TMU Research Center of Cancer Translational Medicine

2024

An ensemble machine learning model generates a focused screening library for the identification of CDK8 inhibitors

Lin, T. E., Yen, D., HuangFu, W. C., Wu, Y. W., Hsu, J. Y., Yen, S. C., Sung, T. Y., Hsieh, J. H., Pan, S. L., Yang, C. R., Huang, W. J. & Hsu, K. C., Jun 2024, In: Protein Science. 33, 6, e5007.

Research output: Contribution to journal › Article › peer-review

Open Access

A new potential therapeutic approach for ALS: A case report with NGS analysis

Hu, C. J., Chen, P. C., Padmanabhan, N., Zahn, A., Ho, C. M., Wang, K. & Yen, Y., Mar 1 2024, In: Medicine (United States). 103, 9, p. E37401

Research output: Contribution to journal › Article › peer-review

Open Access

An Infant-Type Hemispheric Glioma With SOX5::ALK: A Novel Fusion

Tsai, C. C., Huang, M. H., Fang, C. L., Hsieh, K. L. C., Hsieh, T. H., Ho, W. L., Chang, H., Tsai, M. L., Kao, Y. C., Miser, J. S., Su, M. Y., Wong, T. T. & Liu, Y. L., Feb 2024, In: JNCCN Journal of the National Comprehensive Cancer Network. 22, 1

Research output: Contribution to journal › Article › peer-review

Open Access

An investigation into the cognitive flexibility of undergraduate dental hygiene students at two dental schools in Asia

Liao, S. R., Seki, N., Foxton, R., Sireerat, K., Akiyama, M., Kanamori, Y., Moross, J., Shinada, K., Chen, S. L. S. & Morio, I., 2024, (Accepted/In press) In: Journal of Dental Sciences.

Research output: Contribution to journal › Article › peer-review

Open Access

A novel HDAC8 inhibitor H7E exerts retinoprotective effects against glaucomatous injury via ameliorating aberrant Müller glia activation and oxidative stress

Wu, L. H., Cheng, Y. W., Lin, F. L., Hsu, K. C., Wang, M. H., Yen, J. L., Wang, T. J., Lin, T. E., Liu, Y. C., Huang, W. J. & Hsiao, G., May 2024, In: Biomedicine and Pharmacotherapy. 174, 116538.

Research output: Contribution to journal › Article › peer-review

Open Access

A prospective reappraisal of motor outcome prediction in patients with acute stroke by using atlas-based diffusion tensor imaging biomarkers

Chen, Y.-C., Cheng, S.-J., Hsieh, L.-C., Shyu, H.-Y., Chen, M.-H., Chen, C.-Y. & Kuo, D.-P., Mar 2024, In: Topics in Stroke Rehabilitation. 31, 2, p. 199-210 12 p.

Research output: Contribution to journal › Article › peer-review

ASPM stabilizes the NOTCH intracellular domain 1 and promotes oncogenesis by blocking FBXW7 binding in hepatocellular carcinoma cells

Chan, T. S., Cheng, L. H., Hsu, C. C., Yang, P. M., Liao, T. Y., Hsieh, H. Y., Lin, P. C., HuangFu, W. C., Chuu, C. P. & Tsai, K. K., 2024, (Accepted/In press) In: Molecular Oncology. 18, 3, p. 562-579 18 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Atrophy of the cholinergic regions advances from early to late mild cognitive impairment

Lai, Y. L. L., Hsu, F. T., Yeh, S. Y., Kuo, Y. T., Lin, H. H., Lin, Y. C., Kuo, L. W., Chen, C. Y. & Liu, H. S., 2024, (Accepted/In press) In: Neuroradiology. 66, 4, p. 543-556 14 p.

Research output: Contribution to journal › Article › peer-review

A tumor on a chip for studying immune-cell infiltration into tumor under chemo/immunotherapy treatments

Chen, Y. C., Lee, K. Y., Liao, H. J., Sun, W. L., Huang, W. C., Wang, Y. S., Chang, W. C. & Liu, C. H., May 1 2024, In: Sensors and Actuators B: Chemical. 406, 135409.

