TMU Research Center of Cancer Translational Medicine

Projects

Projects per year 2010 2014 2015 2016 2017 2018 2024

• 5 Active
• 540 Finished

Projects per year

Search results

• Active

  腫瘤微環境中癌細胞與免疫因子的串擾：頭頸癌的組織蛋白酶S相關調節機制鑑定和治療策略－溶酶體半胱氨酸蛋白酶組織蛋白酶S在頭頸癌腫瘤免疫中的作用：聚焦對IL-7的調節角色和潛在的免疫調節機制(3/3)

  Chang, J.

  8/1/23 → 7/31/24

  Project: A - Government Institution › b - National Science and Technology Council

• 以整合學習模型來預測一般細胞與癌細胞之特有表面蛋白

  Chen, S.

  8/1/23 → 7/31/24

  Project: A - Government Institution › b - National Science and Technology Council

• 利用多樣化CRISPR衍生技術來探討及標靶STING1基因以克服令癌莎之抗藥性(1/3)

  Chu, C.

  7/1/23 → 6/30/24

  Project: A - Government Institution › b - National Science and Technology Council

• 112年高教深耕-癌症轉譯研究中心計畫

  Chang, J.

  1/1/23 → 12/31/23

  Project: B - Project of TMU › h - Higher Education Sprout Project

• 新聘教師研究補助

  Chu, C.

  12/20/22 → 12/19/23

  Project: B - Project of TMU › g - Research Grants for Newly Hired Faculty

• Finished

  Generate Anti-Erythropoietin Producing Hepatocellular Receptor Type-A2 (Epha2) Antibody-Drug Conjugate and Study Its Potential Application against Pancreatic Cancer

  Lee, Y.

  8/1/22 → 7/31/23

  Project: A - Government Institution › b - National Science and Technology Council

• Study the Combination Effects of Selenium Yeast and Fish Oil to Synergistically Regulate the Glycogen Synthase Kinase-3 (Gsk-3)/Tbet/Pd-1 Axis of T Cells for Enhanced Anti-Tumor Immunity

  Yao, C.

  8/1/22 → 7/31/23

  Project: A - Government Institution › b - National Science and Technology Council

• 探討cathepsin S在奧沙利鉑引起的神經病變的作用角色: 預測和預防周邊神經病變的潛在生物標誌(3/3)

  Chang, J.

  8/1/22 → 7/31/23

  Project: A - Government Institution › b - National Science and Technology Council

• 腫瘤微環境中癌細胞與免疫因子的串擾：頭頸癌的組織蛋白酶S相關調節機制鑑定和治療策略－溶酶體半胱氨酸蛋白酶組織蛋白酶S在頭頸癌腫瘤免疫中的作用：聚焦對IL-7的調節角色和潛在的免疫調節機制(2/3)

  Chang, J.

  8/1/22 → 7/31/23

  Project: A - Government Institution › b - National Science and Technology Council

• Phosphorylation of Dicer Targets on Metabolic Vulnerability and Gemcitabine Resistance in Translational Pancreatic Cancer Research

  Chiu, C.

  8/1/22 → 7/31/23

  Project: A - Government Institution › b - National Science and Technology Council

• 魚油多元不飽和脂肪酸對胰臟癌細胞脂質代謝與癌轉移之研究

  Chiu, C.

  7/1/22 → 2/28/23

  Project: A - Government Institution › b - National Science and Technology Council

• Targeting O-Glycans of Iga1 to Develop Diagnostic Reagents for Iga Nephropathy and Reshape Its Clinical Assessment Protocol( III )

  Lee, Y.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - National Science and Technology Council

  • Immunoglobulin A 100%
  • Clinical Protocols 35%
  • Taiwan 35%
  • Polysaccharides 33%
  • Therapeutics 5%

• Strategy for Treatment of Osimertinib-Resistant Lung Adenocarcinoma by Jnk Activation

  Yao, C.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - National Science and Technology Council

• Studies on the Carcinogenic Mechanisms of Serine/Threonine-Protein Kinase (Sik3) Involved in the Process of Breast Tumor Formation

  Chen, L.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - National Science and Technology Council

• Identify Human Surfaceome in Deep Learning for Cell-Type Annotation and Isolation from Scrna-Seq

  Chen, S.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - National Science and Technology Council

• Targeting O-Glycans of Iga1 to Develop Diagnostic Reagents for Iga Nephropathy and Reshape Its Clinical Assessment Protocol( II )

  Lee, Y.

