Taipei Heart Institute (THI), Taipei Medical University

Projects

Projects per year 2010 2012 2013 2014 2015 2016 2019 2021

• 151 Finished

Projects per year

Search results

• Finished

  Molecular Mechanism of the Effect of Cafestol on Growth Factor-Induced Cardiomyocyte Hypertrophy

  Liu, J.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • cafestol 100%
  • urotensin II 55%
  • Cardiac Myocytes 49%
  • Hypertrophy 40%
  • Intercellular Signaling Peptides and Proteins 21%

• Cellular and Molecular Mechanisms with Epigenetic Regulation by Histone Deacetylation on Postopratetive Atrial and Pulmonary Vein Arrhythmogenesis

  Chen, Y.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Histone Deacetylases 100%
  • Atrial Fibrillation 85%
  • Pulmonary Veins 63%
  • Calcium 44%
  • Heart Atria 40%

• Ionic Currents and Calcium Homeostasis in Atrial Arrhythmogenesis of Chronic Obstructive Pulmonary Disease Animal Model

  Lin, Y.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Chronic Obstructive Pulmonary Disease 100%
  • Atrial Fibrillation 70%
  • Calcium 18%
  • difebarbamate, febarbamate, phenobarbital drug combination 13%
  • Homeostasis 9%

• Anxiety, Depression and Coronary Spasm: a Synthesis of Epidemiological and Experimental Studies

  Hung, M.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Spasm 100%
  • Coronary Vessels 78%
  • Anxiety 22%
  • Coronary Artery Disease 22%
  • Depression 17%

• A Multi-Sensitive Chitosan Nanomicelles for Targeted Anticancer Drug Delivery

  Mi, F.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Chitosan 100%
  • Hyaluronic Acid 93%
  • Sodium Nitrite 51%
  • Deacetylation 47%
  • Pluronic 45%

• Epigenetic Role of Pitx2c in Atrial Myocyte and Fibroblast: Therapeutic Implications of Atrial Fibrillation Mechanisms

  Kao, Y.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Fibroblasts 100%
  • Calcium 50%
  • Histone Deacetylases 42%
  • MicroRNAs 41%
  • Electrophysiology 41%

• Pathophysiology of Macrophage Migration Inhibitory Factor on Electrical and Structural Remodelings in Heart Failure-Induced Atrial Arrhythmogenesis

  Chen, Y.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Heart Failure 100%
  • Atrial Fibrillation 95%
  • Atrial Remodeling 81%
  • Histone Deacetylases 68%
  • Pulmonary Veins 44%

• 神經醯胺調控左心房與肺靜脈心肌細胞電生理特性及離子流 – 肥胖導致心房快速心律不整之關鍵

  Lin, Y.

  3/1/16 → 2/28/17

  Project: C - Project of Alliance › q - Cathay General Hospital

• Edoxaban對於肺靜脈心肌組織及左心房肌之電生理特性及心律不整活性之調控

  Chen, Y.

  3/1/16 → 2/28/17

  Project: C - Project of Alliance › o - Chi Mei Medical Center

• 親血球蛋白胜肽改善心肌梗塞之藥物研發評估

  Cheng, T.

  3/1/16 → 2/28/17

  Project: C - Project of Alliance › s - Shin Kong Wu Ho-Su Memorial Hospital

• 發展具有近紅外光熱效應與螢光影像之奈米金抗癌藥物載體

  Mi, F.

  1/1/16 → 12/31/16

  Project: C - Project of Alliance › j - National Taipei University of Technology

• Implantable Rat ECG Measurement Device Based on Wireless Charge Technique and IMU motion Detection

  Liu, J.

  1/1/16 → 12/31/16

  Project: C - Project of Alliance › m - National Taiwan University of Science and Technology

• 血壓波臨床診斷參數自動化之研究

  Huang, C.

  1/1/16 → 12/31/16

  Project: C - Project of Alliance › m - National Taiwan University of Science and Technology

• Electrophysiological and Molecular Insights into the Cardiac Regulations of ZFHX3 Gene---Implication in the Pathophysiology of Atrial Fibrillation

  Chen, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Atrial Fibrillation 100%
  • MicroRNAs 68%
  • Calcium 48%
  • Electrophysiology 45%
  • Small Interfering RNA 34%

• Pitx2c Modulations on Atrial Fibroblast Activity, Electrical Characteristic, and Myocyte-Fibroblast Interaction: Implications in the Genesis of Atrial Fibrillation

  Kao, Y. & Chen, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Fibroblasts 100%
  • Atrial Fibrillation 36%
  • Electrophysiology 26%
  • Angiotensin II 22%
  • Cardiac Myocytes 21%

• Kidney Injury and Heat Shock Protein Modulate the Atrial Electrophysiological Characterisitcs

  Hsieh, M., Chen, Y. & Lin, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Chronic Renal Insufficiency 100%
  • Atrial Fibrillation 87%
  • Heat-Shock Proteins 68%
  • Indican 66%
  • Neomycin 41%

