TMU Research Center of Cancer Translational Medicine

Projects

Projects per year 2010 2014 2015 2016 2017 2018 2023

• 6 Active
• 535 Finished

Projects per year

Search results

• Differential Expression of microRNAs in Osteoblasts and Their Roles in Regulation of Cell Survival and Metabolism

  Chen, R.

  8/1/10 → 7/31/11

  Project: A - Government Institution › b - Ministry of Science and Technology

  • osteoblasts 100%
  • microRNA 82%
  • bones 31%
  • genetic markers 27%
  • apoptosis 21%

• Differential Machinery of Pluripotency Regulation in Stem Cells in Embryonic Stage and Somatic Cancers and Its Clinical Implications in Human Diseases---Crosstalk among Niche Growth Factor/Cytokine Signaling, Extracellular Matrix, and Epigenetic Netw (I)

  Huang, Y.

  10/1/14 → 9/30/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Testicular Germ Cell Tumor 100%
  • Embryonic Stem Cells 77%
  • Epigenomics 75%
  • Seminoma 73%
  • Germ Cells 71%

• Differential Machinery of Pluripotency Regulation in Stem Cells in Embryonic Stage and Somatic Cancers and Its Clinical Implications in Human Diseases --Crosstalk among Niche Growth Factor/Cytokine Signaling, Extracellular Matrix, and Epigenetic Netw (II)

  Huang, Y.

  10/1/15 → 9/30/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• Discovering Blood Circulating and Bone Micrornas as Biomarker Signatures for Diagnosis or Therapy of Osteoporosis in Men and Male Osteoporotic Fracture

  Chen, R.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • osteoporosis 100%
  • microRNA 57%
  • bones 36%
  • biomarkers 27%
  • bone fractures 19%

• Discovering Blood Circulating and Bone Micrornas as Biomarker Signatures for Diagnosis or Therapy of Osteoporosis in Men and Male Osteoporotic Fracture

  Chen, R.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

  • osteoporosis 100%
  • microRNA 57%
  • bones 36%
  • biomarkers 27%
  • bone fractures 19%

• Discovering Blood Circulating and Bone Micrornas as Biomarker Signatures for Diagnosis or Therapy of Osteoporosis in Men and Male Osteoporotic Fracture(2/3)

  Chen, R.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • osteoporosis 100%
  • microRNA 57%
  • bones 36%
  • biomarkers 27%
  • bone fractures 19%

• Discovery of Novel DNA Methylation Biomarker of Ovarian Cancer Using New Generation Sequencing Technology

  Lai, H.

  11/1/13 → 4/30/14

  Project: A - Government Institution › c - Ministry of Health and Welfare

  • Ovarian Neoplasms 100%
  • DNA Methylation 90%
  • Biomarkers 47%
  • Neoplasms 41%
  • Early Detection of Cancer 34%

• Discovery of Novel DNA Methylation Biomarker of Ovarian Cancer Using New Generation Sequencing Technology

  Lai, H.

  5/1/14 → 4/30/15

  Project: A - Government Institution › c - Ministry of Health and Welfare

  • Ovarian Neoplasms 100%
  • DNA Methylation 90%
  • Biomarkers 47%
  • Neoplasms 41%
  • Early Detection of Cancer 34%

• Disease Trajectories and Its Association with Metabolic Dysfunction of Prostate Cancer Men Following Androgen Deprivation Therapy and the Potential of Pharmacological Medication in Preventing Metastatic Diseases.

  Shao, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• Disease Trajectories and Its Association with Metabolic Dysfunction of Prostate Cancer Men Following Androgen Deprivation Therapy and the Potential of Pharmacological Medication in Preventing Metastatic Diseases.

