Taipei Medical University

Projects

Projects per year 2002 2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 2026

• 2 Not started
• 589 Active
• 7312 Finished

Projects per year

Search results

• 利用三段式螢光共振能量轉移觀察基因藥物與聚合微膠體在不同角膜分佈穿透(2/3)

  Liaw, J.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Discovery of Rare and Common Variants in Genetic Association Studies

  Cheng, K.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Genome-Wide Association Study 100%
  • Genetic Association Studies 50%
  • Gene Frequency 46%
  • Inborn Genetic Diseases 44%
  • Case-Control Studies 38%

• TMU101-AE1-B65

  Wang, T.

  8/1/13 → 7/31/14

  Project: C - Project of Alliance › p - Taipei Medical University Hospital

• Prp: Platelet-Rich Plasma Effects in the Articular Chondrocytes and Synovial Fibroblasts with the Associated Mechanism---A Fibronectin Fragment Model

  Lee, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • fibronectins 100%
  • Toll-like receptor 2 91%
  • cartilage 74%
  • growth factors 68%
  • chondrocytes 66%

• 臺蒙(MN)國合計畫－台灣及蒙古之洋蔥及蔥屬蔬菜對骨質疏鬆症的影響(1/3)

  Chen, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• 山藥儲藏性蛋白質功能性月生月太之延緩衰老功能評估與機制探討(1/3)

  Hou, W.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Investigation of the Effect of Androgen Receptor Knockout on Pathophysiology of Traumatic Brain Injury

  Yang, L.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Traumatic Brain Injury 100%
  • Androgen Receptors 45%
  • collapsin response mediator protein-2 40%
  • Organized Financing 28%
  • Androgens 16%

• Studies of Anti-Cancer Activity of Folic Acid

  Lee, W.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Exploratory Study of Self-Identity and Medical Professionalism Among Medical Students

  Chiu, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • professionalism 100%
  • medical student 35%
  • empathy 24%
  • curriculum 21%
  • role model 13%

• The exploitation of Taiwan native plants in promoting bone growth and establishment of the system biology platform

  Lee, M.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Uraria crinita 100%
  • osteoblasts 67%
  • Taiwan 65%
  • bones 48%
  • Biological Sciences 27%

• Glucagon-Like Peptide-1 in the Regulation of PPARs and Calcium Handling in Hyperglycemia or Hypertensive HL-1 Cells

  Huang, J.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Glucagon-Like Peptide 1 100%
  • Peroxisome Proliferator-Activated Receptors 80%
  • Calcium 38%
  • Hyperglycemia 25%
  • Calcium-Transporting ATPases 22%

• Real-Time Single-Cell Probing of the Action Mechanism of Amphotericin B Ion Channels---From Extracellular to Intracellular

  Yang, T.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Amphotericin B 100%
  • Ergosterol 57%
  • Aquaporins 51%
  • Ion Channels 49%
  • Cell Membrane 29%

• Mechanism and Functional Study of Sumoylation in Mammalian System

  Hwang, J.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Sumoylation 100%
  • Yeasts 17%
  • Phosphorylation 17%
  • Cyclic AMP-Dependent Protein Kinases 6%
  • Lysine 6%

• Roles of toll-like receptor-4 and hif-1 in propofol-involved protection against traumatic brain injury-induced dysfunction of the blood-brain barrier

  Chang, H.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Blood-Brain Barrier 100%
  • Propofol 73%
  • Hypoxia 63%
  • Brain Edema 25%
  • Craniocerebral Trauma 22%

• Molecular mechanisms of propofol-involved protection against ischemia brain injuries

  Chen, T.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Propofol 100%
  • Ischemia 76%
  • Brain Injuries 75%
  • Reperfusion 34%
  • Mitogen-Activated Protein Kinases 30%

• Study of Postoperative Adverse Outcomes of Surgical Patients Using Taiwan National Health Insurance Database

  Chen, T.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• The effect of endothelin-1 on myofibroblast transformation of pleural mesothelial cells and its implications for pleural and pulmonary fibrosis

  Chung, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Myofibroblasts 100%
  • Endothelin-1 85%
  • Fibrosis 70%
  • Pulmonary Fibrosis 54%
  • Epithelial-Mesenchymal Transition 49%

• Plant metabolomics (1. Agave sisalana, 2. Anoectochilus formosanus, 3. phalaenopsis spp.)

