TMU Research Center of Cancer Translational Medicine

Projects

Projects per year 2010 2014 2015 2016 2017 2018 2024

• 5 Active
• 540 Finished

Projects per year

Search results

• Active

  以整合學習模型來預測一般細胞與癌細胞之特有表面蛋白

  Chen, S.

  8/1/23 → 7/31/24

  Project: A - Government Institution › b - National Science and Technology Council

• 腫瘤微環境中癌細胞與免疫因子的串擾：頭頸癌的組織蛋白酶S相關調節機制鑑定和治療策略－溶酶體半胱氨酸蛋白酶組織蛋白酶S在頭頸癌腫瘤免疫中的作用：聚焦對IL-7的調節角色和潛在的免疫調節機制(3/3)

  Chang, J.

  8/1/23 → 7/31/24

  Project: A - Government Institution › b - National Science and Technology Council

• 利用多樣化CRISPR衍生技術來探討及標靶STING1基因以克服令癌莎之抗藥性(1/3)

  Chu, C.

  7/1/23 → 6/30/24

  Project: A - Government Institution › b - National Science and Technology Council

• 112年高教深耕-癌症轉譯研究中心計畫

  Chang, J.

  1/1/23 → 12/31/23

  Project: B - Project of TMU › h - Higher Education Sprout Project

• 新聘教師研究補助

  Chu, C.

  12/20/22 → 12/19/23

  Project: B - Project of TMU › g - Research Grants for Newly Hired Faculty

• Finished

  腫瘤微環境中癌細胞與免疫因子的串擾：頭頸癌的組織蛋白酶S相關調節機制鑑定和治療策略－溶酶體半胱氨酸蛋白酶組織蛋白酶S在頭頸癌腫瘤免疫中的作用：聚焦對IL-7的調節角色和潛在的免疫調節機制(2/3)

  Chang, J.

  8/1/22 → 7/31/23

  Project: A - Government Institution › b - National Science and Technology Council

• Phosphorylation of Dicer Targets on Metabolic Vulnerability and Gemcitabine Resistance in Translational Pancreatic Cancer Research

  Chiu, C.

  8/1/22 → 7/31/23

  Project: A - Government Institution › b - National Science and Technology Council

• 探討cathepsin S在奧沙利鉑引起的神經病變的作用角色: 預測和預防周邊神經病變的潛在生物標誌(3/3)

  Chang, J.

  8/1/22 → 7/31/23

  Project: A - Government Institution › b - National Science and Technology Council

• Generate Anti-Erythropoietin Producing Hepatocellular Receptor Type-A2 (Epha2) Antibody-Drug Conjugate and Study Its Potential Application against Pancreatic Cancer

  Lee, Y.

  8/1/22 → 7/31/23

  Project: A - Government Institution › b - National Science and Technology Council

• Study the Combination Effects of Selenium Yeast and Fish Oil to Synergistically Regulate the Glycogen Synthase Kinase-3 (Gsk-3)/Tbet/Pd-1 Axis of T Cells for Enhanced Anti-Tumor Immunity

  Yao, C.

  8/1/22 → 7/31/23

  Project: A - Government Institution › b - National Science and Technology Council

• 魚油多元不飽和脂肪酸對胰臟癌細胞脂質代謝與癌轉移之研究

  Chiu, C.

  7/1/22 → 2/28/23

  Project: A - Government Institution › b - National Science and Technology Council

• Identify Human Surfaceome in Deep Learning for Cell-Type Annotation and Isolation from Scrna-Seq

  Chen, S.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - National Science and Technology Council

• Targeting O-Glycans of Iga1 to Develop Diagnostic Reagents for Iga Nephropathy and Reshape Its Clinical Assessment Protocol( III )

  Lee, Y.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - National Science and Technology Council

  • Immunoglobulin A 100%
  • Clinical Protocols 35%
  • Taiwan 35%
  • Polysaccharides 33%
  • Therapeutics 5%

• Studies on the Carcinogenic Mechanisms of Serine/Threonine-Protein Kinase (Sik3) Involved in the Process of Breast Tumor Formation

  Chen, L.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - National Science and Technology Council

• Strategy for Treatment of Osimertinib-Resistant Lung Adenocarcinoma by Jnk Activation

  Yao, C.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - National Science and Technology Council

• 奈米HEVnp於晚期大腸直腸癌患者的治療策略(2/3)

  Whang-Peng, J.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - National Science and Technology Council

• Targeting O-Glycans of Iga1 to Develop Diagnostic Reagents for Iga Nephropathy and Reshape Its Clinical Assessment Protocol( II )

  Lee, Y.

