TMU Research Center of Cancer Translational Medicine

Projects

Projects per year 2010 2014 2015 2016 2017 2018 2023

• 6 Active
• 535 Finished

Projects per year

Search results

• 探討miR-296-5p/Pin1/XPO5調控與大腸直腸癌相關之oncomiRs的表現

  Lee, K.

  3/1/18 → 3/31/19

  Project: C - Project of Alliance › n - Yuan's General Hospital

• PRIM1為乳癌標靶治療之細胞與動物模式分析

  Chen, L.

  7/1/18 → 2/28/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Environmental Factors and Genetic Polymorphisms Associate with the Development and Prognosis of Oral Squamous Cell Carcinoma

  Yeh, C.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Squamous Cell Carcinoma 100%
  • Genes 26%
  • Taiwan 21%
  • DNA Repair 20%
  • Genome 14%

• Investigating the Role of Ck1 Delta in Tumor Progression, and as a Therapeutic Target for New Drug Discovery in Bladder Cancer.

  Chen, C.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Marker 100%
  • Threonine 63%
  • Serine 53%
  • Pharmacokinetics 43%
  • Flow 36%

• 新聘教師研究補助

  Shih, J.

  8/1/18 → 7/31/20

  Project: B - Project of TMU › g - Research Grants for Newly Hired Faculty

• Studies on the Role of Stomatin-Like Protein 2 (Stoml2) in Thrombin-Stimulated Il-8/Cxcl8 Expression and Airway Inflammation(2/3)

  Chen, B.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討腸道菌相在抗精神病藥物誘發思覺失調症患者代謝症候群之作用

  Liu, Y.

  8/1/18 → 10/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Gastrointestinal Microbiome 100%
  • Antipsychotic Agents 74%
  • Schizophrenia 49%
  • Treatment Adherence and Compliance 46%
  • Metabolic Diseases 42%

• The Role of Mirna and Gut Microbiota in Pathogenesis of Post-Stroke Vascular Cognitive Impairment

  Chiou, H.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Role of Ribonucleotide Reductase (Rnr) in Skeletal Muscle with Age: the Functionality of Rrm2b in Repair and Regeneration

  Chen, Y.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Skeletal Muscle 100%
  • Sarcopenia 58%
  • Regeneration 52%
  • Muscles 47%
  • Muscular Diseases 33%

• Study of the Angiogenesis Promoting Effect of Irradiation Induced Mir-17-5p in Oral Cancer Cells

  Wu, S.

  8/1/18 → 7/31/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Mouth Neoplasms 100%
  • Neoplasms 51%
  • Angiogenesis Inducing Agents 51%
  • Angiogenesis Inhibitors 27%
  • Cell Culture Techniques 26%

• Using Genome-Wide Linkage Analysis and Next Generation Sequencing Approaches to Identify the Genes Responsible for the Familial Colorectal Cancer Type X(2/3)

  Wang, W.

  8/1/18 → 7/31/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Study of the Role of L1cam on Neuroendocrine Prostate Cancer Progression

  Hsieh, C.

  8/1/18 → 9/30/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Prostatic Neoplasms 100%
  • Neural Cell Adhesion Molecule L1 91%
  • Castration 16%
  • Phenotype 9%
  • RNA-Binding Proteins 5%

• A Translational Investigation of the Role of Myc/Pd-L1/Akt Axis as a Therapeutic Target for Treating Glioblastoma Multiforme

  Lin, C.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Role of Hbx and Androgen Receptor in Regulating Senp1/Stemess-Related Properties in Hbv-Related Hcc and Its Clinical Impact

  Huang, Y.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Hepatocellular Carcinoma 100%
  • Hep G2 Cells 36%
  • Androgens 30%
  • Neoplasms 29%
  • sulfoenolpyruvate 21%

• Nano-Diamino-Tetrac (Ndat) Enhances Resveratrol-Induced Anti-Proliferation by Action on the Rrm2 Pathway in Colorectal Cancers

  Lin, H.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Resveratrol 100%
  • Ribonucleotide 49%
  • Antiproliferative 13%
  • Bellow 10%
  • Stilbenoid 10%

• To Study the Role of Sp1 in Cancer Drug Resistance(3/3)

  Chuang, J.

