Ph.D. Program in Drug Discovery and Development Industry

2025

Aspartame consumption linked to delayed puberty and mitochondrial Dysfunction: Evidence from human and animal studies

Chen, Y. C., Wang, Z. L., Lin, Y. F., Lin, C. Y., Hsu, S. Y., Nacis, J. S. & Hsieh, R. H., Jun 2025, In: Journal of Nutritional Biochemistry. 140, 109889.

Research output: Contribution to journal › Article › peer-review

Associations between paraoxonase-1 activity and therapeutic drug monitoring indicators in schizophrenia patients treated with olanzapine: A cross-sectional study

Wu, T. H., Hu, S. C., Sylfa, N., Liao, J. H., Raza, A., Chen, B. L., Chen, C. H. & Lu, M. L., 2025, (Accepted/In press) In: Journal of Psychopharmacology. 39, 2, p. 141-146 6 p.

Research output: Contribution to journal › Article › peer-review

Bioprospection of Hura crepitans metabolites against oxidative stress and inflammation: An in vitro and in silico exploration

Kuo, Y. C., Lawal, B., Lukman, H. Y., Chen, L. C., Huang, S. L., Chen, Y. F., Fadaka, A. O., Olawale, F., Olasupo, A., Ajenifujah, O. T., Fouad, D., Papadakis, M., Batiha, G. E. S., Sabiu, S., Wu, A. T. H. & Huang, H. S., 2025, In: International Journal of Medical Sciences. 22, 8, p. 1837-1851 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Chemical constituents from marine medicinal brown alga-derived Scytalidium lignicola SC228

Hsi, H. Y., Hsiao, G., Wang, S. W., Huang, S. J. & Lee, T. H., Jan 2025, In: Phytochemistry. 229, 114289.

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

CircRNA hsa_circ_0004781 promoted cell proliferation by acting as a sponge for miR-9-5p and miR-338-3p and upregulating KLF5 and ADAM17 expression in pancreatic ductal adenocarcinoma

Lee, K. L., Liu, J. J., Huang, W. J., Hung, C. S. & Liang, Y. C., Dec 2025, In: Cancer Cell International. 25, 1, 56.

Research output: Contribution to journal › Article › peer-review

Open Access

Development of BACE2-IN-1/tranylcypromine-based compounds to induce steroidogenesis-dependent neuroprotection

Banerjee, S., Hsu, Y. T., Nguyen, D. H., Yeh, S. H., Liou, K. C., Liu, J. J., Liou, J. P. & Chuang, J. Y., Feb 2025, In: Biomedicine and Pharmacotherapy. 183, 117851.

Research output: Contribution to journal › Article › peer-review

Open Access

Discovery and biological evaluation of potent 2-trifluoromethyl acrylamide warhead-containing inhibitors of protein disulfide isomerase

Chu, J. C., Tsai, K. C., Wang, T. Y., Chen, T. Y., Tsai, J. Y., Lee, T., Lin, M. H., Hsieh, Y. S. Y., Wu, C. C. & Huang, W. J., Feb 5 2025, In: European Journal of Medicinal Chemistry. 283, p. 117169 117169.

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Dynamic changes in the metabolome and microbiome during Citrus depressa Hayata liquid fermentation

Liu, T. W., Iskandar, B., Chu, M. H., Wang, Y. H., Huang, T. A., Hsu, S. J., Hsieh, Y. S. Y. & Lee, C. K., Jan 15 2025, In: Food Chemistry. 463, 141225.

Research output: Contribution to journal › Article › peer-review

Genome-wide association study of the fatty liver index in the Taiwanese population reveals shared and population-specific genetic risk factors across ethnicities

Lau, P. P., Wei, C. Y., Lin, M. R., Chou, W. H., Wan, Y. J. Y. & Chang, W. C., Dec 2025, In: Cell and Bioscience. 15, 1, 19.

Research output: Contribution to journal › Article › peer-review

Open Access

Histamine N-methyltransferase (HNMT) as a potential auxiliary biomarker for predicting adaptability to anti-HER2 drug treatment in breast cancer patients

Cheng, T.-C., Hung, M.-C., Wang, L.-H., Tu, S.-H., Wu, C.-H., Yen, Y., Chen, C.-L., Whang-Peng, J., Lee, W.-J., Liao, Y.-C., Lee, Y.-C., Pan, M.-H., Lin, H.-K., Tzeng, H.-E., Guo, P., Chu, C.-Y. & Chen, L.-C., Jan 9 2025, In: Biomarker Research. 13, 1, p. 7

Research output: Contribution to journal › Article › peer-review

Histamine N-methyltransferase (HNMT) as a potential auxiliary biomarker for predicting adaptability to anti-HER2 drug treatment in breast cancer patients

Cheng, T. C., Hung, M. C., Wang, L. H., Tu, S.-H., Wu, C.-H., Yen, Y., Chen, C. L., Whang-Peng, J., Lee, W. J., Liao, Y. C., Lee, Y.-C., Pan, M. H., Lin, H. K., Tzeng, H.-E., Guo, P., Chu, C.-Y., Chen, L. C. & Ho, Y.-S., Dec 2025, In: Biomarker Research. 13, 1, 7.

Research output: Contribution to journal › Article › peer-review

Open Access

Identification and Biological Evaluation of a Novel CLK4 Inhibitor Targeting Alternative Splicing in Pancreatic Cancer Using Structure-Based Virtual Screening

Yang, C. L., Wu, Y. W., Tu, H. J., Yeh, Y. H., Lin, T. E., Sung, T. Y., Li, M. C., Yen, S. C., Hsieh, J. H., Yu, M. C., Hsieh, S. Y., Hsieh, H. P., Pan, S. L. & Hsu, K. C., 2025, (Accepted/In press) In: Advanced Science.

Research output: Contribution to journal › Article › peer-review

Open Access

Identification of a Potent CDK8 Inhibitor Using Structure-Based Virtual Screening

Lin, T. E., Chou, C. H., Wu, Y. W., Sung, T. Y., Hsu, J. Y., Yen, S. C., Hsieh, J. H., Chang, Y. W., Pan, S. L., Huang, W. J., Hsu, K. C. & Yang, C. R., Jan 13 2025, In: Journal of Chemical Information and Modeling. 65, 1, p. 378-389 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Increased risk of breast cancer among premenopausal women with pituitary gland disorders in Taiwan: a population-based matched-cohort study

Lin, C. C., Lin, C. J., Hsieh, Y. C., Lin, J. H., Tsai, H. Y., Wu, C. Y. & Chiou, H. Y., Mar 2025, In: Journal of Endocrinological Investigation. 48, 3, p. 681-689 9 p.

Research output: Contribution to journal › Article › peer-review

Plasma extracellular vesicle pathognomonic proteins as the biomarkers of the progression of Parkinson’s disease

Hong, C. T., Chung, C. C., Hsieh, Y. C. & Chan, L., 2025, In: BioScience Trends. 19, 1, p. 116-124 9 p.

Research output: Contribution to journal › Article › peer-review

Polystyrene microplastics induce hepatic lipid metabolism and energy disorder by upregulating the NR4A1-AMPK signaling pathway

Chiu, H. W., Chu, C. W., Huang, C. C., Chia, Z. C., Wang, Y. L. & Lee, Y. H., Mar 15 2025, In: Environmental Pollution. 369, 125850.

Research output: Contribution to journal › Article › peer-review

Potential role of solid lipid curcumin particle (SLCP) as estrogen replacement therapy in mitigating TDP-43-related neuropathy in the mouse model of ALS disease

Majumder, P., Hsu, T. I., Hu, C. J., Huang, J. K., Lee, Y. C., Hsieh, Y. C., Ahsan, A. & Huang, C. C., Jan 2025, In: Experimental Neurology. 383, 114999.

Research output: Contribution to journal › Article › peer-review

Open Access

Repurposing Linezolid in Conjunction with Histone Deacetylase Inhibitor Access in the Realm of Glioblastoma Therapies

Chen, I. C., Lin, H. Y., Liu, Z. Y., Cheng, W. J., Yeh, T. Y., Yang, W. B., Tran, H. Y., Lai, M. J., Wang, C. H., Kao, T. Y., Hung, C. Y., Huang, Y. L., Liou, K. C., Hsieh, C. M., Hsu, T. I. & Liou, J. P., 2025, In: Journal of Medicinal Chemistry. 68, 3, p. 2779-2803 25 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Sequential Treatment of Metastatic Colorectal Cancer in Taiwan: Real-World Evidence From Regorafenib and Trifluridine/Tipiracil Use

Chang, Y. W., Kuo, C. N., Chang, C. L., Hsu, J. & Ko, Y., 2025, (Accepted/In press) In: Journal of Gastroenterology and Hepatology (Australia).

Research output: Contribution to journal › Article › peer-review

Treadmill intervention attenuates motor deficit with 6-OHDA- induced Parkinson's disease rat via changes in lipid profiles in brain and muscle

Panunggal, B., Yeh, T. H., Tsao, S. P., Pan, C. H., Shih, W. T., Lin, Y. T., Faradina, A., Fang, C. L., Huang, H. Y. & Huang, S. Y., 2025, In: Aging. 17, 1, p. 232-250 19 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2024

10 weeks low intensity treadmill exercise intervention ameliorates motor deficits and sustains muscle mass via decreasing oxidative damage and increasing mitochondria function in a rat model of Parkinson's disease

Tung, Y. T., Liao, Y. C., Yeh, T. H., Tsao, S. P., Chang, C. C., Shih, W. T. & Huang, H. Y., Aug 1 2024, In: Life Sciences. 350, 122733.

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Agar-altered foaming bacterial cellulose with carvacrol for active food packaging applications

Kusuma, A. C., Chou, Y. C., Hsieh, C. C., Santoso, S. P., Go, A. W., Lin, H. T. V., Hsiao, I. L. & Lin, S. P., Mar 2024, In: Food Packaging and Shelf Life. 42, 101269.

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

AIM2 promotes irradiation resistance, migration ability and PD-L1 expression through STAT1/NF-κB activation in oral squamous cell carcinoma

Chiu, H. W., Lee, H. L., Lee, H. H., Lu, H. W., Lin, K. Y. H., Lin, Y. F. & Lin, C. H., Dec 2024, In: Journal of Translational Medicine. 22, 1, 13.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Citations (Scopus)

Alleviation of PM2.5-induced alveolar macrophage inflammation using extract of fermented Chenopodium formosanum Koidz sprouts via regulation of NF-κB pathway

Hsieh, C. C., Yu, S. H., Kuo, H. C., Cheng, K. W., Hsu, C. C., Lin, Y. P., Khumsupan, D., Lin, S. P., Angkawijaya, A. E. & Cheng, K. C., Jan 10 2024, In: Journal of Ethnopharmacology. 318, 116980.

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Amelioration of the brain structural connectivity is accompanied with changes of gut microbiota in a tuberous sclerosis complex mouse model

Hsieh, C. C. J., Lo, Y. C., Wang, H. H., Shen, H. Y., Chen, Y. Y. & Lee, Y. C., Dec 2024, In: Translational Psychiatry. 14, 1, 68.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Citations (Scopus)

A Mobile-Based Nutrition Tracker App Enhanced Dietitian-Guided 2:1:1 Diet-Induced Weight Loss: An 8-Week Retrospective Cohort Study in Taiwan

Chueh, T. L., Wang, Z. L., Ngu, Y. J., Lin, P. L., Owaga, E. & Hsieh, R. H., Jul 2024, In: Nutrients. 16, 14, 2331.

Research output: Contribution to journal › Article › peer-review

Open Access

An ensemble machine learning model generates a focused screening library for the identification of CDK8 inhibitors

Lin, T. E., Yen, D., HuangFu, W. C., Wu, Y. W., Hsu, J. Y., Yen, S. C., Sung, T. Y., Hsieh, J. H., Pan, S. L., Yang, C. R., Huang, W. J. & Hsu, K. C., Jun 2024, In: Protein Science. 33, 6, e5007.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Citations (Scopus)

A novel HDAC8 inhibitor H7E exerts retinoprotective effects against glaucomatous injury via ameliorating aberrant Müller glia activation and oxidative stress

Wu, L. H., Cheng, Y. W., Lin, F. L., Hsu, K. C., Wang, M. H., Yen, J. L., Wang, T. J., Lin, T. E., Liu, Y. C., Huang, W. J. & Hsiao, G., May 2024, In: Biomedicine and Pharmacotherapy. 174, 116538.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Citations (Scopus)

Anti-inflammatory constituents from a sea anemone-derived fungus Arthrinium arundinis MA30

Lee, Y. S., Wu, H. C., Huang, S. J., Hsiao, G., Chi, W. C. & Lee, T. H., Mar 2024, In: Phytochemistry. 219, 113998.

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Anti-osteoporotic effects of Yi Mai Jian on bone metabolism of ovariectomized rats

Shi, B., Lin, C. C., Lee, C. J., Ning, D. S., Lin, C. C., Zhao, H. W., Yang, C. S., Deng, S. X., Chiu, Y. J. & Wang, C. C., 2024, In: Frontiers in Pharmacology. 15, 1326415.

Research output: Contribution to journal › Article › peer-review

Open Access

A rapid optimization method for Sepbox system separation using HPTLC: an application of Cerbera manghas L. separation

Liu, T. W., Lin, P. Y., Chu, M. H., Wang, S. Y. & Lee, C. K., Sept 3 2024, In: Analytical Methods. 16, 37, p. 6420-6428 9 p.

Research output: Contribution to journal › Article › peer-review

A Robust α-l-Fucosidase from Prevotella nigrescens for Glycoengineering Therapeutic Antibodies

Kao, M.-R., Ma, T.-H., Chou, H.-Y., Chang, S.-C., Cheng, L.-C., Liao, K.-S., Shie, J.-J., Harris, P. J., Wong, C.-H. & Hsieh, Y. S. Y., Jul 19 2024, In: ACS Chemical Biology. 19, 7, p. 1515-1524 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Aromatherapy for the prevention of postoperative nausea and vomiting: A systematic review and meta-analysis

Wang, J. Y., Huang, H. Y., Chu, W. O., Peng, T. R., Lee, M. C., Chen, S. M. & Lee, J. A., 2024, In: Tzu Chi Medical Journal. 36, 3, p. 330-339 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Citations (Scopus)

Ascophyllum nodosum and Fucus vesiculosus ameliorate restenosis via improving infl ammation and regulating the PTEN/PI3K/AKT signaling pathway

Zumbi, C. N., Pan, C. H., Huang, H. Y. & Wu, C. H., May 2024, In: Food Science and Human Wellness. 13, 3, p. 1711-1728 18 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Citation (Scopus)

Aspartame Intake Delayed Puberty Onset in Female Offspring Rats and Girls

Lin, C. Y., Nguyen, N. N., Tsai, W. L., Hsieh, R. H., Wu, H. T. & Chen, Y. C., Mar 2024, In: Molecular Nutrition and Food Research. 68, 5, 2300270.

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Aspartame intake during pregnancy induces placental dysfunction through impaired mitochondrial function and biogenesis modulation

Chen, Y. C., Yeh, Y. C., Lin, Y. F., Hsu, S. Y., Nacis, J. S., Hsu, J. W. & Hsieh, R. H., Dec 2024, In: Placenta. 158, p. 285-292 8 p.

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

ASPM stabilizes the NOTCH intracellular domain 1 and promotes oncogenesis by blocking FBXW7 binding in hepatocellular carcinoma cells

Chan, T. S., Cheng, L. H., Hsu, C. C., Yang, P. M., Liao, T. Y., Hsieh, H. Y., Lin, P. C., HuangFu, W. C., Chuu, C. P. & Tsai, K. K., 2024, (Accepted/In press) In: Molecular Oncology. 18, 3, p. 562-579 18 p.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Citations (Scopus)

Association between high-density lipoprotein and functional outcome of ischemic stroke patients in a Taiwanese population

Lin, T. C., Huang, C. Y., Li, Y. L., Chiou, H. Y., Hu, C. J., Jeng, J. S., Tang, S. C., Chan, L., Lien, L. M., Lin, H. J., Lin, C. C. & Hsieh, Y. C., Dec 2024, In: Lipids in Health and Disease. 23, 1, 275.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Citation (Scopus)

Associations of diabetes status and glucose measures with outcomes after endovascular therapy in patients with acute ischemic stroke: an analysis of the nationwide TREAT-AIS registry

Hsieh, M. T., Hsieh, C. Y., Yang, T. H., Sung, S. F., Hsieh, Y. C., Lee, C. W., Lin, C. J., Chen, Y. W., Lin, K. H., Sung, P. S., Tang, C. W., Chu, H. J., Tsai, K. C., Chou, C. L., Lin, C. H., Wei, C. Y., Chen, T. Y., Yan, S. Y., Chen, P. L. & Hsiao, C. Y. & 9 others, Chan, L., Huang, Y. C., Liu, H. M., Tang, S. C., Lee, I. H., Lien, L. M., Chiou, H. Y., Lee, J. T. & Jeng, J. S., 2024, In: Frontiers in Neurology. 15, 1351150.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Citation (Scopus)

A tumor on a chip for studying immune-cell infiltration into tumor under chemo/immunotherapy treatments

Chen, Y. C., Lee, K. Y., Liao, H. J., Sun, W. L., Huang, W. C., Wang, Y. S., Chang, W. C. & Liu, C. H., May 1 2024, In: Sensors and Actuators B: Chemical. 406, 135409.

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Bacillus coagulans TCI711 Supplementation Improved Nonalcoholic Fatty Liver by Modulating Gut Microbiota: A Randomized, Placebo-Controlled, Clinical Trial

Hsieh, R. H., Chien, Y. J., Lan, W. Y., Lin, Y. K., Lin, Y. H., Chiang, C. F. & Yang, M. T., Mar 2024, In: Current Developments in Nutrition. 8, 3, 102083.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Citations (Scopus)

Bioactive matrix scaffold of oxidized sacchachitin via green catalyst of siliacat tempo for enhancing bone regeneration

Sheu, M. T., Lin, S. Y., Cheng, W. J., Lin, H. L., Hsieh, C. M., Ho, H. O., Chen, L. C. & Wu, M. H., Dec 2024, In: Carbohydrate Polymer Technologies and Applications. 8, 100576.

Research output: Contribution to journal › Article › peer-review

Open Access

Celecoxib attenuates interleukin 33-induced expression of vascular cell adhesion molecule-1 in human ovarian endometriotic stromal cells

Lin, T. C., Wang, K. H., Chuang, K. H., Kao, A. P. & Kuo, T. C., Mar 2024, In: Taiwanese Journal of Obstetrics and Gynecology. 63, 2, p. 178-185 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Citation (Scopus)

Cerebrospinal Fluid Proteome Map Reveals Molecular Signatures of Reversible Cerebral Vasoconstriction Syndrome

Yang, J. C., Chen, S. P., Wang, Y. F., Chang, C. H., Chang, K. H., Fuh, J. L., Chow, L. H., Han, C. L., Chen, Y. J. & Wang, S. J., Jul 1 2024, In: Molecular & cellular proteomics : MCP. 23, 7, p. 100794 1 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Characteristics and Effects of Chinese Herbal Medicine in the Management of Female Infertility: A Hospital-Based Study

Chou, P. Y., Chen, C. M., Wang, C. C., Tai, C. J., Lin, Y. K. & Tang, Y. J., Jan 1 2024, In: Complementary Medicine Research. 30, 6, p. 481-491 11 p.

Research output: Contribution to journal › Article › peer-review

Characterization of primary Sjögren's syndrome in the Taiwan Han population through a genome-wide association study and polygenic risk score analysis

Liu, T. Y., Lin, M. R., Lu, H. F., Chen, Y. C., Lin, H. J., Chou, W. H., Wei, C. Y., Palupi, P. D., Liao, C. C., Chang, Y. T., Chang, W. C. & Tsai, F. J., Dec 2024, In: Clinical Immunology. 269, 110381.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Citation (Scopus)

Characterization of the genetic variation and evolutionary divergence of the CLEC18 family

Chang, C. M., Chang, W. C. & Hsieh, S., Dec 2024, In: Journal of Biomedical Science. 31, 1, 53.

Research output: Contribution to journal › Article › peer-review

Open Access

Chemical constituents from a marine medicinal brown alga-derived Xylaria acuta SC1019

Hsi, H. Y., Wang, S. W., Hsiao, G., Chang, L. K., Cheng, Y. C., Huang, S. J., Lu, Y. S. & Lee, T. H., Jun 2024, In: Journal of Food and Drug Analysis. 32, 2, p. 155-167 13 p., 3.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Citations (Scopus)

Chronopharmacology of diuresis via metabolic profiling and key biomarker discovery of the traditional Chinese prescription Ji-Ming-San using tandem mass spectrometry in rat models

Hsieh, C. Y., Tsai, P. W., Tomioka, Y., Matsumoto, Y., Akiyama, Y., Wang, C. C., Tayo, L. L. & Lee, C. J., Feb 2024, In: Phytomedicine. 124, 155260.

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Combined HDAC8 and checkpoint kinase inhibition induces tumor-selective synthetic lethality in preclinical models

Chang, T. Y., Yan, Y., Yu, Z. Y., Rathore, M., Lee, N. Z., Tseng, H. J., Cheng, L. H., Huang, W. J., Zhang, W., Chan, E. R., Qing, Y., Kang, M. L., Wang, R., Tsai, K. K., Pink, J. J., Harte, W. E., Gerson, S. L. & Lee, S. B., Dec 2 2024, In: Journal of Clinical Investigation. 134, 23, e165448.

Research output: Contribution to journal › Article › peer-review

Open Access

Ph.D. Program in Drug Discovery and Development Industry

Research output

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