TMU Research Center of Cancer Translational Medicine

Projects

Projects per year 2010 2014 2015 2016 2017 2018 2027

• 4 Active
• 545 Finished

Projects per year

Search results

• Finished

  以整合學習模型來預測一般細胞與癌細胞之特有表面蛋白

  Chen, S.-H. (PI)

  8/1/23 → 7/31/24

  Project: A - Government Institution › b - National Science and Technology Council

• 腫瘤微環境中癌細胞與免疫因子的串擾：頭頸癌的組織蛋白酶S相關調節機制鑑定和治療策略－溶酶體半胱氨酸蛋白酶組織蛋白酶S在頭頸癌腫瘤免疫中的作用：聚焦對IL-7的調節角色和潛在的免疫調節機制(3/3)

  Chang, J.-Y. (PI)

  8/1/23 → 7/31/24

  Project: A - Government Institution › b - National Science and Technology Council

• 利用多樣化CRISPR衍生技術來探討及標靶STING1基因以克服令癌莎之抗藥性(1/3)

  Chu, C.-Y. (PI)

  7/1/23 → 6/30/24

  Project: A - Government Institution › b - National Science and Technology Council

• 112年高教深耕-癌症轉譯研究中心計畫

  Chang, J.-Y. (PI)

  1/1/23 → 12/31/23

  Project: B - Project of TMU › h - Higher Education Sprout Project

• 新聘教師研究補助

  Chu, C.-Y. (PI)

  12/20/22 → 12/19/23

  Project: B - Project of TMU › g - Research Grants for Newly Hired Faculty

• Phosphorylation of Dicer Targets on Metabolic Vulnerability and Gemcitabine Resistance in Translational Pancreatic Cancer Research

  Chiu, C.-F. (PI)

  8/1/22 → 7/31/23

  Project: A - Government Institution › b - National Science and Technology Council

• 腫瘤微環境中癌細胞與免疫因子的串擾：頭頸癌的組織蛋白酶S相關調節機制鑑定和治療策略－溶酶體半胱氨酸蛋白酶組織蛋白酶S在頭頸癌腫瘤免疫中的作用：聚焦對IL-7的調節角色和潛在的免疫調節機制(2/3)

  Chang, J.-Y. (PI)

  8/1/22 → 7/31/23

  Project: A - Government Institution › b - National Science and Technology Council

• Study the Combination Effects of Selenium Yeast and Fish Oil to Synergistically Regulate the Glycogen Synthase Kinase-3 (Gsk-3)/Tbet/Pd-1 Axis of T Cells for Enhanced Anti-Tumor Immunity

  Yao, C.-J. (PI)

  8/1/22 → 7/31/23

  Project: A - Government Institution › b - National Science and Technology Council

• Generate Anti-Erythropoietin Producing Hepatocellular Receptor Type-A2 (Epha2) Antibody-Drug Conjugate and Study Its Potential Application against Pancreatic Cancer

  Lee, Y.-C. (PI)

  8/1/22 → 7/31/23

  Project: A - Government Institution › b - National Science and Technology Council

• 探討cathepsin S在奧沙利鉑引起的神經病變的作用角色: 預測和預防周邊神經病變的潛在生物標誌(3/3)

  Chang, J.-Y. (PI)

  8/1/22 → 7/31/23

  Project: A - Government Institution › b - National Science and Technology Council

• 魚油多元不飽和脂肪酸對胰臟癌細胞脂質代謝與癌轉移之研究

  Chiu, C.-F. (PI)

  7/1/22 → 2/28/23

  Project: A - Government Institution › b - National Science and Technology Council

• Studies on the Carcinogenic Mechanisms of Serine/Threonine-Protein Kinase (Sik3) Involved in the Process of Breast Tumor Formation

  Chen, L.-C. (PI)

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - National Science and Technology Council

• Strategy for Treatment of Osimertinib-Resistant Lung Adenocarcinoma by Jnk Activation

  Yao, C.-J. (PI)

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - National Science and Technology Council

• Identify Human Surfaceome in Deep Learning for Cell-Type Annotation and Isolation from Scrna-Seq

  Chen, S.-H. (PI)

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - National Science and Technology Council

• Targeting O-Glycans of Iga1 to Develop Diagnostic Reagents for Iga Nephropathy and Reshape Its Clinical Assessment Protocol( III )

  Lee, Y.-C. (PI)

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - National Science and Technology Council

  • Nephropathy 100%
  • Glycan 100%
  • Diagnosis 100%
  • Clinical Assessment 100%
  • Immunoglobulin A Nephropathy 100%

• Nano-Hevnp Theranostic Strategy for Late-Stage Colorectal Cancer Patients( II )

  Whang-Peng, J. (PI)

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - National Science and Technology Council

• Targeting O-Glycans of Iga1 to Develop Diagnostic Reagents for Iga Nephropathy and Reshape Its Clinical Assessment Protocol( II )