  8/1/18 → 10/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Studies on the Mechanisms of Histamine N-Methyltransferase (Hnmt)-Mediated Herceptinr Drug-Resistance in Breast Cancer Cells(3/3)

  Ho, Y.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Histamine N-Methyltransferase 100%
  • Trastuzumab 89%
  • Breast Neoplasms 16%
  • Tissue Array Analysis 9%
  • Gene Expression Profiling 8%

• Investigation of Astrocytic Cebpd-Regulated Mirnas and Their Effects on Angiogenesis during Neuroinflammation

  Ko, C.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Alzheimer Disease 100%
  • MicroRNAs 77%
  • Astrocytes 67%
  • Angiogenesis Inducing Agents 41%
  • Endothelial Cells 40%

• Development a Risk Scoring System for Predicting the Risk of Poststroke Epilepsy to Improve the Quality of Care among Patients with Stroke

  Chien, L.

  8/1/18 → 7/31/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Epilepsy 100%
  • Stroke 45%
  • Anticonvulsants 24%
  • National Health Programs 20%
  • University Hospitals 15%

• The Role of Angiopoietin-Like Protein 1 in Sorafenib Resistance and Cancer Stemness of Hepatocellular Carcinoma Cells

  Huang, M.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Angiopoietin-like Proteins 100%
  • Sorafenib 97%
  • Hepatocellular Carcinoma 53%
  • Gastropoda 44%
  • Neoplasms 17%

• 新聘教師研究補助

  Huang, Y.

  8/1/18 → 7/31/19

  Project: B - Project of TMU › g - Research Grants for Newly Hired Faculty

• A Novel Lifr Axis in Metabolism Unhinged and Neuroendocrine Differentiation of Prostate Cancer(I)

  Liu, Y.

  8/1/18 → 10/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Deciphering the Mechanisms of Multiple Myeloma Tumor Driving Factor Whsc1 in Kras Mutated Colon Cancer Progression and Investigate the Whsc1 Targeting Combination Therapy

  Cho, E.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Colonic Neoplasms 100%
  • Fluorouracil 18%
  • Oxaliplatin 15%
  • Multiple Myeloma 12%
  • Drug Resistance 11%

• Investigation of Role of Adam17/Preadipocyte Factor-1 in Hypoxia-Induced Ctgf Expression and Airway Fibrosis(1/3)

  Chen, B.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Functional Study of a Novel Long Non-Coding Rna Linat in Colorectal Cancer Progression(2/3)

  Chen, H.

  8/1/18 → 7/31/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Investigation of the Role and Underlying Mechanism of Methylenetetrahydrofolate Dehydrogenase 2(Mthfd2) in the Cancer Stem Cell Properties and Tumorigenesis of Lung Cancer

  Deng, W.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Methylenetetrahydrofolate Dehydrogenase (NADP) 100%
  • Neoplastic Stem Cells 29%
  • Lung Neoplasms 27%
  • NAD 21%
  • Serine 20%

• A Preclinical Study of the Therapeutic Targeting of Inflammatory-Cytokine-Addicted Cancer Stem Cells in Advanced Pancreatic Cancer

  Tsai, K. K.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effects of Genetic Polymorphisms on Efficacy and Safety of Opioid Analgesics in Patients with Postoperative Pain in a Taiwanese Population

  Tai, Y.

  8/1/18 → 10/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Opioid Analgesics 100%
  • Genetic Polymorphisms 59%
  • Analgesics 38%
  • Pain Management 34%
  • Postoperative Pain 22%

• Studies on the Mechanisms of Dna Primase（Prim1）Involved in Smoking-Induced Breast Cancer Formations and Its Translational Applications

  Chen, L.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Molecular Mechanisms of Secretory Rab Gtpase 3c in Promoting Colon Cancer Metastasis

  Chen, C.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Epigenetic Editing as a Novel Therapeutics for Gynecological Cancer

  Lai, H.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Epigenomics 100%
  • Clustered Regularly Interspaced Short Palindromic Repeats 43%
  • Tumor Biomarkers 27%
  • Neoplasms 24%
  • Gene Editing 23%

• Investigation of Long Noncoding Rna in Dicer-Mediated Micro-Rna Reprogramming and Sorafenib Resistance in Hepatocellular Carcinoma

  Chen, H.

