TMU Research Center of Cancer Translational Medicine

Projects

Projects per year 2010 2014 2015 2016 2017 2018 2023

• 6 Active
• 535 Finished

Projects per year

Search results

• b - Ministry of Science and Technology

  Application of High-Throughput Sequencing Approaches in Immunogenomic Research : Diversity and Clonal Selection in the Human T-Cell Repertoire for Colonrectal Cancers

  Chang, W.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Colorectal Neoplasms 100%
  • T-Cell Antigen Receptor 54%
  • V(D)J Recombination 52%
  • T-Lymphocytes 44%
  • Neoplasms 28%

• Investigation on the Suppressive Mechanisms of Novel Anti-Glypican3 Antibody Drugs

  Yang, Y.

  8/1/14 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Glypicans 100%
  • Hepatocellular Carcinoma 20%
  • Antibodies 18%
  • Single-Chain Antibodies 10%
  • Heparan Sulfate Proteoglycans 10%

• Bone-Marrow-Derived Mesenchymal Stem Cells in Prostate Cancer-Induced Bone Remodeling

  Hsieh, C., Chen, K. & Sung, S.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Adipogenic 100%
  • Osteogenic 37%

• Chemokine Factors Concomitantly Induce Prostate Cancer Organ Specific Bone Metastasis

  Sung, S.

  8/1/12 → 9/30/13

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Prostatic Neoplasms 100%
  • Neoplasm Metastasis 77%
  • Chemokine Receptors 70%
  • Stromal Cells 31%
  • Androgens 28%

• Role of Hbx and Androgen Receptor in Regulating Senp1/Stemess-Related Properties in Hbv-Related Hcc and Its Clinical Impact

  Huang, Y.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Hepatocellular Carcinoma 100%
  • Hep G2 Cells 36%
  • Androgens 30%
  • Neoplasms 29%
  • sulfoenolpyruvate 21%

• Role of HBX and IL-6 in Regulating SENP1/Stemness Properties of HBV-Related HCC under Hypoxia and Its Clinical Implication

  Huang, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Interleukin-6 100%
  • Hepatocellular Carcinoma 94%
  • Hypoxia 55%
  • Drug Resistance 32%
  • Neoplasms 30%

• 臺北醫學大學萌芽創業推廣計畫

  Yen, Y.

  6/1/17 → 12/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Role of Inflammatory Gene Polymorphisms on Risk of Post-Stroke Vascular Dementia (I)

  Chiou, H., Chi, N., Lin, H., Wu, C., Hsieh, F., Hu, C. & Hsieh, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Stroke 93%
  • Cognitive Dysfunction 89%
  • Blood Vessels 52%
  • Inflammation 36%
  • Whole Exome Sequencing 16%

• 探討cathepsin S在奧沙利鉑引起的神經病變的作用角色: 預測和預防周邊神經病變的潛在生物標誌(3/3)

  Chang, J.

  8/1/22 → 7/31/23

  Project: A - Government Institution › b - Ministry of Science and Technology

• To Study the Role of Sp1 in Cancer Drug Resistance( I )

  Chuang, J.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Drug Resistance 100%
  • Temozolomide 84%
  • Neoplasms 48%
  • superoxide dismutase 2 40%
  • Reactive Oxygen Species 32%

• Identification of Rewired APC Mutation Signaling Network in Chemotherapy Resistant Response in Colorectal Cancer (II)

  Huang, T.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• Two Populations-Based Pharmacogenomics Investigation in Osteoporosis Susceptibility and Raloxifene Treatment Efficacy – across Taiwanese and Japanese

  Chang, W.

  4/1/17 → 3/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Osteoporosis 100%
  • Genome-Wide Association Study 59%
  • Raloxifene Hydrochloride 38%
  • Bone Density 25%
  • Population 22%

• Effect of Hmga2 in Chemotherapy Response of Colorectal Cancer Patients with Different Apc Status( III )

  Yen, Y.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• A Preclinical Study of the Therapeutic Targeting of Inflammatory-Cytokine-Addicted Cancer Stem Cells in Advanced Pancreatic Cancer

  Tsai, K. K.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• Analyses the Role of ADAM9-Hemidesmosome Components Interaction in Malignant Cancer Metastasis and Future Therapeutic Strategy

  Sung, S.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • metastasis 100%
  • integrins 49%
  • neoplasms 44%
  • neoplasm cells 41%
  • neoplasm progression 39%

• Role of HBX and IL-6 in Regulating SENP1/Stemness Properties of HBV-Related HCC under Hypoxia and Its Clinical Implication

  Huang, Y.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Interleukin-6 100%
  • Hepatocellular Carcinoma 94%
  • Hypoxia 55%
  • Drug Resistance 32%
  • Neoplasms 30%

• 再生醫學科技發展計畫－全身安全性異體移植策略之細胞治療產品開發:標靶醫療未滿足慢性發炎相關疾病-糖尿病/褥瘡/嚴重燒燙傷之傷口癒合與多發性硬化症(1/3)

  Yen, Y.

