Ph.D. Program in Drug Discovery and Development Industry

Projects

Projects per year 2010 2012 2013 2014 2015 2025

• 2 Active
• 299 Finished

Projects per year

Search results

• Finished

  Pharmacological investigation of HDAC8 inhibitor in perturbationof chromatin replication

  Lee, S.-B. (PI)

  8/1/23 → 7/31/24

  Project: A - Government Institution › b - National Science and Technology Council

• Investigation and Mechanism Validation of the Combination Therapy of Pan- or Selective Histone Deacetylase Inhibitors with Immune Checkpoint Blockade Agent

  Huang, H.-L. (PI)

  8/1/22 → 7/31/23

  Project: A - Government Institution › b - National Science and Technology Council

• Pharmacological Investigation of Hdac8 Inhibitor in Perturbation of Chromatin Replication and Evaluation of Its Cancer Therapeutic Potential in Combination with Checkpoint Kinase Inhibitors

  Lee, S.-B. (PI)

  8/1/22 → 7/31/23

  Project: A - Government Institution › b - National Science and Technology Council

• DYRK1B抑制劑於胰臟癌中之活體藥效測試

  Huang, H.-L. (PI)

  1/1/22 → 12/31/22

  Project: B - Project of TMU › h - Higher Education Sprout Project

• Investigation and Mechanism Validation of the Combination Therapy of Pan- or Selective Histone Deacetylase Inhibitors with Immune Checkpoint Blockade Agent

  Huang, H.-L. (PI)

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - National Science and Technology Council

• 以無患子油治療牙周病和促進口腔黏膜及植牙骨癒合之機轉探討並製備其釋放水膠體

  Huang, H.-M. (PI)

  1/1/21 → 12/31/21

  Project: B - Project of TMU › h - Higher Education Sprout Project

• Discovery of agents disturbing genome stability during chromatin replication (2nd-4th years)

  Lee, S.-B. (PI)

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - National Science and Technology Council

• International Training Program in Advanced Implant Dentistry and Digital Dentistry

  Huang, H.-M. (PI)

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - National Science and Technology Council

• Targeting replication stress in cancer therapy(II)

  Lee, S.-B. (PI)

  7/1/20 → 6/30/21

  Project: B - Project of TMU › i - Other (Funded by TMU)

• Discovery of Agents Disturbing Genome Stability during Chromatin Replication

  Lee, S.-B. (PI)

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - National Science and Technology Council

• Design and Potency Optimization of Kinase Inhibitors for Cancer Treatment(1/3)

  Hsu, K.-C. (PI)

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - National Science and Technology Council

• Study on the Use of Static Magnetic Field to Induce Mechanobiological Effects to Enhance the Killing Ability of Natural Killer Cell

  Huang, H.-M. (PI)

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - National Science and Technology Council

• The Mechanism and Efficacy Investigation of Using Histone Deacetylase Inhibitors to Enhance the Immune Modulation of Immune Checkpoint Blockade Agent

  Huang, H.-L. (PI)

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - National Science and Technology Council

• Investigating the Therapeutic Potential and Molecular Mechanism of Natural Products for Platinum-Resistant Bladder Cancer(1/3)

  Chen, M.-C. (PI)

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - National Science and Technology Council

• Integrated Bioinformatics Approaches to Study the Mechanisms and Discover Drugs of Hcv-Induced Type 2 Diabetes Mellitus(3/3)

  Hsu, K.-C. (PI)

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - National Science and Technology Council

• Targeting replication stress in cancer therapy (I)

  Lee, S.-B. (PI)

  7/1/19 → 6/30/20

  Project: B - Project of TMU › i - Other (Funded by TMU)

• 組蛋白去乙醯酶在血管認知功能損傷中的作用-組蛋白去乙醯酶調節者在血管認知損傷動物可作為新的治療

  Lai, M.-J. (PI)

  1/1/19 → 12/1/19

  Project: A - Government Institution › d - Ministry of Education

• 開發整合二維材料、智慧微機電與微尺度光學系統之智慧型微量血液凝血偵測系統-以智慧型手機為平臺整合電阻抗式凝血偵測晶片

  Huang, H.-M. (PI)

  1/1/19 → 12/1/19

  Project: A - Government Institution › d - Ministry of Education

• 發展抗肺纖維化劑-治療肺部纖維化小分子藥物之藥理活性機轉探討

  Chen, M.-C. (PI)

  1/1/19 → 12/1/19

  Project: A - Government Institution › d - Ministry of Education

• Investigation on the Effect and Mechanism of Static Magnetic Field Coupled with Magnesium Ion for Promoting Odontogensis and Migration of Wharton'S Jelly Mesenchymal Stem Cells