  8/1/18 → 7/31/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Sorafenib 100%
  • Liver Neoplasms 80%
  • Long Noncoding RNA 75%
  • MicroRNAs 63%
  • Hepatocellular Carcinoma 23%

• The Role of Sp1-Regulated Neurosteroidogenesis in Glioma Development(2/2)

  Hsu, T.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Neurosteroids 100%
  • Glioma 74%
  • Glioblastoma 67%
  • Temozolomide 54%
  • Astrocytes 34%

• Involvement of Genes Encoding Apoptosis Regulatory Pathway in the Pathogenesis of Hyperglycemia in Acute Ischemic Stroke

  Hsieh, Y.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• To Study the Role of Pctk1 in the Progression of Colorectal Cancer and Molecular Mechanism (Continuation Project)(1/3)

  Wei, P.

  8/1/18 → 7/31/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Role of Niche Inflammatory Cytokine and Epigenetic Regulation in Expressions of Pluripotent Transcription Factor Oct4 and Sorafenib Refractoriness in Hbv-Related Hepatocellular Carcinoma and Its Clinical Implication.(I)(1/3)

  Huang, Y.

  8/1/18 → 10/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Use of Organometallic Reaction in the Syntheses of Anticancer Agents(2/2)

  Liou, J.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Impacts of Particulate Air Pollution on Repair and Abnormal Inflammation in Copd: the Role of Itih4 and the Regeneration Pathways

  Lee, K.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Chronic Obstructive Pulmonary Disease 100%
  • inter-alpha-inhibitor 82%
  • Particulate Matter 74%
  • Inflammation 30%
  • human ITIH4 protein 25%

• Dissected the Role of Thrombomodulin in the Clinical Diagnostic and Therapeutic Impacts for Breast Cancer and the Regulation Mechanisms(3/3)

  Hung, C.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Thrombomodulin 100%
  • Breast Neoplasms 90%
  • Therapeutics 20%
  • Neoplasms 12%
  • Steroid Receptors 11%

• Role and Molecular Mechanisms of N-Α-Acetyltransferase in Driving Tumor Invasion and Metastasis of Osteosarcoma(3/3)

  Chien, M.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • osteosarcoma 100%
  • gelatinase A 66%
  • metastasis 59%
  • neoplasms 30%
  • acetyltransferases 21%

• Identifying Cancer-Stem-Cell-Invadopodia-Related Prognostic Biomarkers in Gastric Cancer

  Chan, T.

  8/1/18 → 7/31/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Podosomes 100%
  • Neoplastic Stem Cells 71%
  • Stomach Neoplasms 27%
  • Neoplasms 18%
  • Neoplasm Metastasis 11%

• A Translational Study to Verify Roles of Circulating Mir-19b and Mir-93 as Biomarker Signatures for Early Diagnosis of Osteoporosis in Men

  Chen, R.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Effectiveness of Hormonal Therapy on Prostate Cancer Bone Metastasis Determined by Klf4

  Liu, Y.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Development of Novel Dyrk1a Inhibitors for the Treatment of Alzheimer'S Disease

  HuangFu, W.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Dyrk kinase 100%
  • Alzheimer Disease 43%
  • Neurofibrillary Tangles 17%
  • Amyloid beta-Peptides 15%
  • Memory 10%

• Anti-Egfr×Anti-Fap Bi-Specific Targeting Antibody Combined with Irinotecan Encapsulated Liposomes for Pancreatic Cancer Therapy

  Lin, S.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Drug Discovery and Pharmacological Investigation of Novel Selective Hdac Inhibitors as Anticancer Drugs(1/3)

  Pan, S.

  8/1/18 → 7/31/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Generate Anti-Fibroblast Growth Factor Receptor 2 (Fgfr2) Antibody Drugs and Study on Their Potential Application against Gastric Cancer

  Lee, Y.

  8/1/18 → 10/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• To Develop Novel Treatment Options for Hepatocellular Carcinoma via Drug Repurposing(1/2)

  Whang-Peng, J.

  8/1/18 → 7/31/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Application of High-Throughput Sequencing Approaches in Immunogenomic Research : Diversity and Clonal Selection in the Human T-Cell Repertoire for Colonrectal Cancers(3/4)

  Chang, W.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Development of Mass Spectrometry-Based Quantification Strategies for Onco-Proteogenomics Investigation of Cancer-Specific Mutated Proteins (2nd~3rd Year)

  Han, C.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Mutation 100%
  • Proteogenomics 74%
  • Mass Spectrometry 70%
  • Proteins 49%
  • Peptides 35%