School of Medicine

Projects

Projects per year 2010 2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 2023 2026

• 3 Not started
• 256 Active
• 2493 Finished

Projects per year

Search results

• Finished

  Molecular Epidemiological Study of Renal Cell Carcinoma---Arsenic Methylation Capability, 8-OHdG and Polymorphism of IRS and RAAS Exploration

  Hsueh, Y.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - National Science and Technology Council

  • Arsenic 100%
  • Renal Cell Carcinoma 62%
  • Methylation 54%
  • Insulin Receptor 26%
  • Enzymes 25%

• Mechanisms Underlying Airway Hypersensitivity Induced by Hydrogen Sulfide

  Lin, Y.

  8/1/14 → 10/31/15

  Project: A - Government Institution › b - National Science and Technology Council

  • Unmyelinated Nerve Fibers 100%
  • Lung 65%
  • Hypersensitivity 50%
  • Reflex 39%
  • Ankyrins 37%

• Investigation of Mechanisms of SSRI Antidepressants and GABAAR Modulators Inhibit High-Grade Glioma Invasion

  Shen, S.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - National Science and Technology Council

  • Glioma 100%
  • Ions 24%
  • Ion Channels 23%
  • Hydrodynamics 20%
  • GABA Receptors 14%

• Therapeutic Strategies for Traumatic Brain Injury with Novelly Desinged Drugs (III)

  Wang, J.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - National Science and Technology Council

• A Multidisciplinary Study of the Pathophysiology of Blast-Induced Mild Traumatic Brain Injury

  Chiang, Y.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - National Science and Technology Council

  • Wounds and Injuries 100%
  • Dizziness 86%
  • N-nitrosoiminodiacetic acid 71%
  • Headache 70%
  • Animal Models 59%

• Study of Nano-Size Memberane Tube for Tendon to Bone in Anterior Cruciate Ligament Reconstruction

  Chen, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - National Science and Technology Council

  • tendons 100%
  • anterior cruciate ligament 79%
  • periosteum 55%
  • polyhydroxyalkanoates 53%
  • bones 46%

• 探討芳香烴受體(AhR)改變血管內皮細胞功能之新角色：經由表觀基因或後轉譯修飾(細胞週期蛋白/內皮細胞一氧化氮合成酉每)的調控與白蘆黎醇/史達汀臨床治療及應用(2/3)

  Juan, S.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - National Science and Technology Council

• Genomic and Non-Genomic Estrogen Effects on the Spinal NR2B-Related Uterus-Colon Crosstalk in Rats

  Lin, T.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - National Science and Technology Council

  • uterus 100%
  • colon 95%
  • estrogens 62%
  • irritable bowel syndrome 33%
  • comorbidity 31%

• The Effect of Long Acting GnRH Agonist Treatment on Mitochondrial Function in

  Tzeng, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - National Science and Technology Council

  • hormone agonists 100%
  • mitochondria 91%
  • pathophysiology 42%
  • granulosa cells 38%
  • agonists 32%

• Biomarkers Associated with Toll-Like Receptors and Neuroimage Study in Ischemic Stroke Patients (II)

  Hu, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - National Science and Technology Council

• Explore the Molecular Mechanisms and Application of microRNA-16 in In Acute Kidney Injury

  Chen, H.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - National Science and Technology Council

  • Acute Kidney Injury 100%
  • Biomarkers 15%
  • MicroRNAs 9%
  • Creatinine 9%
  • Kidney Function Tests 9%

• An Investigation of the Effects of Tea Component on the Inhibition of Leukocyte Nicotinic Acetylcholine Receptor Expression on Breast Cancer Patients

  Tu, S.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - National Science and Technology Council

  • Leukocytes 100%
  • Tea 92%
  • Breast Neoplasms 87%
  • Nicotine 31%
  • Capsules 28%

• Relationship between Lumbar Vertebral Perfusion and Fat Marrow Content in Normal Subjects, Osteoporosis and Bone Metastases Using DCE-MRI and Fat-Water Separation

  Chan, W. P.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - National Science and Technology Council

  • Perfusion 100%
  • Bone Marrow 87%
  • Fats 39%
  • Osteoporosis 35%
  • Neoplasm Metastasis 32%

• 榖胱甘月太硫轉移酉每參與乳癌致癌之分子機制探討(3/3)

  Wu, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - National Science and Technology Council

• Establish the Research Platform for Studying Triple-Negative Breast Tumor Microenvironment Regulation: the Hyaluronan Synthase-3 Mediated Antitumor Effects as an Example.

