Projects per year
Organisation profile
Organisation profile
Graduate Institute of Pharmacognosy was established in1992. The first chairman was professor Yen Kun-Ying. Through 22 sessions, Institute has been educating over 197 Masters.
The research of Graduate Institute of Pharmacognosy cultivates outstanding professionals for industry, research and professional practice. Our research focuses on isolation and structural chemistry of medical herbs, and the development of Chinese herbs and functional foods for anti-hypertension, anti-hepatitis, anti-hyperglycemia, anti-cancer, and immune regulation. By the cooperation with government and biotechnology industry, pharmacognosy development can fit up with people’s need and government’s policy. In education, the core value is applying pharmacognosy, crude drugs development, and clinical research on Chinese herbal medicine. Students are instructed the ability to research chemical substances and reactivity of Chinese herbal medicine as well as skills for isolating and analyzing the structures of natural products, natural products pharmacology, molecular mechanisms and knowledge associated with applying Chinese herbal medicine to clinical medical needs. After graduation, students seek careers associated with Chinese herbal medicine or biotechnology.
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Collaborations and top research areas from the last five years
Profiles
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Mei-Chuan Chen
- Department of Pharmaceutical Sciences - Professor
- Graduate Institute of Pharmacognosy - Joint-Appointment Professor
- Ph.D. Program in Drug Discovery and Development Industry - Joint-Appointment Professor
- Master Program in Clinical Genomics and Proteomics - Joint-Appointment Professor
- Ph. D. Program in the Clinical Drug Development of Herbal Medicine - Joint-Appointment Professor
- TMU Research Center of Thoracic Medicine - Member
Person: Researcher
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Kuo-Hsiang Chuang
- Graduate Institute of Pharmacognosy - Professor
- The Ph.D. Program for Translational Medicine - Joint-Appointment Professor
- Ph.D. Program in Drug Discovery and Development Industry - Joint-Appointment Professor
- Ph. D. Program in the Clinical Drug Development of Herbal Medicine - Joint-Appointment Professor
- Master Program in Clinical Genomics and Proteomics - Joint-Appointment Professor
- TMU Research Center of Drug Discovery - Member
- TMU Research Center of Cancer Translational Medicine - Member
- TMU Research Center of Cell Therapy and Regeneration Medicine - Member
Person: Researcher
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Wen-Chi Hou
- Graduate Institute of Pharmacognosy - Professor
- Ph. D. Program in the Clinical Drug Development of Herbal Medicine - Joint-Appointment Professor
Person: Researcher
Projects
- 171 Finished
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Studies on Mechanisms of Rhizomes of Alpinia Officinarum Hance on Improvements of Blood Glucose Levels in Type 2 Diabetes Mellitus Mice and Their Learning Behaviors by Scopolamine-Induced Cognitive Impairments, and Their Complications of Critical Limb Ischemia
Hou, W.-C. (PI)
8/1/25 → 7/31/26
Project: A - Government Institution › b - National Science and Technology Council
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Development of Humanized Antagonistic Bace-2 Antibody and Its Derivative Pd-L1 Fusion Protein Drug as a Novel Islet-Protective Strategy for Comprehensive Application in the Treatment of Type 1 and Type 2 Diabetes
Chuang, K.-H. (PI)
8/1/25 → 7/31/26
Project: A - Government Institution › b - National Science and Technology Council
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Multi-Omics Analysis of Yang-Tonifying Herbal Medicine Combinations: Clinical Potential in Osteoporosis Prevention/Treatment
Lee, M.-H. (PI)
8/1/25 → 7/31/26
Project: A - Government Institution › b - National Science and Technology Council
Research output
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2-Hydroxyl hispolon reverses high glucose-induced endothelial progenitor cell dysfunction through the PI3K/Akt/eNOS and AMPK/HO-1 pathways
Wang, T. J., Hou, W. C., Hsiao, B. Y., Lo, T. H., Chen, Y. T., Yang, C. H., Shih, Y. T. & Liu, J. C., 2026, In: British Journal of Pharmacology. 183, 1, p. 189-211 23 p.Research output: Contribution to journal › Article › peer-review
Open Access5 Link opens in a new tab Citations (Scopus) -
A heavy-chain antibody-drug conjugate targeting glycosylated CEACAM6 inhibits brain metastatic tumor growth
Tsai, Y. T., Yen, M. H., Hu, P. J., Lee, C. C., Liu, C. Y., Cheng, T. M., Shen, H. T., Benjamin Zhang, B. X., Lee, H. L., Chuang, K. H., Yap, C. V., Wang, W. C. & Wu, M. H., Jun 28 2026, In: Cancer Letters. 648, 218463.Research output: Contribution to journal › Article › peer-review
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Briarane-type diterpenes from a closed-system cultured soft coral Briareum stechei
Chen, L. Y., Peng, B. R., Huynh, T. H., Chen, Y. Y., Chen, Y. C., Pham, N. T., Le, H. G., Pham, Q. V., Luu, P. V., Lai, Y. M., El-Shazly, M., Hwang, T. L. & Lai, K. H., Apr 2026, In: Phytochemistry. 244, 114760.Research output: Contribution to journal › Article › peer-review
Datasets
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Hypermethylation and decreased expression of TMEM240 are potential early-onset biomarkers for colorectal cancer detection, poor prognosis, and early recurrence prediction
Lin, S.-Y. (Creator), Ansar, M. (Creator), Hung, C.-S. (Contributor), Lin, R.-K. (Creator), Chang, S.-C. (Contributor), Chen, J.-Y. (Creator), Jain, S. (Creator), Liew, P.-L. (Contributor) & Wang, S.-C. (Contributor), Figshare, 2020
DOI: 10.6084/m9.figshare.c.4974518.v1, https://doi.org/10.6084%2Fm9.figshare.c.4974518.v1
Dataset
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Additional file 1: of Combination of the novel histone deacetylase inhibitor YCW1 and radiation induces autophagic cell death through the downregulation of BNIP3 in triple-negative breast cancer cells in vitro and in an orthotopic mouse model
Yeh, Y.-L. (Creator), Wang, Y.-J. (Contributor), Chiu, H.-W. (Creator), Ho, S.-Y. (Contributor), Wang, Y.-C. (Contributor), Lin, P. (Contributor) & Huang, W.-J. (Contributor), Figshare, 2016
DOI: 10.6084/m9.figshare.c.3697276_d1.v1, https://doi.org/10.6084%2Fm9.figshare.c.3697276_d1.v1
Dataset
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CCDC 801020: Experimental Crystal Structure Determination
Liu, P.-C. (Creator), Wang, L.-H. (Creator), Lin, S.-J. (Creator), Lin, W.-K. (Creator), Chou, B.-H. (Creator), Chang, S.-F. (Creator), Hsu, F.-L. (Creator) & Yang, L.-M. (Creator), Cambridge Crystallographic Data Centre, 2011
DOI: 10.5517/ccvwjcl, https://doi.org/10.5517%2Fccvwjcl
Dataset