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Beneficial carry-over effects of chronic at-home genital nerve stimulation on incontinence in individuals with spinal cord injury: A pragmatic trial

Yeh, S. D., Khasanah, N., Gustafson, K. J., Sun, C., Tsai, M. L., Lin, B. S., Wu, C. W. & Peng, C. W., Mar 2024, In: Annals of Physical and Rehabilitation Medicine. 67, 2, 101799.

Research output: Contribution to journal › Article › peer-review

CCN1 Is a Therapeutic Target for Reperfused Ischemic Brain Injury

Lee, G. A., Chang, Y. W., Lai, J. H., Chang, T. H., Huang, S. W., Yang, C., Shen, T. A., Lin, W. L., Wu, Y. C., Tseng, L. W., Tseng, S. H., Chen, Y. C., Chiang, Y. H. & Chen, C. Y., 2024, (Accepted/In press) In: Translational Stroke Research.

Research output: Contribution to journal › Article › peer-review

Characterization of the genetic variation and evolutionary divergence of the CLEC18 family

Chang, C. M., Chang, W. C. & Hsieh, S., Dec 2024, In: Journal of Biomedical Science. 31, 1, 53.

Research output: Contribution to journal › Article › peer-review

Open Access

CXCR7 activation evokes the anti-PD-L1 antibody against glioblastoma by remodeling CXCL12-mediated immunity

Liu, C. C., Yang, W. B., Chien, C. H., Wu, C. L., Chuang, J. Y., Chen, P. Y., Chu, J. M., Cheng, S. M., Qiu, L. Y., Chang, Y. C., Hwang, D. Y., Huang, C. Y., Lee, J. S. & Chang, K. Y., Jun 2024, In: Cell Death and Disease. 15, 6, 434.

Research output: Contribution to journal › Article › peer-review

Open Access

Cyclic increase in the ADAMTS1-L1CAM-EGFR axis promotes the EMT and cervical lymph node metastasis of oral squamous cell carcinoma

Chien, M. H., Yang, Y. C., Ho, K. H., Ding, Y. F., Chen, L. H., Chiu, W. K., Chen, J. Q., Tung, M. C., Hsiao, M. & Lee, W. J., Jan 2024, In: Cell Death and Disease. 15, 1, 82.

Research output: Contribution to journal › Article › peer-review

Open Access

Discovery of a mu-opioid receptor modulator that in combination with morphinan antagonists induces analgesia

Huang, Y. H., Lin, S. Y., Ou, L. C., Huang, W. C., Chao, P. K., Chang, Y. C., Chang, H. F., Lee, P. T., Yeh, T. K., Kuo, Y. H., Tien, Y. W., Xi, J. H., Tao, P. L., Chen, P. Y., Chuang, J. Y., Shih, C., Chen, C. T., Tung, C. W., Loh, H. H. & Ueng, S. H. & 1 others, Yeh, S. H., 2024, (Accepted/In press) In: Cell Chemical Biology.

Research output: Contribution to journal › Article › peer-review

Dual inhibition of CYP17A1 and HDAC6 by abiraterone-installed hydroxamic acid overcomes temozolomide resistance in glioblastoma through inducing DNA damage and oxidative stress

Sharma, R., Chiang, Y. H., Chen, H. C., Lin, H. Y., Yang, W. B., Nepali, K., Lai, M. J., Chen, K. Y., Liou, J. P. & Hsu, T. I., Apr 1 2024, In: Cancer Letters. 586, 216666.

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Dynamics of T-cell receptor repertoire in patients with ankylosing spondylitis after biologic therapy

Liu, W. C., Chang, C. M., Zhang, Y., Liao, H. T. & Chang, W. C., Jan 25 2024, In: International Immunopharmacology. 127, 111342.

