Division of Neurosurgery

Projects

Projects per year 2010 2013 2014 2015 2021 2022 2023

• 5 Active
• 71 Finished

Projects per year

Search results

• Active

  新聘教師研究補助

  Liu, H.

  11/1/22 → 10/31/23

  Project: B - Project of TMU › g - Research Grants for Newly Hired Faculty

• Preclinical Investigation of Combined Targeting the Immune Signaling Axis Btk/Pd-L1/Pd-L2 for Combating Drug Resistant Glioblastoma Multiforme (1/3)

  Lin, C.

  8/1/22 → 7/31/23

  Project: A - Government Institution › b - Ministry of Science and Technology

• Overcoming Treatment-Induced Cancer Stemness and Resistance through Approaching Tumoral Heterogeneity (2/2)

  Lo, W.

  8/1/22 → 7/31/23

  Project: A - Government Institution › b - Ministry of Science and Technology

• Investigation of the Role of Bcyrn1-Induced De Novo Purine Synthesis in Glioblastoma Progression and the Potential of Serum Exosomal Bcyrn1 as Rognostic Biomarker

  Lin, J.

  8/1/22 → 7/31/23

  Project: A - Government Institution › b - Ministry of Science and Technology

• 新聘教師研究補助

  Lo, W.

  9/15/21 → 9/14/23

  Project: B - Project of TMU › g - Research Grants for Newly Hired Faculty

• Finished

  Neurobiological Basis of Sngception and Its Therapeutic Potential for Neurological Disorders( II )

  Lin, J.

  1/1/22 → 12/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 以誘發電位探查意識障礙患者的大腦電生理活性

  Lo, W.

  1/1/22 → 12/31/22

  Project: B - Project of TMU › h - Higher Education Sprout Project

• 緩激肽 B1 受體-水通道蛋白 4 信號軸在多形性膠質母細胞瘤中腫瘤旁腦水腫形成和癌思平療效的角色探討

  Su, I.

  1/1/22 → 12/31/22

  Project: B - Project of TMU › h - Higher Education Sprout Project

• Evaluation of the Regulatory Functions of Eno1/Hmgb2 in Glutamine Metabolism Reprogramming in Glioblastoma and Translational Applications

  Liu, H.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 藉由研究腫瘤異質性來克服治療引發的癌細胞幹細胞特性及治療抵抗性(1/2)

  Lo, W.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 競爭性內源RNA-BC200調控網絡誘導腦瘤中嘌呤體形成之分子機制與臨床意義

  Lin, J.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討膠質母細胞瘤外泌體中Btk/PD-L1/PD-L2 訊號途徑在腫瘤免疫所扮演的致病角色及其精準治療應用

  Lin, C.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• A Preclinical Evaluation of a Niclosamide-based new small molecule, GBM_INT001 as an oncoimmune therapeutic agent targeting CDK4/DRD4/PD-L1 signature, for glioblastoma multiforme

  Wen, Y.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Niclosamide 100%
  • Health Services Research 68%
  • Glioblastoma 59%
  • Industry 55%
  • Pharmacology 40%

• 針對熱休克蛋白70-葡萄糖調節蛋白78驅動癌幹細胞之路徑以克服髓母細胞瘤對常規化學療法的抗藥性

  Chen, S.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 新聘教師研究補助

  Su, I.

  6/1/21 → 5/31/22

  Project: B - Project of TMU › g - Research Grants for Newly Hired Faculty

• 新聘教師研究補助

  Chen, S.

  5/1/21 → 4/30/22

  Project: B - Project of TMU › g - Research Grants for Newly Hired Faculty

• Neurobiological Basis of Sngception and Its Therapeutic Potential for Neurological Disorders( I )

  Lin, J.

  1/1/21 → 12/31/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 樺木酸可作為IRE1/XBP1/Herp路徑抑制劑以阻斷膠質母細胞瘤的增殖和存活(3/3)

  Lo, W.

  8/1/20 → 7/31/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討以Myc/PD-L1/Akt作為治療惡性腦癌標靶之轉譯研究(3/3)

  Lin, C.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討以Myc/PD-L1/Akt作為治療惡性腦癌標靶之轉譯研究

  Lin, C.

  1/1/20 → 12/31/20

  Project: A - Government Institution › a - National Health Research Institutes

• Biodegradable Multi-Agents Incorporated Nanoparticles Supported Chemoprotective Gene Therapy Enhances Chemotherapy Tolerance and Efficacy in Malignant Glioma Rats

  Tseng, Y.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• 樺木酸可作為IRE1/XBP1/Herp路徑抑制劑以阻斷膠質母細胞瘤的增殖和存活(2/3)

  Lo, W.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• A Translational Investigation of the Role of Myc/Pd-L1/Akt Axis as a Therapeutic Target for Treating Glioblastoma Multiforme

  Lin, C.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• 從腦科學與語言文化來探討體感覺神經迴路的差異-從腦科學與語言文化來探討體感覺神經迴路的差異(1/2)

  Lin, J.

  6/1/19 → 5/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• 腦震盪潛伏效應：早期認知功能衰退診斷與預防的前瞻性轉譯研究-輕度腦外傷後引起神經發炎之生物標誌物:長期和縱向評估

  Chiang, Y.

  1/1/19 → 12/1/19

  Project: A - Government Institution › d - Ministry of Education

• 樺木酸可作為IRE1/XBP1/Herp路徑抑制劑以阻斷膠質母細胞瘤的增殖和存活(1/3)

  Lo, W.

  8/1/18 → 7/31/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Traumatic Brain Injury: Degenerative Mechanisms, Phenserine Treatment and Exosome Biomarkers of Response

  Chiang, Y.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Traumatic Brain Injury 100%
  • phenserine 49%
  • Exosomes 29%
  • Alzheimer Disease 24%
  • Oxidative Stress 14%

• A Translational Investigation of the Role of Myc/Pd-L1/Akt Axis as a Therapeutic Target for Treating Glioblastoma Multiforme

  Lin, C.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Overcoming Chemo-Resistance in Glioma-Bearing Rats by Using Sequential and Biodegradable Multidrug-Loaded Nanofibrous Membranes(2/2)

  Tseng, Y.

  8/1/18 → 10/31/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Nanofibers 100%
  • Carmustine 85%
  • Temozolomide 63%
  • Glioblastoma 50%
  • Membranes 30%

• 腦震盪潛伏效應：早期認知功能衰退診斷與預防的前瞻性轉譯研究

  Chiang, Y.

  1/1/18 → 12/31/18

  Project: B - Project of TMU › h - Higher Education Sprout Project

• Overcoming Chemo-Resistance in Glioma-Bearing Rats by Using Sequential and Biodegradable Multidrug-Loaded Nanofibrous Membranes

  Tseng, Y.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Nanofibers 100%
  • Carmustine 85%
  • Temozolomide 63%
  • Glioblastoma 50%
  • Membranes 30%

• 三叉神經痛病患之腦影像技術研究

  Lo, W.

  1/1/17 → 4/30/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• Sequential Delivery of Gene Therapy and Chemotherapeutic Agents to the Rat Brain Malignant Glioma by Using Drug-Loaded Nanofibrous Membranes

  Tseng, Y.

  8/1/16 → 10/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Nanofibers 100%
  • Carmustine 85%
  • Temozolomide 63%
  • Glioblastoma 50%
  • Membranes 30%

• 研究神經生長因子誘導Znf179表達對氧化損傷的保護作用

  Wu, C.

  6/1/16 → 5/31/17

  Project: C - Project of Alliance › p - Taipei Medical University Hospital

• 水通道蛋白4在惡性神經膠細胞重排對血瘤障壁之影響研究

  Tseng, Y.

  3/1/16 → 2/28/17

  Project: C - Project of Alliance › o - Chi Mei Medical Center

• Functional Outcomes and Cognitive Interventions in Older People following Traumatic Brain Injury

  Lin, M., Tsai, S., Chen, S., Chiang, Y., Liou, T., Lin, Y. & Shu Kei Lam, C.

  1/1/16 → 12/31/16

  Project: A - Government Institution › a - National Health Research Institutes

  • Traumatic Brain Injury 100%
  • Tai Ji 13%
  • Brain Death 11%
  • Executive Function 9%
  • Activities of Daily Living 9%

• A Multidisciplinary Study of the Pathophysiology of Blast-Induced Mild Traumatic Brain Injury

  Chiang, Y., Wu, C. & Lee, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Wounds and Injuries 100%
  • Dizziness 86%
  • N-nitrosoiminodiacetic acid 71%
  • Headache 70%
  • Animal Models 59%

• Genomic, Epigenomic and Epiproteomic Analysis of Etk/Bmx Traumatic Brain Injury

  Chen, K., Chiang, Y. & Wu, C.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Traumatic Brain Injury 100%
  • Protein Kinases 15%
  • Epigenomics 14%
  • Tec protein-tyrosine kinase 14%
  • Inflammation Mediators 10%

• The Study of Therapeutic Effects for Stroke with Phenserine, an Amyloid Precursor Protein Inhibitor, in Rodent Focal Cerebral Ischemia Model

  Chang, C. & Chiang, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • phenserine 100%
  • Stroke 75%
  • Amyloid beta-Protein Precursor 49%
  • Stem Cells 31%
  • pifithrin 27%

• Concurrent and Sequential Chemotherapy of Glioblastoma Multiforme in Rats Using Biodegradable Drug-Eluting Nanofibers

  Tseng, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Glioblastoma 100%
  • Drug Therapy 59%
  • Brain Neoplasms 37%
  • Membranes 36%
  • Pharmaceutical Preparations 33%

• Radiogenomics of Malignant Gliomas by Linking Physiological Mr Imaging, Histopathological Patterns, and Genetic Alternations: a Translational Study from Rat to Man

  Chen, C., Tsai, P., Liu, H., Lin, Y. & Chiang, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Glioblastoma 100%
  • Glioma 51%
  • Biomarkers 36%
  • Multiparametric Magnetic Resonance Imaging 15%
  • Neoplasms 14%

• Characterization of Thalamocortical Dysrhythmia in Mild Traumatic Brain Injury Using Simultaneous Mri and Eeg Measurements and Pre-Clinical N-Acetylcysteine Treatment Response

  Chen, C., Liu, H., Tseng, S., Lane, T. J., Lu, C., Chiang, Y. & Tsai, P.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Acetylcysteine 44%
  • Post-Concussion Syndrome 17%
  • Neuroimaging 15%
  • Electroencephalography 14%
  • Atrophy 9%

• Repositioning Drug Therapies for Traumatic Brain Injury

  Chiu, W., Chang, C. & Chiang, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Traumatic Brain Injury 100%
  • Wounds and Injuries 37%
  • Dipeptidyl-Peptidase IV Inhibitors 33%
  • Incretins 33%
  • Acetylcysteine 28%

• Development of Cortical Electrical Stimulation Technique for Improving Neuroplasticity and Motor Function in Parkinsonian Rats

  Hsieh, T., Chiang, Y. & Peng, C.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• 低氧在多型性神經膠母細胞瘤生成過程調控血管新生之機轉研究

  Tseng, Y.

  3/1/15 → 2/29/16

  Project: C - Project of Alliance › o - Chi Mei Medical Center

• Functional Outcomes and Cognitive Interventions in Older People following Traumatic Brain Injury

  Lin, M., Tsai, S., Chen, S., Chiang, Y., Liou, T., Lin, Y. & Shu Kei Lam, C.

  1/1/15 → 12/31/15

  Project: A - Government Institution › a - National Health Research Institutes

  • Traumatic Brain Injury 100%
  • Tai Ji 13%
  • Brain Death 11%
  • Executive Function 9%
  • Activities of Daily Living 9%

• Valproate治療腦外傷病人的臨床研究

  Chang, C., Chiang, Y., Liao, K., Yang, S., Wu, C. & Chen, K.

  8/7/14 → 8/6/16

  Project: A - Government Institution › c - Ministry of Health and Welfare

  • Traumatic Brain Injury 100%
  • Valproic Acid 97%
  • Therapeutic Uses 31%
  • Histone Deacetylases 29%
  • Glycogen 26%

• The Neurotrophic/Neuroprotective Role of GIP in Cellular and Rodent Models of Mild Traumatic Brain Injury (III)

  Lin, J.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• New Strategies of Parkinson’s Disease Treatment

  Chiang, Y.

  8/1/14 → 12/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Parkinson Disease 100%
  • Neurodegenerative Diseases 66%
  • Transplantation 58%
  • Exercise 42%
  • Induced Pluripotent Stem Cells 36%

• A Multidisciplinary Study of the Pathophysiology of Blast-Induced Mild Traumatic Brain Injury

  Chiang, Y.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Wounds and Injuries 100%
  • Dizziness 86%
  • N-nitrosoiminodiacetic acid 71%
  • Headache 70%
  • Animal Models 59%