  8/1/20 → 7/31/22

  Project: A - Government Institution › b - National Science and Technology Council

  • Immunoglobulin A 100%
  • Clinical Protocols 35%
  • Taiwan 35%
  • Polysaccharides 33%
  • Therapeutics 5%

• 奈米HEVnp於晚期大腸直腸癌患者的治療策略(2/3)

  Whang-Peng, J.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - National Science and Technology Council

• Synthetic and Medicinal Utility of Organometallics in the Development of Anticancer Epigenetic Inhibitors: Applications and Explorations( I )( I )(1/2)

  Liou, J.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - National Science and Technology Council

• A Translational Study to Verify Roles of Circulating Mir-19b and Mir-93 as Biomarker Signatures for Early Diagnosis of Osteoporosis in Men(2/3)

  Chen, R.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - National Science and Technology Council

• To Develop Novel Treatment Options for Hepatocellular Carcinoma via Drug Repurposing(2/2)

  Whang-Peng, J.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - National Science and Technology Council

• Investigation of the Role of Gut Microbiota in Antipsychoticinduced Metabolic Dysfunction in Patient with Schizophrenia

  Liu, Y.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - National Science and Technology Council

• Development of Leukemia Based Precision Medicine Research Model on Non-Invasive Apoptosis Detection Platform – Application of Crispr/Cas9 Gene and Target Therapy on Philadelphia Chromosome of Chronic Myelogenous Leukemia as an Example

  Chen, S.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - National Science and Technology Council

  • Precision Medicine 100%
  • Leukemia 88%
  • Heterografts 41%
  • Philadelphia Chromosome 39%
  • Myeloid Leukemia 37%

• The Role and Mechanism of Dendritic Cell Pd-L1/Pd-L2 Dysregulation in Aberrant Inflammation of Copd

  Lee, K.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - National Science and Technology Council

• The Role and Mechanism of Cd155/Tigit in Mdsc/Tam Induced Nk Cell Dysfunction -A Link to Lung Cancer Resistance to Immune Checkpoint Blockade

  Feng, P.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - National Science and Technology Council

• Roles of the Hdacs/Sp1-Mediated Microrna-106b~25 Axis in Drug Resistance of Glioblastomas(1/3)

  Chen, R.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - National Science and Technology Council

• Nano-Hevnp Theranostic Strategy for Late-Stage Colorectal Cancer Patients(1/3)

  Whang-Peng, J.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - National Science and Technology Council

• Studies on the Mechanisms of Histamine N-Methyl-Transferase (Hnmt) as a Novel Molecular Marker to Help Clinician for Identifying of Herceptin Responder in Breast Cancer Patients(1/3)

  Ho, Y.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - National Science and Technology Council

• Investigating the Oncogenic Roles of A9-Nicotinic Acetylcholine Receptor Variants on Breast Cancer( III )

  Ho, Y.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - National Science and Technology Council

• 調節第一型神經衍生孤兒核受體 (Neuron-derived orphan receptor 1, NOR-1)之蛋白質表現可能是 Pomalidomide對創傷性腦損傷之神經保護作用之一

  Chen, R.

  7/1/19 → 2/1/20

  Project: A - Government Institution › b - National Science and Technology Council

• 激肽釋放酶-激肽系統調控惡性神經膠質瘤細胞基質金屬蛋白酶表現之機轉

  Chen, R.

  3/1/19 → 2/1/20

  Project: C - Project of Alliance › o - Chi Mei Medical Center

• PM2.5對慢性阻塞性肺病在肺修復和再生受損的影響-IL-17和新穎生物標記在環境PM2.5誘導COPD肺損傷的影響

  Lee, K.

  1/1/19 → 12/1/19

  Project: A - Government Institution › d - Ministry of Education

• Repurposing of a Positive Allosteric Modulator of M5 Muscarinic Acetylcholine Receptor as a Microtubule-Targeting Agent and Its Application for Treating Pancreatic Ductal Adenocarcinoma

  Hsieh, Y.

  1/1/19 → 6/1/20

  Project: A - Government Institution › b - National Science and Technology Council

• 神經內分泌型前列腺癌的轉譯研究-ADAM9在神經內分泌型前列腺癌的轉譯研究

  Sung, S.

  1/1/19 → 12/1/19

  Project: A - Government Institution › d - Ministry of Education

• 發展抗肺纖維化劑-合成抗肺纖維化合物

  Liou, J.

  1/1/19 → 12/1/19

  Project: A - Government Institution › d - Ministry of Education

• 探討CD155/TIGIT 在類骨髓衍生抑制細胞/腫瘤衍生巨噬細胞誘導自然殺手細胞失調的機轉- 研究肺癌病人免疫檢查點阻斷藥物抗藥性機轉

  Feng, P.