Research output: Contribution to journal › Article › peer-review

Effect of Sulfotyrosine and Negatively Charged Amino Acid of Leech-Derived Peptides on Binding and Inhibitory Activity Against Thrombin

Chen, T.-Y., Shyur, E., Ma, T.-H., Wijeyewickrema, L., Lin, S.-W., Kao, M.-R., Liang, P.-H., Shie, J.-J., Chuang, E.-Y., Liou, J.-P. & Hsieh, Y. S., Feb 1 2024, In: ChemBioChem. 25, 3, p. e202300744 e202300744.

Research output: Contribution to journal › Article › peer-review

Open Access

Enhancement of Tumorigenicity, Spheroid Niche, and Drug Resistance of Pancreatic Cancer Cells in Three-Dimensional Culture System

Hung, H. C., Mao, T. L., Fan, M. H., Huang, G. Z., Minhalina, A. P., Chen, C. L. & Liu, C. L., 2024, In: Journal of Cancer. 15, 8, p. 2292-2305 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Enhancing anti-cancer capacity: Novel class I/II HDAC inhibitors modulate EMT, cell cycle, and apoptosis pathways

Lee, H. Y., Hsu, M. J., Chang, H. H., Chang, W. C., Huang, W. C. & Cho, E. C., Jul 15 2024, In: Bioorganic and Medicinal Chemistry. 109, 117792.

Research output: Contribution to journal › Article › peer-review

Epidermal growth factor potentiates EGFR(Y992/1173)-mediated therapeutic response of triple negative breast cancer cells to cold atmospheric plasma-activated medium

Wang, P., Zhou, R., Zhou, R., Feng, S., Zhao, L., Li, W., Lin, J., Rajapakse, A., Lee, C. H., Furnari, F. B., Burgess, A. W., Gunter, J. H., Liu, G., Ostrikov, K., Richard, D. J., Simpson, F., Dai, X. & Thompson, E. W., Feb 2024, In: Redox Biology. 69, 102976.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Citations (Scopus)

Estimating the volume of penumbra in rodents using DTI and stack-based ensemble machine learning framework

Kuo, D. P., Chen, Y. C., Li, Y. T., Cheng, S. J., Hsieh, K. L. C., Kuo, P. C., Ou, C. Y. & Chen, C. Y., Dec 2024, In: European radiology experimental. 8, 1, 59.

Research output: Contribution to journal › Article › peer-review

Open Access

Exploring neuron-specific steroid synthesis and DHEAS therapy in Alzheimer's disease

Lin, H. Y., Feng, Y. H., Kao, T. J., Chen, H. C., Chen, G. Y., Ko, C. Y. & Hsu, T. I., Oct 2024, In: Journal of Steroid Biochemistry and Molecular Biology. 243, 106585.

Research output: Contribution to journal › Article › peer-review

Exploring the biphasic dose-response effects of photobiomodulation on the viability, migration, and extracellular vesicle secretion of human adipose mesenchymal stem cells

Chang, C. Y., Aviña, A. E., Chang, C. J., Lu, L. S., Chong, Y. Y., Ho, T. Y. & Yang, T. S., Jul 2024, In: Journal of Photochemistry and Photobiology B: Biology. 256, 112940.

Research output: Contribution to journal › Article › peer-review

Galectin-3 contributes to pathogenesis of IgA nephropathy

Chou, Y. L., Chen, H. L., Hsu, B. G., Yang, C. Y., Chen, C. H., Lee, Y. C., Tsai, I. L., Sung, C. C., Wu, C. C., Yang, S. R., Suzuki, Y., Yates, E., Hua, K. F., Yu, L. G., Liu, F. T., Chen, A. & Ka, S. M., 2024, (Accepted/In press) In: Kidney International.

