mechanisms of Chemotherapy in Recruit Inflammatory Cells into Tumor Microenvironment of Lung Cancer Patients

  Feng, P. & Lee, K.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Myeloid-Derived Suppressor Cells 100%
  • Neoplasms 26%
  • Tumor Microenvironment 25%
  • Lung Neoplasms 19%
  • Drug Therapy 19%

• The Neuroprotection Effect and Mechanism of Long Non-Coding RNA MALAT1 in Acute Ischemic Stroke

  Chi, N. & Hu, C.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Stroke 100%
  • Long Noncoding RNA 67%
  • Ischemia 47%
  • Untranslated RNA 47%
  • Cell Line 24%

• Application of Magnetic Cryopreservation Technique for the Development of Drug-Containing Silk Fibroin Scaffolds in DPSC-Based Cartilage Repair of Knee Osteoarthritis

  Lee, S.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • fibroins 100%
  • cartilage 81%
  • osteoarthritis 81%
  • stem cells 58%
  • chondrogenesis 56%

• Application of Scaffold in Ovarian Transplantation for Female Fertility Preservation: an in vivo Transgenic Mouse Model (II)

  Chen, C., Tzeng, C. & Tseng, H.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • sphingosine 100%
  • vascular endothelial growth factors 67%
  • phosphates 52%
  • female fertility 30%
  • autografting 18%

• Subproject 2---Establishment of a General Multi-Input Multi-Output Platform for Assistive Technology Followed by Developing Individual-Specific Systems: for the Quadriplegic (Themes: E1)

  Chen, S., Peng, C., Pan, L., Jian, W. & Liou, T.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Education 100%
  • Demonstrations 96%
  • Set theory 75%
  • Feedback 74%
  • Industry 51%

• Development of a Computerized Adaptive Testing of the Health Literacy in Stroke Rehabilitation.

  Hou, W. & Chen, S.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Health Literacy 100%
  • Stroke Rehabilitation 86%
  • Psychometrics 23%
  • Stroke 21%
  • Rehabilitation 19%

• Neuroprotective Effects of Sig-1R-Znf179-Sp1 Pathway on Brain Injury

  Chang, W. & Chuang, J.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • sigma-1 receptor 100%
  • Traumatic Brain Injury 50%
  • Hydrogen Peroxide 31%
  • Neuroprotective Agents 19%
  • Wounds and Injuries 12%

• Development of Cortical Electrical Stimulation Technique for Improving Neuroplasticity and Motor Function in Parkinsonian Rats

  Hsieh, T., Chiang, Y. & Peng, C.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• Application of Wearable Wireless Pulse Positioning System to Predict the Prognosis and to Avoid Sudden Death of Dialysis Patients

  Kao, W., Wu, M., Chen, R. & Chen, H.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Dialysis 100%
  • Particle accelerators 6%

• Short-Chain Fatty Acids Act as Anti-Allergic Regulators on Immune Effector Cells and Exert Immune-Modulatory Effects on Ovalbumin-Induced Allergic Diseases in Mice

  Lee, Y. & Hsiao, G.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Volatile Fatty Acids 100%
  • Phenylbutyrates 27%
  • Mast Cells 25%
  • Immunoglobulin E 19%
  • Asthma 16%

• Roles of calcium channel in ER(先期補助)

  Wu, M.

  8/1/15 → 7/31/16

  Project: B - Project of TMU › i - Other (Funded by TMU)

• HMGA2, a New Target of Thyroid Hormone-Induced Progression in Colorectal Cancers

  Lin, H., Chang, T. & Yen, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • AT-Hook Motifs 100%
  • Thyroid Hormones 75%
  • tetraiodothyroacetic acid 70%
  • Colorectal Neoplasms 43%
  • Catenins 31%

• The Investigation of Anti-Neuroinflammatory Mechanisms of Differential Histone Deacetylase Regulators and Their Therapeutic Profiles in Experimental Intracerebral Haemorrahge and Encephalitis

  Hsiao, G.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Encephalitis 100%
  • Monocytes 77%
  • Acetylation 73%
  • Microglia 71%
  • Psychological Inhibition 57%

• Neural and Glutamatergic Correlates of Resting State Activity and Stimulus-Induced Activity in Major Depressive Disorder---Can Multimodal Imaging (fMRI and MRS) Reveal Therapeutic Predictors?

  Chen, C., Lane, T. J., Hu, C., Tseng, Y. & Lee, H.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Major Depressive Disorder 100%
  • Magnetic Resonance Spectroscopy 53%
  • Magnetic Resonance Imaging 42%
  • Multimodal Imaging 42%
  • Gyrus Cinguli 33%

• The Role of Inflammatory Gene Polymorphisms on Risk of Post-Stroke Vascular Dementia (I)

  Chiou, H., Chi, N., Lin, H., Wu, C., Hsieh, F., Hu, C. & Hsieh, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Stroke 93%
  • Cognitive Dysfunction 89%
  • Blood Vessels 52%
  • Inflammation 36%
  • Whole Exome Sequencing 16%

• To Identify Whether Ion Conductance Dysfunction Is an Early Electrophsiological Biomarker of Polyneuropathy in Diabetic Patients: a Longitudinal Study of Nerve Excitability in Diabetic Patients

  Sung, J. & Hu, C.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Neural Conduction 100%
  • Diabetic Neuropathies 69%
  • Ions 24%
  • Biomarkers 19%
  • Polyneuropathies 17%

• Antibody-Mediated Immune Suppression of Fetal and Neonatal Alloimmune Thrombocytopenia ( FNAIT)

  Burnouf, T. P. R.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • thrombocytopenia 100%
  • immunoglobulin G 34%
  • antigens 26%
  • antibodies 23%
  • hemorrhage 14%

• 發展包覆兒茶多酚的奈米藥物於異位性皮膚炎治療應用研究

  Tseng, C.

  6/1/15 → 5/31/16

  Project: C - Project of Alliance › p - Taipei Medical University Hospital

• 評估以血小板釋放物擴增培養細胞於再生醫學之應用

  Burnouf, T. P. R.

  6/1/15 → 5/31/16

  Project: C - Project of Alliance › p - Taipei Medical University Hospital

• 探討缺氧環境中透過Hif-2α支配的Igf-1r—Cxcr4訊號迴路調控小鼠生殖系幹細胞爬行作用機制

  Huang, Y.

  6/1/15 → 5/31/16

  Project: C - Project of Alliance › p - Taipei Medical University Hospital

• 子宮胎盤機能不全及出生後高氧暴露對新生幼鼠肺臟發育的影響

  Chen, C.

  5/1/15 → 4/30/16

  Project: C - Project of Alliance › t - Taipei Municipal Wanfang Hospital