  5/1/17 → 4/30/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• 可卡因促使Sig-1R局部化於核膜與emerin-HDACs抑制因子複合物結合來調節MAOB表達(3/3)

  Chuang, J.

  8/1/16 → 10/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • sigma-1 receptor 100%
  • Cocaine 63%
  • Monoamine Oxidase 40%
  • Co-Repressor Proteins 25%
  • emerin 24%

• NF-kB以及NF-kB repressing factor (NRF) 在慢性阻塞性肺疾病引發系統性發炎之角色探討(3/3)

  Lee, K.

  8/1/12 → 10/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• A Preclinical Study of the Therapeutic Targeting of Inflammatory-Cytokine-Addicted Cancer Stem Cells in Advanced Pancreatic Cancer

  Tsai, K. K.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• Role of Niche Inflammatory Cytokine and Epigenetic Regulation in Expressions of Pluripotent Transcription Factor Oct4 and Sorafenib Refractoriness in Hbv-Related Hepatocellular Carcinoma and Its Clinical Implication.(I)(1/3)

  Huang, Y.

  8/1/18 → 10/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Role of miR-21 in Regulating TET I-Hydroxymethylcytosine and Chemotherapeutic Response in Colorectal Cancer (I)

  Yang, P.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Colorectal Neoplasms 100%
  • 5-hydroxymethylcytosine 84%
  • APC Genes 58%
  • DNA Methylation 55%
  • Adenomatous Polyposis Coli 51%

• The Development and Preclinical Evaluation of a Theronostic Nanovehicle Drug for Treating Acute Myeloid Leukemia and Leukemia Stem Cells.( III )

  Yen, Y.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• Analysis the Role of Adam9 as Novel Biosignature in Prostate Cancer Malignant Progression

  Sung, S.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Prostatic Neoplasms 100%
  • Neoplasms 29%
  • Neoplasm Metastasis 28%
  • Biomarkers 22%
  • Plectin 18%

• Effect of HMGA2 in Chemotherapy Response of Colorectal Cancer Patients with Different APC Status (II)

  Yen, Y., Cheng, Y. & Wei, P.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• 以白色念珠菌 alpha-enolase 為目標的單株抗體的人源化與其可能的應用

  Yang, Y.

  2/1/17 → 1/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• Identification of Rewired APC Mutation Signaling Network in Chemotherapy Resistant Response in Colorectal Cancer (I)

  Huang, T.

  8/1/14 → 10/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Adenomatous Polyposis Coli 100%
  • Colorectal Neoplasms 44%
  • Mutation 34%
  • Drug Resistance 28%
  • Fluorouracil 17%

• Differential Machinery of Pluripotency Regulation in Stem Cells in Embryonic Stage and Somatic Cancers and Its Clinical Implications in Human Diseases---Crosstalk among Niche Growth Factor/Cytokine Signaling, Extracellular Matrix, and Epigenetic Netw (I)

  Huang, Y.

  10/1/14 → 9/30/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Testicular Germ Cell Tumor 100%
  • Embryonic Stem Cells 77%
  • Epigenomics 75%
  • Seminoma 73%
  • Germ Cells 71%

• Strategy for Treatment of Osimertinib-Resistant Lung Adenocarcinoma by Jnk Activation

  Yao, C.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• Disease trajectories and its association with metabolic dysfunction of prostate cancer men following androgen deprivation therapy and the potential of pharmacological medication in preventing metastatic diseases.(2/3)

  Shao, Y.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Androgens 100%
  • Prostatic Neoplasms 60%
  • Hyperlipidemias 44%
  • Taiwan 32%
  • Metabolic Syndrome 30%

• Disease Trajectories and Its Association with Metabolic Dysfunction of Prostate Cancer Men Following Androgen Deprivation Therapy and the Potential of Pharmacological Medication in Preventing Metastatic Diseases.

  Shao, Y.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• Disease Trajectories and Its Association with Metabolic Dysfunction of Prostate Cancer Men Following Androgen Deprivation Therapy and the Potential of Pharmacological Medication in Preventing Metastatic Diseases.

  Shao, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• 建立多構面癌症防治預測模式:以大腸癌為例－建立多構面癌症防治預測模式:以大腸癌為例

  Shao, Y.

  9/1/15 → 8/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• Service for Sharing Precious Instruments of Taipei Medical University

  Lin, C.