Research output: Contribution to journal › Article › peer-review

Gene set correlation enrichment analysis for interpreting and annotating gene expression profiles

Chang, L. Y., Lee, M. Z., Wu, Y., Lee, W. K., Ma, C. L., Chang, J. M., Chen, C. W., Huang, T. C., Lee, C. H., Lee, J. C., Tseng, Y. Y. & Lin, C. Y., Feb 9 2024, In: Nucleic Acids Research. 52, 3, p. E17

Research output: Contribution to journal › Article › peer-review

Open Access

1 Citation (Scopus)

Hinokitiol Inhibits Breast Cancer Cells In Vitro Stemness-Progression and Self-Renewal with Apoptosis and Autophagy Modulation via the CD44/Nanog/SOX2/Oct4 Pathway

Chiang, Y. F., Huang, K. C., Chen, H. Y., Hamdy, N. M., Huang, T. C., Chang, H. Y., Shieh, T. M., Huang, Y. J. & Hsia, S. M., Apr 2024, In: International journal of molecular sciences. 25, 7, 3904.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Citation (Scopus)

Hypoxia-induced long non-coding RNA HIF1A‑AS2 regulates stability of MHC class I protein in head and neck cancer

Liao, T.-T., Chen, Y.-H., Li, Z.-Y., Hsiao, A.-C., Huang, Y.-L., Hao, R.-X., Tai, S.-K., Chu, P.-Y., Shih, J.-W., Kung, H.-J. & Yang, M.-H., Jun 26 2024, (E-pub ahead of print) In: Cancer immunology research.

Research output: Contribution to journal › Article › peer-review

Identification of selective dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors and their effects on tau and microtubule

Wu, Y. W., HuangFu, W. C., Lin, T. E., Peng, C. H., Tu, H. J., Sung, T. Y., Sung, T. Y., Yen, S. C., Pan, S. L. & Hsu, K. C., Feb 2024, In: International Journal of Biological Macromolecules. 259, 129074.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Citation (Scopus)

Immunosuppressive role of BDNF in therapy-induced neuroendocrine prostate cancer

Liu, Y. N., Chen, W. Y., Liu, M. K., Yeh, H. L., Chen, W. H., Jiang, K. C., Li, H. R., Chen, Z. Q., Wang, W. H., Abou-Kheir, W. & Wen, Y. C., 2024, (Accepted/In press) In: Molecular Oncology. 18, 6, p. 1665-1686 22 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Citation (Scopus)

Impacts of hyperthermic chemotherapeutic agent on cytotoxicity, chemoresistance-related proteins and PD-L1 expression in human gastric cancer cells

Su, B. C., Chen, G. Y., Yang, C. M., Chuang, W. T., Lin, M. C., Hsu, P. L., Lee, C. W., Cheng, C. C., Wu, S. Y., Pan, B. S. & Yu, H. H., 2024, In: International Journal of Hyperthermia. 41, 1, 2310017.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Citations (Scopus)

Inhibition of Polyinosinic-Polycytidylic Acid-Induced Acute Pulmonary Inflammation and NF-κB Activation in Mice by a Banana Plant Extract

Liao, C. H., Lai, T. Y., Lin, Y. Y., Liao, Y. C., Lai, G. M., Chu, T. H., Wu, S. Y., Tsai, W. L., Whang-Peng, J., Liu, F., Chiou, T. J. & Yao, C. J., 2024, In: International Journal of Medical Sciences. 21, 1, p. 107-122 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

In silico identification of a novel Cdc2-like kinase 2 (CLK2) inhibitor in triple negative breast cancer

Huang, C. C., Hsu, C. M., Chao, M. W., Hsu, K. C., Lin, T. E., Yen, S. C., Tu, H. J. & Pan, S. L., Jun 2024, In: Protein Science. 33, 6, e5004.

Research output: Contribution to journal › Article › peer-review

Open Access

Intracellular domain of epithelial cell adhesion molecule induces Wnt receptor transcription to promote colorectal cancer progression

Panda, S. S., Lee, C. C., Geevimaan, K., Chen, K. C., Yang, S. H., Shen, C. N., HuangFu, W. C. & Wu, H. C., Dec 2024, In: Journal of Biomedical Science. 31, 1, 72.