• The Effects of High Mobility Group Box-1 Protein in Human Vascular Smooth Muscle Progenitor Cells in Regard to the Occurrence of Allograft Vasculopathy after Heart Transplantation

  Lin, F.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • High Mobility Group Proteins 100%
  • Vascular Smooth Muscle 97%
  • Smooth Muscle Myocytes 87%
  • Heart Transplantation 62%
  • Allografts 60%

• The Effects of Lipoprotein on Endothelial Progenitor Cells Function and Endothelial-to-Mesenchymal Transition Process

  Huang, C. & Lin, F.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Endothelial Progenitor Cells 100%
  • HDL Lipoproteins 39%
  • oxidized low density lipoprotein 31%
  • Dyslipidemias 12%
  • Atherosclerosis 10%

• Evaluation of Haptoglobin and Its Subunits as Protein Drugs for Ischemic Heart Diseases

  Cheng, T. & Shih, C.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Myocardial Ischemia 100%
  • Nanocapsules 63%
  • Pharmaceutical Preparations 40%
  • Haptoglobins 35%
  • Hemoglobins 34%

• Expression of Deptor Gene and Its Effect on the Early Development of Liver and Gut in Zebrafish

  Cheng, C.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • digestive system 100%
  • Danio rerio 84%
  • liver 72%
  • rapamycin 53%
  • immunohistochemistry 41%

• Study of Expression and Functional Mechanisms of Histamine N-Methyltransferase (HNMT) in Tumorigenesis and Correlation with Progression in Lung Cancer

  Wang, L., Lee, W., Ho, Y. & Wu, A. T.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Histamine N-Methyltransferase 100%
  • Lung Neoplasms 43%
  • Carcinogenesis 18%
  • Neoplasms 10%
  • Genes 9%

• Cellular and Molecular Mechanisms with Epigenetic Regulation by Histone Deacetylation on Postopratetive Atrial and Pulmonary Vein Arrhythmogenesis

  Chen, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Histone Deacetylases 100%
  • Atrial Fibrillation 85%
  • Pulmonary Veins 63%
  • Calcium 44%
  • Heart Atria 40%

• The Development and Preclinical Evaluation of a Theronostic Nanovehicle Drug for Treating Acute Myeloid Leukemia and Leukemia Stem Cells (I)

  Yen, Y., Cheng, T. & Wu, A. T.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Leukemia 100%
  • haptoglobin-hemoglobin complex 54%
  • Calicheamicins 53%
  • Neoplasms 49%
  • Multifunctional Nanoparticles 49%

• Chronic Obstructive Pulmonary Disease Modulate Electrophysiological Properties and Arrhythmogenesis of Pulmonary Vein and Atrium

  Lin, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Chronic Obstructive Pulmonary Disease 100%
  • Atrial Fibrillation 76%
  • Atrial Remodeling 12%
  • Volition 11%
  • Atrial Flutter 10%

• 探討檜木醇在缺血性腦中風老鼠的神經保護作用及其機轉

  Chang, N.

  6/1/15 → 5/31/16

  Project: C - Project of Alliance › p - Taipei Medical University Hospital

• 臨床前FGFR抑制劑對於抗藥性胰臟癌療效之評估

  Wu, A. T.

  5/1/15 → 4/30/16

  Project: C - Project of Alliance › u - Taipei Medical University Shuang Ho Hospital

• 以全基因組外顯子分析家族性淋巴水腫致病機轉

  Cheng, C.

  5/1/15 → 4/30/16

  Project: C - Project of Alliance › t - Taipei Municipal Wanfang Hospital

• 選擇性SGLT-2抑制劑在糖尿病的心臟代謝，電生理特性，以及鈣穩態的效果

  Huang, J.

  5/1/15 → 4/30/16

  Project: C - Project of Alliance › t - Taipei Municipal Wanfang Hospital

• 秋水仙素對於心房肌細胞之鈣離子恆定及電生理特性調控的影響

  Chen, Y.

  3/1/15 → 2/29/16

  Project: C - Project of Alliance › o - Chi Mei Medical Center

• 以矽奈米線元件檢測F1-ATPase 與ATP、ADP或抑制劑的相互作用

  Mi, F.

  1/1/15 → 12/31/15

  Project: C - Project of Alliance › j - National Taipei University of Technology

• 應用微循環血流量測技術於病患冠狀動脈狹窄程度之評估

  Liu, J.

  1/1/15 → 4/30/16

  Project: C - Project of Alliance › m - National Taiwan University of Science and Technology

• Development of Portable Wireless Implantable Rat ECG Measurement Device for Identifying the Effects of Statin/ Metformin(奈米藥物傳導Doxorubicin、Statin and Metformin 肝腫瘤超音波分子影像模型整合性研

  Liu, J.

