Projects per year
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Role of ER stress in Evodiamine-induced apoptosis and G2/M arrest of human colorectal carcinoma cells
Chen, Y.
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Effects of Functional Electrical Stimulation Cycling and Central Neuromodulation on Motor Control in Stroke
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Saliva Alkaloids of Areca Nut or Tobacco, Inflammatory and Antioxidants Status and Oral Hygiene in Periodontitis Patients
Huang, Y.
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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The Role of CISD2 in the Female Reproductive System of Mammal
Chang, H.
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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To Study the Correlation between Serum Markers of Oxidative Stress, Inflammation, and Endocrine-Disrupting Chemicals (Edcs) and Their Impact on the Menstrual Cycle and Reproductive Hormone in Taiwanese Women
Hsu, M.
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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The association of early-onset ischemic stroke and the aging of vascular system using the telomere length related genes
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Cellular and Molecular Mechanisms of Nicotine and Nitrosamines Promote Tumorigenic Behaviors in Renal Cell Carcinoma (Ii)
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Pharmaceuticals Removal in Hospital wastwater and effluent by Electro-coagulation-flotation
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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The Effects of Metabolic Abnormalities on Cognitive Function in Schizophrenic Patients
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Dietary Advanced Glycation Endproducts Are Associated with the Development of Polycystic Ovary Syndrome: The Mechanisms of Action
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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山藥儲藏性蛋白質功能性月生月太之延緩衰老功能評估與機制探討(1/3)
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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The Effects of LED Light on Porphyromonas gingivalis in Periodontitis for Anti-Inflammation and Alveolar Bone Regeneration
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Effects of Exercise Training on Sleep Disturbances, Anxiety, and Depression among Newly Diagnosed Elderly Lung Cancer Patients
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Role of HBX and IL-6 in Regulating SENP1/Stemness Properties of HBV-Related Hcc under Hypoxia and Its Clinical Implication
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Dissected the role of Glucosed-regulated portein 78 in the progression, metastasis and therapy of colorectal cancer
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Molecular Epidemiological Study of Renal Cell Carcinoma - Arsenic Methylation Capability, 8OHdG and Polymorphism of IRS and RAAS Exploration
Hsueh, Y.
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Synthesis and Antihyperglycemic Evaluation of Isosteviol Derivatives
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Immune Alteration and Immunogenic Cell Death in Advanced Non-Small Cell Lung Cancer Patients
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Using Cometing Risk Model for Death and Multi-state Stochastic Process for the Behaviour of Betel-quid Chewing and Smoking to Estimate the Potential Years of Life Lost Due to Betel Quid and to Estiamte the Impact of Qutiing Betel-quid chewing
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Study the Role of GRP78 in E1A-Mediated Metastasis Suppression of Breast Cancer
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Association Study of Persistent Metabolic Syndrome, Inflammatory Markers and Mild Cognitive Decline
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Immature Testicular Tissue Engineering for Male Fertility Preservation---A Transgenic Mouse Model
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Chitosan nanoparticle as a macrophage-targeting drug delivery carrier
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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設計並評估新型含藥人工骨凝膠對齒槽骨缺損的修復作用
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Fabricating Bioengineered Corneal Endothelium on Chitosan-Polycaprolactone Blends---Experiment, Mechanism, and Application
8/1/13 → 12/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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大腸直腸癌已躍居世界上癌症死亡率第二名，屬於固體型腫瘤，缺氧常見於此類 腫瘤，並誘發HIF-1α 表現而導致抗藥性及預後較差，因此抑制HIF-1α 被視為新的抗 癌策略。Zebularine (Zeb)是較穩定之DNA methyltransferase (DNMT)抑制劑，可殺死癌 細胞而不影響正常細胞，對小鼠也不具毒性。我們初步結果顯示，Zeb 可抑制人類大 腸癌細胞株HCT116 之HIF-1α表現，代表Zeb 是治療大腸直腸癌之潛力藥物。我們的 初步也證明Zeb對HCT116具毒殺性，對小鼠大腸癌也有療效。細胞自我吞噬(autophagy) 是指細胞在惡劣環境下，經由吞噬細胞內物質產生能量渡過外界壓力的一種保護機 制；也有研究報導指出，藥物會誘導癌細胞產生autophagy，造成細胞過度吞噬其內容 物而死亡，因此，autophagy在癌細胞為保護或是引發毒殺作用，目前仍無定論。缺氧 也會透過HIF-1α 導致autophagy 而促進細胞存活，但嚴重缺氧或無氧狀態則可透過活 化AMPK及unfolded protein response (UPR)造成autophagic cell death。我們初步結果顯 示，除抑制HIF-1α 表現外，Zeb 也可活化AMPK、UPR/ER stress、以及autophagy， 因此我們推測Zeb 可在缺氧狀態下，促進autophagic cell death。3 年內我們將執行4 項 目標： (1) 探討Zeb 在各種癌細胞及活體模式之抗癌作用。（第一年） (2) 研究Zeb 抑制HIF-1α表現之分子機轉。（第一年到第二年） (3) 研究Zeb 誘發autophagy之分子機轉。（第二年到第三年） (4) 探討Zeb 對缺氧導致抗藥性之作用。（第三年）