  1/1/14 → 12/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• 臺北醫學大學自有貴重儀器共用服務計畫

  Lin, C.

  11/1/14 → 12/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Role of Ribonucleotide Reductase (Rnr) in Skeletal Muscle with Age: the Functionality of Rrm2b in Repair and Regeneration

  Chen, Y.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Skeletal Muscle 100%
  • Sarcopenia 58%
  • Regeneration 52%
  • Muscles 47%
  • Muscular Diseases 33%

• A Translational Study to Verify Roles of Circulating Mir-19b and Mir-93 as Biomarker Signatures for Early Diagnosis of Osteoporosis in Men(2/3)

  Chen, R.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Roles of the Hdacs/Sp1-Mediated Microrna-106b~25 Axis in Drug Resistance of Glioblastomas(1/3)

  Chen, R.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Discovering Blood Circulating and Bone Micrornas as Biomarker Signatures for Diagnosis or Therapy of Osteoporosis in Men and Male Osteoporotic Fracture

  Chen, R.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • osteoporosis 100%
  • microRNA 57%
  • bones 36%
  • biomarkers 27%
  • bone fractures 19%

• Discovering Blood Circulating and Bone Micrornas as Biomarker Signatures for Diagnosis or Therapy of Osteoporosis in Men and Male Osteoporotic Fracture

  Chen, R.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

  • osteoporosis 100%
  • microRNA 57%
  • bones 36%
  • biomarkers 27%
  • bone fractures 19%

• Discovering Blood Circulating and Bone Micrornas as Biomarker Signatures for Diagnosis or Therapy of Osteoporosis in Men and Male Osteoporotic Fracture(2/3)

  Chen, R.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • osteoporosis 100%
  • microRNA 57%
  • bones 36%
  • biomarkers 27%
  • bone fractures 19%

• Age-Related Hearing Loss (Presbycusis)---Cisd2 Deficiency Accelerate the Hearing Defect during Aging Process-Renew

  Chen, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Presbycusis 100%
  • Hearing 57%
  • Longevity 37%
  • Inner Ear 22%
  • Cochlea 22%

• Gene Knock out Mice Model for Studying the Molecular Mechanisms of Early Onset Breast Tumor Microenvironment Regulation.

  Wu, C., Ho, Y. & Tu, S.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Antitumor 100%
  • Growth Factor 25%
  • Apoptotic 24%
  • Cell Death 23%
  • Hormone 21%

• MTHFR和TYMS基因多形性與茶攝取之間的交互作用對口腔癌發生風險的影響

  Yeh, C.

  7/1/17 → 2/28/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• Study of the Role of L1cam on Neuroendocrine Prostate Cancer Progression

  Hsieh, C.

  8/1/18 → 9/30/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Prostatic Neoplasms 100%
  • Neural Cell Adhesion Molecule L1 91%
  • Castration 16%
  • Phenotype 9%
  • RNA-Binding Proteins 5%

• Molecular and Translational Study of L1cam in Metastatic Castraction Resistant Prostate Cancer (Mcrpc)

  Hsieh, C.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Neural Cell Adhesion Molecule L1 100%
  • Prostatic Neoplasms 37%
  • Radiation 14%
  • Phosphorylation 13%
  • Bone Neoplasms 11%

• The Roles of Genetic Polymorphisms for Susceptibility and Clinical Outcomes of Colorectal Cancer in Taiwanese Lynch Syndrome Families

  Yeh, C.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Hereditary Nonpolyposis Colorectal Neoplasms 100%
  • DNA Mismatch Repair 57%
  • Colorectal Neoplasms 54%
  • Genetic Polymorphisms 29%
  • Genes 19%

• Differential Expression of microRNAs in Osteoblasts and Their Roles in Regulation of Cell Survival and Metabolism

  Chen, R.

  8/1/10 → 7/31/11

  Project: A - Government Institution › b - Ministry of Science and Technology

  • osteoblasts 100%
  • microRNA 82%
  • bones 31%
  • genetic markers 27%
  • apoptosis 21%

• Investigation of Long Noncoding Rna in Dicer-Mediated Micro-Rna Reprogramming and Sorafenib Resistance in Hepatocellular Carcinoma

  Chen, H.

  8/1/18 → 7/31/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Sorafenib 100%
  • Liver Neoplasms 80%
  • Long Noncoding RNA 75%
  • MicroRNAs 63%
  • Hepatocellular Carcinoma 23%

• Antitumor Activity and Pharmacological Mechanisms of Pik3c3 Inhibitor in Bladder Cancer Cells

  Chen, C.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Urinary Bladder Neoplasms 100%
  • Autophagy 72%
  • Endosomes 31%
  • Cachexia 23%
  • Phosphatidylinositol 3-Kinases 18%