  Lee, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Anoectochilus formosanus 100%
  • Agave sisalana 91%
  • Phalaenopsis 75%
  • secondary metabolites 71%
  • metabolomics 55%

• 大腸直腸癌已躍居世界上癌症死亡率第二名，屬於固體型腫瘤，缺氧常見於此類 腫瘤，並誘發HIF-1α 表現而導致抗藥性及預後較差，因此抑制HIF-1α 被視為新的抗 癌策略。Zebularine (Zeb)是較穩定之DNA methyltransferase (DNMT)抑制劑，可殺死癌 細胞而不影響正常細胞，對小鼠也不具毒性。我們初步結果顯示，Zeb 可抑制人類大 腸癌細胞株HCT116 之HIF-1α表現，代表Zeb 是治療大腸直腸癌之潛力藥物。我們的 初步也證明Zeb對HCT116具毒殺性，對小鼠大腸癌也有療效。細胞自我吞噬(autophagy) 是指細胞在惡劣環境下，經由吞噬細胞內物質產生能量渡過外界壓力的一種保護機 制；也有研究報導指出，藥物會誘導癌細胞產生autophagy，造成細胞過度吞噬其內容 物而死亡，因此，autophagy在癌細胞為保護或是引發毒殺作用，目前仍無定論。缺氧 也會透過HIF-1α 導致autophagy 而促進細胞存活，但嚴重缺氧或無氧狀態則可透過活 化AMPK及unfolded protein response (UPR)造成autophagic cell death。我們初步結果顯 示，除抑制HIF-1α 表現外，Zeb 也可活化AMPK、UPR/ER stress、以及autophagy， 因此我們推測Zeb 可在缺氧狀態下，促進autophagic cell death。3 年內我們將執行4 項 目標： (1) 探討Zeb 在各種癌細胞及活體模式之抗癌作用。（第一年） (2) 研究Zeb 抑制HIF-1α表現之分子機轉。（第一年到第二年） (3) 研究Zeb 誘發autophagy之分子機轉。（第二年到第三年） (4) 探討Zeb 對缺氧導致抗藥性之作用。（第三年）

  Yang, P.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • pyrimidin-2-one beta-ribofuranoside 100%
  • Autophagy 29%
  • Hypoxia 16%
  • Autophagic Cell Death 13%
  • Colorectal Neoplasms 12%

• Molecular Mechanism Underlying Progesterone-Regulated p27 Gene Expression

  Hsu, S.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • transcription (genetics) 100%
  • angiogenesis 82%
  • 5' untranslated regions 73%
  • promoter regions 72%
  • 3' untranslated regions 72%

• 探討 GRP78 作為攝護腺癌化學治療之癒後因子之潛能

  Chang, Y.

  6/1/13 → 7/31/14

  Project: C - Project of Alliance › p - Taipei Medical University Hospital

• End-of-Life Care for Elderly with Advanced Dementia in Long-Term Care Facilities

  Chang, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Application of clinical anti-arthralgia formulas of traditional Chinese medicine to arthritis

  Wang, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • medicine 100%
  • health insurance 57%
  • Taiwan 46%
  • basic research 30%
  • literature 23%

• 抗氧化防禦基因標籤單核?酸多形性、氧化壓力生物標記與冠狀動脈心臟病之相關性(1/2)

  Yeh, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• CAAT/enhancer binding protein beta訊息路徑參與thrombin誘導人類肺部上皮細胞IL-8/CXCL8表現之研究(3/3)

  Chen, B.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Bullying Experience, Attitude and Suicide Attempts among Adolescents

  Chen, P.

  8/1/12 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Bullying 100%
  • Suicide 41%
  • Taiwan 7%
  • Psychometrics 7%
  • Mental Health 5%

• 探討小泛素蛋白酶Sentrin-specific protease 2 參與轉型生長因子-beta訊息傳遞的作用機制(1/2)

  Chang, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Explore of Toll-Like Receptors Associated Mirna Expression in Ischemic Stroke Patients (I)

  Wu, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Therapeutic Strategies for Traumatic Brain Injury with Novelly Desinged Drugs( I )

  Wang, J.

  8/1/12 → 7/31/14

  Project: B - Project of TMU › i - Other (Funded by TMU)

  • Traumatic Brain Injury 100%
  • Research Personnel 51%
  • Pharmaceutical Preparations 22%
  • Touch 18%
  • MicroRNAs 15%

• Explore of Toll-Like Receptors Associated Mirna Expression in Ischemic Stroke Patients (I)

  Wu, C.