  Huang, H.-M. (PI)

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - National Science and Technology Council

  • Mesenchymal Stem Cell 100%
  • Magnesium Ion 100%
  • Odontoblast 44%
  • Dental Pulp Stem Cell 33%
  • Stem Cell 33%

• Discovery and Design of Kinase Inhibitors for Cancer Treatment

  Hsu, K.-C. (PI)

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - National Science and Technology Council

  • Malignant Neoplasm 100%
  • Phosphotransferase Inhibitor 100%
  • Janus Kinase 45%
  • Phosphotransferase 36%
  • Drug Development 36%

• Tlk Function and Regulation in Chromatin Replication (2nd Years)

  Lee, S.-B. (PI)

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - National Science and Technology Council

  • Phosphotransferase 100%
  • Kinase 100%
  • Proteomics 11%
  • Replisome 5%
  • Epigenetics 5%

• 研發選擇性非異羥肟酸組蛋白去乙醯酶 4抑制劑

  Hsu, K.-C. (PI)

  7/1/18 → 2/28/19

  Project: A - Government Institution › b - National Science and Technology Council

• 新聘教師研究補助

  Huang, H.-L. (PI)

  5/1/18 → 4/30/20

  Project: B - Project of TMU › g - Research Grants for Newly Hired Faculty

• Tlk Function and Regulation in Chromatin Replication

  Lee, S.-B. (PI)

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - National Science and Technology Council

  • Histone 100%
  • DNA Synthesis 100%
  • Micrococcal Nuclease 50%
  • Copurification 50%
  • Chromosome Instability 50%

• 藉由全方位探索新致病機制發現新的第2型糖尿病之肝臟治療靶點：基於慢性C型肝炎病毒感染模式到一般族群、連結基礎，生物信息學和臨床的系統性探討之轉譯研究－整合生物資訊方法研究C型肝炎誘發之第二型糖尿病的機轉與藥物開發(1/3)

  Hsu, K.-C. (PI)

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - National Science and Technology Council

• Investigation on the Role of Cytoskeleton Reorientation and Calcium Ion Transportation in Static Magnetic Field Induced Mesenchymal Stem Cells Proliferation

  Huang, H.-M. (PI)

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - National Science and Technology Council

  • Cytoskeleton 100%
  • Calcium Ion 100%
  • Mesenchymal Stem Cell 100%
  • Cell Proliferation 100%
  • Magnetic Field 100%

• Mechanism of Anticancer Activity of Dihydroartemisinin Derivatives for Colorectal Cancer Treatment

  Chen, M.-C. (PI)

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - National Science and Technology Council

  • Dihydroartemisinin 100%
  • Dihydroartemisinin Derivative 100%
  • Colorectal Carcinoma 100%
  • Artemisinin 66%
  • Antitumor Activity 22%

• Integrated Bioinformatics Approaches to Study the Mechanisms and Discover Drugs of Hcv-Induced Type 2 Diabetes Mellitus( I )

  Hsu, K.-C. (PI)

  8/1/17 → 7/1/18

  Project: A - Government Institution › b - National Science and Technology Council

• Discovery of Selective Inhibitors for Oncoprotein Kinases

  Hsu, K.-C. (PI)

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - National Science and Technology Council

  • Oncoprotein 100%
  • Protein Kinases 100%
  • Malignant Neoplasm 50%
  • Diseases 30%
  • Abdominal Cancer 20%

• Anticancer Drug Discovery of New Tegafur-Derivatives for Colorectal Cancer Therapy(3/3)

  Chen, M.-C. (PI)

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - National Science and Technology Council

  • Cancer Therapy 100%
  • Anticarcinogen 100%
  • Tegafur 100%
  • Colorectal Carcinoma 100%
  • Drug Discovery 100%

• Development of the Fully Humanized Bispecific Antibody to One-Step Expand and Arm T Cells for Selective Tumor Therapy

  Chuang, K.-H. (PI)

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - National Science and Technology Council

  • Arm 100%
  • Bispecific Antibody 100%
  • T Cell 100%
  • CD3 Antigen 63%
  • Colon 15%

• Design and Synthesis of Biaryl and Biphenylamino Sulfonamides as Novel Anticancer Agents

  Lai, M.-J. (PI)

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - National Science and Technology Council

  • Sulfonamide 100%
  • Anticancer Drug 100%
  • Hydroxamic Acid 66%
  • STAT3 Protein 50%
  • IC50 50%

• 分析TLK訊息傳遞網絡及其於染色質維護與防止腫瘤生成之功能

  Lee, S.-B. (PI)