  Lee, Y.-C. (PI)

  8/1/20 → 7/31/22

  Project: A - Government Institution › b - National Science and Technology Council

  • Nephropathy 100%
  • Glycan 100%
  • Diagnosis 100%
  • Clinical Assessment 100%
  • Immunoglobulin A Nephropathy 100%

• Roles of the Hdacs/Sp1-Mediated Microrna-106b~25 Axis in Drug Resistance of Glioblastomas(1/3)

  Chen, R.-M. (PI)

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - National Science and Technology Council

• The Role and Mechanism of Cd155/Tigit in Mdsc/Tam Induced Nk Cell Dysfunction -A Link to Lung Cancer Resistance to Immune Checkpoint Blockade

  Feng, P.-H. (PI)

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - National Science and Technology Council

• Development of Leukemia Based Precision Medicine Research Model on Non-Invasive Apoptosis Detection Platform – Application of Crispr/Cas9 Gene and Target Therapy on Philadelphia Chromosome of Chronic Myelogenous Leukemia as an Example

  Chen, S.-H. (PI)

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - National Science and Technology Council

  • Leukemia 100%
  • Programmed Cell Death 100%
  • Chronic Myelogenous Leukemia 100%
  • Personalized Medicine 100%
  • Cas9 100%

• To Develop Novel Treatment Options for Hepatocellular Carcinoma via Drug Repurposing(2/2)

  Whang-Peng, J. (PI)

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - National Science and Technology Council

• Nano-Hevnp Theranostic Strategy for Late-Stage Colorectal Cancer Patients(1/3)

  Whang-Peng, J. (PI)

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - National Science and Technology Council

• The Role and Mechanism of Dendritic Cell Pd-L1/Pd-L2 Dysregulation in Aberrant Inflammation of Copd

  Lee, K.-Y. (PI)

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - National Science and Technology Council

• Investigating the Oncogenic Roles of A9-Nicotinic Acetylcholine Receptor Variants on Breast Cancer( III )

  Ho, Y.-S. (PI)

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - National Science and Technology Council

• A Translational Study to Verify Roles of Circulating Mir-19b and Mir-93 as Biomarker Signatures for Early Diagnosis of Osteoporosis in Men(2/3)

  Chen, R.-M. (PI)

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - National Science and Technology Council

• Synthetic and Medicinal Utility of Organometallics in the Development of Anticancer Epigenetic Inhibitors: Applications and Explorations( I )( I )(1/2)

  Liou, J.-P. (PI)

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - National Science and Technology Council

• Investigation of the Role of Gut Microbiota in Antipsychoticinduced Metabolic Dysfunction in Patient with Schizophrenia

  Liu, Y.-R. (PI)

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - National Science and Technology Council

• Studies on the Mechanisms of Histamine N-Methyl-Transferase (Hnmt) as a Novel Molecular Marker to Help Clinician for Identifying of Herceptin Responder in Breast Cancer Patients(1/3)

  Ho, Y.-S. (PI)

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - National Science and Technology Council

• 調節第一型神經衍生孤兒核受體 (Neuron-derived orphan receptor 1, NOR-1)之蛋白質表現可能是 Pomalidomide對創傷性腦損傷之神經保護作用之一

  Chen, R.-M. (PI)

  7/1/19 → 2/1/20

  Project: A - Government Institution › b - National Science and Technology Council

• 激肽釋放酶-激肽系統調控惡性神經膠質瘤細胞基質金屬蛋白酶表現之機轉

  Chen, R.-M. (PI)

  3/1/19 → 2/1/20

  Project: C - Project of Alliance › o - Chi Mei Medical Center

• PM2.5對慢性阻塞性肺病在肺修復和再生受損的影響-IL-17和新穎生物標記在環境PM2.5誘導COPD肺損傷的影響

  Lee, K.-Y. (PI)

  1/1/19 → 12/1/19

  Project: A - Government Institution › d - Ministry of Education

• 發展抗肺纖維化劑-合成抗肺纖維化合物

  Liou, J.-P. (PI)

  1/1/19 → 12/1/19

  Project: A - Government Institution › d - Ministry of Education

• 雙打擊在瀰漫大B細胞淋巴瘤所扮演的角色-致病機轉與臨床特色之探討-JARID1B蛋白在雙打擊瀰漫大B細胞淋巴瘤的角色及其臨床定義

  Liu, Y.-R. (PI)

  1/1/19 → 12/1/19

  Project: A - Government Institution › d - Ministry of Education

• 21121 發展特色研究，推動轉譯醫學（CRISPR基因編輯核心實驗室）

  Chu, C.-Y. (PI)

  1/1/19 → 12/31/19

  Project: B - Project of TMU › h - Higher Education Sprout Project

• 神經內分泌型前列腺癌的轉譯研究-ADAM9在神經內分泌型前列腺癌的轉譯研究

  Sung, S.-Y. (PI)