  8/1/20 → 7/31/22

  Project: A - Government Institution › b - National Science and Technology Council

  • Immunoglobulin A 100%
  • Clinical Protocols 35%
  • Taiwan 35%
  • Polysaccharides 33%
  • Therapeutics 5%

• Studies on the Mechanisms of Histamine N-Methyl-Transferase (Hnmt) as a Novel Molecular Marker to Help Clinician for Identifying of Herceptin Responder in Breast Cancer Patients(1/3)

  Ho, Y.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - National Science and Technology Council

• To Develop Novel Treatment Options for Hepatocellular Carcinoma via Drug Repurposing(2/2)

  Whang-Peng, J.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - National Science and Technology Council

• Investigation of the Role of Gut Microbiota in Antipsychoticinduced Metabolic Dysfunction in Patient with Schizophrenia

  Liu, Y.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - National Science and Technology Council

• Synthetic and Medicinal Utility of Organometallics in the Development of Anticancer Epigenetic Inhibitors: Applications and Explorations( I )( I )(1/2)

  Liou, J.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - National Science and Technology Council

• The Role and Mechanism of Cd155/Tigit in Mdsc/Tam Induced Nk Cell Dysfunction -A Link to Lung Cancer Resistance to Immune Checkpoint Blockade

  Feng, P.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - National Science and Technology Council

• Nano-Hevnp Theranostic Strategy for Late-Stage Colorectal Cancer Patients(1/3)

  Whang-Peng, J.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - National Science and Technology Council

• A Translational Study to Verify Roles of Circulating Mir-19b and Mir-93 as Biomarker Signatures for Early Diagnosis of Osteoporosis in Men(2/3)

  Chen, R.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - National Science and Technology Council

• Investigating the Oncogenic Roles of A9-Nicotinic Acetylcholine Receptor Variants on Breast Cancer( III )

  Ho, Y.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - National Science and Technology Council

• Development of Leukemia Based Precision Medicine Research Model on Non-Invasive Apoptosis Detection Platform – Application of Crispr/Cas9 Gene and Target Therapy on Philadelphia Chromosome of Chronic Myelogenous Leukemia as an Example

  Chen, S.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - National Science and Technology Council

  • Precision Medicine 100%
  • Leukemia 88%
  • Heterografts 41%
  • Philadelphia Chromosome 39%
  • Myeloid Leukemia 37%

• Roles of the Hdacs/Sp1-Mediated Microrna-106b~25 Axis in Drug Resistance of Glioblastomas(1/3)

  Chen, R.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - National Science and Technology Council

• The Role and Mechanism of Dendritic Cell Pd-L1/Pd-L2 Dysregulation in Aberrant Inflammation of Copd

  Lee, K.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - National Science and Technology Council

• 調節第一型神經衍生孤兒核受體 (Neuron-derived orphan receptor 1, NOR-1)之蛋白質表現可能是 Pomalidomide對創傷性腦損傷之神經保護作用之一

  Chen, R.

  7/1/19 → 2/1/20

  Project: A - Government Institution › b - National Science and Technology Council

• 激肽釋放酶-激肽系統調控惡性神經膠質瘤細胞基質金屬蛋白酶表現之機轉

  Chen, R.

  3/1/19 → 2/1/20

  Project: C - Project of Alliance › o - Chi Mei Medical Center

• 亞太生醫矽谷精準醫療旗艦計畫-臺北醫學大學合作案

  Liou, J.

  1/1/19 → 12/1/19

  Project: A - Government Institution › a - National Health Research Institutes

• Repurposing of a Positive Allosteric Modulator of M5 Muscarinic Acetylcholine Receptor as a Microtubule-Targeting Agent and Its Application for Treating Pancreatic Ductal Adenocarcinoma

  Hsieh, Y.

  1/1/19 → 6/1/20

  Project: A - Government Institution › b - National Science and Technology Council

• 具抗藥性多形性膠質母細胞瘤的新穎治療策略研究-Bradykinin-TIMP-MMP 軸在抗藥性神經膠質瘤細胞調控血瘤障壁通透性過程中扮演的角色

  Chen, R.

  1/1/19 → 12/1/19

  Project: A - Government Institution › d - Ministry of Education

• 雙打擊在瀰漫大B細胞淋巴瘤所扮演的角色-致病機轉與臨床特色之探討-JARID1B蛋白在雙打擊瀰漫大B細胞淋巴瘤的角色及其臨床定義

  Liu, Y.

