Division of Thoracic Surgery

2025

Targeting FABP4/UCP2 axis to overcome cetuximab resistance in obesity-driven CRC with drug-tolerant persister cells

Cheng, Y. C., Chen, M. Y., Yadav, V. K., Pikatan, N. W., Fong, I. H., Kuo, K. T., Yeh, C. T. & Tsai, J. T., Mar 2025, In: Translational Oncology. 53, 102274.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Citation (Scopus)

2024

A Study of Disease Prognosis in Lung Adenocarcinoma Using Single-Cell Decomposition and Immune Signature Analysis

Lee, C. Y., Wu, Y. C., Liao, T. C., Hsiao, S. H., Hsu, J. B. K. & Chang, T. H., Sept 2024, In: Cancers. 16, 18, 3207.

Research output: Contribution to journal › Article › peer-review

Open Access

Relationships among Physical Activity, Daylight Exposure, and Rest-Activity Circadian Rhythm in Patients with Esophageal and Gastric Cancer: An Exploratory Study

Chen, H. M., Lee, M. C., Tian, J. Y., Dai, M. F., Wu, Y. C., Huang, C. S., Hsu, P. K. & Duong, L. T., Mar 1 2024, In: Cancer Nursing. 47, 2, p. 112-120 9 p.

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Targeting of FSP1 regulates iron homeostasis in drug-tolerant persister head and neck cancer cells via lipid-metabolism-driven ferroptosis

Wu, Y. C., Huang, C. S., Hsieh, M. S., Huang, C. M., Setiawan, S. A., Yeh, C. T., Kuo, K. T. & Liu, S. C., 2024, In: Aging. 16, 1, p. 627 1 p.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Citations (Scopus)

2023

Feasibility and Toxicity of Interval-Compressed Chemotherapy in Asian Children and Young Adults with Sarcoma: Journal of Personalized Medicine

Huang, J.-H., Chen, S.-H., Liao, Y.-M., Kao, Y.-C., Ho, W.-L., Chang, H., Tsai, M.-L., Lee, H.-L., Kuo, C.-C., Tseng, S.-H., Chang, C.-Y., Hsieh, K. L., Lu, L.-S., Chen, Y.-J., Chiou, J.-F., Hsieh, T.-H., Liu, Y.-R., Hsu, W., Li, W.-T. & Wu, Y.-C. & 8 others, Wu, W.-C., Wang, J.-L., Tsai, J.-J., Terashima, K., Kiyotani, C., Wong, T.-T., Miser, J. S. & Liu, Y.-L., Apr 2023

Research output: Other contribution

Open Access

Mediation and Dose-Response Relationship Among Physical Activity, Daylight Exposure, and Rest-Activity Circadian Rhythm in Patients With Esophageal and Gastric Cancer

Chen, H.-M., Cheung, D. S. T., Huang, C.-S., Wu, Y.-C. & Hsu, P.-K., Nov 27 2023, (E-pub ahead of print) In: Cancer Nursing.

Research output: Contribution to journal › Article › peer-review

Modified En Bloc Esophagectomy for Squamous Cell Carcinoma After Neoadjuvant Chemoradiotherapy

Hsu, P. K., Chien, L. I., Chuang, L. C., Lee, Y. Y., Huang, C. S., Hsu, H. S., Wu, Y. C. & Hsu, W. H., Apr 2023, In: Annals of Thoracic Surgery. 115, 4, p. 862-869 8 p.

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Old age and EGFR mutation status in inoperable early-stage non-small cell lung cancer patients receiving stereotactic ablative radiotherapy: A single institute experience of 71 patients in Taiwan

Wu, Y. H., Kang, Y. M., Hu, Y. W., Lan, K. L., Yen, S. H., Lai, T. Y., Lan, T. L., Chen, Y. M., Chiu, C. H., Luo, Y. H., Chao, H. S., Chiang, C. L., Shiao, T. H., Yang, C. N., Hsu, W. H., Wu, Y. C., Hsu, H. S., Hung, J. J., Huang, C. S. & Hsu, P. K. & 1 others, Chen, Y. W., Mar 2023, In: Thoracic Cancer. 14, 7, p. 654-661 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Citations (Scopus)

Proliferative ability of circulating tumor cells is a prognostic factor in Early-Stage lung adenocarcinoma

Che, T. F., Chiu, C. H., Wu, Y. C., Chen, J. Y., Chou, T. Y., Cheng, Y. C., Chiang, C. L., Huang, C. S., Tuang, I. S., Ho, Y. H., Hong, J. H., Huang, Y. J., Ho, H. L. & Chang, Y. C., Apr 2023, In: Lung Cancer. 178, p. 198-205 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Citations (Scopus)

The determinants of health-related quality of life among patients with newly diagnosed lung cancer in Taiwan: A cross-sectional study

Liao, C. H., Yu, S., Lin, K. C., Wu, Y. C., Wang, T. J. & Wang, K. Y., Mar 1 2023, In: Journal of the Chinese Medical Association. 86, 3, p. 338-344 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Citations (Scopus)

The injections of mitochondrial fusion promoter M1 during proestrus disrupt the progesterone secretion and the estrous cycle in the mouse

Budi, Y. P., Hsu, M. C., Lin, Y. C., Lee, Y. J., Chiu, H. Y., Chiu, C. H. & Jiang, Y. F., Feb 10 2023, In: Scientific Reports. 13, 1, p. 2392 1 p., 2392.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Citations (Scopus)

2022

Apolipoprotein (a)/Lipoprotein(a)-Induced Oxidative-Inflammatory α 7-nAChR/p38 MAPK/IL-6/RhoA-GTP Signaling Axis and M1 Macrophage Polarization Modulate Inflammation-Associated Development of Coronary Artery Spasm

Lin, Y. K., Yeh, C. T., Kuo, K. T., Fong, I. H., Yadav, V. K., Kounis, N. G., Hu, P. & Hung, M. Y., 2022, In: Oxidative Medicine and Cellular Longevity. 2022, 9964689.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Citations (Scopus)

Effects of Rehabilitation Program on Quality of Life, Sleep, Rest-Activity Rhythms, Anxiety, and Depression of Patients with Esophageal Cancer: A Pilot Randomized Controlled Trial

Chen, H. M., Lin, Y. Y., Wu, Y. C., Huang, C. S., Hsu, P. K., Chien, L. I., Lin, Y. J. & Huang, H. L., 2022, In: Cancer Nursing. 45, 2, p. E582-E593

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

HNMT Upregulation Induces Cancer Stem Cell Formation and Confers Protection against Oxidative Stress through Interaction with HER2 in Non‐Small‐Cell Lung Cancer

Kuo, K. T., Lin, C. H., Wang, C. H., Pikatan, N. W., Yadav, V. K., Fong, I. H., Yeh, C. T., Lee, W. H. & Huang, W. C., Feb 1 2022, In: International journal of molecular sciences. 23, 3, 1663.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Citations (Scopus)

Predictors of adherence, contamination and dropout in home-based walking by lung and oesophageal cancer patients from two randomised control trials: An exploratory study

Chen, H. M., Lee, M. C., Wu, Y. C., Huang, C. S., Hsu, P. K., Chien, L. I., Tian, J. Y. & Duong, L. T., Sept 2022, In: European Journal of Cancer Care. 31, 5, e13635.

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Pseudomyocardial Infarction: An Atypical Presentation of Chest Wall Necrotizing Fasciitis

Chen, C. C., Kuo, K. T., Chang, S. C. & Liu, S. H., Jan 2022, In: International Journal of Infectious Diseases. 114, p. 192-194 3 p.

Research output: Contribution to journal › Comment/debate › peer-review

Open Access

Spectral Entropy Monitoring Accelerates the Emergence from Sevoflurane Anesthesia in Thoracic Surgery: A Randomized Controlled Trial

Chen, J. T., Wu, Y. M., Tiong, T. Y., Cata, J. P., Kuo, K. T., Li, C. C., Liu, H. Y., Cherng, Y. G., Wu, H. L. & Tai, Y. H., Mar 1 2022, In: Journal of Clinical Medicine. 11, 6, 1631.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Citations (Scopus)

Targeting the SREBP-1/Hsa-Mir-497/SCAP/FASN Oncometabolic Axis Inhibits the Cancer Stem-Like and Chemoresistant Phenotype of Non-Small Cell Lung Carcinoma Cells

Tiong, T. Y., Weng, P. W., Wang, C. H., Setiawan, S. A., Yadav, V. K., Pikatan, N. W., Fong, I. H., Yeh, C. T., Hsu, C. H. & Kuo, K. T., Jul 1 2022, In: International journal of molecular sciences. 23, 13, 7283.

Research output: Contribution to journal › Article › peer-review

Open Access

15 Citations (Scopus)

2021

Adipose-derived stem cell induced-tissue repair or wound healing is mediated by the concomitant upregulation of miR-21 and miR-29b expression and activation of the AKT signaling pathway

Liu, S. C., Bamodu, O. A., Kuo, K. T., Fong, I. H., Lin, C. C., Yeh, C. T. & Chen, S. G., Jul 15 2021, In: Archives of Biochemistry and Biophysics. 705, 108895.

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Bruton’s tyrosine kinase (BTK) mediates resistance to EGFR inhibition in non-small-cell lung carcinoma

Yeh, C. T., Chen, T. T., Satriyo, P. B., Wang, C. H., Wu, A. T. H., Chao, T. Y., Lee, K. Y., Hsiao, M., Wang, L. S. & Kuo, K. T., Jul 2021, In: Oncogenesis. 10, 7, 56.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Citations (Scopus)

Garcinol attenuates lipoprotein(A)-induced oxidative stress and inflammatory cytokine production in ventricular cardiomyocyte through α7-nicotinic acetylcholine receptor-mediated inhibition of the p38 mapk and nf-κb signaling pathways

Chang, N. C., Yeh, C. T., Lin, Y. K., Kuo, K. T., Fong, I. H., Kounis, N. G., Hu, P. & Hung, M. Y., Mar 2021, In: Antioxidants. 10, 3, p. 1-19 19 p., 461.

Research output: Contribution to journal › Article › peer-review

Open Access

21 Citations (Scopus)

Gene expression profile in primary tumor is associated with brain-tropism of metastasis from lung adenocarcinoma

Lin, Y. Y., Wang, Y. C., Yeh, D. W., Hung, C. Y., Yeh, Y. C., Ho, H. L., Mon, H. C., Chen, M. Y., Wu, Y. C. & Chou, T. Y., Dec 1 2021, In: International journal of molecular sciences. 22, 24, 13374.

Research output: Contribution to journal › Article › peer-review

Open Access

13 Citations (Scopus)

Pdk1 inhibitor bx795 improves cisplatin and radio-efficacy in oral squamous cell carcinoma by downregulating the pdk1/cd47/akt-mediated glycolysis signaling pathway

Pai, S., Yadav, V. K., Kuo, K. T., Pikatan, N. W., Lin, C. S., Chien, M. H., Lee, W. H., Hsiao, M., Chiu, S. C., Yeh, C. T. & Tsai, J. T., Nov 1 2021, In: International journal of molecular sciences. 22, 21, 11492.

Research output: Contribution to journal › Article › peer-review

Open Access

39 Citations (Scopus)

Pterostilbene increases LDL metabolism in HL-1 cardiomyocytes by modulating the PCSK9/HNF1α/SREBP2/LDLR signaling cascade, upregulating epigenetic hsa-miR-335 and hsa-miR-6825, and LDL receptor expression

Lin, Y. K., Yeh, C. T., Kuo, K. T., Yadav, V. K., Fong, I. H., Kounis, N. G., Hu, P. & Hung, M. Y., Aug 2021, In: Antioxidants. 10, 8, 1280.

Research output: Contribution to journal › Article › peer-review

Open Access

14 Citations (Scopus)

Recommendation for management of patients with their first episode of primary spontaneous pneumothorax, using video-assisted thoracoscopic surgery or conservative treatment

Chiu, H. Y., Ho, Y. C., Yang, P. C., Chiang, C. M., Chung, C. C., Wu, W. C., Lin, Y. C., Chen, C. Y. & Wu, Y. C., Dec 2021, In: Scientific Reports. 11, 1, 10874.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Citations (Scopus)

Role of kisspeptin on cell proliferation and steroidogenesis in luteal cells in vitro and in vivo

Chiang, C. M., Chiu, H. Y., Chang, C. S., Chien, Y. Y., Jong, D. S., Wu, L. S. & Chiu, C. H., Apr 1 2021, In: Journal of the Chinese Medical Association. 84, 4

Research output: Contribution to journal › Article › peer-review

Open Access

7 Citations (Scopus)

Role of the kisspeptin/KISS1 receptor system in the testicular development of mice

Chiang, C. M., Chiu, H. Y., Jong, D. S., Wu, L. S., Lee, Y. J. & Chiu, C. H., Feb 2021, In: Journal of the Chinese Medical Association. 84, 2, p. 203-211 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Citations (Scopus)

2020

An Unexpected Smile

Wu, W. C. & Wang, A. Y., Oct 2020, In: Gastroenterology. 159, 4, p. 1238-1241 4 p.

Research output: Contribution to journal › Comment/debate › peer-review

Association between the presence of distolingual root in mandibular first molars and the presence of C-shaped mandibular second molars: a CBCT study in a Taiwanese population

Wu, Y. C., Su, W. S., Mau, L. P., Cheng, W. C., Weng, P. W., Tsai, Y. W. C., Su, C. C., Chiang, H. S., Lin, J., Shieh, Y. S. & Huang, R. Y., 2020, In: Quintessence international (Berlin, Germany : 1985). 51, 10, p. 798-807 10 p.

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

CT-Guided Core Biopsy for Peripheral Sub-solid Pulmonary Nodules to Predict Predominant Histological and Aggressive Subtypes of Lung Adenocarcinoma

Tsai, P. C., Yeh, Y. C., Hsu, P. K., Chen, C. K., Chou, T. Y. & Wu, Y. C., Oct 2020, In: Annals of Surgical Oncology. 27, 11, p. 4405-4412 8 p.

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

Effects of hyperinsulinemia on acquired resistance to epidermal growth factor receptor-tyrosine kinase inhibitor via the PI3K/AKT pathway in non-small cell lung cancer cells in vitro

Chiu, H. Y., Chiang, C. M., Yeh, S. P., Jong, D. S., Wu, L. S., Liu, H. C. & Chiu, C. H., Nov 2020, In: Oncology Letters. 20, 5, 12069.

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Electromagnetic Navigation-Guided Preoperative Localization of Small Malignant Pulmonary Tumors

Hsu, P. K., Chuang, L. C. & Wu, Y. C., May 2020, In: Annals of Thoracic Surgery. 109, 5, p. 1566-1573 8 p.

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Gender differences in the acquisition of suturing skills with the da Vinci surgical system

Chiu, H. Y., Kang, Y. N., Wang, W. L., Tong, Y. S., Chang, S. W., Fong, T. H. & Wei, P. L., Jan 2020, In: Journal of the Formosan Medical Association. 119, 1 Pt 3, p. 462-470 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

22 Citations (Scopus)

Low-dose nicotine activates egfr signaling via α5-nAChR and promotes lung adenocarcinoma progression

Wang, M. L., Hsu, Y. F., Liu, C. H., Kuo, Y. L., Chen, Y. C., Yeh, Y. C., Ho, H. L., Wu, Y. C., Chou, T. Y. & Wu, C. W., Sept 2020, In: International journal of molecular sciences. 21, 18, p. 1-18 18 p., 6829.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Citations (Scopus)

Minimization of the complications associated with bar removal after the Nuss procedure in adults

Hsieh, M. S., Tong, S. S., Wei, B. C., Chung, C. C. & Cheng, Y. L., Apr 21 2020, In: Journal of Cardiothoracic Surgery. 15, 1, 65.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Citations (Scopus)

Relationships of exercise timing with sleep, fatigue and rest–activity rhythms of lung cancer patients in Taiwan: An exploratory study

Chen, H.-M., Cheung, D. S. T., Lin, Y.-Y., Wu, Y.-C., Liu, C.-Y., Lin, K.-C., Lin, Y.-J. & Lin, C.-C., Jul 1 2020, In: European Journal of Cancer Care. 29, 4, e13233.

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Taiwanofungus camphoratus Combined With Amphotericin B for Metastatic Cancer Patients Unresponsive to or Unwilling to Undergo Chemotherapy: A pilot study

Tai, C. J., Shi, Y. C., Tai, C. J., Kuo, L. J., Chen, R. J., Chang, Y. J., Tzao, C., Wu, C. H., Chang, C. C., Chiou, H. Y. & Su, C. H., Mar 2020, In: Alternative Therapies in Health and Medicine. 26, 2, p. 18-22

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

γ-Mangostin isolated from Garcinia mangostana L. suppresses inflammation and alleviates symptoms of osteoarthritis via modulating miR-124-3p/IL-6/NF-κB signaling

Chiu, Y.-S., Wu, J.-L., Yeh, C.-T., Yadav, V. K., Huang, H.-S. & Wang, L.-S., Apr 16 2020, In: Aging. 12, 8, p. 6630-6643 14 p.

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

2019

Astragalus polysaccharide (PG2) ameliorates cancer symptom clusters, as well as improves quality of life in patients with metastatic disease, through modulation of the inflammatory cascade

Huang, W. C., Kuo, K. T., Bamodu, O. A., Lin, Y. K., Wang, C. H., Lee, K. Y., Wang, L. S., Yeh, C. T. & Tsai, J. T., Aug 1 2019, In: Cancers. 11, 8, 1054.

Research output: Contribution to journal › Article › peer-review

Open Access

42 Citations (Scopus)

Astragalus polysaccharides (PG2) Enhances the M1 Polarization of Macrophages, Functional Maturation of Dendritic Cells, and T Cell-Mediated Anticancer Immune Responses in Patients with Lung Cancer

Bamodu, O. A., Kuo, K. T., Wang, C. H., Huang, W. C., Wu, A. T. H., Tsai, J. T., Lee, K. Y., Yeh, C. T. & Wang, L. S., Jan 1 2019, In: Nutrients. 11, 10, 2264.

Research output: Contribution to journal › Article › peer-review

Open Access

136 Citations (Scopus)

Cisplatin resistant lung cancer cells promoted M2 polarization of tumor-associated macrophages via the Src/CD155/MIF functional pathway

Huang, W. C., Kuo, K. T., Wang, C. H., Yeh, C. T. & Wang, Y., Apr 29 2019, In: Journal of Experimental and Clinical Cancer Research. 38, 1, 180.

Research output: Contribution to journal › Article › peer-review

Open Access

83 Citations (Scopus)

The Role of Active Engagement of Peer Observation in the Acquisition of Surgical Skills in Virtual Reality Tasks for Novices

Chiu, H. Y., Kang, Y. N., Wang, W. L., Chen, C. C., Hsu, W., Tseng, M. F. & Wei, P. L., Nov 1 2019, In: Journal of Surgical Education. 76, 6, p. 1655-1662 8 p.

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

2018

4-acetyl-antroquinonol B suppresses SOD2-enhanced cancer stem cell-like phenotypes and chemoresistance of colorectal cancer cells by inducing hsa-miR-324 re-expression

Bamodu, O. A., Yang, C. K., Cheng, W. H., Tzeng, D. T. W., Kuo, K. T., Huang, C. C., Deng, L., Hsiao, M., Lee, W. H. & Yeh, C. T., Aug 10 2018, In: Cancers. 10, 8, 269.

Research output: Contribution to journal › Article › peer-review

32 Citations (Scopus)

A Systematic Review and Meta-Analysis Comparing Pigtail Catheter and Chest Tube as the Initial Treatment for Pneumothorax

Chang, S. H., Kang, Y. N., Chiu, H. Y. & Chiu, Y. H., May 1 2018, In: Chest. 153, 5, p. 1201-1212 12 p.

Research output: Contribution to journal › Article › peer-review

66 Citations (Scopus)

Downregulation of Cancer Stemness by Novel Diterpenoid Ovatodiolide Inhibits Hepatic Cancer Stem Cell-Like Traits by Repressing Wnt/β-Catenin Signaling

Liu, M., Bamodu, O. A., Kuo, K. T., Lee, W. H., Lin, Y. K., Wu, A. T. H., M, H., Tzeng, Y. M., Yeh, C. T. & Tsai, J. T., 2018, In: American Journal of Chinese Medicine. 46, 4, p. 891-910 20 p.

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Garcinol inhibits cancer stem cell-like phenotype via suppression of the Wnt/β-catenin/STAT3 axis signalling pathway in human non-small cell lung carcinomas

Huang, W. C., Kuo, K. T., Adebayo, B. O., Wang, C. H., Chen, Y. J., Jin, K., Tsai, T. H. & Yeh, C. T., Apr 2018, In: Journal of Nutritional Biochemistry. 54, p. 140-150 11 p.

Research output: Contribution to journal › Article › peer-review

44 Citations (Scopus)

Histone demethylase JARID1B/KDM5B promotes aggressiveness of non-small cell lung cancer and serves as a good prognostic predictor

Kuo, K. T., Huang, W. C., Bamodu, O. A., Lee, W. H., Wang, C. H., Hsiao, M., Wang, L. S. & Yeh, C. T., Aug 9 2018, In: Clinical Epigenetics. 10, 1, 107.

Research output: Contribution to journal › Article › peer-review

52 Citations (Scopus)

Investigation of ovatodiolide, a macrocyclic diterpenoid, as a potential inhibitor of oral cancer stem-like cells properties via the inhibition of the JAK2/STAT3/JARID1B signal circuit

Lin, C. S., Bamodu, O. A., Kuo, K. T., Huang, C. M., Liu, S. C., Wang, C. H., Tzeng, Y. M., Chao, T. Y. & Yeh, C. T., Jul 15 2018, In: Phytomedicine. 46, p. 93-103 11 p.

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Knockdown of POLDIP2 suppresses tumor growth and invasion capacity and is linked to unfavorable transformation ability and metastatic feature in non-small cell lung cancer

Chen, Y. C., Kuo, C. C., Chian, C. F., Tzao, C., Chang, S. Y., Shih, Y. L., Lin, Y. W., Yu, M. H. & Su, H. Y., Jul 1 2018, In: Experimental Cell Research. 368, 1, p. 42-49 8 p.

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Predicted Coronary Heart Disease Risk Decreases in Obese Patients After Laparoscopic Sleeve Gastrectomy

Huang, C. C., Wang, W., Chen, R. J., Wei, P. L., Tzao, C. & Chen, P. L., Jul 1 2018, In: World Journal of Surgery. 42, 7, p. 2173-2182 10 p.

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Division of Thoracic Surgery

Research output

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