Division of General Surgery

Finished

探討乳酸去氫?對胰臟癌Gemcitabine抗藥性的調控與影響

Huang, M.-T. (PI)

5/1/15 → 4/30/16

Project: C - Project of Alliance › u - Taipei Medical University Shuang Ho Hospital

探討Hsp27在大腸癌的進行、轉移能力與治療上的角色及其作用機制

Wei, P.-L. (PI)

5/1/15 → 4/30/16

Project: C - Project of Alliance › u - Taipei Medical University Shuang Ho Hospital

低氧調控多型性神經膠母細胞瘤遷移與侵襲之研究

Wang, W. (PI)

3/1/15 → 2/29/16

Project: C - Project of Alliance › o - Chi Mei Medical Center

使用超音波導引腹橫肌平面神經阻斷術於減重手術後之止痛作用

Tam, K.-W. (PI)

3/1/15 → 6/30/16

Project: C - Project of Alliance › o - Chi Mei Medical Center

In vitro, ex vivo and clinical characterization of novel Salmonella virulence genes

Fang, S.-B. (PI) & Huang, M.-T. (CoI)

1/1/15 → 12/31/15

Project: A - Government Institution › a - National Health Research Institutes

Promoting and Establishing Technology Exchange of Evidence-Based Medicine and Knowledge Sharing of Electronic Database in Taiwan

Chen, C. (PI), Tam, K.-W. (CoI), Chen, K.-H. (CoI), Hou, W.-H. (CoI) & Bai, C.-H. (CoI)

1/1/15 → 12/31/15

Project: A - Government Institution › c - Ministry of Health and Welfare

Dissected the Role of Glucosed-Regulated Portein 78 in the Progression, Metastasis and Therapy of Colorectal Cancer

Wei, P.-L. (PI)

8/1/14 → 7/31/15

Project: A - Government Institution › b - National Science and Technology Council

Study the Function and Regulation of miRNAs in Pancreatic Cancer Progression (I)

Huang, M.-T. (PI)

8/1/14 → 7/31/15

Project: A - Government Institution › b - National Science and Technology Council

Determined the Role and the Mechanims of GRP94 in Mediating the Progression and Therapeutic Responses of HCC

Huang, M.-T. (PI)

8/1/14 → 7/31/15

Project: A - Government Institution › b - National Science and Technology Council

乳癌是目前世界上女性癌症病患中為數最多的癌症之ㄧ。腺病毒蛋白type 5 E1A (E1A)和許多抗腫瘤作用有關，曾於多種癌症如乳癌、卵巢癌及頭頸癌之病患進行臨床基因治療試驗。許多的研究指出E1A具有多項抗腫瘤的功能，包括抑制腫瘤的發生、增加腫瘤細胞對於化療藥物的感受性以及減少腫瘤轉移的現象。腫瘤的轉移對於癌症患者的死亡率有極大的影響當然也包括了乳癌的患者。E1A於抑制腫瘤發展的過程中具有多重生物學上的意義，這也促使我們想要釐清E1A抑制癌症的機制。因此，我們對於了解E1A抑制癌症轉移相關的分子機制感到有興趣，並期望藉以作為未來改進乳癌病人臨床試驗的基石。我們初步的實驗結果顯示，E1A可以有效的抑制Glucose-regulated protein 78 (GRP78)這種已被廣泛報導和腫瘤惡化及轉移相關的蛋白的表現。提出此研究計劃之目的在於詳細探討E1A所造成的抑制癌轉移作用中，GRP78所扮演的生物功能及其調控的機轉。為了達到此目的，我們將著重於E1A如何調控GRP78表現並進而展現對乳癌轉移的抑制作用。以下為此項研究計畫的四大主要目標：目標一：探討GRP78在E1A所抑制之癌細胞移行及侵入作用中所扮演的角色目標二：研究E1A抑制GRP78表現之分子機轉目標三：於動物模式中驗證GRP78的表現對於E1A抗腫瘤作用的影響目標四：探討GRP78及其相關分子的表現在乳癌病人的臨床重要性完成以上的主要目標能夠幫助我們對於E1A之抗腫瘤轉移作用建立更加詳細的分子訊息傳遞機制。另外，藉由此研究計畫的新發現也許可以對未來發展癌症治療上提供更多具有潛力的標的物。

Wang, W. (PI)

8/1/14 → 7/31/15

Project: A - Government Institution › b - National Science and Technology Council

榖胱甘月太硫轉移酉每參與乳癌致癌之分子機制探討(3/3)

Wu, C.-H. (PI)

8/1/14 → 7/31/15

Project: A - Government Institution › b - National Science and Technology Council

Establish the Research Platform for Studying Triple-Negative Breast Tumor Microenvironment Regulation: the Hyaluronan Synthase-3 Mediated Antitumor Effects as an Example.

Ho, Y.-S. (PI) & Wu, C.-H. (CoI)

8/1/14 → 7/31/15

Project: A - Government Institution › b - National Science and Technology Council

Tetrac於初代大腸癌細胞中強化白藜蘆醇誘導之

Chang, T.-C. (PI)

6/1/14 → 5/31/15

Project: C - Project of Alliance › u - Taipei Medical University Shuang Ho Hospital

Development of Novel Therapeutic Agents for Breast Cancer through Targeting Nicotinic Acetylcholine Receptors.

Wu, C.-H. (PI), Ho, Y.-S. (CoI) & Lee, C.-H. (CoI)

5/1/14 → 7/30/15

Project: A - Government Institution › c - Ministry of Health and Welfare

經表皮塗抹硝酸甘油軟膏於痔瘡切除術後之止痛作用

Tam, K.-W. (PI)

3/1/14 → 10/31/15

Project: C - Project of Alliance › s - Shin Kong Wu Ho-Su Memorial Hospital

Honokiol與temozolomide用於治療多型性神經膠母細胞瘤之研究

Wang, W. (PI)

3/1/14 → 2/28/15

Project: C - Project of Alliance › o - Chi Mei Medical Center

提升臨床試驗創新及競爭力計畫

Yen, Y. (PI), Chen, T.-W. (CoI), Lee, F.-P. (CoI), Wu, C.-H. (CoI) & Whang-Peng, J. (CoI)

2/27/14 → 12/31/14

Project: A - Government Institution › c - Ministry of Health and Welfare

In vitro, ex vivo and clinical characterization of novel Salmonella virulence genes

Fang, S.-B. (PI) & Huang, M.-T. (CoI)

1/1/14 → 12/31/14

Project: A - Government Institution › a - National Health Research Institutes

外科系醫學(一)學門規劃研究推動計畫

Wu, C.-H. (PI)

1/1/14 → 12/31/14

Project: A - Government Institution › b - National Science and Technology Council

TMU102-AE1-B10

Tam, K.-W. (PI)

10/1/13 → 3/31/15

Project: C - Project of Alliance › p - Taipei Medical University Hospital

Study the Role of GRP78 in E1A-Mediated Metastasis Suppression of Breast Cancer

Wang, W. (PI)

8/1/13 → 7/31/14

Project: A - Government Institution › b - National Science and Technology Council

Studies on the carcinogenic mechanisms of histamine N-methyltransferase-mediated breast cancer formation

Wu, C.-H. (PI)

8/1/13 → 7/31/14

Project: A - Government Institution › b - National Science and Technology Council

Study the role of the endoplasmic reticulum stress related proteins, Glycoprotein 96(GP96), in liver cancer progression and metastasis and the clinically therapeutic implication

Huang, M.-T. (PI)

8/1/13 → 7/31/14

Project: A - Government Institution › b - National Science and Technology Council

Dissected the role of Glucosed-regulated portein 78 in the progression, metastasis and therapy of colorectal cancer

Wei, P.-L. (PI)

8/1/13 → 7/31/14

Project: A - Government Institution › b - National Science and Technology Council

榖胱甘月太硫轉移酉每參與乳癌致癌之分子機制探討(2/3)

Wu, C.-H. (PI)

8/1/13 → 7/31/14

Project: A - Government Institution › b - National Science and Technology Council

Beta-catenin在乳癌化學治療之角色的研究

Huang, M.-T. (PI)

5/1/13 → 4/30/14

Project: C - Project of Alliance › u - Taipei Medical University Shuang Ho Hospital

探討antimycin A 在抗輻射性肝癌幹細胞之功效

Chang, T.-C. (PI)

5/1/13 → 4/30/14

Project: C - Project of Alliance › u - Taipei Medical University Shuang Ho Hospital

探討honokiol和temozolomide對多型性神經膠母細胞瘤可能具有的治療作用

Wang, W. (PI)

3/1/13 → 2/28/14

Project: C - Project of Alliance › o - Chi Mei Medical Center

外科系醫學(一)學門規劃研究推動計畫

Wu, C.-H. (PI)

1/1/13 → 12/31/13

Project: A - Government Institution › b - National Science and Technology Council

探討尼古丁接受器在胃癌化學治療上的角色及其作用機制

Wang, W. (PI)

1/1/13 → 12/31/13

Project: B - Project of TMU › i - Other (Funded by TMU)

Study the Role of the Endoplasmic Reticulum Stress Related Proteins, Glycoprotein 96(Gp96), in Liver Cancer Progression and Metastasis and the Clinically Therapeutic Implication

Huang, M.-T. (PI)

8/1/12 → 7/31/13

Project: A - Government Institution › b - National Science and Technology Council

榖胱甘月太硫轉移酉每參與乳癌致癌之分子機制探討(1/3)

Wu, C.-H. (PI)

8/1/12 → 7/31/13

Project: A - Government Institution › b - National Science and Technology Council

Studies on the Carcinogenic Mechanisms of Histamine N-Methyltransferase-Mediated Breast Cancer Formation

Wu, C.-H. (PI)

8/1/12 → 7/31/13

Project: A - Government Institution › b - National Science and Technology Council

第四型類鐸接受器在大腸直腸癌化學治療效果上的角色及其作用機制探討

Huang, M.-T. (PI)

5/1/12 → 4/30/13

Project: C - Project of Alliance › p - Taipei Medical University Hospital

Development of Novel Therapeutic Agents for Breast Cancer through Targeting Nicotinic Acetylcholine Receptors.

Wu, C.-H. (PI), Ho, Y.-S. (CoI) & Lee, C.-H. (CoI)

5/1/12 → 4/30/13

Project: A - Government Institution › c - Ministry of Health and Welfare

人類凝血脢調節素在乳癌上診斷及治療上的意義

Huang, M.-T. (PI)

5/1/12 → 4/30/13

Project: C - Project of Alliance › u - Taipei Medical University Shuang Ho Hospital

Dexmedetomidine應用於保護小鼠腦神經免於腦創傷危害之研究

Wang, W. (PI)

3/1/12 → 2/28/13

Project: C - Project of Alliance › o - Chi Mei Medical Center

探討尼古丁接受器在胃癌化學治療上的角色及其作用機制

Wang, W. (PI)

1/1/12 → 12/31/12

Project: B - Project of TMU › i - Other (Funded by TMU)

外科系醫學(一)學門規劃研究推動計畫

Wu, C.-H. (PI)

1/1/12 → 12/31/12

Project: A - Government Institution › b - National Science and Technology Council

Studies on the Carcinogenic Mechanisms of Histamine N-Methyltransferase-Mediated Breast Cancer Formation

Wu, C.-H. (PI) & Ho, Y.-S. (CoI)

8/1/11 → 7/31/12

Project: A - Government Institution › b - National Science and Technology Council

Studies on the Mechanisms of a9-Nicotinic Acetylcholine Receptor Confers Tamoxifen-Induced Drug Resistance in Human Breast Cancer Cells

Ho, Y.-S. (PI) & Wu, C.-H. (CoI)

8/1/11 → 7/31/12

Project: A - Government Institution › b - National Science and Technology Council

Studies on the Mechanisms of A9-Nicotinic Acetylcholine Receptor Confers Tamoxifen-Induced Drug Resistance in Human Breast Cancer Cells

Ho, Y.-S. (PI) & Wu, C.-H. (CoI)

8/1/10 → 7/31/11

Project: A - Government Institution › b - National Science and Technology Council

Studies on the Mechanisms of Apple Polyphenol (Phloretin)-Induced Apoptosis in Human Breast Cancer Cells

Wu, C.-H. (PI) & Ho, Y.-S. (CoI)

8/1/10 → 7/31/11

Project: A - Government Institution › b - National Science and Technology Council

Division of General Surgery

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