  4/1/16 → 7/31/17

  Project: A - Government Institution › b - National Science and Technology Council

• 新聘教師研究補助

  Lee, S.-B. (PI)

  4/1/16 → 7/19/21

  Project: B - Project of TMU › g - Research Grants for Newly Hired Faculty

• 腦指蛋白(Brain Finger Protein), ZNF179, 影響突觸可塑性之分子機轉研究

  Lee, Y.-C. (PI)

  3/1/16 → 2/28/17

  Project: C - Project of Alliance › s - Shin Kong Wu Ho-Su Memorial Hospital

• 下顎前牙擁擠矯正治療之力學生物學探討

  Huang, H.-M. (PI)

  3/1/16 → 2/28/17

  Project: C - Project of Alliance › q - Cathay General Hospital

• 將生物資訊之方法和功能性研究應用於基因表達與乳癌危險性相關性

  Chang, W.-C. (PI)

  3/1/16 → 2/28/17

  Project: C - Project of Alliance › q - Cathay General Hospital

• Study of prevention policy and management of emerging substances and controlled drugs in the United Nations and advanced countries.

  Chen, S.H.-Y. (PI), Lee, C.-H. (CoI), Chang, E. H. (CoI), Lee, H.-C. (CoI) & Walther, B. A. (CoI)

  2/26/16 → 12/31/16

  Project: A - Government Institution › c - Ministry of Health and Welfare

  • Drug Abuse 100%
  • Controlled Substance 100%
  • Decision Making 37%
  • Benzodiazepine Derivative 12%
  • Diamorphine 12%

• 105年度國民營養法律服務工作計畫

  Lee, C.-H. (PI)

  2/18/16 → 12/31/16

  Project: A - Government Institution › c - Ministry of Health and Welfare

• 105年度大豆(毛豆)產品動物功效驗證之研究委辦計畫

  Chuang, K.-H. (PI)

  2/1/16 → 12/15/16

  Project: A - Government Institution › e - Council of Agriculture

• 人文思維在科學脈絡的闡發

  Lin, C.-H. (PI)

  2/1/16 → 1/31/17

  Project: A - Government Institution › d - Ministry of Education

• Discovery of multitarget inhibitors for colorectal cancer treatment using Pharmalogs

  Hsu, K.-C. (PI) & Cheng, Y.-W. (CoI)

  2/1/16 → 1/31/17

  Project: A - Government Institution › b - National Science and Technology Council

• Outcomes research in gout: economic impact, humanistic burden, and pharmacoeconomic evaluation

  Ko, Y. (PI)

  1/1/16 → 12/31/16

  Project: A - Government Institution › b - National Science and Technology Council

• The academic communications of cross Straits for establish the quality rules of single herb products(2-2)

  Wang, C.-C. (PI)

  1/1/16 → 12/15/16

  Project: A - Government Institution › c - Ministry of Health and Welfare

  • Herbs 100%
  • Herbal Medicines 100%
  • Traditional Chinese Medicine 100%
  • Decoction 50%
  • Quality Control 50%

• Generate an Endogenous Reporter Transgenic Mouse to Track Cell Fates and Transplant Survival

  Chuang, K.-H. (PI)

  1/1/16 → 12/31/16

  Project: A - Government Institution › a - National Health Research Institutes

  • Cell Fate 100%
  • Transgenic Mouse 100%
  • Polyethylene Glycol 100%
  • Stem Cell 37%
  • Reporter Gene 25%

• 健康食品之綜合性管理機制研析-健康食品保健功效之科學研究

  Hsieh, R.-H. (PI)

  1/1/16 → 12/31/16

  Project: A - Government Institution › c - Ministry of Health and Welfare

• 生物矽轉換成中孔生物活性玻璃應用於肌腱骨頭癒合

  Chen, C.-H. (PI)

  1/1/16 → 12/31/16

  Project: C - Project of Alliance › l - National Taiwan Ocean University

• 合成選擇性HDAC6?抑制劑

  Liou, J.-P. (PI)

  1/1/16 → 12/31/16

  Project: A - Government Institution › c - Ministry of Health and Welfare

• Preclinical evaluation of novel selective HDAC6 inhibitors for human cancers treatment

  Pan, S.-L. (PI)

  1/1/16 → 12/31/16

  Project: A - Government Institution › c - Ministry of Health and Welfare

  • Histone Deacetylase 6 100%
  • Methanesulfonic Acid 60%
  • Cancer Inhibition 20%
  • Therapeutic Effect 20%
  • Anticarcinogen 20%