Ph.D. Program in Drug Discovery and Development Industry

2024

Current Progress Regarding Cordyceps militaris, Its Metabolite Function, and Its Production

Chou, Y. C., Sung, T. H., Hou, S. J., Khumsupan, D., Santoso, S. P., Cheng, K. C. & Lin, S. P., Jun 2024, In: Applied Sciences (Switzerland). 14, 11, 4610.

Research output: Contribution to journal › Review article › peer-review

Open Access

3 Citations (Scopus)

Efficacy of Zinc Supplementation in the Management of Primary Dysmenorrhea: A Systematic Review and Meta-Analysis

Hsu, T. J., Hsieh, R. H., Huang, C. H., Chen, C. S., Lin, W. Y., Huang, Y. C., Lin, J. H., Huang, K. T., Liu, Y. L., Tsai, H. M. & Ho, D. R., Dec 2024, In: Nutrients. 16, 23, 4116.

Research output: Contribution to journal › Review article › peer-review

Open Access

2 Citations (Scopus)

Mitochondrial Mechanisms in Temozolomide Resistance: Unraveling the Complex Interplay and Therapeutic Strategies in Glioblastoma

Li, H. Y., Feng, Y. H., Lin, C. L. & Hsu, T. I., Mar 2024, In: Mitochondrion. 75, 101836.

Research output: Contribution to journal › Review article › peer-review

8 Citations (Scopus)

Oxidative stress and potential effects of metal nanoparticles: A review of biocompatibility and toxicity concerns

Wang, Y. L., Lee, Y. H., Chou, C. L., Chang, Y. S., Liu, W. C. & Chiu, H. W., Apr 1 2024, In: Environmental Pollution. 346, p. 123617 123617.

Research output: Contribution to journal › Review article › peer-review

35 Citations (Scopus)

Production of therapeutic glycoproteins in glycoengineered plant: old farm for new crops

Kao, M.-R., Karmarkar Saldivar, R. & Hsieh, Y. S. Y., Jun 2024, In: Current Opinion in Biotechnology. 87, 103145.

Research output: Contribution to journal › Review article › peer-review

2 Citations (Scopus)

Recent advances and future directions on small molecule VEGFR inhibitors in oncological conditions

Thakur, A., Rana, M., Mishra, A., Kaur, C., Pan, C. H. & Nepali, K., Jun 5 2024, In: European Journal of Medicinal Chemistry. 272, 116472.

Research output: Contribution to journal › Review article › peer-review

7 Citations (Scopus)

Scaffold hopping approaches for dual-target antitumor drug discovery: opportunities and challenges

Mishra, A., Thakur, A., Sharma, R., Onuku, R., Kaur, C., Liou, J. P., Hsu, S. P. & Nepali, K., 2024, (Accepted/In press) In: Expert Opinion on Drug Discovery. 19, 11, p. 1355-1381 27 p.

Research output: Contribution to journal › Review article › peer-review

Spleen tyrosine kinase (SYK): an emerging target for the assemblage of small molecule antitumor agents

Kaur, C., Thakur, A., Liou, K.-C., Rao, N. V. & Nepali, K., Aug 2024, In: Expert Opinion on Investigational Drugs. 33, 9, p. 897-914 18 p.

Research output: Contribution to journal › Review article › peer-review

1 Citation (Scopus)

The effects of incretin-based therapies on weight reduction and metabolic parameters in children with obesity: A systematic review and meta-analysis

Wang, J. Y., Kang, J. W., Wu, C. Y., Peng, T. R., Liao, L. M., Lee, M. C., Lee, J. A. & Chen, S. M., Apr 2024, In: Obesity Reviews. 25, 4, e13686.

Research output: Contribution to journal › Review article › peer-review

4 Citations (Scopus)

2023

An updated patent review of histone deacetylase (HDAC) inhibitors in cancer (2020–present)

Liu, Y. M. & Liou, J. P., 2023, (Accepted/In press) In: Expert Opinion on Therapeutic Patents. 33, 5, p. 349-369 21 p.

Research output: Contribution to journal › Review article › peer-review

15 Citations (Scopus)

Application of Design of Experiments in the Development of Self-Microemulsifying Drug Delivery Systems

Hsieh, C. M., Yang, T. L., Putri, A. D. & Chen, C. T., Feb 2023, In: Pharmaceuticals. 16, 2, 283.

Research output: Contribution to journal › Review article › peer-review

Open Access

24 Citations (Scopus)

Current and Potential Applications of Atmospheric Cold Plasma in the Food Industry

Khumsupan, D., Lin, S. P., Hsieh, C. W., Santoso, S. P., Chou, Y. J., Hsieh, K. C., Lin, H. W., Ting, Y. & Cheng, K. C., Jul 2023, In: Molecules. 28, 13, 4903.