  Ho, Y. & Wu, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - National Science and Technology Council

  • Breast Neoplasms 100%
  • Gene Expression 46%
  • Tumor Microenvironment 40%
  • Hyaluronan Synthases 30%
  • Fibroblasts 29%

• Relationships of One-Carbon Cycle Pathways with Psychopathology and Metabolic Abnormalities in Patients with Schizophrenia and Potential Intervention Strategy with 5-Methyltetrahydrofolate and Vitamin B12

  Chen, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - National Science and Technology Council

  • Folic Acid 100%
  • Vitamin B 12 74%
  • Carbon Cycle 71%
  • Schizophrenia 54%
  • 5-methyltetrahydrofolate 51%

• Oncolytic Measles Virus for the Treatment of Breast Adenocarcinoma

  Lin, L. T.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - National Science and Technology Council

  • Measles virus 100%
  • Breast Neoplasms 40%
  • Adenocarcinoma 27%
  • Reverse Genetics 18%
  • Breast 16%

• 組蛋白去甲基酉每JARID1B基因在肺腺癌之腫瘤形成與影響腫瘤生物行為機轉之探討(1/2)

  Kuo, K.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - National Science and Technology Council

• Investigation of Glioblastoma Cell-Secreted microRNA Signatures and Their Functional Effects on Tumor Angiogenesis

  Chen, K.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - National Science and Technology Council

  • Circulating MicroRNA 100%
  • Glioblastoma 91%
  • MicroRNAs 54%
  • Temozolomide 35%
  • Glioma 26%

• Chitosan Nanoparticle as a Macrophage-Targeting Drug Delivery Carrier

  Mi, F.

  8/1/14 → 8/31/15

  Project: A - Government Institution › b - National Science and Technology Council

  • Reactive Oxygen Metabolite 100%
  • Nanoparticle 63%
  • Folate 50%
  • Superoxide 41%
  • Chitosan 34%

• The Effect of Endothelin-1 on Myofibroblast Transformation of Pleural Mesothelial Cells and Its Implications for Pleural and Pulmonary Fibrosis

  Chung, C. & Hsiao, G.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - National Science and Technology Council

  • Myofibroblasts 100%
  • Endothelin-1 85%
  • Fibrosis 70%
  • Pulmonary Fibrosis 54%
  • Epithelial-Mesenchymal Transition 49%

• Characterization of 5-Hydroxymethylcytosine and Ten-to-Eleven Translocation Gene (TET) in Cervical Cancer

  Lai, H.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - National Science and Technology Council

  • 5-hydroxymethylcytosine 100%
  • Uterine Cervical Neoplasms 38%
  • Epigenomics 20%
  • 5-Methylcytosine 17%
  • Carcinogenesis 9%

• Unraveling the Impact of Deletion of Androgen Receptor on Brain Trauma

  Yang, L.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - National Science and Technology Council

  • Traumatic Brain Injury 100%
  • Androgen Receptors 63%
  • collapsin response mediator protein-2 45%
  • Phosphorylation 18%
  • Organized Financing 12%

• Study of Mechanotransduction in Hair Cell

  Horng, J.

  8/1/14 → 12/31/15

  Project: A - Government Institution › b - National Science and Technology Council

  • hairs 100%
  • sodium-hydrogen antiporter 60%
  • mechanotransduction 35%
  • inner ear 29%
  • neomycin 28%

• Effects of Functional Electrical Stimulation Cycling and Central Neuromodulation on Motor Control in Stroke

  Chen, S.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - National Science and Technology Council

  • Transcranial Direct Current Stimulation 100%
  • Rehabilitation 59%
  • Stroke 58%
  • Electric Stimulation 55%
  • Exercise 44%

• To Study the Correlation between Serum Markers of Oxidative Stress, Inflammation, and Endocrine-Disrupting Chemicals (Edcs) and Their Impact on the Menstrual Cycle and Reproductive Hormone in Taiwanese Women.

  Hsu, M.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - National Science and Technology Council

  • oxidative stress 100%
  • woman 46%
  • chemical 27%
  • hormone 25%
  • reactive oxygen species 22%

• Reflex Pelvic Floor Muscle Activities in Women with Urinary Incontinence (II)

  Yang, J.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - National Science and Technology Council

  • muscle contraction 100%
  • urinary incontinence 92%
  • reflexes 85%
  • muscles 36%
  • perineum 21%

• Application and Mechanism of Novel Fluoro-Rutaecarpine on Inhibition of Inflammation Induced Endomt

  Lin, C.

  8/1/14 → 12/31/15

  Project: A - Government Institution › b - National Science and Technology Council

  • Fibrosis 19%
  • Inflammation 15%
  • Sumoylation 5%

• Effects of Indoor Air Quality Improvement on Cardiovascular Health in General Population

  Chuang, K.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - National Science and Technology Council

  • Indoor Air Pollution 100%
  • Air Pollution 15%
  • Taiwan 13%
  • Cardiovascular System 13%
  • Quality Improvement 13%

• The Relationship and Predictors of Electrocardiography, Inflammatory Markers, Clinical Features in Older Bipolar and Schizophrenia Patients Concurrent with Coronary Heart and Cerebro-Vascular Diseases

  Tsai, S.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - National Science and Technology Council

  • Cardiovascular Diseases 100%
  • Schizophrenia 80%
  • Bipolar Disorder 76%
  • Cardiovascular System 58%
  • Electrocardiography 48%

• Efficacy Studies of Tn-Directed Therapeutic Antibody and Immunotoxin in Syngeneic Mouse Tumor Models

  Hwang, J.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - National Science and Technology Council

  • antibodies 100%
  • mice 94%
  • prostatic neoplasms 51%
  • neoplasms 48%
  • vaccines 21%

• The Effects of the APOE4 Allele on Cerebral Structural and Functional Connectivity---A Diffusion Tensor Imaging and Resting-State MRI Study

  Chen, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - National Science and Technology Council

  • Apolipoprotein E4 100%
  • Alleles 83%
  • Brain 39%
  • Short-Term Memory 31%
  • Magnetic Resonance Imaging 26%

• Application of Scaffold in Ovarian Transplantation for Female Fertility Preservation---An in vivo Transgenic Mouse Model (I)

  Chen, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - National Science and Technology Council

  • angiogenesis 100%
  • sphingosine 55%
  • tissue engineering 47%
  • ischemia 45%
  • animal models 35%

• 醫學與影像美學

  Chang, H.

  8/1/14 → 1/31/15

  Project: A - Government Institution › d - Ministry of Education

• Effects of Uteroplacental Insufficiency and Hyperoxia on Lung Development and Epigenetic Alterations in the Rat Offspring

  Chen, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - National Science and Technology Council

  • Fetal Growth Retardation 100%
  • Hyperoxia 99%
  • Receptor for Advanced Glycation End Products 74%
  • Epigenomics 69%
  • Lung 48%

• Investigation on Developing Novel Biomarkers and Treatments in the Patients with Fibromyalgia

  Kang, J.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - National Science and Technology Council

  • Fibromyalgia 100%
  • Transcranial Direct Current Stimulation 38%
  • Exercise 32%
  • Virtual Reality 30%
  • Biomarkers 12%

• Role of Oxidative Stress-triggered Redox Adaptation Mechanism and Genetically Endowed Expression Profile of Antioxidant Enzymes in the modulation of Intrinsic and Acquired Chemoand Radio-resistance of Human Hepatocellular Carcinoma Cells

  Chiou, J.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - National Science and Technology Council

  • Hepatocellular Carcinoma 100%
  • Radio 90%
  • Survivin 42%
  • Antioxidants 39%
  • Oxidation-Reduction 34%

• Molecular Mechanisms of a Novel Aliphatic Hydroxamate, WMJ-S-001, in Suppressing Colorectal Cancer Progression---The Causal Role of AMPK-p53 Modification-miRNAs Cascade

  Hsu, M.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - National Science and Technology Council

  • WMJ-S-001 100%
  • Neoplasms 11%
  • MicroRNAs 10%
  • Colorectal Neoplasms 8%
  • Lymphangiogenesis 7%

• Evaluate the Radio-Biological Roles of miR-17-5P in Oral Cancer Cell Line OC3

  Wu, S.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - National Science and Technology Council

  • Mouth Neoplasms 100%
  • Proteins 87%
  • MicroRNAs 61%
  • Radio 56%
  • Areca 53%

• 探討不同選擇作用之組織蛋白去乙醯?調節成分抑制神經發炎之機制及其對腦內出血與腦炎之治療特性評估(2/3)

  Hsiao, G.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - National Science and Technology Council

• 肝醣合成酉每激酉每3於登革病毒感染單核吞噬細胞的潛在角色(2/3)

  Lin, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - National Science and Technology Council

• Evaluation of the Mechanism of Post-Traumatic Immunosuppression---The Role of TLR4 Trafficking and microRNA

  Lin, J. A.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - National Science and Technology Council

  • immunosuppression 100%
  • bones 72%
  • monocytes 53%
  • inflammation 46%
  • orthopedics 45%

• The Influence of Porphyromonas gingivalis Groel in Vascular Cells

  Lin, F.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - National Science and Technology Council

  • Porphyromonas gingivalis 100%
  • blood vessels 46%
  • myocytes 40%
  • smooth muscle 39%
  • atherosclerosis 36%

• The Role and Molecular Mechanism of PPARα in Acute Kidney Injury---Focus on the Protective Effect in Renal Tubular Cell

  Hsu, Y., Chen, T. & Chen, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - National Science and Technology Council

  • PPAR alpha 100%
  • MicroRNAs 54%
  • Type C Phospholipases 39%
  • Kidney 30%
  • Acute Kidney Injury 20%

• Evaluate the Molecluar Mechanims and Clinical Application on Atf3 Regulated microRNAs

  Lin, H.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - National Science and Technology Council

  • MicroRNAs 100%
  • Acute Kidney Injury 43%
  • Kidney 29%
  • Biomarkers 17%
  • Activating Transcription Factor 3 14%

• 乳癌是目前世界上女性癌症病患中為數最多的癌症之ㄧ。腺病毒蛋白type 5 E1A (E1A)和許多抗腫瘤作用有關，曾於多種癌症如乳癌、卵巢癌及頭頸癌之病患進行臨床基因治療試驗。許多的研究指出E1A具有多項抗腫瘤的功能，包括抑制腫瘤的發生、增加腫瘤細胞對於化療藥物的感受性以及減少腫瘤轉移的現象。腫瘤的轉移對於癌症患者的死亡率有極大的影響當然也包括了乳癌的患者。E1A於抑制腫瘤發展的過程中具有多重生物學上的意義，這也促使我們想要釐清E1A抑制癌症的機制。因此，我們對於了解E1A抑制癌症轉移相關的分子機制感到有興趣，並期望藉以作為未來改進乳癌病人臨床試驗的基石。我們初步的實驗結果顯示，E1A可以有效的抑制Glucose-regulated protein 78 (GRP78)這種已被廣泛報導和腫瘤惡化及轉移相關的蛋白的表現。 提出此研究計劃之目的在於詳細探討E1A所造成的抑制癌轉移作用中，GRP78所扮演的生物功能及其調控的機轉。為了達到此目的，我們將著重於E1A如何調控GRP78表現並進而展現對乳癌轉移的抑制作用。以下為此項研究計畫的四大主要目標： 目標一：探討GRP78在E1A所抑制之癌細胞移行及侵入作用中所扮演的角色 目標二：研究E1A抑制GRP78表現之分子機轉 目標三：於動物模式中驗證GRP78的表現對於E1A抗腫瘤作用的影響 目標四：探討GRP78及其相關分子的表現在乳癌病人的臨床重要性 完成以上的主要目標能夠幫助我們對於E1A之抗腫瘤轉移作用建立更加詳細的分子訊息傳遞機制。另外，藉由此研究計畫的新發現也許可以對未來發展癌症治療上提供更多具有潛力的標的物。

  Wang, W.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - National Science and Technology Council

  • glucose-regulated proteins 100%
  • Neoplasm Metastasis 39%
  • Neoplasms 36%
  • Breast Neoplasms 25%
  • Psychological Inhibition 19%

• Association Study of Persistent Metabolic Syndrome, Inflammatory Markers, Adipose Markers and Mild Cognitive Decline

  Bai, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - National Science and Technology Council

  • Cognitive Dysfunction 100%
  • Metabolic Syndrome 67%
  • Mental Status and Dementia Tests 50%
  • Thromboplastin 27%
  • Waist Circumference 24%

• Short-Chain Fatty Acids Act as Anti-Allergic Regulators on Immune Effector Cells and Exert Immune-Modulatory Effects on Ovalbumin-Induced Allergic Diseases in Mice

  Lee, Y.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - National Science and Technology Council

  • Volatile Fatty Acids 100%
  • Phenylbutyrates 27%
  • Mast Cells 25%
  • Immunoglobulin E 19%
  • Asthma 16%

• The Study of Therapeutic Effects for Stroke with Phenserine, an Amyloid Precursor Protein Inhibitor, in Rodent Focal Cerebral Ischemia Model(2/3)

  Chang, C. & Chiang, Y.

  8/1/14 → 7/31/15

  Project: A - Government Institution › a - National Health Research Institutes

  • phenserine 100%
  • Stroke 75%
  • Amyloid beta-Protein Precursor 49%
  • Stem Cells 31%
  • pifithrin 27%

• The Effect of Muscle Strength Training on Body Composition and Sarcopenic Obesity among the Female Overweight Elderly

  Liou, T.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - National Science and Technology Council

  • medication 100%
  • study group 58%
  • Group 52%
  • Taiwan 48%
  • expert 36%