Research output: Contribution to journal › Article › peer-review

Open Access

Ischemia-reperfusion injury in a salvaged penumbra: Longitudinal high-tesla perfusion magnetic resonance imaging in a rat model

Kuo, D.-P., Chen, Y.-C., Cheng, S.-J., Hsieh, K.L.-C., Ou, C.-Y., Li, Y.-T. & Chen, C.-Y., Jun 21 2024, (E-pub ahead of print) In: Magnetic Resonance Imaging.

Research output: Contribution to journal › Article › peer-review

Layer-by-layer assembly of quercetin-loaded zein/γPGA/low-molecular-weight chitosan/fucoidan nanosystem for targeting inflamed blood vessels

Lu, H. Y., Mi, F. L., Chou, C. M., Lin, C., Chen, Y. Y., Chu, C. Y., Liu, C. Y., Lee, Y. L. A., Shih, C. C. & Cheng, C. H., May 2024, In: International Journal of Biological Macromolecules. 267, 131369.

Research output: Contribution to journal › Article › peer-review

Lessons learned: establishing a CLIA-equivalent laboratory for targeted mass spectrometry assays – navigating the transition from research to clinical practice

Han, C. L., Lai, C. T., Reyes, A. J., Yang, H. C., Lu, J. Y., Shih, S. R., Chen, K. Y., Hoofnagle, A. N., Yu, S. L., Bocik, W., Hiltke, T., Chiu, H. C., Wan, C. Y., Rodriguez, H., Zhang, V. & Chen, Y. J., Dec 2024, In: Clinical Proteomics. 21, 1, 12.

Research output: Contribution to journal › Article › peer-review

Open Access

Leveraging a rationally designed veliparib-based anilide eliciting anti-leukemic effects for the design of pH-responsive polymer nanoformulation

Thakur, A., Chu, Y. H., Rao, N. V., Mathew, J., Grewal, A. S., Prabakaran, P., Guru, S., Liou, J. P., Pan, C. H. & Nepali, K., Jul 5 2024, In: European Journal of Medicinal Chemistry. 273, 116507.

Research output: Contribution to journal › Article › peer-review

LOXL1-AS1 contributes to metastasis in sonic-hedgehog medulloblastoma by promoting cancer stem-like phenotypes

Do, A. D., Wu, K. S., Chu, S. S., Giang, L. H., Lin, Y. L., Chang, C. C., Wong, T. T., Hsieh, C. L. & Sung, S. Y., Dec 2024, In: Journal of Experimental and Clinical Cancer Research. 43, 1, 130.

Research output: Contribution to journal › Article › peer-review

Open Access

MAOB expression correlates with a favourable prognosis in prostate cancer, and its genetic variants are associated with the metastasis of the disease

Huang, H. C., Hsieh, Y. H., Hsiao, C. H., Lin, C. Y., Wang, S. S., Ho, K. H., Chang, L. C., Huang, H. M., Yang, S. F. & Chien, M. H., Apr 2024, In: Journal of Cellular and Molecular Medicine. 28, 8, e18229.

Research output: Contribution to journal › Article › peer-review

Open Access

MCTP1 increases the malignancy of androgen-deprived prostate cancer cells by inducing neuroendocrine differentiation and EMT

Liu, Y. N., Chen, W. Y., Yeh, H. L., Chen, W. H., Jiang, K. C., Li, H. R., Thuy Dung, P. V., Chen, Z. Q., Lee, W. J., Hsiao, M., Huang, J. & Wen, Y. C., 2024, In: Science Signaling. 17, 840, adc9142.

Research output: Contribution to journal › Article › peer-review

Modified enhanced recovery after surgery protocol in octogenarians undergoing minimally invasive colorectal cancer surgery

Wei, P. L., Huang, Y. J., Wang, W. & Huang, Y. M., 2024, (Accepted/In press) In: Journal of the American Geriatrics Society. 72, 9, p. 2679-2689 11 p.