Research output: Contribution to journal › Review article › peer-review

Open Access

10 Citations (Scopus)

Current insights of factors interfering the stability of lytic polysaccharide monooxygenases

Dan, M., Zheng, Y., Zhao, G., Hsieh, Y. S. Y. & Wang, D., Oct 2023, In: Biotechnology Advances. 67, p. 108216

Research output: Contribution to journal › Review article › peer-review

2 Citations (Scopus)

Currently Used Methods to Evaluate the Efficacy of Therapeutic Drugs and Kidney Safety

Huang, H. J., Chou, C. L., Sandar, T. T., Liu, W. C., Yang, H. C., Lin, Y. C., Zheng, C. M. & Chiu, H. W., Nov 2023, In: Biomolecules. 13, 11, 1581.

Research output: Contribution to journal › Review article › peer-review

Open Access

3 Citations (Scopus)

Current Trends in Neoantigen-Based Cancer Vaccines

Ho, S. Y., Chang, C. M., Liao, H. N., Chou, W. H., Guo, C. L., Yen, Y., Nakamura, Y. & Chang, W. C., Mar 2023, In: Pharmaceuticals. 16, 3, 392.

Research output: Contribution to journal › Review article › peer-review

Open Access

14 Citations (Scopus)

Dysregulated lipid metabolism in TMZ-resistant glioblastoma: pathways, proteins, metabolites and therapeutic opportunities

Kao, T. J., Lin, C. L., Yang, W. B., Li, H. Y. & Hsu, T. I., Dec 2023, In: Lipids in Health and Disease. 22, 1, 114.

Research output: Contribution to journal › Review article › peer-review

Open Access

11 Citations (Scopus)

Endothelial Dysfunction in Neurodegenerative Diseases

Fang, Y. C., Hsieh, Y. C., Hu, C. J. & Tu, Y. K., Feb 2023, In: International journal of molecular sciences. 24, 3, 2909.

Research output: Contribution to journal › Review article › peer-review

Open Access

43 Citations (Scopus)

Nanoparticles augment the therapeutic window of RT and immunotherapy for treating cancers: pivotal role of autophagy

Wu, Y. H., Chen, R. J., Chiu, H. W., Yang, L. X., Wang, Y. L., Chen, Y. Y., Yeh, Y. L., Liao, M. Y. & Wang, Y. J., 2023, In: Theranostics. 13, 1, p. 40-58 19 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

17 Citations (Scopus)

N-heterocycle based degraders (Protacs) manifesting anticancer efficacy: Recent advances

Banerjee, S., Sharma, S., Thakur, A., Sachdeva, R., Sharma, R., Nepali, K. & Liou, J. P., 2023, In: Current Drug Targets. 24, 15, p. 1184-1208 25 p.

Research output: Contribution to journal › Review article › peer-review

3 Citations (Scopus)

Perivascular adipose tissue and adipocyte-derived exosomal miRNAs maintain vascular homeostasis

Chen, H. H., Li, H. F., Tseng, T. L. & Lin, H., Dec 2023, In: Heliyon. 9, 12, e22607.

Research output: Contribution to journal › Review article › peer-review

Open Access

2 Citations (Scopus)

Prudent tactics to sail the boat of PARP inhibitors as therapeutics for diverse malignancies

Rana, M., Thakur, A., Kaur, C., Pan, C. H., Lee, S. B., Liou, J. P. & Nepali, K., 2023, (Accepted/In press) In: Expert Opinion on Drug Discovery. 18, 10, p. 1169-1193 25 p.

Research output: Contribution to journal › Review article › peer-review

2 Citations (Scopus)

Small molecule tractable PARP inhibitors: Scaffold construction approaches, mechanistic insights and structure activity relationship

Thakur, A., Rana, M., Ritika, Mathew, J., Nepali, S., Pan, C. H., Liou, J. P. & Nepali, K., Dec 2023, In: Bioorganic Chemistry. 141, 106893.

Research output: Contribution to journal › Review article › peer-review

7 Citations (Scopus)

The complex role of eicosanoids in the brain: Implications for brain tumor development and therapeutic opportunities

Chen, H. C., Chang, W. C., Chuang, J. Y., Chang, K. Y., Liou, J. P. & Hsu, T. I., Sept 2023, In: Biochimica et Biophysica Acta - Reviews on Cancer. 1878, 5, 188957.