  1/1/19 → 12/1/19

  Project: A - Government Institution › d - Ministry of Education

• 具抗藥性多形性膠質母細胞瘤的新穎治療策略研究-Bradykinin-TIMP-MMP 軸在抗藥性神經膠質瘤細胞調控血瘤障壁通透性過程中扮演的角色

  Chen, R.-M. (PI)

  1/1/19 → 12/1/19

  Project: A - Government Institution › d - Ministry of Education

• 亞太生醫矽谷精準醫療旗艦計畫-臺北醫學大學合作案

  Liou, J.-P. (PI)

  1/1/19 → 12/1/19

  Project: A - Government Institution › a - National Health Research Institutes

• Repurposing of a Positive Allosteric Modulator of M5 Muscarinic Acetylcholine Receptor as a Microtubule-Targeting Agent and Its Application for Treating Pancreatic Ductal Adenocarcinoma

  Hsieh, Y.-Y. (PI)

  1/1/19 → 6/1/20

  Project: A - Government Institution › b - National Science and Technology Council

• 探討CD155/TIGIT 在類骨髓衍生抑制細胞/腫瘤衍生巨噬細胞誘導自然殺手細胞失調的機轉- 研究肺癌病人免疫檢查點阻斷藥物抗藥性機轉

  Feng, P.-H. (PI)

  1/1/19 → 12/1/19

  Project: A - Government Institution › d - Ministry of Education

• Investigation of Role of Adam17/Preadipocyte Factor-1 in Hypoxia-Induced Ctgf Expression and Airway Fibrosis(1/3)

  Chen, B.-C. (PI)

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - National Science and Technology Council

• Anti-Egfr×Anti-Fap Bi-Specific Targeting Antibody Combined with Irinotecan Encapsulated Liposomes for Pancreatic Cancer Therapy

  Lin, S.-Y. (PI)

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - National Science and Technology Council

• Environmental Factors and Genetic Polymorphisms Associate with the Development and Prognosis of Oral Squamous Cell Carcinoma

  Yeh, C.-C. (PI)

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - National Science and Technology Council

  • Genetic Polymorphism 100%
  • Genetics 100%
  • DNA Repair 100%
  • Cohort Study 50%
  • Axion 50%

• The Effectiveness of Hormonal Therapy on Prostate Cancer Bone Metastasis Determined by Klf4

  Liu, Y.-N. (PI)

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - National Science and Technology Council

• Molecular Mechanisms of Secretory Rab Gtpase 3c in Promoting Colon Cancer Metastasis

  Chen, C.-L. (PI)

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - National Science and Technology Council

• Study of the Angiogenesis Promoting Effect of Irradiation Induced Mir-17-5p in Oral Cancer Cells

  Wu, S.-Y. (PI)

  8/1/18 → 7/31/19

  Project: A - Government Institution › b - National Science and Technology Council

  • Mouth Cancer 100%
  • Neoplasm 100%
  • Cancer Cell 100%
  • Angiogenesis 100%
  • Angiogenic Factor 33%

• 新聘教師研究補助

  Huang, Y.-J. (PI)

  8/1/18 → 7/31/19

  Project: B - Project of TMU › g - Research Grants for Newly Hired Faculty

• The Cross-Talk between Endothelial Cell-Specific Molecule-1 (Esm1) and Epidermal Growth Factor Receptor (Egfr) in the Progression of Non-Small-Cell Lung Cancer (Nsclc)(1/3)

  Chien, M.-H. (PI)

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - National Science and Technology Council

• Development of Mass Spectrometry-Based Quantification Strategies for Onco-Proteogenomics Investigation of Cancer-Specific Mutated Proteins (2nd~3rd Year)

  Han, C.-L. (PI)

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - National Science and Technology Council

  • Proteogenomics 100%
  • Mass Spectrometry 100%
  • Epidermal Growth Factor Receptor 100%
  • Proteomics 18%
  • Tandem Mass Spectrometry 12%

• Effects of Genetic Polymorphisms on Efficacy and Safety of Opioid Analgesics in Patients with Postoperative Pain in a Taiwanese Population

  Tai, Y.-T. (PI)

  8/1/18 → 10/1/19

  Project: A - Government Institution › b - National Science and Technology Council

  • Opiate 100%
  • Postoperative Pain 100%
  • Genetic Polymorphism 100%
  • Narcotic Analgesic Agent 100%
  • Analgesic Agent 71%

• The Role of Angiopoietin-Like Protein 1 in Sorafenib Resistance and Cancer Stemness of Hepatocellular Carcinoma Cells

  Huang, M.-T. (PI)

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - National Science and Technology Council

  • Sorafenib 100%
  • Liver Cell Carcinoma 100%
  • Synapsin I 100%
  • Angiopoietin Related Protein 100%
  • Malignant Neoplasm 100%