  1/1/19 → 12/1/19

  Project: A - Government Institution › d - Ministry of Education

• 21121 發展特色研究，推動轉譯醫學（CRISPR基因編輯核心實驗室）

  Chu, C.

  1/1/19 → 12/31/19

  Project: B - Project of TMU › h - Higher Education Sprout Project

• 亞太生醫矽谷精準醫療旗艦計畫-臺北醫學大學合作案

  Liou, J.

  1/1/19 → 12/1/19

  Project: A - Government Institution › a - National Health Research Institutes

• 具抗藥性多形性膠質母細胞瘤的新穎治療策略研究-Bradykinin-TIMP-MMP 軸在抗藥性神經膠質瘤細胞調控血瘤障壁通透性過程中扮演的角色

  Chen, R.

  1/1/19 → 12/1/19

  Project: A - Government Institution › d - Ministry of Education

• 雙打擊在瀰漫大B細胞淋巴瘤所扮演的角色-致病機轉與臨床特色之探討-JARID1B蛋白在雙打擊瀰漫大B細胞淋巴瘤的角色及其臨床定義

  Liu, Y.

  1/1/19 → 12/1/19

  Project: A - Government Institution › d - Ministry of Education

• The Role of Sp1-Regulated Neurosteroidogenesis in Glioma Development(2/2)

  Hsu, T.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - National Science and Technology Council

  • Neurosteroids 100%
  • Glioma 74%
  • Glioblastoma 67%
  • Temozolomide 54%
  • Astrocytes 34%

• Role of Ribonucleotide Reductase (Rnr) in Skeletal Muscle with Age: the Functionality of Rrm2b in Repair and Regeneration

  Chen, Y.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - National Science and Technology Council

  • Skeletal Muscle 100%
  • Sarcopenia 58%
  • Regeneration 52%
  • Muscles 47%
  • Muscular Diseases 33%

• Drug Discovery and Pharmacological Investigation of Novel Selective Hdac Inhibitors as Anticancer Drugs(1/3)

  Pan, S.

  8/1/18 → 7/31/19

  Project: A - Government Institution › b - National Science and Technology Council

• Development of Novel Dyrk1a Inhibitors for the Treatment of Alzheimer'S Disease

  HuangFu, W.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - National Science and Technology Council

  • Dyrk kinase 100%
  • Alzheimer Disease 43%
  • Neurofibrillary Tangles 17%
  • Amyloid beta-Peptides 15%
  • Memory 10%

• A Translational Investigation of the Role of Myc/Pd-L1/Akt Axis as a Therapeutic Target for Treating Glioblastoma Multiforme

  Lin, C.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - National Science and Technology Council

• Studies on the Role of Stomatin-Like Protein 2 (Stoml2) in Thrombin-Stimulated Il-8/Cxcl8 Expression and Airway Inflammation(2/3)

  Chen, B.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - National Science and Technology Council

• Therapeutic Potentials of Exosomes from Mesenchymal Stem Cell on Mitigating Cardiac Alterations and Their Effects on Modulating Oxidation, Inflammation, Mitochondrial Dysfunction and Insulin Resistance in Obesity Mice and Obesity Mice with Sepsis

  Huang, C.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - National Science and Technology Council

• Role of Hbx and Androgen Receptor in Regulating Senp1/Stemess-Related Properties in Hbv-Related Hcc and Its Clinical Impact

  Huang, Y.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - National Science and Technology Council

  • Hepatocellular Carcinoma 100%
  • Hep G2 Cells 36%
  • Androgens 30%
  • Neoplasms 29%
  • sulfoenolpyruvate 21%

• Anti-Egfr×Anti-Fap Bi-Specific Targeting Antibody Combined with Irinotecan Encapsulated Liposomes for Pancreatic Cancer Therapy

  Lin, S.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - National Science and Technology Council

• 新聘教師研究補助

  Huang, Y.

  8/1/18 → 7/31/19

  Project: B - Project of TMU › g - Research Grants for Newly Hired Faculty

• Nano-Diamino-Tetrac (Ndat) Enhances Resveratrol-Induced Anti-Proliferation by Action on the Rrm2 Pathway in Colorectal Cancers

  Lin, H.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - National Science and Technology Council

  • Resveratrol 100%
  • Ribonucleotide 49%
  • Antiproliferative 13%
  • Bellow 10%
  • Stilbenoid 10%