  8/1/13 → 7/31/14

  Project: B - Project of TMU › i - Other (Funded by TMU)

• The role of microRNA let-7g in cytosolic Ca2+ regulation and COX-2 gene expression

  Chang, W.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • MicroRNAs 100%
  • Atherosclerosis 57%
  • Calcium Channels 51%
  • Gene Expression 42%
  • Epigenomics 41%

• Modifying the Impact of Maternal Psychopathology on Adverse Infant Health Outcomes---Effects of Paternal Involvement and a Trial on Positive Activity Intervention

  Chen, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Investigation on developing novel biomarkers and treatments in the patients with fibromyalgia

  Kang, J.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Fibromyalgia 100%
  • Transcranial Direct Current Stimulation 38%
  • Exercise 32%
  • Virtual Reality 30%
  • Biomarkers 12%

• A Clinical Correlation study of DNA Methyltransferases Alterations in Breast Cancer and Evaluation of DNA Methyltransferases as a Therapeutic Target in Cell and Animal Models

  Lin, R.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Breast Neoplasms 100%
  • Tumor Suppressor Genes 95%
  • DNA (Cytosine-5-)-Methyltransferase 1 67%
  • Methyltransferases 40%
  • DNA Methylation 35%

• Study on the Preventive Effect and Mechanism of Germinated Brown Rice and Its Components on Colorectal Cancer

  Shih, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • brown rice 100%
  • colorectal neoplasms 49%
  • carcinogenesis 43%
  • health promotion 34%
  • rice 26%

• Dissected the role of Glucosed-regulated portein 78 in the progression, metastasis and therapy of colorectal cancer

  Wei, P.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • colorectal neoplasms 100%
  • metastasis 69%
  • neoplasms 55%
  • endoplasmic reticulum 32%
  • death 27%

• Role of Androgen on Breast Cancer Development and Treatment

  Lin, H.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Androgen 100%
  • Testosterone 31%
  • Signal Transduction 21%
  • Chemopreventive 9%
  • Silencing RNA 8%

• A Novel Porcine Bone Xenograft Development

  Chang, W.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • bones 100%
  • dentistry 66%
  • testing 36%
  • skeletal development 31%
  • biocompatibility 27%

• Molecular and cellular mechanism of adipocyte modulatory effects on pulmonary vein and atrium

  Chen, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Adipocytes 100%
  • Atrial Fibrillation 64%
  • Cardiac Myocytes 60%
  • Calcium 44%
  • Adipokines 37%

• Evaluation on Cervical Cancer Prevention and Treatment Policy in Taiwan

  Tang, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Association of Epidermal Growth Factor Receptor mutations with HPV16/18 E6 Oncoprotein Expression in Non-Small Cell Lung Cancer

  Lee, H.

  8/1/13 → 7/31/14

  Project: C - Project of Alliance › r - Tung's Taichung MetroHarbor Hospital

• Immature Testicular Tissue Engineering for Male Fertility Preservation---A Transgenic Mouse Model

  Chen, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • cryopreservation 100%
  • stem cells 80%
  • reproductive performance 53%
  • germ cells 50%
  • bioluminescence 50%

• The role of DDX3 in human papillomavirus-infected lung tumorigenesis

  Lee, H.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Papillomavirus Infections 100%
  • Cisplatin 96%
  • Lung 86%
  • Neoplasms 63%
  • Gastropoda 47%

• The Role of ADAM 17 in Hypoxia-Induced CTGF Expression and Pulmonary Fibrosis (I)

  Chen, B.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Potential of Capsaicin against Advanced Glycation Endproducts Formation

  Wu, C.

  12/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Capsaicin 100%
  • Glycation 34%
  • Protective 14%
  • Aminoguanidine 12%
  • Oxidative Stress 8%

• Roles of Central OX2R Activities in the Pathophysiology of Hypertension in SHR

  Hwang, L.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• α9-型尼古丁乙醯膽鹼受體在乳癌幹細胞的角色與防治藥物的篩選

  Lai, G.

  8/1/13 → 7/31/14

  Project: B - Project of TMU › i - Other (Funded by TMU)

• Role of HBX and IL-6 in Regulating SENP1/Stemness Properties of HBV-Related Hcc under Hypoxia and Its Clinical Implication

  Huang, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Effects of Metabolic Abnormalities on Cognitive Function in Schizophrenic Patients

  Lu, M.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• 抽菸、α9-型尼古丁乙醯膽鹼受體、表皮生長因子受體及動情激素相關基因與乳癌之分子流行病學研究

  Chiou, H.

  8/1/13 → 7/31/14

  Project: B - Project of TMU › i - Other (Funded by TMU)