  Shao, Y.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• Disease trajectories and its association with metabolic dysfunction of prostate cancer men following androgen deprivation therapy and the potential of pharmacological medication in preventing metastatic diseases.(2/3)

  Shao, Y.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Androgens 100%
  • Prostatic Neoplasms 60%
  • Hyperlipidemias 44%
  • Taiwan 32%
  • Metabolic Syndrome 30%

• Dissected the Role of Defensin 6 (Def 6),The Clinically Therapeutic Implication and Drug Development in Colon Cancer

  Wei, P.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • colorectal neoplasms 100%
  • neoplasms 37%
  • therapeutics 31%
  • metastasis 31%
  • death 25%

• Dissected the Role of Glucosed-Regulated Portein 78 in the Progression, Metastasis and Therapy of Colorectal Cancer

  Wei, P.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • colorectal neoplasms 100%
  • metastasis 69%
  • neoplasms 55%
  • endoplasmic reticulum 32%
  • death 27%

• Dissected the Role of Glucose-Regulated Protein 94 (GRP94),The Clinically Therapeutic Implication and Drug Development in Colon Cancer

  Wei, P. & Chang, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • glucose-regulated proteins 100%
  • Colonic Neoplasms 43%
  • Colorectal Neoplasms 38%
  • Neoplasms 23%
  • Neoplasm Metastasis 19%

• Dissected the Role of Thrombomodulin in the Clinical Diagnostic and Therapeutic Impacts for Breast Cancer and the Regulation Mechanisms

  Hung, C.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Thrombomodulin 100%
  • Breast Neoplasms 90%
  • Therapeutics 20%
  • Neoplasms 12%
  • Steroid Receptors 11%

• Dissected the Role of Thrombomodulin in the Clinical Diagnostic and Therapeutic Impacts for Breast Cancer and the Regulation Mechanisms

  Hung, C.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Thrombomodulin 100%
  • Breast Neoplasms 90%
  • Therapeutics 20%
  • Neoplasms 12%
  • Steroid Receptors 11%

• Dissected the Role of Thrombomodulin in the Clinical Diagnostic and Therapeutic Impacts for Breast Cancer and the Regulation Mechanisms(3/3)

  Hung, C.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Thrombomodulin 100%
  • Breast Neoplasms 90%
  • Therapeutics 20%
  • Neoplasms 12%
  • Steroid Receptors 11%

• Drug Discovery and Pharmacological Investigation of Novel Selective Hdac Inhibitors as Anticancer Drugs(1/3)

  Pan, S.

  8/1/18 → 7/31/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Drug Discovery and Pharmacological Investigation of Selective Hdac1 and 2 Inhibitors as Novel Anticancer Drugs

  Pan, S.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Histone 100%
  • Antitumor 34%
  • Antineoplastic Agent 33%
  • Drug 29%
  • DNA Sequence 19%

• Drug Discovery and Pharmacological Study of Novel pan-HDAC Inhibitors as Anti-Angiogenic Drugs

  Pan, S.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Histone Deacetylase Inhibitors 100%
  • Histone Deacetylases 36%
  • Drug Discovery 23%
  • 3-(1-benzenesulfonyl-2,3-dihydro-1H-indol-5-yl)-N-hydroxyacrylamide 18%
  • Animal Models 16%

• Drug Discovery and Pharmacological Study of Novel pan-HDAC Inhibitors as Anti-Angiogenic Drugs

  Pan, S.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Histone Deacetylase Inhibitors 100%
  • Histone Deacetylases 36%
  • Drug Discovery 23%
  • 3-(1-benzenesulfonyl-2,3-dihydro-1H-indol-5-yl)-N-hydroxyacrylamide 18%
  • Animal Models 16%

• Effect of HMGA2 in Chemotherapy Response of Colorectal Cancer Patients with Different APC Status (II)

  Yen, Y., Cheng, Y. & Wei, P.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effect of Hmga2 in Chemotherapy Response of Colorectal Cancer Patients with Different Apc Status( III )

  Yen, Y.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effects of Genetic Polymorphisms on Efficacy and Safety of Opioid Analgesics in Patients with Postoperative Pain in a Taiwanese Population

  Tai, Y.

  8/1/18 → 10/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Opioid Analgesics 100%
  • Genetic Polymorphisms 59%
  • Analgesics 38%
  • Pain Management 34%
  • Postoperative Pain 22%

• Effects of Propofol on Traumatic Brain Injury-Induced Insults to the Mouse Blood-Brain Barrier and Its Possible Mechanisms

  Chang, H. & Chen, R.

  8/1/10 → 7/31/11

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Traumatic Brain Injury 100%
  • Propofol 90%
  • Blood-Brain Barrier 73%
  • Brain Edema 28%
  • Craniocerebral Trauma 16%

• Effects of Ultrafine Particles on Cardiopulmonary System: a Population-Based Approach

  Chuang, K. & Feng, P.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Particulate Matter 100%
  • Air Pollution 68%
  • Taiwan 34%
  • United States Environmental Protection Agency 33%
  • Organized Financing 13%

• Effects of Uteroplacental Insufficiency and Hyperoxia on Lung Development and Epigenetic Alterations in the Rat Offspring

  Chen, C. & Lin, C.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Fetal Growth Retardation 100%
  • Hyperoxia 99%
  • Receptor for Advanced Glycation End Products 74%
  • Epigenomics 69%
  • Lung 48%

• EGFR反式活化依賴NADPH oxidase/ROS/NF-kB路徑媒介thrombin誘導肺部上皮細胞IL-8/CXCL8表現之探討

  Chen, B.

  6/1/15 → 5/31/16

  Project: C - Project of Alliance › p - Taipei Medical University Hospital

• Elucidation of the Molecular Mechnism of Aglaia Elliptifolia Extract Rocaglamide Induced Cell Death in Breast Cancer Cells---PHB as a Target

  Huang, T.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Rocaglamide 100%
  • Oncogenic 11%
  • Cell Death 8%

• Environmental Factors and Genetic Polymorphisms Associate with the Development and Prognosis of Oral Squamous Cell Carcinoma

  Yeh, C.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Squamous Cell Carcinoma 100%
  • Genes 26%
  • Taiwan 21%
  • DNA Repair 20%
  • Genome 14%

• Epigenetic Characterization of Ovarian Cancer Initiating Cells

  Lai, H. & Huang, R.

  1/1/15 → 12/31/15

  Project: A - Government Institution › a - National Health Research Institutes

  • Ovarian Neoplasms 100%
  • Neoplastic Stem Cells 64%
  • Epigenomics 43%
  • 5-hydroxymethylcytosine 16%
  • Stem Cell Research 14%

• Epigenetic Characterization of Ovarian Cancer Initiating Cells

  Lai, H.

  1/1/16 → 12/31/16

  Project: A - Government Institution › a - National Health Research Institutes

  • Ovarian Neoplasms 100%
  • Neoplastic Stem Cells 64%
  • Epigenomics 43%
  • 5-hydroxymethylcytosine 16%
  • Stem Cell Research 14%

• Epigenetic Editing as a Novel Therapeutics for Gynecological Cancer

  Lai, H.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Epigenomics 100%
  • Clustered Regularly Interspaced Short Palindromic Repeats 43%
  • Tumor Biomarkers 27%
  • Neoplasms 24%
  • Gene Editing 23%

• Epigenetic Editing as a Novel Therapeutics for Gynecological Cancer

  Lai, H.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Epigenomics 100%
  • Clustered Regularly Interspaced Short Palindromic Repeats 43%
  • Tumor Biomarkers 27%
  • Neoplasms 24%
  • Gene Editing 23%

• Epigenetic Editing as a Novel Therapeutics for Gynecological Cancer

  Lai, H.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Epigenomics 100%
  • Clustered Regularly Interspaced Short Palindromic Repeats 43%
  • Tumor Biomarkers 27%
  • Neoplasms 24%
  • Gene Editing 23%

• Establishing Health and Welfare Biotechnology Electronic Database Sharing Platform, Promoting Evidence-Based Medicine and Disseminating Technology Knowledge in Taiwan

  Chen, C., Tam, K., Chen, K., Hou, W. & Bai, C.

  1/1/16 → 12/31/16

  Project: A - Government Institution › c - Ministry of Health and Welfare

  • Healthcare 100%
  • evidence 76%
  • welfare 56%
  • ministry 47%
  • health 44%

• Establishing the Disease and Genetic Risk Prediction Score of Cognitive Impairment to Early Prevent the Threat of Dementia

  Hsieh, Y.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Dementia 100%
  • Neurodegenerative Diseases 80%
  • Iron-Deficiency Anemias 78%
  • Taiwan 65%
  • Cognitive Dysfunction 65%

• Establishing the Hub for “Learning Health System” for South Asia

  Li, Y.

  12/26/16 → 8/25/17

  Project: A - Government Institution › c - Ministry of Health and Welfare

  • Health 100%
  • eHealth 85%
  • Information technology 30%
  • Industry 22%
  • Medicine 17%

• Establish the Research Platform for Studying Triple-Negative Breast Tumor Microenvironment Regulation: the Hyaluronan Synthase-3 Mediated Antitumor Effects as an Example.

  Ho, Y. & Wu, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Breast Neoplasms 100%
  • Gene Expression 46%
  • Tumor Microenvironment 40%
  • Hyaluronan Synthases 30%
  • Fibroblasts 29%

• Establish the Research Platform for Studying Triple-Negative Breast Tumor Microenvironment Regulation---The Hyaluronan Synthase-3 Mediated Antitumor Effects as an Example

  Ho, Y. & Wu, C.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Breast Neoplasms 100%
  • Gene Expression 46%
  • Tumor Microenvironment 40%
  • Hyaluronan Synthases 30%
  • Fibroblasts 29%

• Evaluate and Engineer Anti-Fibroblast Growth Factor Receptor 2 (Fgfr2) Antibody Drugs and Study on Their Potential Application against Cancer

  Lee, Y.

  4/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Fibroblast Growth Factor Receptors 100%
  • Stomach Neoplasms 22%
  • Antibodies 20%
  • Receptor, Fibroblast Growth Factor, Type 2 15%
  • Neoplasms 15%

• Evaluate the Radio-Biological Roles of miR-17-5P in Oral Cancer Cell Line OC3

  Wu, S.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Mouth Neoplasms 100%
  • Proteins 87%
  • MicroRNAs 61%
  • Radio 56%
  • Areca 53%

• Evaluation on prevention for metabolic syndrome and diabetes mellitus through lifestyle modification intervention in pre-diabetic subjects (100-104)

  Chiou, H.

  12/31/15 → 12/30/16

  Project: A - Government Institution › c - Ministry of Health and Welfare

• Evaluation on prevention for metabolic syndrome and diabetes mellitus through lifestyle modification intervention in pre-diabetic subjects (100-104)

  Chiou, H., Bai, C., Tang, C., Yang, S., Su, C., Liou, T., Wang, S., Chen, J., Hsieh, A. & Huang, C.

  12/24/14 → 12/5/15

  Project: A - Government Institution › c - Ministry of Health and Welfare

  • Metabolic Syndrome 100%
  • Life Style 88%
  • Diabetes Mellitus 86%

• "First-in-Class"新穎性抗癌藥物ITCH E3 ubiquitinligase 抑制劑之新藥開發

  Yen, Y.

  7/1/17 → 6/30/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• Functional Study of a Novel Long Non-Coding Rna Linat in Colorectal Cancer Progression

  Chen, H.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• Functional Study of a Novel Long Non-Coding Rna Linat in Colorectal Cancer Progression(2/3)

  Chen, H.

  8/1/18 → 7/31/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Gene Knock out Mice Model for Studying the Molecular Mechanisms of Early Onset Breast Tumor Microenvironment Regulation.

  Wu, C., Ho, Y. & Tu, S.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Antitumor 100%
  • Growth Factor 25%
  • Apoptotic 24%
  • Cell Death 23%
  • Hormone 21%

• Generate Anti-Erythropoietin Producing Hepatocellular Receptor Type-A2 (Epha2) Antibody-Drug Conjugate and Study Its Potential Application against Pancreatic Cancer

  Lee, Y.

  8/1/22 → 7/31/23

  Project: A - Government Institution › b - Ministry of Science and Technology

• Generate anti-Fibroblast growth factor receptor 2 (FGFR2) antibody drugs and study on their potential application against gastric cancer

  Lee, Y.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology