School of Medicine

Finished

A Study on Trans-Neuronal Striato-Nigral Degeneration-Induced Movement Disorders after Stroke---Evaluation with Grey Matter Suppression Ir and Diffusion Tensor Imaging (III)

Chen, C.-Y. (PI)

8/1/14 → 10/31/15

Project: A - Government Institution › b - National Science and Technology Council

To Predict the Recurrence of Major Depressive Disorder Within an Integrated Bio-Psycho-Social Framework---A Follow-up Study

Lee, H.-C. (PI)

8/1/14 → 7/31/15

Project: A - Government Institution › b - National Science and Technology Council

Studies of Anti-Cancer Activity of Folic Acid

Lee, W.-S. (PI)

8/1/14 → 7/31/15

Project: A - Government Institution › b - National Science and Technology Council

Role of HBX and IL-6 in Regulating SENP1/Stemness Properties of HBV-Related HCC under Hypoxia and Its Clinical Implication

Huang, Y.-H. (PI)

8/1/14 → 7/31/15

Project: A - Government Institution › b - National Science and Technology Council

Highly Reliable Surface-Enhanced Raman Scattering Sensors

Liu, Y.-C. (PI)

8/1/14 → 7/31/15

Project: A - Government Institution › b - National Science and Technology Council

Serum Free Cultivation of Multi-Layered Oral Mucosa Epithelial Cell Sheet for Autologous Corneal Epithelium Repairing and Its Animal Model

Tseng, H. (PI)

8/1/14 → 7/31/15

Project: A - Government Institution › b - National Science and Technology Council

Characterization of 5-Hydroxymethylcytosine and Ten-to-Eleven Translocation Gene (TET) in Cervical Cancer

Lai, H.-C. (PI)

8/1/14 → 7/31/15

Project: A - Government Institution › b - National Science and Technology Council

Investigating of Transcranial Direct Current Stimulation and Robot-Assisted Gait Training Effects in Subjects with Stroke (II)

Lai, C.-H. (PI)

8/1/14 → 7/31/15

Project: A - Government Institution › b - National Science and Technology Council

Mechanisms Underlying Airway Hypersensitivity Induced by Hydrogen Sulfide

Lin, Y.-S. (PI)

8/1/14 → 10/31/15

Project: A - Government Institution › b - National Science and Technology Council

Molecular Epidemiological Study of Renal Cell Carcinoma---Arsenic Methylation Capability, 8-OHdG and Polymorphism of IRS and RAAS Exploration

Hsueh, Y.-M. (PI)

8/1/14 → 7/31/15

Project: A - Government Institution › b - National Science and Technology Council

Role of Organic Anion Transporter in Renal Tubular Injury---A Gateway to Hurt

Wu, M.-S. (PI)

8/1/14 → 7/31/15

Project: A - Government Institution › b - National Science and Technology Council

Arsenic Methylation Capacity, Methylenetetrahydrofolate Reductase and Dna Methylation Gene Polymorphisms, Plasma Selenium Concentration and Selenoprotein Gene Polymorphisms and Renal Cell Carcinoma

Hsueh, Y.-M. (PI)

8/1/14 → 7/31/15

Project: A - Government Institution › b - National Science and Technology Council

The Role and Molecular Mechanism of PPARα in Acute Kidney Injury---Focus on the Protective Effect in Renal Tubular Cell

Hsu, Y.-H. (PI), Chen, T.-H. (CoI) & Chen, C.-H. (CoI)

8/1/14 → 7/31/15

Project: A - Government Institution › b - National Science and Technology Council

Evaluate the Radio-Biological Roles of miR-17-5P in Oral Cancer Cell Line OC3

Wu, S.-Y. (PI)

8/1/14 → 7/31/15

Project: A - Government Institution › b - National Science and Technology Council

Effects of Indoor Air Quality Improvement on Cardiovascular Health in General Population

Chuang, K.-J. (PI)

8/1/14 → 7/31/15

Project: A - Government Institution › b - National Science and Technology Council

Unraveling the Impact of Deletion of Androgen Receptor on Brain Trauma

Yang, L.-Y. (PI)

8/1/14 → 7/31/15

Project: A - Government Institution › b - National Science and Technology Council

腫瘤相關巨噬細胞在誘發產生表皮生長因子受器酪胺酸酉每抑制劑的抗藥性的角色

Feng, P.-H. (PI)

8/1/14 → 7/31/15

Project: A - Government Institution › b - National Science and Technology Council

Effects of Central Neuromodulation with Functional Electrical Stimulation on Bladder Functions in Traumatic Brain Injured Rats

Peng, C.-W. (PI)

8/1/14 → 7/31/15

Project: A - Government Institution › b - National Science and Technology Council

醫學與影像美學

Chang, H.-M. (PI)

8/1/14 → 1/31/15

Project: A - Government Institution › d - Ministry of Education

The Effect of Endothelin-1 on Myofibroblast Transformation of Pleural Mesothelial Cells and Its Implications for Pleural and Pulmonary Fibrosis

Chung, C.-L. (PI) & Hsiao, G. (CoI)

8/1/14 → 7/31/15

Project: A - Government Institution › b - National Science and Technology Council

Short-Chain Fatty Acids Act as Anti-Allergic Regulators on Immune Effector Cells and Exert Immune-Modulatory Effects on Ovalbumin-Induced Allergic Diseases in Mice

Lee, Y.-L. (PI)

8/1/14 → 7/31/15

Project: A - Government Institution › b - National Science and Technology Council

Study on the Mechanism of Cross-Talk between Ahr and Autophagy, and Autophagy---Associated Physiological or Pathological Phenomenon on Vascular and Airway Systems (I)

Li, C.-H. (PI)

8/1/14 → 7/31/15

Project: A - Government Institution › b - National Science and Technology Council

Application of Scaffold in Ovarian Transplantation for Female Fertility Preservation---An in vivo Transgenic Mouse Model (I)

Chen, C.-H. (PI)

8/1/14 → 7/31/15

Project: A - Government Institution › b - National Science and Technology Council

Biomarkers Associated with Toll-Like Receptors and Neuroimage Study in Ischemic Stroke Patients (II)

Hu, C.-J. (PI)

8/1/14 → 7/31/15

Project: A - Government Institution › b - National Science and Technology Council

Anti-Aging Effect with the Associated Mechanism by PRP (Platelet-Rich Plasma) in Cartilage---A Fibronectin Fragment Model

Lee, C.-H. (PI)

8/1/14 → 7/31/15

Project: A - Government Institution › b - National Science and Technology Council

臨床醫學與生命倫理研究組織與參與設計人才培育計劃

Tsai, D.-J. (PI)

8/1/14 → 7/31/15

Project: A - Government Institution › d - Ministry of Education

Role of Oxidative Stress-triggered Redox Adaptation Mechanism and Genetically Endowed Expression Profile of Antioxidant Enzymes in the modulation of Intrinsic and Acquired Chemoand Radio-resistance of Human Hepatocellular Carcinoma Cells

Chiou, J.-F. (PI)

8/1/14 → 7/31/15

Project: A - Government Institution › b - National Science and Technology Council

Effects of Functional Electrical Stimulation Cycling and Central Neuromodulation on Motor Control in Stroke

Chen, S.-C. (PI)

8/1/14 → 7/31/15

Project: A - Government Institution › b - National Science and Technology Council

Down-Regulation of RanGAP Augments Nucleus BCR-ABL Level to Potentiate the Drug Efficacy of Imatinib in Chronic Myelogenous Leukemia

Shih, C.-M. (PI)

8/1/14 → 10/31/15

Project: A - Government Institution › b - National Science and Technology Council

The Effects of Metabolic Abnormalities on Cognitive Function in Schizophrenic Patients

Lu, M.-L. (PI)

8/1/14 → 7/31/15

Project: A - Government Institution › b - National Science and Technology Council

CXCL5/CXCR2/JNK Axis Is the Shared Pathway of Neuroinflammation and Microvascular Damage That Contributes to White Matter Injury in the Immature Brain

Huang, C.-C. (PI)

8/1/14 → 7/31/15

Project: A - Government Institution › b - National Science and Technology Council

Investigation of Glioblastoma Cell-Secreted microRNA Signatures and Their Functional Effects on Tumor Angiogenesis

Chen, K.-C. (PI)

8/1/14 → 7/31/15

Project: A - Government Institution › b - National Science and Technology Council

Study of Postoperative Adverse Outcomes of Surgical Patients Using Taiwan National Health Insurance Database

Chen, T.-L. (PI)

8/1/14 → 7/31/15

Project: A - Government Institution › b - National Science and Technology Council

Kidney Injury and Heat Shock Protein Modulate the Atrial Electrophysiological Characterisitcs

Hsieh, M.-H. (PI)

8/1/14 → 7/31/15

Project: A - Government Institution › b - National Science and Technology Council

Evaluation of the Mechanism of Post-Traumatic Immunosuppression---The Role of TLR4 Trafficking and microRNA

Lin, J. A. (PI)

8/1/14 → 7/31/15

Project: A - Government Institution › b - National Science and Technology Council

肝醣合成酉每激酉每3於登革病毒感染單核吞噬細胞的潛在角色(2/3)

Lin, C.-F. (PI)

8/1/14 → 7/31/15

Project: A - Government Institution › b - National Science and Technology Council

Evaluation of Clinical Feasibility of Quantitative MR Perfusion Imaging and Its Calibration

Tseng, Y.-C. (PI)

8/1/14 → 7/31/15

Project: A - Government Institution › b - National Science and Technology Council

Efficacy Studies of Tn-Directed Therapeutic Antibody and Immunotoxin in Syngeneic Mouse Tumor Models

Hwang, J.-L. (PI)

8/1/14 → 7/31/15

Project: A - Government Institution › b - National Science and Technology Council

The Role of ADAM 17 in Hypoxia-Induced CTGF Expression and Pulmonary Fibrosis (II)

Chen, B.-C. (PI)

8/1/14 → 7/31/15

Project: A - Government Institution › b - National Science and Technology Council

Studies on the Role of ORMDL3 in Thrombin-Induced IL-8/CXCL8 Expression and Airway Inflammation

Chen, B.-C. (PI)

8/1/14 → 7/31/15

Project: A - Government Institution › b - National Science and Technology Council

Functional Investigation of Heat Shock Protein in Esophageal Squamous Cell Cancer with Implications in Prognostic Prediction and Therapeutic Targeting

Tzao, C. (PI)

8/1/14 → 7/31/15

Project: A - Government Institution › b - National Science and Technology Council

Dissected the Role of Glucosed-Regulated Portein 78 in the Progression, Metastasis and Therapy of Colorectal Cancer

Wei, P.-L. (PI)

8/1/14 → 7/31/15

Project: A - Government Institution › b - National Science and Technology Council

榖胱甘月太硫轉移酉每參與乳癌致癌之分子機制探討(3/3)

Wu, C.-H. (PI)

8/1/14 → 7/31/15

Project: A - Government Institution › b - National Science and Technology Council

Determined the Role and the Mechanims of GRP94 in Mediating the Progression and Therapeutic Responses of HCC

Huang, M.-T. (PI)

8/1/14 → 7/31/15

Project: A - Government Institution › b - National Science and Technology Council

乳癌是目前世界上女性癌症病患中為數最多的癌症之ㄧ。腺病毒蛋白type 5 E1A (E1A)和許多抗腫瘤作用有關，曾於多種癌症如乳癌、卵巢癌及頭頸癌之病患進行臨床基因治療試驗。許多的研究指出E1A具有多項抗腫瘤的功能，包括抑制腫瘤的發生、增加腫瘤細胞對於化療藥物的感受性以及減少腫瘤轉移的現象。腫瘤的轉移對於癌症患者的死亡率有極大的影響當然也包括了乳癌的患者。E1A於抑制腫瘤發展的過程中具有多重生物學上的意義，這也促使我們想要釐清E1A抑制癌症的機制。因此，我們對於了解E1A抑制癌症轉移相關的分子機制感到有興趣，並期望藉以作為未來改進乳癌病人臨床試驗的基石。我們初步的實驗結果顯示，E1A可以有效的抑制Glucose-regulated protein 78 (GRP78)這種已被廣泛報導和腫瘤惡化及轉移相關的蛋白的表現。提出此研究計劃之目的在於詳細探討E1A所造成的抑制癌轉移作用中，GRP78所扮演的生物功能及其調控的機轉。為了達到此目的，我們將著重於E1A如何調控GRP78表現並進而展現對乳癌轉移的抑制作用。以下為此項研究計畫的四大主要目標：目標一：探討GRP78在E1A所抑制之癌細胞移行及侵入作用中所扮演的角色目標二：研究E1A抑制GRP78表現之分子機轉目標三：於動物模式中驗證GRP78的表現對於E1A抗腫瘤作用的影響目標四：探討GRP78及其相關分子的表現在乳癌病人的臨床重要性完成以上的主要目標能夠幫助我們對於E1A之抗腫瘤轉移作用建立更加詳細的分子訊息傳遞機制。另外，藉由此研究計畫的新發現也許可以對未來發展癌症治療上提供更多具有潛力的標的物。

Wang, W. (PI)

8/1/14 → 7/31/15

Project: A - Government Institution › b - National Science and Technology Council

New Strategies of Parkinson’s Disease Treatment

Chiang, Y.-H. (PI)

8/1/14 → 12/31/15

Project: A - Government Institution › b - National Science and Technology Council

Effects of Ultrafine Particles on Cardiopulmonary System: a Population-Based Approach

Chuang, K.-J. (PI)

8/1/14 → 7/31/15

Project: A - Government Institution › b - National Science and Technology Council

A Multidisciplinary Study of the Pathophysiology of Blast-Induced Mild Traumatic Brain Injury

Chiang, Y.-H. (PI)

8/1/14 → 7/31/15

Project: A - Government Institution › b - National Science and Technology Council

Association Study of Persistent Metabolic Syndrome, Inflammatory Markers, Adipose Markers and Mild Cognitive Decline

Bai, C.-H. (PI)

8/1/14 → 7/31/15

Project: A - Government Institution › b - National Science and Technology Council

Effects of Different Sources of n-3 Fatty Acids on Bone Loss, Body Fat and Inflammatory Markers in Osteoporotic Condition with Diabetes

Chiu, W.-C. (PI) & Fong, T.-H. (CoI)

8/1/14 → 7/31/15

Project: A - Government Institution › b - National Science and Technology Council

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