  1/1/15 → 3/31/16

  Project: C - Project of Alliance › m - National Taiwan University of Science and Technology

• Effect of Vasopressin Receptor Agonist and Antagonist on Pulmonary Vein and Atrial Arrhythmogenesis

  Huang, J.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Heart Atria 100%
  • Antidiuretic Hormone Receptor Antagonists 94%
  • Pulmonary Veins 76%
  • Heart Failure 48%
  • Sinoatrial Node 41%

• The Influence of Porphyromonas gingivalis Groel in Vascular Cells

  Lin, F.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Porphyromonas gingivalis 100%
  • blood vessels 46%
  • myocytes 40%
  • smooth muscle 39%
  • atherosclerosis 36%

• Kidney Injury and Heat Shock Protein Modulate the Atrial Electrophysiological Characterisitcs

  Hsieh, M.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Chronic Renal Insufficiency 100%
  • Atrial Fibrillation 87%
  • Heat-Shock Proteins 68%
  • Indican 66%
  • Neomycin 41%

• Molecular and Cellular Mechanism of Adipocyte Modulatory Effects on Pulmonary Vein and Atrium

  Chen, Y.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Adipocytes 100%
  • Atrial Fibrillation 64%
  • Cardiac Myocytes 60%
  • Calcium 44%
  • Adipokines 37%

• Chitosan Nanoparticle as a Macrophage-Targeting Drug Delivery Carrier

  Mi, F.

  8/1/14 → 8/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Reactive Oxygen Metabolite 100%
  • Nanoparticle 63%
  • Folate 50%
  • Superoxide 41%
  • Chitosan 34%

• Electrophysiological and Molecular Insights into the Cardiac Regulations of ZFHX3 Gene---Implication in the Pathophysiology of Atrial Fibrillation

  Chen, Y.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Atrial Fibrillation 100%
  • MicroRNAs 68%
  • Calcium 48%
  • Electrophysiology 45%
  • Small Interfering RNA 34%

• Effects and Mechanisms of Pitx2c Modulation for Atrial Electrophysiological and Structural Remodelings in Heart Failure

  Kao, Y. & Chen, Y.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Heart Failure 100%
  • Atrial Fibrillation 64%
  • Electrophysiology 45%
  • Methylation 43%
  • MicroRNAs 40%

• 第二型糖尿病人與高血壓合併腎衰竭病人之脂蛋白對血管內皮前驅細胞功能之影響。

  Huang, C.

  6/1/14 → 5/31/15

  Project: C - Project of Alliance › p - Taipei Medical University Hospital

• 檢測家族性淋巴水腫的致病基因

  Cheng, C.

  6/1/14 → 5/31/16

  Project: C - Project of Alliance › t - Taipei Municipal Wanfang Hospital

• 探討LncRNA MALAT1 在惡性乳癌幹細胞生成之角色以及pterostilbene 對於透過抑制MALAT1而抑制乳癌幹細胞功能之研究

  Wu, A. T.

  6/1/14 → 5/31/15

  Project: C - Project of Alliance › u - Taipei Medical University Shuang Ho Hospital

• Calcitriol調控高等糖化終產物受體在糖尿病心臟上的病理生理機轉

  Kao, Y.

  6/1/14 → 5/31/15

  Project: C - Project of Alliance › p - Taipei Medical University Hospital

• 冬蟲夏草多醣體CME-1抑制內毒素誘發巨噬細胞發炎反應的機轉探討

  Chang, N.

  5/1/14 → 6/30/15

  Project: C - Project of Alliance › n - Yuan's General Hospital

• TMU102-AE1-B36

  Cheng, T.

  4/1/14 → 3/31/15

  Project: B - Project of TMU › g - Research Grants for Newly Hired Faculty

• 纖維母細胞生長因子23誘發心房心律不整及鈣離子調控之作用機轉研究

  Chen, Y.

  3/1/14 → 2/28/15

  Project: C - Project of Alliance › o - Chi Mei Medical Center

• Functional evaluation of Cnidii Fructus and osthole on endothelial progenitor cells by animal and cell models (2-2)

  Hou, W. & Huang, C.

  1/24/14 → 12/15/14

  Project: A - Government Institution › c - Ministry of Health and Welfare

  • Cnidium 100%
  • fruit extracts 21%
  • fruits 20%
  • pruritus 12%
  • insulin resistance 10%

• Identifying the change of statin/netformin on microcirculatory blood flow of transplanted HCC tumor by Laser Doppler Flowemetry

  Liu, J.

  1/1/14 → 3/3/15

  Project: C - Project of Alliance › m - National Taiwan University of Science and Technology

• Study of glycosyl hydrolase and carbohydrate interaction by silicon nanowire effect

  Mi, F.

  1/1/14 → 9/30/15

  Project: C - Project of Alliance › j - National Taipei University of Technology

• TMU102-AE1-B14

  Yeh, J. S.

  1/1/14 → 6/30/15

  Project: C - Project of Alliance › t - Taipei Municipal Wanfang Hospital