Research output: Contribution to journal › Review article › peer-review

3 Citations (Scopus)

2022

Applications of atmospheric cold plasma in agricultural, medical, and bioprocessing industries

Lin, S. P., Khumsupan, D., Chou, Y. J., Hsieh, K. C., Hsu, H. Y., Ting, Y. & Cheng, K. C., Dec 2022, In: Applied Microbiology and Biotechnology. 106, 23, p. 7737-7750 14 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

25 Citations (Scopus)

Beyond the vaccines: a glance at the small molecule and peptide-based anti-COVID19 arsenal

Nepali, K., Sharma, R., Sharma, S., Thakur, A. & Liou, J. P., Sept 2022, In: Journal of Biomedical Science. 29, 1, p. 65 1 p., 65.

Research output: Contribution to journal › Review article › peer-review

Open Access

22 Citations (Scopus)

Bioactive Graphene Quantum Dots Based Polymer Composite for Biomedical Applications

Mousavi, S. M., Hashemi, S. A., Kalashgrani, M. Y., Omidifar, N., Bahrani, S., Rao, N. V., Babapoor, A., Gholami, A. & Chiang, W. H., Feb 1 2022, In: Polymers. 14, 3, 617.

Research output: Contribution to journal › Review article › peer-review

Open Access

95 Citations (Scopus)

Clinical Trials of New Drugs for Vascular Cognitive Impairment and Vascular Dementia

Linh, T. T. D., Hsieh, Y. C., Huang, L. K. & Hu, C. J., Oct 2022, In: International journal of molecular sciences. 23, 19, 11067.

Research output: Contribution to journal › Review article › peer-review

Open Access

27 Citations (Scopus)

Crosstalk between Schizophrenia and Metabolic Syndrome: The Role of Oxytocinergic Dysfunction

Goh, K. K., Chen, C. Y. A., Wu, T. H., Chen, C. H. & Lu, M. L., Jul 1 2022, In: International journal of molecular sciences. 23, 13, 7092.

Research output: Contribution to journal › Review article › peer-review

Open Access

19 Citations (Scopus)

Effectiveness of Botulinum Toxin Type A Injection on Scars: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Li, M. Y., Chiu, W. K., Wang, H. J., Chen, I. F., Chen, J. H., Chang, T. P., Ko, Y. & Chen, C., Dec 1 2022, In: Plastic and Reconstructive Surgery. 150, 6, p. 1249E-1258E

Research output: Contribution to journal › Review article › peer-review

2 Citations (Scopus)

Emergent Roles of Circular RNAs in Metabolism and Metabolic Disorders

Wu, Y. L., Li, H. F., Chen, H. H. & Lin, H., Feb 1 2022, In: International journal of molecular sciences. 23, 3, 1032.

Research output: Contribution to journal › Review article › peer-review

Open Access

14 Citations (Scopus)

Glioblastoma: Current Status, Emerging Targets, and Recent Advances

Thakur, A., Faujdar, C., Sharma, R., Sharma, S., Malik, B., Nepali, K. & Liou, J. P., Jul 2022, In: Journal of Medicinal Chemistry. 65, 13, p. 8596-8685 90 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

58 Citations (Scopus)

Plasma‐Enabled Smart Nanoexosome Platform as Emerging Immunopathogenesis for Clinical Viral Infection

Mousavi, S. M., Hashemi, S. A., Gholami, A., Kalashgrani, M. Y., Rao, N. V., Omidifar, N., Hsiao, W. W. W., Lai, C. W. & Chiang, W. H., May 2022, In: Pharmaceutics. 14, 5, 1054.

Research output: Contribution to journal › Review article › peer-review

Open Access

17 Citations (Scopus)

Recent Advances in Bioutilization of Marine Macroalgae Carbohydrates: Degradation, Metabolism, and Fermentation

Zheng, Y., Li, Y., Yang, Y., Zhang, Y., Wang, D., Wang, P., Wong, A. C. Y., Hsieh, Y. S. Y. & Wang, D., Feb 9 2022, In: Journal of Agricultural and Food Chemistry. 70, 5, p. 1438-1453 16 p.

Research output: Contribution to journal › Review article › peer-review

22 Citations (Scopus)

Recent Advances in Plasma-Engineered Polymers for Biomarker-Based Viral Detection and Highly Multiplexed Analysis

Mousavi, S. M., Hashemi, S. A., Kalashgrani, M. Y., Gholami, A., Omidifar, N., Babapoor, A., Vijayakameswara Rao, N. & Chiang, W. H., May 2022, In: Biosensors. 12, 5, 286.

Research output: Contribution to journal › Review article › peer-review

Open Access

27 Citations (Scopus)

Role of Calcimimetics in Treating Bone and Mineral Disorders Related to Chronic Kidney Disease

Hou, Y. C., Zheng, C. M., Chiu, H. W., Liu, W. C., Lu, K. C. & Lu, C. L., Aug 2022, In: Pharmaceuticals. 15, 8, 952.