Research output: Contribution to journal › Article › peer-review

Morphologic and Molecular Heterogeneity of High-grade Serous Carcinoma Precursor Lesions

Chien, Y.-W., Wang, Y., Huang, P., Lawson, B. C., Kolin, D. L., Chui, M. H., Vang, R., Numan, T. A., Soong, T. R., Wang, B. G., Smith, S. A., Chen, C.-L., Stone, R., Douville, C., Wang, T.-L. & Shih, I.-M., Apr 1 2024, In: American Journal of Surgical Pathology. 48, 4, p. 475-486 12 p.

Research output: Contribution to journal › Article › peer-review

MPT0E028, a novel pan-HDAC inhibitor, prevents pulmonary fibrosis through inhibition of TGF-β-induced CTGF expression in human lung fibroblasts: Involvement of MKP-1 activation

Liu, C. H., Lee, H. S., Liou, J. P., Hua, H. S., Cheng, W. H., Yuliani, F. S., Chen, B. C. & Lin, C. H., Aug 15 2024, In: European Journal of Pharmacology. 977, 176711.

Research output: Contribution to journal › Article › peer-review

Neurocutaneous Melanosis with Meningeal Melanocytosis: A Rare Case of Intracranial Hypertension and Cutaneous Manifestations

Chen, H. C., Hsu, T. I., Chao, T. Y. & Yang, S. T., Jan 2024, In: Life. 14, 1, 139.

Research output: Contribution to journal › Article › peer-review

Open Access

New insights into three trajectories of omicron-related all-cause death reduced by COVID-19 booster vaccination

Yeh, Y. P., Lin, T. Y., Yao, Y. C., Hsu, C. Y., Yen, A. M. F., Chen, S. L. S. & Chen, T. H. H., May 2024, In: Journal of Infection and Public Health. 17, 5, p. 735-740 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Citation (Scopus)

Phenomic landscape and pharmacogenomic implications for HLA region in a Taiwan Han Chinese population

Chou, W. H., Chen, L. C., Wong, H. S. C., Chao, C. H., Chu, H. W. & Chang, W. C., Dec 2024, In: Biomarker Research. 12, 1, 46.

Research output: Contribution to journal › Article › peer-review

Open Access

Photothermal Temperature-Modulated Cancer Metastasis Harnessed Using Proteinase-Triggered Assembly of Near-Infrared II Photoacoustic/Photothermal Nanotheranostics

Chuang, Y. C., Hsia, Y., Chu, C. H., Maharajan, S., Hsu, F. C., Lee, H. L., Chiou, J. F., Ch’ang, H. J., Liao, L. D. & Lo, L. W., Aug 7 2024, In: ACS Applied Materials and Interfaces. 16, 31, p. 40611-40627 17 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Preclinical Repurposing of Sitagliptin as a Drug Candidate for Colorectal Cancer by Targeting CD24/CTNNB1/SOX4-Centered Signaling Hub

Shih, J. W., Wu, A. T. H., Mokgautsi, N., Wei, P. L. & Huang, Y. J., Jan 2024, In: International journal of molecular sciences. 25, 1, 609.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Citations (Scopus)

Progesterone modulates cell growth via integrin αvβ3-dependent pathway in progesterone receptor-negative MDA-MB-231 cells

Tsai, C. C., Yang, Y. N., Wang, K., Chen, Y. C. E., Chen, Y. F., Yang, J. C., Li, Z. L., Huang, H. M., Pedersen, J. Z., Incerpi, S., Lee, S. Y., Lin, H. Y. & Whang-Peng, J., Jul 15 2024, In: Heliyon. 10, 13, e34006.

Research output: Contribution to journal › Article › peer-review

Open Access

TMU Research Center of Cancer Translational Medicine

Research output

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