  1/1/19 → 12/1/19

  Project: A - Government Institution › d - Ministry of Education

• 21121 發展特色研究，推動轉譯醫學（CRISPR基因編輯核心實驗室）

  Chu, C.

  1/1/19 → 12/31/19

  Project: B - Project of TMU › h - Higher Education Sprout Project

• 發展抗肺纖維化劑-合成抗肺纖維化合物

  Liou, J.

  1/1/19 → 12/1/19

  Project: A - Government Institution › d - Ministry of Education

• 探討CD155/TIGIT 在類骨髓衍生抑制細胞/腫瘤衍生巨噬細胞誘導自然殺手細胞失調的機轉- 研究肺癌病人免疫檢查點阻斷藥物抗藥性機轉

  Feng, P.

  1/1/19 → 12/1/19

  Project: A - Government Institution › d - Ministry of Education

• 神經內分泌型前列腺癌的轉譯研究-ADAM9在神經內分泌型前列腺癌的轉譯研究

  Sung, S.

  1/1/19 → 12/1/19

  Project: A - Government Institution › d - Ministry of Education

• PM2.5對慢性阻塞性肺病在肺修復和再生受損的影響-IL-17和新穎生物標記在環境PM2.5誘導COPD肺損傷的影響

  Lee, K.

  1/1/19 → 12/1/19

  Project: A - Government Institution › d - Ministry of Education

• To Develop Novel Treatment Options for Hepatocellular Carcinoma via Drug Repurposing(1/2)

  Whang-Peng, J.

  8/1/18 → 7/31/19

  Project: A - Government Institution › b - National Science and Technology Council

• Therapeutic Potentials of Exosomes from Mesenchymal Stem Cell on Mitigating Cardiac Alterations and Their Effects on Modulating Oxidation, Inflammation, Mitochondrial Dysfunction and Insulin Resistance in Obesity Mice and Obesity Mice with Sepsis

  Huang, C.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - National Science and Technology Council

• 新聘教師研究補助

  Shih, J.

  8/1/18 → 7/31/20

  Project: B - Project of TMU › g - Research Grants for Newly Hired Faculty

• The Role of Aspm-Wnt Signaling in Hepatoma Cancer Stemness and Progression and the Development of the Related Nano- and Gene-Therapy(2/3)

  Tsai, K. K.

  8/1/18 → 7/31/19

  Project: A - Government Institution › b - National Science and Technology Council

• Studies on the Mechanisms of Dna Primase（Prim1）Involved in Smoking-Induced Breast Cancer Formations and Its Translational Applications

  Chen, L.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - National Science and Technology Council

• Epigenetic Editing as a Novel Therapeutics for Gynecological Cancer

  Lai, H.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - National Science and Technology Council

  • Epigenomics 100%
  • Clustered Regularly Interspaced Short Palindromic Repeats 43%
  • Tumor Biomarkers 27%
  • Neoplasms 24%
  • Gene Editing 23%

• Investigation of Role of Adam17/Preadipocyte Factor-1 in Hypoxia-Induced Ctgf Expression and Airway Fibrosis(1/3)

  Chen, B.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - National Science and Technology Council

• To Study the Role of Pctk1 in the Progression of Colorectal Cancer and Molecular Mechanism (Continuation Project)(1/3)

  Wei, P.

  8/1/18 → 7/31/19

  Project: A - Government Institution › b - National Science and Technology Council

• Anti-Egfr×Anti-Fap Bi-Specific Targeting Antibody Combined with Irinotecan Encapsulated Liposomes for Pancreatic Cancer Therapy

  Lin, S.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - National Science and Technology Council

• Environmental Factors and Genetic Polymorphisms Associate with the Development and Prognosis of Oral Squamous Cell Carcinoma

  Yeh, C.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - National Science and Technology Council

  • Squamous Cell Carcinoma 100%
  • Genes 26%
  • Taiwan 21%
  • DNA Repair 20%
  • Genome 14%

• Impacts of Particulate Air Pollution on Repair and Abnormal Inflammation in Copd: the Role of Itih4 and the Regeneration Pathways

  Lee, K.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - National Science and Technology Council

  • Chronic Obstructive Pulmonary Disease 100%
  • inter-alpha-inhibitor 82%
  • Particulate Matter 74%
  • Inflammation 30%
  • human ITIH4 protein 25%