Research output: Contribution to journal › Review article › peer-review

Open Access

12 Citations (Scopus)

The Pivotal Role of Quantum Dots-Based Biomarkers Integrated with Ultra-Sensitive Probes for Multiplex Detection of Human Viral Infections

Mousavi, S. M., Hashemi, S. A., Yari Kalashgrani, M., Omidifar, N., Lai, C. W., Vijayakameswara Rao, N., Gholami, A. & Chiang, W. H., Jul 2022, In: Pharmaceuticals. 15, 7, 880.

Research output: Contribution to journal › Review article › peer-review

Open Access

30 Citations (Scopus)

The power of heteronemin in cancers

Wang, K., Chen, Y. F., Yang, Y.-C., Huang, H.-M., Lee, S. Y., Shih, Y. J., Li, Z. L., Whang-Peng, J., Lin, H.-Y. & Davis, P. J., Jun 15 2022, In: Journal of Biomedical Science. 29, 1

Research output: Contribution to journal › Review article › peer-review

Open Access

8 Citations (Scopus)

The Role of Epigenetic Mechanisms in Autoimmune, Neurodegenerative, Cardiovascular, and Imprinting Disorders

Sharma, R., Sharma, S., Thakur, A., Singh, A., Singh, J., Nepali, K. & Liou, J. P., Aug 2022, In: Mini-Reviews in Medicinal Chemistry. 22, 15, p. 1977-2011 35 p.

Research output: Contribution to journal › Review article › peer-review

1 Citation (Scopus)

Toxicologic Concerns with Current Medical Nanoparticles

Cheng, T. M., Chu, H. Y., Huang, H. M., Li, Z. L., Chen, C. Y., Shih, Y. J., Whang-Peng, J., Cheng, R. H., Mo, J. K., Lin, H. Y. & Wang, K., Jul 8 2022, In: International journal of molecular sciences. 23, 14, 7597.

Research output: Contribution to journal › Review article › peer-review

Open Access

27 Citations (Scopus)

2021

Brown Algae Carbohydrates: Structures, Pharmaceutical Properties, and Research Challenges

Li, Y., Zheng, Y., Zhang, Y., Yang, Y., Wang, P., Imre, B., Wong, A. C. Y., Hsieh, Y. S. Y. & Wang, D., Oct 2021, In: Marine Drugs. 19, 11, 620.

Research output: Contribution to journal › Review article › peer-review

Open Access

110 Citations (Scopus)

Comparison of minimally invasive percutaneous fixation and open reduction internal fixation for patella fractures: a meta-analysis

Lo, C. H. & Chen, C. H., Dec 2021, In: Journal of Orthopaedic Surgery and Research. 16, 1, 506.

Research output: Contribution to journal › Review article › peer-review

Open Access

7 Citations (Scopus)

Current strategies in assessment of nanotoxicity: Alternatives to in vivo animal testing

Huang, H. J., Lee, Y. H., Hsu, Y. H., Liao, C. T., Lin, Y. F. & Chiu, H. W., Apr 2 2021, In: International journal of molecular sciences. 22, 8, 4216.

Research output: Contribution to journal › Review article › peer-review

Open Access

65 Citations (Scopus)

Dissecting the mechanism of temozolomide resistance and its association with the regulatory roles of intracellular reactive oxygen species in glioblastoma

Chien, C. H., Hsueh, W. T., Chuang, J. Y. & Chang, K. Y., Dec 2021, In: Journal of Biomedical Science. 28, 1, 18.

Research output: Contribution to journal › Review article › peer-review

Open Access

58 Citations (Scopus)

Emerging role of terpenoids for the treatment of cancer: A review

Chopra, B., Dhingra, A. K., Dhar, K. L. & Nepali, K., 2021, In: Mini-Reviews in Medicinal Chemistry. 21, 16, p. 2300-2336 37 p.

Research output: Contribution to journal › Review article › peer-review

35 Citations (Scopus)

Micro- and Nanosized Substances Cause Different Autophagy-Related Responses

Wang, Y. L., Zheng, C. M., Lee, Y. H., Cheng, Y. Y., Lin, Y. F. & Chiu, H. W., Apr 30 2021, In: International journal of molecular sciences. 22, 9, 4787.

Research output: Contribution to journal › Review article › peer-review

Open Access

12 Citations (Scopus)

Polyketides with Anti-neuroinflammatory Activity fromTheissenia cinerea

Hsieh, M. H., Hsiao, G., Chang, C. H., Yang, Y. L., Ju, Y. M., Kuo, Y. H. & Lee, T. H., Jul 23 2021, In: Journal of Natural Products. 84, 7, p. 1898-1903 6 p.

Research output: Contribution to journal › Review article › peer-review