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Belongingness: The Mental Ownership Theory and Research Program
8/1/13 → 9/30/14
Project: A - Government Institution › b - Ministry of Science and Technology
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The Neuroendocrine-Immune Mechanisms of Physical Activity on Behavioral Symptoms in Lung Cancer Patients---A Comparison of Patients Receiving Active Treatments and Survivors
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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晚期乳癌組織中尼古丁受體(α9-nAChR)表現與Trastuzumab (Herceptin®)產生抗藥性之分子機制探討
Ho, Y.
8/1/13 → 7/31/14
Project: B - Project of TMU › i - Other (Funded by TMU)
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Characterization of 5-Hydroxymethylcytosine and Ten-to-Eleven Translocation Gene (TET) in Cervical Cancer
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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To Predict the Recurrence of Major Depressive Disorder Within an Integrated Bio-Psycho-Social Framework---A Follow-up Study
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Application of clinical anti-arthralgia formulas of traditional Chinese medicine to arthritis
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Investigation on developing novel biomarkers and treatments in the patients with fibromyalgia
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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The Sumoylation of Histone Deacetylase 2 Contributes to CTGF Expression and Pulmonary Fibrosis in Chronic Obstructive Asthma (I)
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Effects of a program of mind-body interventions on psychological resilience, vagal tone, emotional states, and outcomes of heart failure
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Translational studies of Mycobacterium tuberculosis-induced lung and pleural fibrosis
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Development of measurement technology of surface-enhanced Raman spectroscopy for detection of biomolecules
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Studies on a Thermosensitive Hydrogel of Doxorubicin as Locally Controlled Delivery of Cancer Therapeutics
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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The relationship and predictors of electrocardiography, inflammatory markers, clinical features in older bipolar and schizophrenia patients concurrent with coronary heart and cerebro-vascular diseases
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Study the Therapeutic Effects and Novel Molecular Mechanisms of Resveratrol in Human Osteosarcoma: the Treatment of Metastatic Cancer
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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The Neurotrophic/Neuroprotective Role of GIP in Cellular and Rodent Models of Mild Traumatic Brain Injury (II)
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Molecular Epidemiology of Urothelial Carcinoma Prognosis Based on Microrna Expression Profiles
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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In vitro and in vivo evaluation for silk fibroin-coated electrospun resorbable poly(lactic acid) GTR barriers
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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The Effects of Music Therapy on Psychological Distress and Functional Recovery in Patients With Stroke
Chang, H.
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Victorian Sanitation: Narratives of Poverty, Filth and Economy of Morality
Chen, C.
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Lipid Raft Associated Signaling in Regulation of Osteoclast Activation in Inflammatory Arthritis
Tsai, H.
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Development of Novel Degradable Biomaterial for Dental Hemostatic Sponge Applications
Lin, C.
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Functional Characterization of Niemann-Pick Type C2 Protein in Hepatocellular Carcinoma
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Degradation of nitrogen-containing PPCPs: kinetic study, application, and balancing the toxicity of N-DBP and intermediates through bioassay
Chang, E.
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Study of Context Aware Knowledge Supporting Systems---A Case Study of Premature Neonates Care
Liu, C.
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology